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B cells drive auto-T cells to the brain.

Pappalardo JL, O'Connor KC.

Sci Immunol. 2018 Oct 5;3(28). pii: eaav4512. doi: 10.1126/sciimmunol.aav4512.


Bats are "blind" to the deadly effects of viruses.

O'Connor KC.

Sci Immunol. 2018 Jun 1;3(24). pii: eaau2559. doi: 10.1126/sciimmunol.aau2259.


Mechanisms underlying B cell immune dysregulation and autoantibody production in MuSK myasthenia gravis.

Stathopoulos P, Kumar A, Heiden JAV, Pascual-Goñi E, Nowak RJ, O'Connor KC.

Ann N Y Acad Sci. 2018 Jan;1412(1):154-165. doi: 10.1111/nyas.13535. Review.


Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells.

Madsen SD, Russell KC, Tucker HA, Glowacki J, Bunnell BA, O'Connor KC.

Stem Cell Res Ther. 2017 Sep 29;8(1):201. doi: 10.1186/s13287-017-0649-4.


B cells in the pathophysiology of myasthenia gravis.

Yi JS, Guptill JT, Stathopoulos P, Nowak RJ, O'Connor KC.

Muscle Nerve. 2018 Feb;57(2):172-184. doi: 10.1002/mus.25973. Epub 2017 Sep 30.


Autoantibody-producing plasmablasts after B cell depletion identified in muscle-specific kinase myasthenia gravis.

Stathopoulos P, Kumar A, Nowak RJ, O'Connor KC.

JCI Insight. 2017 Sep 7;2(17). pii: 94263. doi: 10.1172/jci.insight.94263. [Epub ahead of print]


Characteristics and functional outcomes of chordoma patients admitted for inpatient rehabilitation.

Knowlton SE, Zafonte R, O'Connor KC, Schwab J, Hornicek F.

Disabil Rehabil. 2018 Sep;40(19):2275-2280. doi: 10.1080/09638288.2017.1334233. Epub 2017 Jun 7.


Variables affecting functional improvement in chordoma patients admitted to an inpatient rehabilitation facility: A retrospective review.

Knowlton SE, Goldstein R, O'Connor KC, Schwab J, Hornicek F, Zafonte R.

J Spinal Cord Med. 2018 May;41(3):355-360. doi: 10.1080/10790268.2017.1321820. Epub 2017 May 2.


In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence.

Hillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP.

Mol Psychiatry. 2017 Dec;22(12):1759-1766. doi: 10.1038/mp.2017.10. Epub 2017 Feb 28.


Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing.

Vander Heiden JA, Stathopoulos P, Zhou JQ, Chen L, Gilbert TJ, Bolen CR, Barohn RJ, Dimachkie MM, Ciafaloni E, Broering TJ, Vigneault F, Nowak RJ, Kleinstein SH, O'Connor KC.

J Immunol. 2017 Feb 15;198(4):1460-1473. doi: 10.4049/jimmunol.1601415. Epub 2017 Jan 13.


Durability of the Rituximab Response in Acetylcholine Receptor Autoantibody-Positive Myasthenia Gravis.

Robeson KR, Kumar A, Keung B, DiCapua DB, Grodinsky E, Patwa HS, Stathopoulos PA, Goldstein JM, O'Connor KC, Nowak RJ.

JAMA Neurol. 2017 Jan 1;74(1):60-66. doi: 10.1001/jamaneurol.2016.4190.


A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.

Cui A, Di Niro R, Vander Heiden JA, Briggs AW, Adams K, Gilbert T, O'Connor KC, Vigneault F, Shlomchik MJ, Kleinstein SH.

J Immunol. 2016 Nov 1;197(9):3566-3574. Epub 2016 Oct 5.


Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis.

Lee JY, Stathopoulos P, Gupta S, Bannock JM, Barohn RJ, Cotzomi E, Dimachkie MM, Jacobson L, Lee CS, Morbach H, Querol L, Shan JL, Vander Heiden JA, Waters P, Vincent A, Nowak RJ, O'Connor KC.

Ann Clin Transl Neurol. 2016 Apr 27;3(6):443-54. doi: 10.1002/acn3.311. eCollection 2016 Jun.


Current and future immunotherapy targets in autoimmune neurology.

Hu MY, Stathopoulos P, O'connor KC, Pittock SJ, Nowak RJ.

Handb Clin Neurol. 2016;133:511-36. doi: 10.1016/B978-0-444-63432-0.00027-X. Review.


Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis.

Chastre A, Hafler DA, O'Connor KC.

N Engl J Med. 2016 Apr 14;374(15):1495-6. doi: 10.1056/NEJMc1513302. No abstract available.


Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production.

Cao Y, Amezquita RA, Kleinstein SH, Stathopoulos P, Nowak RJ, O'Connor KC.

J Immunol. 2016 Mar 1;196(5):2075-84. doi: 10.4049/jimmunol.1501339. Epub 2016 Jan 29.


Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins.

Willis SN, Stathopoulos P, Chastre A, Compton SD, Hafler DA, O'Connor KC.

Front Immunol. 2015 Nov 25;6:600. doi: 10.3389/fimmu.2015.00600. eCollection 2015.


Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.

Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12468-73. doi: 10.1073/pnas.1511003112. Epub 2015 Sep 18.


Traumatic spinal cord injury in the United States, 1993-2012.

Jain NB, Ayers GD, Peterson EN, Harris MB, Morse L, O'Connor KC, Garshick E.

JAMA. 2015 Jun 9;313(22):2236-43. doi: 10.1001/jama.2015.6250.


Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.

Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ.

Science. 2015 Jun 5;348(6239):aaa0698. doi: 10.1126/science.aaa0698.


B lymphocytes in neuromyelitis optica.

Bennett JL, O'Connor KC, Bar-Or A, Zamvil SS, Hemmer B, Tedder TF, von Büdingen HC, Stuve O, Yeaman MR, Smith TJ, Stadelmann C.

Neurol Neuroimmunol Neuroinflamm. 2015 May 7;2(3):e104. doi: 10.1212/NXI.0000000000000104. eCollection 2015 Jun. Review.


(11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas.

Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O'Connor KC, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D.

Eur J Nucl Med Mol Imaging. 2015 Jun;42(7):1081-92. doi: 10.1007/s00259-015-3043-4. Epub 2015 Apr 2.


MOG cell-based assay detects non-MS patients with inflammatory neurologic disease.

Waters P, Woodhall M, O'Connor KC, Reindl M, Lang B, Sato DK, Juryńczyk M, Tackley G, Rocha J, Takahashi T, Misu T, Nakashima I, Palace J, Fujihara K, Leite MI, Vincent A.

Neurol Neuroimmunol Neuroinflamm. 2015 Mar 19;2(3):e89. doi: 10.1212/NXI.0000000000000089. eCollection 2015 Jun.


Demographic and clinical features of inclusion body myositis in North America.

Paltiel AD, Ingvarsson E, Lee DK, Leff RL, Nowak RJ, Petschke KD, Richards-Shubik S, Zhou A, Shubik M, O'Connor KC.

Muscle Nerve. 2015 Oct;52(4):527-33. doi: 10.1002/mus.24562. Epub 2015 Feb 17.


Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens.

Kleffel S, Vergani A, Tezza S, Ben Nasr M, Niewczas MA, Wong S, Bassi R, D'Addio F, Schatton T, Abdi R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O'Connor KC, Fiorina P.

Diabetes. 2015 Jan;64(1):158-71. doi: 10.2337/db13-1639. Epub 2014 Sep 3.


B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.

Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC.

Sci Transl Med. 2014 Aug 6;6(248):248ra107. doi: 10.1126/scitranslmed.3008879.


Association between alendronate, serum alkaline phosphatase level, and heterotopic ossification in individuals with spinal cord injury.

Ploumis A, Donovan JM, Olurinde MO, Clark DM, Wu JC, Sohn DJ, O'Connor KC.

J Spinal Cord Med. 2015 Mar;38(2):193-8. doi: 10.1179/2045772314Y.0000000213. Epub 2014 May 13.


pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires.

Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F, Kleinstein SH.

Bioinformatics. 2014 Jul 1;30(13):1930-2. doi: 10.1093/bioinformatics/btu138. Epub 2014 Mar 10.


A Triple-Option Analgesia Plan for Tactical Combat Casualty Care: TCCC Guidelines Change 13-04.

Butler FK, Kotwal RS, Buckenmaier CC 3rd, Edgar EP, O'Connor KC, Montgomery HR, Shackelford SA, Gandy JV 3rd, Wedmore IS, Timby JW, Gross KR, Bailey JA.

J Spec Oper Med. 2014 Spring;14(1):13-25.


A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data?

Vaughan K, Peters B, O'Connor KC, Martin R, Sette A.

J Neuroimmunol. 2014 Feb 15;267(1-2):73-85. doi: 10.1016/j.jneuroim.2013.12.009. Epub 2013 Dec 12.


Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data.

Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F, Kleinstein SH.

Front Immunol. 2013 Nov 15;4:358. doi: 10.3389/fimmu.2013.00358. eCollection 2013.


The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells.

Fang L, Lowther DE, Meizlish ML, Anderson RC, Bruce JN, Devine L, Huttner AJ, Kleinstein SH, Lee JY, Stern JN, Yaari G, Lovato L, Cronk KM, O'Connor KC.

Neuro Oncol. 2013 Nov;15(11):1479-90. doi: 10.1093/neuonc/not110. Epub 2013 Aug 26.


Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.

Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC.

Neurology. 2013 Sep 10;81(11):956-63. doi: 10.1212/WNL.0b013e3182a43b48. Epub 2013 Aug 6.


The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study.

Hannestad J, DellaGioia N, Gallezot JD, Lim K, Nabulsi N, Esterlis I, Pittman B, Lee JY, O'Connor KC, Pelletier D, Carson RE.

Brain Behav Immun. 2013 Oct;33:131-8. doi: 10.1016/j.bbi.2013.06.010. Epub 2013 Jul 9.


Long-term benefit of rituximab in MuSK autoantibody myasthenia gravis patients.

Keung B, Robeson KR, DiCapua DB, Rosen JB, O'Connor KC, Goldstein JM, Nowak RJ.

J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1407-9. doi: 10.1136/jnnp-2012-303664. Epub 2013 Jun 12. No abstract available.


Specific peripheral B cell tolerance defects in patients with multiple sclerosis.

Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E.

J Clin Invest. 2013 Jun;123(6):2737-41. doi: 10.1172/JCI68775. Epub 2013 May 15.


Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis.

Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH.

Mult Scler. 2013 Nov;19(13):1726-33. doi: 10.1177/1352458513485653. Epub 2013 Apr 23.


Cell-surface expression of neuron-glial antigen 2 (NG2) and melanoma cell adhesion molecule (CD146) in heterogeneous cultures of marrow-derived mesenchymal stem cells.

Russell KC, Tucker HA, Bunnell BA, Andreeff M, Schober W, Gaynor AS, Strickler KL, Lin S, Lacey MR, O'Connor KC.

Tissue Eng Part A. 2013 Oct;19(19-20):2253-66. doi: 10.1089/ten.TEA.2012.0649. Epub 2013 May 30.


PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.

Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ.

J Autoimmun. 2013 Jun;43:1-9. doi: 10.1016/j.jaut.2013.01.013. Epub 2013 Mar 13.


Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis.

Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O'Connor KC.

PLoS One. 2012;7(10):e46709. doi: 10.1371/journal.pone.0046709. Epub 2012 Oct 5.


High-capacity assay to quantify the clonal heterogeneity in potency of mesenchymal stem cells.

O'Connor KC, Russell KC, Phinney DG, Lacey MR, Barrilleaux BL, Meyertholen KE.

BMC Proc. 2011 Nov 22;5 Suppl 8:O14. doi: 10.1186/1753-6561-5-S8-O14. eCollection 2011. No abstract available.


Cortical injury in multiple sclerosis; the role of the immune system.

Walker CA, Huttner AJ, O'Connor KC.

BMC Neurol. 2011 Dec 6;11:152. doi: 10.1186/1471-2377-11-152. Review.


Acute demyelinating disease after oral therapy with herbal extracts.

Kostianovsky A, Maskin P, Noriega MM, Soler C, Bonelli I, Riley CS, O'Connor KC, Saubidet CN, Alvarez PA.

Case Rep Neurol. 2011 May;3(2):141-6. doi: 10.1159/000329734. Epub 2011 Jun 25.


Clonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potency.

Russell KC, Lacey MR, Gilliam JK, Tucker HA, Phinney DG, O'Connor KC.

Biotechnol Bioeng. 2011 Nov;108(11):2716-26. doi: 10.1002/bit.23193. Epub 2011 May 10.


Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.

Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K.

J Neuroimmunol. 2011 Apr;233(1-2):245-8. doi: 10.1016/j.jneuroim.2011.01.010. Epub 2011 Feb 24.


Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.

Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC, Hafler DA.

Brain. 2011 Feb;134(Pt 2):534-41. doi: 10.1093/brain/awq350. Epub 2011 Jan 7.


Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.

Klawiter EC, Piccio L, Lyons JA, Mikesell R, O'Connor KC, Cross AH.

Arch Neurol. 2010 Sep;67(9):1102-8. doi: 10.1001/archneurol.2010.197.


A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.

Ligocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC, Monson NL.

J Neuroimmunol. 2010 Sep 14;226(1-2):192-3. doi: 10.1016/j.jneuroim.2010.06.016. Epub 2010 Jul 23.


Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis.

O'Connor KC, Lopez-Amaya C, Gagne D, Lovato L, Moore-Odom NH, Kennedy J, Krupp L, Tenembaum S, Ness J, Belman A, Boyko A, Bykova O, Mah JK, Stoian CA, Waubant E, Kremenchutzky M, Ruggieri M, Bardini MR, Rensel M, Hahn J, Weinstock-Guttman B, Yeh EA, Farrell K, Freedman MS, Iivanainen M, Bhan V, Dilenge M, Hancock MA, Gano D, Fattahie R, Kopel L, Fournier AE, Moscarello M, Banwell B, Bar-Or A.

J Neuroimmunol. 2010 Jun;223(1-2):92-9. doi: 10.1016/j.jneuroim.2010.02.019. Epub 2010 Apr 8.


Activation of CD74 inhibits migration of human mesenchymal stem cells.

Barrilleaux BL, Fischer-Valuck BW, Gilliam JK, Phinney DG, O'Connor KC.

In Vitro Cell Dev Biol Anim. 2010 Jun;46(6):566-72. doi: 10.1007/s11626-010-9279-1. Epub 2010 Mar 3.


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