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Preface. O'Connor SE et al. Methods Enzymol. (2016)

Engineering of Secondary Metabolism. O'Connor SE et al. Annu Rev Genet. (2015)

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Caputi L et al. Science. (2018)

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Items: 1 to 50 of 180


The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics.

Yamamoto K, Takahashi K, Caputi L, Mizuno H, Rodriguez-Lopez CE, Iwasaki T, Ishizaki K, Fukaki H, Ohnishi M, Yamazaki M, Masujima T, O'Connor SE, Mimura T.

New Phytol. 2019 Oct;224(2):848-859. doi: 10.1111/nph.16138. Epub 2019 Sep 20.


Biosynthesis of an Anti-Addiction Agent from the Iboga Plant.

Farrow SC, Kamileen MO, Caputi L, Bussey K, Mundy JEA, McAtee RC, Stephenson CRJ, O'Connor SE.

J Am Chem Soc. 2019 Aug 21;141(33):12979-12983. doi: 10.1021/jacs.9b05999. Epub 2019 Aug 6.


Biocatalytic Strategies towards [4+2] Cycloadditions.

Lichman BR, O'Connor SE, Kries H.

Chemistry. 2019 May 17;25(28):6864-6877. doi: 10.1002/chem.201805412. Epub 2019 Mar 12. Review.


Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.

Lichman BR, Kamileen MO, Titchiner GR, Saalbach G, Stevenson CEM, Lawson DM, O'Connor SE.

Nat Chem Biol. 2019 Jan;15(1):71-79. doi: 10.1038/s41589-018-0185-2. Epub 2018 Dec 10.


Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis.

Franke J, Kim J, Hamilton JP, Zhao D, Pham GM, Wiegert-Rininger K, Crisovan E, Newton L, Vaillancourt B, Tatsis E, Buell CR, O'Connor SE.

Chembiochem. 2019 Jan 2;20(1):83-87. doi: 10.1002/cbic.201800592. Epub 2018 Nov 13.


Corrigendum to biocatalysts from alkaloid producing plants [Biocatalysts from alkaloid producing plants 31 (2016) 22-30].

Kries H, O'Connor SE.

Curr Opin Chem Biol. 2018 Jun;44:110. doi: 10.1016/j.cbpa.2018.07.007. No abstract available.


Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga.

Farrow SC, Kamileen MO, Meades J, Ameyaw B, Xiao Y, O'Connor SE.

J Biol Chem. 2018 Sep 7;293(36):13821-13833. doi: 10.1074/jbc.RA118.004060. Epub 2018 Jul 20.


Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes.

Dang TT, Franke J, Carqueijeiro IST, Langley C, Courdavault V, O'Connor SE.

Nat Chem Biol. 2018 Aug;14(8):760-763. doi: 10.1038/s41589-018-0078-4. Epub 2018 Jun 25.


Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus.

Carqueijeiro I, Brown S, Chung K, Dang TT, Walia M, Besseau S, Dugé de Bernonville T, Oudin A, Lanoue A, Billet K, Munsch T, Koudounas K, Melin C, Godon C, Razafimandimby B, de Craene JO, Glévarec G, Marc J, Giglioli-Guivarc'h N, Clastre M, St-Pierre B, Papon N, Andrade RB, O'Connor SE, Courdavault V.

Plant Physiol. 2018 Aug;177(4):1473-1486. doi: 10.1104/pp.18.00549. Epub 2018 Jun 22.


Vacuole-Targeted Proteins: Ins and Outs of Subcellular Localization Studies.

Carqueijeiro I, Sepúlveda LJ, Mosquera A, Payne R, Corbin C, Papon N, de Bernonville TD, Besseau S, Lanoue A, Glévarec G, Clastre M, St-Pierre B, Atehortùa L, Giglioli-Guivarc'h N, O'Connor SE, Oudin A, Courdavault V.

Methods Mol Biol. 2018;1789:33-54. doi: 10.1007/978-1-4939-7856-4_4.


Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.

Caputi L, Franke J, Farrow SC, Chung K, Payne RME, Nguyen TD, Dang TT, Soares Teto Carqueijeiro I, Koudounas K, Dugé de Bernonville T, Ameyaw B, Jones DM, Vieira IJC, Courdavault V, O'Connor SE.

Science. 2018 Jun 15;360(6394):1235-1239. doi: 10.1126/science.aat4100. Epub 2018 May 3.


A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids.

Carqueijeiro I, Dugé de Bernonville T, Lanoue A, Dang TT, Teijaro CN, Paetz C, Billet K, Mosquera A, Oudin A, Besseau S, Papon N, Glévarec G, Atehortùa L, Clastre M, Giglioli-Guivarc'h N, Schneider B, St-Pierre B, Andrade RB, O'Connor SE, Courdavault V.

Plant J. 2018 May;94(3):469-484. doi: 10.1111/tpj.13868. Epub 2018 Mar 27.


Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid.

Stavrinides AK, Tatsis EC, Dang TT, Caputi L, Stevenson CEM, Lawson DM, Schneider B, O'Connor SE.

Chembiochem. 2018 May 4;19(9):940-948. doi: 10.1002/cbic.201700621. Epub 2018 Mar 22.


Raising the BAR of specificity.

O'Connor SE.

Nat Plants. 2017 Dec;3(12):924-925. doi: 10.1038/s41477-017-0074-9. No abstract available.


Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry.

Sherden NH, Lichman B, Caputi L, Zhao D, Kamileen MO, Buell CR, O'Connor SE.

Phytochemistry. 2018 Jan;145:48-56. doi: 10.1016/j.phytochem.2017.10.004. Epub 2017 Nov 5.


Identification of Iridoid Glucoside Transporters in Catharanthus roseus.

Larsen B, Fuller VL, Pollier J, Van Moerkercke A, Schweizer F, Payne R, Colinas M, O'Connor SE, Goossens A, Halkier BA.

Plant Cell Physiol. 2017 Sep 1;58(9):1507-1518. doi: 10.1093/pcp/pcx097.


A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate.

Tatsis EC, Carqueijeiro I, Dugé de Bernonville T, Franke J, Dang TT, Oudin A, Lanoue A, Lafontaine F, Stavrinides AK, Clastre M, Courdavault V, O'Connor SE.

Nat Commun. 2017 Aug 22;8(1):316. doi: 10.1038/s41467-017-00154-x.


Inverted stereocontrol of iridoid synthase in snapdragon.

Kries H, Kellner F, Kamileen MO, O'Connor SE.

J Biol Chem. 2017 Sep 1;292(35):14659-14667. doi: 10.1074/jbc.M117.800979. Epub 2017 Jul 12.


Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentina.

Dang TT, Franke J, Tatsis E, O'Connor SE.

Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9440-9444. doi: 10.1002/anie.201705010. Epub 2017 Jul 12.


Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species.

Leisner CP, Kamileen MO, Conway ME, O'Connor SE, Buell CR.

PLoS One. 2017 Jun 13;12(6):e0179417. doi: 10.1371/journal.pone.0179417. eCollection 2017.


Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses.

Dugé de Bernonville T, Carqueijeiro I, Lanoue A, Lafontaine F, Sánchez Bel P, Liesecke F, Musset K, Oudin A, Glévarec G, Pichon O, Besseau S, Clastre M, St-Pierre B, Flors V, Maury S, Huguet E, O'Connor SE, Courdavault V.

Sci Rep. 2017 Jan 17;7:40453. doi: 10.1038/srep40453.


An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.

Payne RM, Xu D, Foureau E, Teto Carqueijeiro MI, Oudin A, Bernonville TD, Novak V, Burow M, Olsen CE, Jones DM, Tatsis EC, Pendle A, Ann Halkier B, Geu-Flores F, Courdavault V, Nour-Eldin HH, O'Connor SE.

Nat Plants. 2017 Jan 13;3:16208. doi: 10.1038/nplants.2016.208.


Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis.

Jakubczyk D, Caputi L, Stevenson CE, Lawson DM, O'Connor SE.

Chem Commun (Camb). 2016 Dec 6;52(99):14306-14309.


Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids.

Parage C, Foureau E, Kellner F, Burlat V, Mahroug S, Lanoue A, Dugé de Bernonville T, Londono MA, Carqueijeiro I, Oudin A, Besseau S, Papon N, Glévarec G, Atehortùa L, Giglioli-Guivarc'h N, St-Pierre B, Clastre M, O'Connor SE, Courdavault V.

Plant Physiol. 2016 Nov;172(3):1563-1577. Epub 2016 Sep 29.



O'Connor SE.

Methods Enzymol. 2016;576:xvii-xviii. doi: 10.1016/S0076-6879(16)30186-0. No abstract available.


Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.

Stavrinides A, Tatsis EC, Caputi L, Foureau E, Stevenson CE, Lawson DM, Courdavault V, O'Connor SE.

Nat Commun. 2016 Jul 15;7:12116. doi: 10.1038/ncomms12116.



O'Connor SE.

Methods Enzymol. 2016;575:xv-xvi. doi: 10.1016/S0076-6879(16)30172-0. No abstract available.


New developments in engineering plant metabolic pathways.

Tatsis EC, O'Connor SE.

Curr Opin Biotechnol. 2016 Dec;42:126-132. doi: 10.1016/j.copbio.2016.04.012. Epub 2016 Apr 29. Review.


Biocatalysts from alkaloid producing plants.

Kries H, O'Connor SE.

Curr Opin Chem Biol. 2016 Apr;31:22-30. doi: 10.1016/j.cbpa.2015.12.006. Epub 2016 Jan 13. Review. Erratum in: Curr Opin Chem Biol. 2018 Jun;44:110.


Identification and Characterization of the Iridoid Synthase Involved in Oleuropein Biosynthesis in Olive (Olea europaea) Fruits.

Alagna F, Geu-Flores F, Kries H, Panara F, Baldoni L, O'Connor SE, Osbourn A.

J Biol Chem. 2016 Mar 11;291(11):5542-54. doi: 10.1074/jbc.M115.701276. Epub 2015 Dec 26.


Structural determinants of reductive terpene cyclization in iridoid biosynthesis.

Kries H, Caputi L, Stevenson CEM, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE.

Nat Chem Biol. 2016 Jan;12(1):6-8. doi: 10.1038/nchembio.1955. Epub 2015 Nov 9.


Engineering of Secondary Metabolism.

O'Connor SE.

Annu Rev Genet. 2015;49:71-94. doi: 10.1146/annurev-genet-120213-092053. Epub 2015 Sep 21. Review.


PLANT BIOCHEMISTRY. Fighting cancer while saving the mayapple.

O'Connor SE.

Science. 2015 Sep 11;349(6253):1167-8. doi: 10.1126/science.aad1801. No abstract available.


Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome.

Dugé de Bernonville T, Foureau E, Parage C, Lanoue A, Clastre M, Londono MA, Oudin A, Houillé B, Papon N, Besseau S, Glévarec G, Atehortùa L, Giglioli-Guivarc'h N, St-Pierre B, De Luca V, O'Connor SE, Courdavault V.

BMC Genomics. 2015 Aug 19;16:619. doi: 10.1186/s12864-015-1678-y.


Halogenase Engineering for the Generation of New Natural Product Analogues.

Brown S, O'Connor SE.

Chembiochem. 2015 Oct 12;16(15):2129-35. doi: 10.1002/cbic.201500338. Epub 2015 Sep 4. Review.


The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus.

Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, Vanden Bossche R, Miettinen K, Espoz J, Purnama PC, Kellner F, Seppänen-Laakso T, O'Connor SE, Rischer H, Memelink J, Goossens A.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8130-5. doi: 10.1073/pnas.1504951112. Epub 2015 Jun 15.


Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway-Enzymatic Formation of a Cyclopropyl Group.

Jakubczyk D, Caputi L, Hatsch A, Nielsen CA, Diefenbacher M, Klein J, Molt A, Schröder H, Cheng JZ, Naesby M, O'Connor SE.

Angew Chem Weinheim Bergstr Ger. 2015 Apr 20;127(17):5206-5210. Epub 2015 Feb 25.


Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids.

Kellner F, Geu-Flores F, Sherden NH, Brown S, Foureau E, Courdavault V, O'Connor SE.

Chem Commun (Camb). 2015 May 4;51(36):7626-8. doi: 10.1039/c5cc01309g.


Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism.

Stavrinides A, Tatsis EC, Foureau E, Caputi L, Kellner F, Courdavault V, O'Connor SE.

Chem Biol. 2015 Mar 19;22(3):336-41. doi: 10.1016/j.chembiol.2015.02.006. Epub 2015 Mar 12.


Genome-guided investigation of plant natural product biosynthesis.

Kellner F, Kim J, Clavijo BJ, Hamilton JP, Childs KL, Vaillancourt B, Cepela J, Habermann M, Steuernagel B, Clissold L, McLay K, Buell CR, O'Connor SE.

Plant J. 2015 May;82(4):680-92. doi: 10.1111/tpj.12827. Epub 2015 Apr 11. Erratum in: Plant J. 2019 May;98(4):760.


Discovery and reconstitution of the cycloclavine biosynthetic pathway--enzymatic formation of a cyclopropyl group.

Jakubczyk D, Caputi L, Hatsch A, Nielsen CA, Diefenbacher M, Klein J, Molt A, Schröder H, Cheng JZ, Naesby M, O'Connor SE.

Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5117-21. doi: 10.1002/anie.201410002. Epub 2015 Feb 25.


De novo production of the plant-derived alkaloid strictosidine in yeast.

Brown S, Clastre M, Courdavault V, O'Connor SE.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3205-10. doi: 10.1073/pnas.1423555112. Epub 2015 Feb 9.


Iridoid synthase activity is common among the plant progesterone 5β-reductase family.

Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Müller-Uri F, Burlat V, O'Connor SE, Memelink J, Kreis W, Goossens A.

Mol Plant. 2015 Jan;8(1):136-52. doi: 10.1016/j.molp.2014.11.005. Epub 2014 Dec 11.


Conversion of substrate analogs suggests a Michael cyclization in iridoid biosynthesis.

Lindner S, Geu-Flores F, Bräse S, Sherden NH, O'Connor SE.

Chem Biol. 2014 Nov 20;21(11):1452-6. doi: 10.1016/j.chembiol.2014.09.010. Epub 2014 Oct 23.


Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family.

Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Müller-Uri F, Burlat V, O'Connor SE, Memelink J, Kreis W, Goossens A.

Mol Plant. 2014 Sep 19. pii: ssu100. [Epub ahead of print]


Biosynthesis of the ergot alkaloids.

Jakubczyk D, Cheng JZ, O'Connor SE.

Nat Prod Rep. 2014 Oct;31(10):1328-38. doi: 10.1039/c4np00062e. Review.


The important ergot alkaloid intermediate chanoclavine-I produced in the yeast Saccharomyces cerevisiae by the combined action of EasC and EasE from Aspergillus japonicus.

Nielsen CA, Folly C, Hatsch A, Molt A, Schröder H, O'Connor SE, Naesby M.

Microb Cell Fact. 2014 Aug 12;13:95. doi: 10.1186/s12934-014-0095-2.


Ketogenic diet for high partial pressure oxygen diving.

Valadao JM, Vigilante JA, DiGeorge NW, O'Connor SE, Bear A, Kenyon J, Annis H, Dituri J, Dituri AE, Whelan HT.

Undersea Hyperb Med. 2014 Jul-Aug;41(4):331-5.


Editorial overview: Growing the future: synthetic biology in plants.

O'Connor SE, Brutnell TP.

Curr Opin Plant Biol. 2014 Jun;19:iv-v. doi: 10.1016/j.pbi.2014.05.005. Epub 2014 May 24. No abstract available.


The ketogenic diet for the treatment of pediatric status epilepticus.

O'Connor SE, Ream MA, Richardson C, Mikati MA, Trescher WH, Byler DL, Sather JD, Michael EH, Urbanik KB, Richards JL, Davis R, Zupanc ML, Zupec-Kania B.

Pediatr Neurol. 2014 Jan;50(1):101-3. doi: 10.1016/j.pediatrneurol.2013.07.020. Epub 2013 Nov 25. Erratum in: Pediatr Neurol. 2014 Aug;51(2):286. Ream, Margie A [added]; Mikati, Mohamad A [added].


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