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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Zhu Y et al. Aging Cell. (2015)

Role of the Intestinal Microbiome in Cholestatic Liver Disease. LaRusso NF et al. Dig Dis. (2017)

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice. Guicciardi ME et al. J Hepatol. (2018)

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Items: 1 to 50 of 54


The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.

O'Hara SP, Splinter PL, Trussoni CE, Guicciardi E, Splinter NP, Al Suraih MS, Nasser-Ghodsi N, Stollenwerk D, Gores GJ, LaRusso NF.

J Biol Chem. 2019 Oct 28. pii: jbc.RA119.010176. doi: 10.1074/jbc.RA119.010176. [Epub ahead of print]


The Gut-Liver Axis in Primary Sclerosing Cholangitis: Are Pathobionts the Missing Link?

O'Hara SP, LaRusso NF.

Hepatology. 2019 Sep;70(3):1058-1060. doi: 10.1002/hep.30673. Epub 2019 May 23. No abstract available.


Metabolomic Profiling of Portal Blood and Bile Reveals Metabolic Signatures of Primary Sclerosing Cholangitis.

Tietz-Bogert PS, Kim M, Cheung A, Tabibian JH, Heimbach JK, Rosen CB, Nandakumar M, Lazaridis KN, LaRusso NF, Sung J, O'Hara SP.

Int J Mol Sci. 2018 Oct 16;19(10). pii: E3188. doi: 10.3390/ijms19103188.


Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.

Guicciardi ME, Trussoni CE, Krishnan A, Bronk SF, Lorenzo Pisarello MJ, O'Hara SP, Splinter PL, Gao Y, Vig P, Revzin A, LaRusso NF, Gores GJ.

J Hepatol. 2018 Sep;69(3):676-686. doi: 10.1016/j.jhep.2018.05.018. Epub 2018 May 24.


Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.

Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC.

Hepatology. 2018 Jan;67(1):247-259. doi: 10.1002/hep.29464. Epub 2017 Nov 29.


Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link?

O'Hara SP, Karlsen TH, LaRusso NF.

Gut. 2017 Nov;66(11):1873-1877. doi: 10.1136/gutjnl-2017-314249. Epub 2017 Jul 21. No abstract available.


Cellular senescence, neuropeptides and hepatic fibrosis: Additional insights into increasing complexity.

O'Hara SP, La Russo NF.

Hepatology. 2017 Aug;66(2):318-320. doi: 10.1002/hep.29243. Epub 2017 Jun 24. No abstract available.


Role of the Intestinal Microbiome in Cholestatic Liver Disease.

LaRusso NF, Tabibian JH, O'Hara SP.

Dig Dis. 2017;35(3):166-168. doi: 10.1159/000450906. Epub 2017 Mar 1. Review.


ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A.

O'Hara SP, Splinter PL, Trussoni CE, Pisarello MJ, Loarca L, Splinter NS, Schutte BF, LaRusso NF.

J Biol Chem. 2017 Mar 24;292(12):4833-4846. doi: 10.1074/jbc.M117.777409. Epub 2017 Feb 8.


The enteric microbiome in hepatobiliary health and disease.

Tabibian JH, Varghese C, LaRusso NF, O'Hara SP.

Liver Int. 2016 Apr;36(4):480-7. doi: 10.1111/liv.13009. Epub 2015 Dec 12. Review.


Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes.

De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC.

Lab Invest. 2015 Oct;95(10):1218. doi: 10.1038/labinvest.2015.99. No abstract available.


Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis.

Tabibian JH, O'Hara SP, Trussoni CE, Tietz PS, Splinter PL, Mounajjed T, Hagey LR, LaRusso NF.

Hepatology. 2016 Jan;63(1):185-96. doi: 10.1002/hep.27927. Epub 2015 Aug 10.


Lipopolysaccharide (LPS)-Induced Biliary Epithelial Cell NRas Activation Requires Epidermal Growth Factor Receptor (EGFR).

Trussoni CE, Tabibian JH, Splinter PL, O'Hara SP.

PLoS One. 2015 Apr 27;10(4):e0125793. doi: 10.1371/journal.pone.0125793. eCollection 2015.


Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes.

De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC.

Lab Invest. 2015 Jun;95(6):684-96. doi: 10.1038/labinvest.2015.51. Epub 2015 Apr 13. Erratum in: Lab Invest. 2015 Oct;95(10):1218.


Microbiome-Immune Interactions and Liver Disease.

Tabibian JH, Varghese C, O'Hara SP, LaRusso NF.

Clin Liver Dis (Hoboken). 2015 Apr;5(4):83-85. doi: 10.1002/cld.453. Epub 2015 May 7. No abstract available.


The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL.

Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22.


MicroRNAs and benign biliary tract diseases.

Gradilone SA, O'Hara SP, Masyuk TV, Pisarello MJ, LaRusso NF.

Semin Liver Dis. 2015 Feb;35(1):26-35. doi: 10.1055/s-0034-1397346. Epub 2015 Jan 29. Review.


MicroRNAs in Cholangiopathies.

O'Hara SP, Gradilone SA, Masyuk TV, Tabibian JH, LaRusso NF.

Curr Pathobiol Rep. 2014 Sep 1;2(3):133-142.


Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis.

Tabibian JH, Trussoni CE, O'Hara SP, Splinter PL, Heimbach JK, LaRusso NF.

Lab Invest. 2014 Oct;94(10):1126-33. doi: 10.1038/labinvest.2014.94. Epub 2014 Jul 21.


Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies.

Tabibian JH, O'Hara SP, Lindor KD.

Scand J Gastroenterol. 2014 Aug;49(8):901-8. doi: 10.3109/00365521.2014.913189. Epub 2014 Jul 3. Review.


Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis.

Tabibian JH, O'Hara SP, Splinter PL, Trussoni CE, LaRusso NF.

Hepatology. 2014 Jun;59(6):2263-75. doi: 10.1002/hep.26993. Epub 2014 Apr 25.


Physiology of cholangiocytes.

Tabibian JH, Masyuk AI, Masyuk TV, O'Hara SP, LaRusso NF.

Compr Physiol. 2013 Jan;3(1):541-65. doi: 10.1002/cphy.c120019. Review.


Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography.

Tabibian JH, Macura SI, O'Hara SP, Fidler JL, Glockner JF, Takahashi N, Lowe VJ, Kemp BJ, Mishra PK, Tietz PS, Splinter PL, Trussoni CE, LaRusso NF.

Lab Invest. 2013 Jun;93(6):733-43. doi: 10.1038/labinvest.2013.52. Epub 2013 Apr 15.


The dynamic biliary epithelia: molecules, pathways, and disease.

O'Hara SP, Tabibian JH, Splinter PL, LaRusso NF.

J Hepatol. 2013 Mar;58(3):575-82. doi: 10.1016/j.jhep.2012.10.011. Epub 2012 Oct 17. Review.


(Z)-(2-bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis.

Woerly EM, Struble JR, Palyam N, O'Hara SP, Burke MD.

Tetrahedron. 2011 Jun 17;67(24):4333-4343. No abstract available.


Primary sclerosing cholangitis: the gut-liver axis.

Tabibian JH, O'Hara SP, Larusso NF.

Clin Gastroenterol Hepatol. 2012 Jul;10(7):819; author reply 819-20. doi: 10.1016/j.cgh.2012.01.024. Epub 2012 Feb 15. No abstract available.


Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation.

O'Hara SP, Splinter PL, Trussoni CE, Gajdos GB, Lineswala PN, LaRusso NF.

J Biol Chem. 2011 Sep 2;286(35):30352-60. doi: 10.1074/jbc.M111.269464. Epub 2011 Jul 13.


MicroRNA regulation of innate immune responses in epithelial cells.

Zhou R, O'Hara SP, Chen XM.

Cell Mol Immunol. 2011 Sep;8(5):371-9. doi: 10.1038/cmi.2011.19. Epub 2011 Jul 4. Review.


TLR4 promotes Cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis.

O'Hara SP, Bogert PS, Trussoni CE, Chen X, LaRusso NF.

J Parasitol. 2011 Oct;97(5):813-21. doi: 10.1645/GE-2703.1. Epub 2011 Mar 23.


The cell biology of cryptosporidium infection.

O'Hara SP, Chen XM.

Microbes Infect. 2011 Aug;13(8-9):721-30. doi: 10.1016/j.micinf.2011.03.008. Epub 2011 Mar 31. Review.


Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte.

Ninlawan K, O'Hara SP, Splinter PL, Yongvanit P, Kaewkes S, Surapaitoon A, LaRusso NF, Sripa B.

Parasitol Int. 2010 Dec;59(4):616-21. doi: 10.1016/j.parint.2010.09.008. Epub 2010 Sep 29.


Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver.

Jagavelu K, Routray C, Shergill U, O'Hara SP, Faubion W, Shah VH.

Hepatology. 2010 Aug;52(2):590-601. doi: 10.1002/hep.23739.


Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization.

O'Hara SP, Gajdos GB, Trussoni CE, Splinter PL, LaRusso NF.

Infect Immun. 2010 Jul;78(7):2927-36. doi: 10.1128/IAI.00077-10. Epub 2010 May 10.


NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection.

O'Hara SP, Splinter PL, Gajdos GB, Trussoni CE, Fernandez-Zapico ME, Chen XM, LaRusso NF.

J Biol Chem. 2010 Jan 1;285(1):216-25. doi: 10.1074/jbc.M109.041640. Epub 2009 Nov 10.


HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum.

O'Hara SP, Small AJ, Gajdos GB, Badley AD, Chen XM, Larusso NF.

J Infect Dis. 2009 Apr 15;199(8):1195-204. doi: 10.1086/597387.


MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes.

Gong AY, Zhou R, Hu G, Li X, Splinter PL, O'Hara SP, LaRusso NF, Soukup GA, Dong H, Chen XM.

J Immunol. 2009 Feb 1;182(3):1325-33.


MicroRNAs: key modulators of posttranscriptional gene expression.

O'Hara SP, Mott JL, Splinter PL, Gores GJ, LaRusso NF.

Gastroenterology. 2009 Jan;136(1):17-25. doi: 10.1053/j.gastro.2008.11.028. Epub 2008 Dec 3. Review. No abstract available.


Host cell actin remodeling in response to Cryptosporidium.

O'Hara SP, Small AJ, Chen XM, LaRusso NF.

Subcell Biochem. 2008;47:92-100. Review.


The immunobiology of cholangiocytes.

Chen XM, O'Hara SP, LaRusso NF.

Immunol Cell Biol. 2008 Aug-Sep;86(6):497-505. doi: 10.1038/icb.2008.37. Epub 2008 May 27. Review.


The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism.

O'Hara SP, Small AJ, Nelson JB, Badley AD, Chen XM, Gores GJ, Larusso NF.

Infect Immun. 2007 Feb;75(2):684-96. Epub 2006 Nov 21.


Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains.

Nelson JB, O'Hara SP, Small AJ, Tietz PS, Choudhury AK, Pagano RE, Chen XM, LaRusso NF.

Cell Microbiol. 2006 Dec;8(12):1932-45. Epub 2006 Jul 18.


Accumulation of tropomyosin isoform 5 at the infection sites of host cells during Cryptosporidium invasion.

O'Hara SP, Lin JJ.

Parasitol Res. 2006 Jun;99(1):45-54. Epub 2006 Feb 15.


Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB.

Chen XM, O'Hara SP, Nelson JB, Splinter PL, Small AJ, Tietz PS, Limper AH, LaRusso NF.

J Immunol. 2005 Dec 1;175(11):7447-56.


Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion.

Chen XM, O'Hara SP, Huang BQ, Splinter PL, Nelson JB, LaRusso NF.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6338-43. Epub 2005 Apr 25.


Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion.

Chen XM, O'Hara SP, Huang BQ, Nelson JB, Lin JJ, Zhu G, Ward HD, LaRusso NF.

Infect Immun. 2004 Dec;72(12):6806-16.


A novel Cryptosporidium parvum antigen, CP2, preferentially associates with membranous structures.

O'Hara SP, Yu JR, Lin JJ.

Parasitol Res. 2004 Mar;92(4):317-27. Epub 2004 Jan 16.


A common oocyst surface antigen of Cryptosporidium recognized by monoclonal antibodies.

Yu JR, O'Hara SP, Lin JL, Dailey ME, Cain G, Lin JL.

Parasitol Res. 2002 May;88(5):412-20.


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