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Items: 22

1.

Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA.

Kim SC, O'Flaherty DK, Zhou L, Lelyveld VS, Szostak JW.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13318-13323. doi: 10.1073/pnas.1814367115. Epub 2018 Dec 3.

2.

Covalent capture of OGT's active site using engineered human-E. coli chimera and intrastrand DNA cross-links.

Copp W, O'Flaherty DK, Wilds CJ.

Org Biomol Chem. 2018 Nov 28;16(46):9053-9058. doi: 10.1039/c8ob02453g.

PMID:
30430154
3.

A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying.

Giurgiu C, Wright TH, O'Flaherty DK, Szostak JW.

Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9844-9848. doi: 10.1002/anie.201805785. Epub 2018 Jul 6.

PMID:
29939457
4.

Copying of Mixed-Sequence RNA Templates inside Model Protocells.

O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW.

J Am Chem Soc. 2018 Apr 18;140(15):5171-5178. doi: 10.1021/jacs.8b00639. Epub 2018 Apr 9.

5.

O4 -Alkylated-2-Deoxyuridine Repair by O6 -Alkylguanine DNA Alkyltransferase is Augmented by a C5-Fluorine Modification.

Sacre L, O'Flaherty DK, Archambault P, Copp W, Peslherbe GH, Muchall HM, Wilds CJ.

Chembiochem. 2018 Mar 16;19(6):575-582. doi: 10.1002/cbic.201700660. Epub 2018 Feb 12.

PMID:
29243336
6.

Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein.

Schoonhoven NM, O'Flaherty DK, McManus FP, Sacre L, Noronha AM, Kornblatt MJ, Wilds CJ.

Molecules. 2017 Nov 11;22(11). pii: E1948. doi: 10.3390/molecules22111948.

7.

A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension.

Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW.

J Am Chem Soc. 2017 Nov 22;139(46):16741-16747. doi: 10.1021/jacs.7b08784. Epub 2017 Nov 7.

8.

AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker.

O'Flaherty DK, Wilds CJ.

Chembiochem. 2017 Dec 5;18(23):2351-2357. doi: 10.1002/cbic.201700450. Epub 2017 Nov 7.

PMID:
28980757
9.

Structural basis of interstrand cross-link repair by O6-alkylguanine DNA alkyltransferase.

Denisov AY, McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ.

Org Biomol Chem. 2017 Oct 11;15(39):8361-8370. doi: 10.1039/c7ob02093g.

PMID:
28937154
10.

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides.

Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW.

J Am Chem Soc. 2017 Feb 8;139(5):1810-1813. doi: 10.1021/jacs.6b13148. Epub 2017 Jan 24.

11.
12.

O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.

Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L.

Chem Res Toxicol. 2016 Nov 21;29(11):1872-1882. Epub 2016 Nov 4.

13.

Preparation of Intrastrand {G}O(6) -Alkylene-O(6) {G} Cross-Linked Oligonucleotides.

O'Flaherty DK, Wilds CJ.

Curr Protoc Nucleic Acid Chem. 2016 Sep 1;66:5.17.1-5.17.24. doi: 10.1002/cpnc.14.

PMID:
27584704
14.

Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η.

O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ.

Chem Sci. 2016 Aug 1;7(8):4896-4904. Epub 2016 Apr 26.

15.

O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.

O'Flaherty DK, Wilds CJ.

Chem Asian J. 2016 Feb 18;11(4):576-83. doi: 10.1002/asia.201501253. Epub 2016 Jan 13.

PMID:
26692563
16.

Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA.

O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ.

Biochemistry. 2015 Dec 29;54(51):7449-56. doi: 10.1021/acs.biochem.5b01078. Epub 2015 Dec 16.

17.

Synthesis, Characterization, and Repair of a Flexible O(6) -2'-Deoxyguanosine-alkylene-O(6) -2'-deoxyguanosine Intrastrand Cross-Link.

O'Flaherty DK, Wilds CJ.

Chemistry. 2015 Jul 13;21(29):10522-9. doi: 10.1002/chem.201501103. Epub 2015 Jun 15.

PMID:
26075346
18.

Synthesis of building blocks and oligonucleotides containing {T}O4-alkylene-O4{T} interstrand cross-links.

O'Flaherty DK, McManus FP, Noronha AM, Wilds CJ.

Curr Protoc Nucleic Acid Chem. 2014 Dec 19;55:5.13.1-19. doi: 10.1002/0471142700.nc0513s55. Review.

PMID:
25631535
19.

Steady-state kinetic analysis of DNA polymerase single-nucleotide incorporation products.

O'Flaherty DK, Guengerich FP.

Curr Protoc Nucleic Acid Chem. 2014 Dec 12;59:7.21.1-13. doi: 10.1002/0471142700.nc0721s59. Review.

20.

NMR structure of an ethylene interstrand cross-linked DNA which mimics the lesion formed by 1,3-bis(2-chloroethyl)-1-nitrosourea.

O'Flaherty DK, Denisov AY, Noronha AM, Wilds CJ.

ChemMedChem. 2014 Sep;9(9):2099-103. doi: 10.1002/cmdc.201402121. Epub 2014 Jun 16.

PMID:
24931822
21.

O4-alkyl-2'-deoxythymidine cross-linked DNA to probe recognition and repair by O6-alkylguanine DNA alkyltransferases.

McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ.

Org Biomol Chem. 2012 Sep 21;10(35):7078-90. doi: 10.1039/c2ob25705j. Epub 2012 Jul 31.

PMID:
22850722
22.

Synthesis, biophysical and repair studies of O6-2'-deoxyguanosine adducts by Escherichia coli OGT.

Schoonhoven NM, Murphy SP, O'Flaherty DK, Noronha AM, Kornblatt MJ, Wilds CJ.

Nucleic Acids Symp Ser (Oxf). 2008;(52):449-50. doi: 10.1093/nass/nrn228.

PMID:
18776447

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