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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.

Fok JHL, Ramos-Montoya A, Vazquez-Chantada M, Wijnhoven PWG, Follia V, James N, Farrington PM, Karmokar A, Willis SE, Cairns J, Nikkilä J, Beattie D, Lamont GM, Finlay MRV, Wilson J, Smith A, O'Connor LO, Ling S, Fawell SE, O'Connor MJ, Hollingsworth SJ, Dean E, Goldberg FW, Davies BR, Cadogan EB.

Nat Commun. 2019 Nov 7;10(1):5065. doi: 10.1038/s41467-019-12836-9.


Impact and predictors of positive response to desensitization in pediatric heart transplant candidates.

Edwards JJ, Seliktar N, White R, Heron SD, Lin K, Rossano J, Monos D, Sesok-Pizzini D, O'Connor MJ.

J Heart Lung Transplant. 2019 Nov;38(11):1206-1213. doi: 10.1016/j.healun.2019.08.018. Epub 2019 Aug 25.


Deficient Resident Memory T-Cell and Cd8 T-Cell Response to Commensals in Inflammatory Bowel Disease.

Noble A, Durant L, Hoyles L, McCartney AL, Man R, Segal J, Costello SP, Hendy P, Reddi D, Bouri S, Lim DNF, Pring T, O'Connor MJ, Datt P, Wilson A, Arebi N, Akbar A, Hart AL, Carding SR, Knight SC.

J Crohns Colitis. 2019 Oct 26. pii: jjz175. doi: 10.1093/ecco-jcc/jjz175. [Epub ahead of print]


Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically.

Riches LC, Trinidad AG, Hughes G, Jones GN, Hughes AM, Thomason AG, Gavine P, Cui A, Ling S, Stott J, Clark R, Peel S, Gill P, Goodwin LM, Smith A, Pike KG, Barlaam B, Pass M, O'Connor MJ, Smith G, Cadogan EB.

Mol Cancer Ther. 2020 Jan;19(1):13-25. doi: 10.1158/1535-7163.MCT-18-1394. Epub 2019 Sep 18.


Klinefelter Syndrome and Diabetes.

O'Connor MJ, Snyder EA, Hayes FJ.

Curr Diab Rep. 2019 Jul 31;19(9):71. doi: 10.1007/s11892-019-1197-3. Review.


Using association rule mining and ontologies to generate metadata recommendations from multiple biomedical databases.

Martínez-Romero M, O'Connor MJ, Egyedi AL, Willrett D, Hardi J, Graybeal J, Musen MA.

Database (Oxford). 2019 Jan 1;2019. pii: baz059. doi: 10.1093/database/baz059.


Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.

Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB.

Cancer Cell. 2019 Jun 10;35(6):851-867.e7. doi: 10.1016/j.ccell.2019.05.001.


Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress.

Young LA, O'Connor LO, de Renty C, Veldman-Jones MH, Dorval T, Wilson Z, Jones DR, Lawson D, Odedra R, Maya-Mendoza A, Reimer C, Bartek J, Lau A, O'Connor MJ.

Cancer Res. 2019 Jul 15;79(14):3762-3775. doi: 10.1158/0008-5472.CAN-18-2480. Epub 2019 May 23.


Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.

Ordonez LD, Hay T, McEwen R, Polanska UM, Hughes A, Delpuech O, Cadogan E, Powell S, Dry J, Tornillo G, Silcock L, Leo E, O'Connor MJ, Clarke AR, Smalley MJ.

Oncotarget. 2019 Apr 5;10(27):2586-2606. doi: 10.18632/oncotarget.26830. eCollection 2019 Apr 5.


PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells.

Nicolae CM, O'Connor MJ, Schleicher EM, Song C, Gowda R, Robertson G, Dovat S, Moldovan GL.

Oncogene. 2019 Jul;38(27):5530-5540. doi: 10.1038/s41388-019-0810-x. Epub 2019 Apr 9.


Echocardiographic Assessment of Right Ventricular Function in Clinically Well Pediatric Heart Transplantation Patients and Comparison With Normal Control Subjects.

White BR, Katcoff H, Faerber JA, Lin KY, Rossano JW, Mercer-Rosa L, O'Connor MJ.

J Am Soc Echocardiogr. 2019 Apr;32(4):537-544.e3. doi: 10.1016/j.echo.2019.01.015.


Fetal cardiomyopathy in neurofibromatosis type I: Novel phenotype and review of the literature.

Ritter A, Cuddapah S, Degenhardt K, Kasperski S, Johnson MP, O'Connor MJ, Ahrens-Nicklas R.

Am J Med Genet A. 2019 Jun;179(6):1042-1046. doi: 10.1002/ajmg.a.61123. Epub 2019 Mar 28.


Characteristics of Patients with Recurrent Emergency Medical Services Utilization for Symptomatic Hypoglycemia in an Urban Setting.

O'Connor L, Kue RC, O'Connor MJ.

Prehosp Emerg Care. 2019 Nov-Dec;23(6):780-787. doi: 10.1080/10903127.2019.1587125. Epub 2019 Mar 28.


PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers.

Pilié PG, Gay CM, Byers LA, O'Connor MJ, Yap TA.

Clin Cancer Res. 2019 Jul 1;25(13):3759-3771. doi: 10.1158/1078-0432.CCR-18-0968. Epub 2019 Feb 13. Review.


Differential neuroimaging indices in prefrontal white matter in prenatal alcohol-associated ADHD versus idiopathic ADHD.

O'Neill J, O'Connor MJ, Yee V, Ly R, Narr K, Alger JR, Levitt JG.

Birth Defects Res. 2019 Jul 15;111(12):797-811. doi: 10.1002/bdr2.1460. Epub 2019 Jan 29.


Suicide risk in adolescents with fetal alcohol spectrum disorders.

O'Connor MJ, Portnoff LC, Lebsack-Coleman M, Dipple KM.

Birth Defects Res. 2019 Jul 15;111(12):822-828. doi: 10.1002/bdr2.1465. Epub 2019 Jan 24.


Significant mortality, morbidity and resource utilization associated with advanced heart failure in congenital heart disease in children and young adults.

Burstein DS, Shamszad P, Dai D, Almond CS, Price JF, Lin KY, O'Connor MJ, Shaddy RE, Mascio CE, Rossano JW.

Am Heart J. 2019 Mar;209:9-19. doi: 10.1016/j.ahj.2018.11.010. Epub 2018 Dec 5.


One-Pot Synthesis of Diverse Collections of Benzoxazepine and Indolopyrazine Fused to Heterocyclic Systems.

Srinivasulu V, Shehadeh I, Khanfar MA, Malik OG, Tarazi H, Abu-Yousef IA, Sebastian A, Baniowda N, O'Connor MJ, Al-Tel TH.

J Org Chem. 2019 Jan 18;84(2):934-948. doi: 10.1021/acs.joc.8b02878. Epub 2019 Jan 4.


Things We Do For No Reason: Sliding-Scale Insulin as Monotherapy for Glycemic Control in Hospitalized Patients.

Ambrus DB, O'Connor MJ.

J Hosp Med. 2019 Feb 1;14(2):114-116. doi: 10.12788/jhm.3109. Epub 2018 Nov 28.


Mortality, Resource Utilization, and Inpatient Costs Vary Among Pediatric Heart Transplant Indications: A Merged Data Set Analysis From the United Network for Organ Sharing and Pediatric Health Information Systems Databases.

Burstein DS, Li Y, Getz KD, Huang YV, Rossano JW, O'Connor MJ, Lin KY, Aplenc R.

J Card Fail. 2019 Jan;25(1):27-35. doi: 10.1016/j.cardfail.2018.11.014. Epub 2018 Nov 25.


Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds.

Srinivasulu V, Schilf P, Ibrahim S, Khanfar MA, Sieburth SM, Omar H, Sebastian A, AlQawasmeh RA, O'Connor MJ, Al-Tel TH.

Nat Commun. 2018 Nov 26;9(1):4989. doi: 10.1038/s41467-018-07521-2.


Imaging the itis: endocarditis, myocarditis, and pericarditis.

O'Connor MJ.

Curr Opin Cardiol. 2019 Jan;34(1):57-64. doi: 10.1097/HCO.0000000000000577.


Outcomes of children supported with an intracorporeal continuous-flow left ventricular assist system.

VanderPluym CJ, Adachi I, Niebler R, Griffiths E, Fynn-Thompson F, Chen S, O'Connor MJ, Machado D, Hawkins B, Bleiweis MS, Koehl DA, Cantor RS, Morales D, Lorts A.

J Heart Lung Transplant. 2019 Apr;38(4):385-393. doi: 10.1016/j.healun.2018.09.015. Epub 2018 Sep 25.


A Cooperative Hydrogen Bond Donor-Brønsted Acid System for the Enantioselective Synthesis of Tetrahydropyrans.

Maskeri MA, O'Connor MJ, Jaworski AA, Davies AV, Scheidt KA.

Angew Chem Int Ed Engl. 2018 Dec 21;57(52):17225-17229. doi: 10.1002/anie.201811383. Epub 2018 Nov 27.


Risk factors for mortality in paediatric cardiac ICU patients managed with extracorporeal membrane oxygenation.

Achuff BJ, Elias MD, Ittenbach RF, Ravishankar C, Nicolson SC, Spray TL, Fuller S, Gaynor JW, O'Connor MJ.

Cardiol Young. 2019 Jan;29(1):40-47. doi: 10.1017/S1047951118001774. Epub 2018 Oct 31.


A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

Castroviejo-Bermejo M, Cruz C, Llop-Guevara A, Gutiérrez-Enríquez S, Ducy M, Ibrahim YH, Gris-Oliver A, Pellegrino B, Bruna A, Guzmán M, Rodríguez O, Grueso J, Bonache S, Moles-Fernández A, Villacampa G, Viaplana C, Gómez P, Vidal M, Peg V, Serres-Créixams X, Dellaire G, Simard J, Nuciforo P, Rubio IT, Dienstmann R, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Déas O, Jonkers J, Masson JY, Cairo S, Judde JG, O'Connor MJ, Díez O, Balmaña J, Serra V.

EMBO Mol Med. 2018 Dec;10(12). pii: e9172. doi: 10.15252/emmm.201809172.


Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes.

Hodgson DR, Dougherty BA, Lai Z, Fielding A, Grinsted L, Spencer S, O'Connor MJ, Ho TW, Robertson JD, Lanchbury JS, Timms KM, Gutin A, Orr M, Jones H, Gilks B, Womack C, Gourley C, Ledermann J, Barrett JC.

Br J Cancer. 2018 Nov;119(11):1401-1409. doi: 10.1038/s41416-018-0274-8. Epub 2018 Oct 24.


Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response.

Min A, Jang H, Kim S, Lee KH, Kim DK, Suh KJ, Yang Y, Elvin P, O'Connor MJ, Im SA.

Mol Cancer Ther. 2018 Dec;17(12):2507-2518. doi: 10.1158/1535-7163.MCT-18-0234. Epub 2018 Sep 19.


Bypassing Glutamic Acid Decarboxylase 1 (Gad1) Induced Craniofacial Defects with a Photoactivatable Translation Blocker Morpholino.

O'Connor MJ, Beebe LL, Deodato D, Ball RE, Page AT, VanLeuven AJ, Harris KT, Park S, Hariharan V, Lauderdale JD, Dore TM.

ACS Chem Neurosci. 2019 Jan 16;10(1):266-278. doi: 10.1021/acschemneuro.8b00231. Epub 2018 Sep 24.


The CAIRR Pipeline for Submitting Standards-Compliant B and T Cell Receptor Repertoire Sequencing Studies to the National Center for Biotechnology Information Repositories.

Bukhari SAC, O'Connor MJ, Martínez-Romero M, Egyedi AL, Willrett D, Graybeal J, Musen MA, Rubelt F, Cheung KH, Kleinstein SH.

Front Immunol. 2018 Aug 16;9:1877. doi: 10.3389/fimmu.2018.01877. eCollection 2018.


Outcomes of Prehospital Chemical Sedation With Ketamine Versus Haloperidol and Benzodiazepine or Physical Restraint Only.

O'Connor L, Rebesco M, Robinson C, Gross K, Castellana A, O'Connor MJ, Restuccia M.

Prehosp Emerg Care. 2019 Mar-Apr;23(2):201-209. doi: 10.1080/10903127.2018.1501445. Epub 2018 Aug 27.


Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP.

Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18.


ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation.

Vendetti FP, Karukonda P, Clump DA, Teo T, Lalonde R, Nugent K, Ballew M, Kiesel BF, Beumer JH, Sarkar SN, Conrads TP, O'Connor MJ, Ferris RL, Tran PT, Delgoffe GM, Bakkenist CJ.

J Clin Invest. 2018 Aug 31;128(9):3926-3940. doi: 10.1172/JCI96519. Epub 2018 Aug 13.


The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer.

Lallo A, Frese KK, Morrow CJ, Sloane R, Gulati S, Schenk MW, Trapani F, Simms N, Galvin M, Brown S, Hodgkinson CL, Priest L, Hughes A, Lai Z, Cadogan E, Khandelwal G, Simpson KL, Miller C, Blackhall F, O'Connor MJ, Dive C.

Clin Cancer Res. 2018 Oct 15;24(20):5153-5164. doi: 10.1158/1078-0432.CCR-17-2805. Epub 2018 Jun 25.


Fast and Accurate Metadata Authoring Using Ontology-Based Recommendations.

Martínez-Romero M, O'Connor MJ, Shankar RD, Panahiazar M, Willrett D, Egyedi AL, Gevaert O, Graybeal J, Musen MA.

AMIA Annu Symp Proc. 2018 Apr 16;2017:1272-1281. eCollection 2017.


Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma.

Verhagen CVM, Vossen DM, Borgmann K, Hageman F, Grénman R, Verwijs-Janssen M, Mout L, Kluin RJC, Nieuwland M, Severson TM, Velds A, Kerkhoven R, O'Connor MJ, van der Heijden M, van Velthuysen ML, Verheij M, Wreesmann VB, Wessels LFA, van den Brekel MWM, Vens C.

Oncotarget. 2018 Apr 6;9(26):18198-18213. doi: 10.18632/oncotarget.24797. eCollection 2018 Apr 6.


Cumulative Effect of Preoperative Risk Factors on Mortality After Pediatric Heart Transplantation.

O'Connor MJ, Glatz AC, Rossano JW, Shaddy RE, Ryan R, Ravishankar C, Fuller S, Mascio CE, Gaynor JW, Lin KY.

Ann Thorac Surg. 2018 Aug;106(2):561-566. doi: 10.1016/j.athoracsur.2018.03.044. Epub 2018 Apr 22.


A Preliminary Study of Left Ventricular Rotational Mechanics in Children with Noncompaction Cardiomyopathy: Do They Influence Ventricular Function?

Nawaytou HM, Montero AE, Yubbu P, Calderón-Anyosa RJC, Sato T, O'Connor MJ, Miller KD, Ursell PC, Hoffman JIE, Banerjee A.

J Am Soc Echocardiogr. 2018 Aug;31(8):951-961. doi: 10.1016/j.echo.2018.02.015. Epub 2018 Apr 13.


Elevated Troponin in the First 72 h of Hospitalization for Pediatric Viral Myocarditis is Associated with ECMO: An Analysis of the PHIS+ Database.

Butto A, Rossano JW, Nandi D, Ravishankar C, Lin KY, O'Connor MJ, Shaddy RE, Shamszad P.

Pediatr Cardiol. 2018 Aug;39(6):1139-1143. doi: 10.1007/s00246-018-1871-2. Epub 2018 Apr 13.


RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.

Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN, Kristel P, de Bustos L, Guzman M, Rodríguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan E, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, O'Connor MJ, Balmaña J, Serra V.

Ann Oncol. 2018 May 1;29(5):1203-1210. doi: 10.1093/annonc/mdy099.


NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation.

Nicolae CM, O'Connor MJ, Constantin D, Moldovan GL.

Oncogene. 2018 Jul;37(27):3647-3656. doi: 10.1038/s41388-018-0219-y. Epub 2018 Apr 6.


Targeting the replication stress response in cancer.

Forment JV, O'Connor MJ.

Pharmacol Ther. 2018 Aug;188:155-167. doi: 10.1016/j.pharmthera.2018.03.005. Epub 2018 Mar 24. Review.


BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.

Sun C, Yin J, Fang Y, Chen J, Jeong KJ, Chen X, Vellano CP, Ju Z, Zhao W, Zhang D, Lu Y, Meric-Bernstam F, Yap TA, Hattersley M, O'Connor MJ, Chen H, Fawell S, Lin SY, Peng G, Mills GB.

Cancer Cell. 2018 Mar 12;33(3):401-416.e8. doi: 10.1016/j.ccell.2018.01.019.


Disopyramide use in infants and children with hypertrophic cardiomyopathy.

O'Connor MJ, Miller K, Shaddy RE, Lin KY, Hanna BD, Ravishankar C, Rossano JW.

Cardiol Young. 2018 Apr;28(4):530-535. doi: 10.1017/S1047951117002384.


Post-Ugi Cascade Transformations for Accessing Diverse Chromenopyrrole Collections.

Srinivasulu V, Sieburth SM, El-Awady R, Kariem NM, Tarazi H, O'Connor MJ, Al-Tel TH.

Org Lett. 2018 Feb 2;20(3):836-839. doi: 10.1021/acs.orglett.7b03986. Epub 2018 Jan 12.


Characteristics and Outcomes of Pediatric Heart Failure-Related Emergency Department Visits in the United States: A Population-Based Study.

Mejia EJ, O'Connor MJ, Lin KY, Song L, Griffis H, Mascio CE, Shamszad P, Donoghue A, Ravishankar C, Shaddy RE, Rossano JW.

J Pediatr. 2018 Feb;193:114-118.e3. doi: 10.1016/j.jpeds.2017.10.009. Epub 2017 Dec 6.


The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study.

Inman CK, Aljunaibi A, Koh H, Abdulle A, Ali R, Alnaeemi A, Al Zaabi E, Oumeziane N, Al Bastaki M, Al-Houqani M, Al-Maskari F, Al Dhaheri A, Shah SM, Abdel Wareth L, Al Mahmeed W, Alsafar H, Al Anouti F, Al Hosani A, Haji M, Galani D, O'Connor MJ, Ahn J, Kirchhoff T, Sherman S, Hayes RB, Li H, Ramasamy R, Schmidt AM.

J Clin Transl Endocrinol. 2017 Aug 14;10:1-8. doi: 10.1016/j.jcte.2017.08.001. eCollection 2017 Dec.


Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.

Borst GR, Kumareswaran R, Yücel H, Telli S, Do T, McKee T, Zafarana G, Jonkers J, Verheij M, O'Connor MJ, Rottenberg S, Bristow RG.

Oncotarget. 2017 Sep 15;8(50):87638-87646. doi: 10.18632/oncotarget.20936. eCollection 2017 Oct 20.


PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.

Parsels LA, Karnak D, Parsels JD, Zhang Q, Vélez-Padilla J, Reichert ZR, Wahl DR, Maybaum J, O'Connor MJ, Lawrence TS, Morgan MA.

Mol Cancer Res. 2018 Feb;16(2):222-232. doi: 10.1158/1541-7786.MCR-17-0455. Epub 2017 Nov 13.


ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.

Moiseeva T, Hood B, Schamus S, O'Connor MJ, Conrads TP, Bakkenist CJ.

Nat Commun. 2017 Nov 9;8(1):1392. doi: 10.1038/s41467-017-01401-x.

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