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T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation.

Ekiz HA, Ramstead AG, Lee SH, Nelson MC, Bauer KM, Wallace JA, Hu R, Round JL, Rutter J, Drummond MJ, Rao DS, O'Connell RM.

J Immunol. 2020 Mar 11. pii: ji1901484. doi: 10.4049/jimmunol.1901484. [Epub ahead of print]


Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.

Ramstead AG, Wallace JA, Lee SH, Bauer KM, Tang WW, Ekiz HA, Lane TE, Cluntun AA, Bettini ML, Round JL, Rutter J, O'Connell RM.

Cell Rep. 2020 Mar 3;30(9):2889-2899.e6. doi: 10.1016/j.celrep.2020.02.042.


Absence of MyD88 from Skeletal Muscle Protects Female Mice from Inactivity-Induced Adiposity and Insulin Resistance.

Mahmassani ZS, Reidy PT, McKenzie AI, Petrocelli JJ, Matthews O, de Hart NM, Ferrara PJ, O'Connell RM, Funai K, Drummond MJ.

Obesity (Silver Spring). 2020 Apr;28(4):772-782. doi: 10.1002/oby.22759. Epub 2020 Feb 28.


Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade.

Snook JP, Soedel AJ, Ekiz HA, O'Connell RM, Williams MA.

Cancer Immunol Res. 2020 Feb 19. doi: 10.1158/2326-6066.CIR-19-0690. [Epub ahead of print]


Should all paediatric appendicectomies be performed in a specialist or high-volume setting?

O'Connell RM, Elwahab SA, Mealy K.

Ir J Med Sci. 2020 Jan 2. doi: 10.1007/s11845-019-02156-8. [Epub ahead of print]


The impact of hospital grade, hospital-volume, and surgeon-volume on outcomes for adults undergoing appendicectomy.

O'Connell RM, Abd Elwahab S, Mealy K.

Surgeon. 2019 Dec 2. pii: S1479-666X(19)30140-4. doi: 10.1016/j.surge.2019.10.006. [Epub ahead of print]


T cell-mediated regulation of the microbiota protects against obesity.

Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL.

Science. 2019 Jul 26;365(6451). pii: eaat9351. doi: 10.1126/science.aat9351.


The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling.

Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL.

Elife. 2019 Jul 16;8. pii: e47117. doi: 10.7554/eLife.47117.


Audit of PPI Prescribing Practices: A Risk to Patient Safety?

O’Connell L, O’Connell RM, Ahmed O, Mealy K.

Ir Med J. 2019 Apr 11;112(4):911.


Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse.

Reidy PT, McKenzie AI, Mahmassani ZS, Petrocelli JJ, Nelson DB, Lindsay CC, Gardner JE, Morrow VR, Keefe AC, Huffaker TB, Stoddard GJ, Kardon G, O'Connell RM, Drummond MJ.

Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E85-E98. doi: 10.1152/ajpendo.00422.2018. Epub 2019 Apr 9.


Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.

Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM.

PLoS Genet. 2019 Feb 15;15(2):e1007970. doi: 10.1371/journal.pgen.1007970. eCollection 2019 Feb.


MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers.

Ekiz HA, Huffaker TB, Grossmann AH, Stephens WZ, Williams MA, Round JL, O'Connell RM.

JCI Insight. 2019 Mar 21;4(6). pii: 126543. doi: 10.1172/jci.insight.126543. eCollection 2019 Mar 21.


Red cell distribution width and neutrophil to lymphocyte ratio as predictors of outcomes in acute pancreatitis: A retrospective cohort study.

O'Connell RM, Boland MR, O'Driscoll J, Salih A, Arumugasamy M, Walsh TN, Allen MJ, Beddy DJ.

Int J Surg. 2018 Jul;55:124-127. doi: 10.1016/j.ijsu.2018.05.028. Epub 2018 May 25.


Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli.

Alexander M, Ramstead AG, Bauer KM, Lee SH, Runtsch MC, Wallace J, Huffaker TB, Larsen DK, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.

J Immunol. 2017 Nov 15;199(10):3559-3570. doi: 10.4049/jimmunol.1700904. Epub 2017 Oct 4.


Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade.

Huffaker TB, Lee SH, Tang WW, Wallace JA, Alexander M, Runtsch MC, Larsen DK, Thompson J, Ramstead AG, Voth WP, Hu R, Round JL, Williams MA, O'Connell RM.

J Biol Chem. 2017 Nov 10;292(45):18530-18541. doi: 10.1074/jbc.M117.808121. Epub 2017 Sep 14.


MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts.

Wallace JA, O'Connell RM.

Blood. 2017 Sep 14;130(11):1290-1301. doi: 10.1182/blood-2016-10-697698. Epub 2017 Jul 27. Review.


Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor.

Soto R, Petersen C, Novis CL, Kubinak JL, Bell R, Stephens WZ, Lane TE, Fujinami RS, Bosque A, O'Connell RM, Round JL.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5497-5502. doi: 10.1073/pnas.1619336114. Epub 2017 May 9.


miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response.

Wallace JA, Kagele DA, Eiring AM, Kim CN, Hu R, Runtsch MC, Alexander M, Huffaker TB, Lee SH, Patel AB, Mosbruger TL, Voth WP, Rao DS, Miles RR, Round JL, Deininger MW, O'Connell RM.

Blood. 2017 Jun 8;129(23):3074-3086. doi: 10.1182/blood-2016-09-740209. Epub 2017 Apr 21.


A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice.

Chiaro TR, Soto R, Zac Stephens W, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, O'Connell RM, Tebo AE, Round JL.

Sci Transl Med. 2017 Mar 8;9(380). pii: eaaf9044. doi: 10.1126/scitranslmed.aaf9044. Erratum in: Sci Transl Med. 2017 May 3;9(388):.


MicroRNA 155 and viral-induced neuroinflammation.

Dickey LL, Hanley TM, Huffaker TB, Ramstead AG, O'Connell RM, Lane TE.

J Neuroimmunol. 2017 Jul 15;308:17-24. doi: 10.1016/j.jneuroim.2017.01.016. Epub 2017 Jan 24. Review.


Intramyocellular ceramides and skeletal muscle mitochondrial respiration are partially regulated by Toll-like receptor 4 during hindlimb unloading.

Kwon OS, Nelson DS, Barrows KM, O'Connell RM, Drummond MJ.

Am J Physiol Regul Integr Comp Physiol. 2016 Nov 1;311(5):R879-R887. doi: 10.1152/ajpregu.00253.2016. Epub 2016 Aug 31.


MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease.

Dickey LL, Worne CL, Glover JL, Lane TE, O'Connell RM.

J Neuroinflammation. 2016 Sep 7;13(1):240. doi: 10.1186/s12974-016-0699-z.


Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth.

Wallace J, Hu R, Mosbruger TL, Dahlem TJ, Stephens WZ, Rao DS, Round JL, O'Connell RM.

PLoS One. 2016 Apr 15;11(4):e0153689. doi: 10.1371/journal.pone.0153689. eCollection 2016.


microRNAs in Psoriasis.

Hawkes JE, Nguyen GH, Fujita M, Florell SR, Callis Duffin K, Krueger GG, O'Connell RM.

J Invest Dermatol. 2016 Feb;136(2):365-371. doi: 10.1038/JID.2015.409. Review.


MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection.

Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round JL.

Nat Commun. 2015 Oct 23;6:8642. doi: 10.1038/ncomms9642.


MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis.

Runtsch MC, Hu R, Alexander M, Wallace J, Kagele D, Petersen C, Valentine JF, Welker NC, Bronner MP, Chen X, Smith DP, Ajami NJ, Petrosino JF, Round JL, O'Connell RM.

Oncotarget. 2015 Oct 6;6(30):28556-72.


MicroRNAs, T follicular helper cells and inflammaging.

Hawkes JE, O'Connell RM.

Oncotarget. 2015 Oct 20;6(32):32295-6. doi: 10.18632/oncotarget.6025. No abstract available.


Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis.

Lochhead RB, Zachary JF, Dalla Rosa L, Ma Y, Weis JH, O'Connell RM, Weis JJ.

PLoS One. 2015 Aug 7;10(8):e0135142. doi: 10.1371/journal.pone.0135142. eCollection 2015.


Noncoding RNAs and chronic inflammation: Micro-managing the fire within.

Alexander M, O'Connell RM.

Bioessays. 2015 Sep;37(9):1005-15. doi: 10.1002/bies.201500054. Epub 2015 Aug 6. Review.


miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof.

Huffaker TB, O'Connell RM.

Immunity. 2015 Jul 21;43(1):3-4. doi: 10.1016/j.immuni.2015.06.020.


Exosome-delivered microRNAs modulate the inflammatory response to endotoxin.

Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.

Nat Commun. 2015 Jun 18;6:7321. doi: 10.1038/ncomms8321.


MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.

Kwon OS, Tanner RE, Barrows KM, Runtsch M, Symons JD, Jalili T, Bikman BT, McClain DA, O'Connell RM, Drummond MJ.

Am J Physiol Endocrinol Metab. 2015 Jul 1;309(1):E11-21. doi: 10.1152/ajpendo.00124.2015. Epub 2015 May 12.


Endogenous miR-29a regulates HSC function in mammals.

O'Connell RM.

Blood. 2015 Apr 2;125(14):2180-1. doi: 10.1182/blood-2015-02-626424. No abstract available.


MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health.

Kubinak JL, Petersen C, Stephens WZ, Soto R, Bake E, O'Connell RM, Round JL.

Cell Host Microbe. 2015 Feb 11;17(2):153-63. doi: 10.1016/j.chom.2014.12.009. Epub 2015 Jan 22.


miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.

Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, Möller T, Garden GA, Round JL, O'Connell RM.

Immunity. 2014 Oct 16;41(4):605-19. doi: 10.1016/j.immuni.2014.09.015.


MicroRNAs and the regulation of intestinal homeostasis.

Runtsch MC, Round JL, O'Connell RM.

Front Genet. 2014 Oct 1;5:347. doi: 10.3389/fgene.2014.00347. eCollection 2014. Review.


Combat veterans with comorbid PTSD and mild TBI exhibit a greater inhibitory processing ERP from the dorsal anterior cingulate cortex.

Shu IW, Onton JA, O'Connell RM, Simmons AN, Matthews SC.

Psychiatry Res. 2014 Oct 30;224(1):58-66. doi: 10.1016/j.pscychresns.2014.07.010. Epub 2014 Aug 8.


MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi.

Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, O'Connell RM, Weis JJ.

PLoS Pathog. 2014 Jun 26;10(6):e1004212. doi: 10.1371/journal.ppat.1004212. eCollection 2014 Jun.


Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis.

Zhao JL, Ma C, O'Connell RM, Mehta A, DiLoreto R, Heath JR, Baltimore D.

Cell Stem Cell. 2014 Apr 3;14(4):445-459. doi: 10.1016/j.stem.2014.01.007. Epub 2014 Feb 20.


Biomarkers Predict Relapse in Granulomatosis with Polyangiitis.

Hogan PC, O'Connell RM, Scollard S, Browne E, Hackett EE, Feighery C.

J Biomark. 2014;2014:596503. doi: 10.1155/2014/596503. Epub 2014 Apr 30.


Combat veterans with PTSD after mild TBI exhibit greater ERPs from posterior-medial cortical areas while appraising facial features.

Shu IW, Onton JA, Prabhakar N, O'Connell RM, Simmons AN, Matthews SC.

J Affect Disord. 2014 Feb;155:234-40. doi: 10.1016/j.jad.2013.06.057. Epub 2013 Nov 17.


The influence of CTGF single-nucleotide polymorphisms on outcomes in Crohn's disease.

Burke JP, O'Connell RM, Lennon G, Doherty GA, Keegan D, O'Donoghue D, Mulcahy H, Hyland J, Winter DC, Sheahan K, O'Connell PR.

Ann Surg. 2013 Nov;258(5):767-73; discussion 773-4. doi: 10.1097/SLA.0000000000000247.


MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice.

Zhao JL, Rao DS, O'Connell RM, Garcia-Flores Y, Baltimore D.

Elife. 2013 May 21;2:e00537. doi: 10.7554/eLife.00537.


MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression.

Hu R, Huffaker TB, Kagele DA, Runtsch MC, Bake E, Chaudhuri AA, Round JL, O'Connell RM.

J Immunol. 2013 Jun 15;190(12):5972-80. doi: 10.4049/jimmunol.1300351. Epub 2013 May 17.


Targeting human microRNA genes using engineered Tal-effector nucleases (TALENs).

Hu R, Wallace J, Dahlem TJ, Grunwald DJ, O'Connell RM.

PLoS One. 2013 May 7;8(5):e63074. doi: 10.1371/journal.pone.0063074. Print 2013.


MicroRNA control in the development of systemic autoimmunity.

Hu R, O'Connell RM.

Arthritis Res Ther. 2013 Jan 25;15(1):202. doi: 10.1186/ar4131. Review.


Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity.

Huffaker TB, Hu R, Runtsch MC, Bake E, Chen X, Zhao J, Round JL, Baltimore D, O'Connell RM.

Cell Rep. 2012 Dec 27;2(6):1697-709. doi: 10.1016/j.celrep.2012.10.025. Epub 2012 Nov 29.


MiR-23b is a safeguard against autoimmunity.

Hu R, O'Connell RM.

Nat Med. 2012 Jul 6;18(7):1009-10. doi: 10.1038/nm.2849. No abstract available.


MicroRNAs function on a new level.

O'Connell RM.

Blood. 2012 Apr 26;119(17):3875-6. doi: 10.1182/blood-2012-02-410977.


Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A.

Chaudhuri AA, So AY, Mehta A, Minisandram A, Sinha N, Jonsson VD, Rao DS, O'Connell RM, Baltimore D.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4233-8. doi: 10.1073/pnas.1200677109. Epub 2012 Feb 24.

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