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Dose Optimization of Valproic Acid in a Lethal Model of Traumatic Brain Injury, Hemorrhage and Polytrauma in Swine.

Biesterveld BE, Williams AM, Pai MP, Dennahy IS, Graham NJ, Chtraklin K, Siddiqui AZ, O'Connell RL, Bhatti UF, Liu B, Russo RM, Li Y, Alam HB.

J Trauma Acute Care Surg. 2019 Aug 5. doi: 10.1097/TA.0000000000002460. [Epub ahead of print]


T cell-mediated regulation of the microbiota protects against obesity.

Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL.

Science. 2019 Jul 26;365(6451). pii: eaat9351. doi: 10.1126/science.aat9351.


PARAGON (ANZGOG-0903): a phase 2 study of anastrozole in asymptomatic patients with estrogen and progesterone receptor-positive recurrent ovarian cancer and CA125 progression.

Kok PS, Beale P, O'Connell RL, Grant P, Bonaventura T, Scurry J, Antill Y, Goh J, Sjoquist K, DeFazio A, Mapagu C, Amant F, Friedlander M; PARAGON Investigators.

J Gynecol Oncol. 2019 Sep;30(5):e86. doi: 10.3802/jgo.2019.30.e86.


The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling.

Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL.

Elife. 2019 Jul 16;8. pii: e47117. doi: 10.7554/eLife.47117.


Audit of PPI Prescribing Practices: A Risk to Patient Safety?

O’Connell L, O’Connell RM, Ahmed O, Mealy K.

Ir Med J. 2019 Apr 11;112(4):911.


Modular imaging system: Rapid scan EPR at 800 MHz.

Tseytlin O, Guggilapu P, Bobko AA, AlAhmad H, Xu X, Epel B, O'Connell R, Hoblitzell EH, Eubank TD, Khramtsov VV, Driesschaert B, Kazkaz E, Tseytlin M.

J Magn Reson. 2019 Aug;305:94-103. doi: 10.1016/j.jmr.2019.06.003. Epub 2019 Jun 8.


PARAGON: A Phase II study of anastrozole in patients with estrogen receptor-positive recurrent/metastatic low-grade ovarian cancers and serous borderline ovarian tumors.

Tang M, O'Connell RL, Amant F, Beale P, McNally O, Sjoquist KM, Grant P, Davis A, Sykes P, Mileshkin L, Moujaber T, Kennedy CJ, deFazio A, Tan K, Antill Y, Goh J, Bonaventura T, Scurry J, Friedlander M.

Gynecol Oncol. 2019 Jun 18. pii: S0090-8258(19)31322-8. doi: 10.1016/j.ygyno.2019.06.011. [Epub ahead of print]


Integrative review; identifying the evidence base for policymaking and analysis in health care.

Kennedy C, O'Reilly P, O'Connell R, O'Leary D, Fealy G, Hegarty JM, Brady AM, Nicholson E, McNamara M, Casey M.

J Adv Nurs. 2019 Jun 21. doi: 10.1111/jan.14121. [Epub ahead of print] Review.


Developing a new health-related policy analysis tool: An action research cooperative inquiry approach.

Casey M, Rohde D, Brady AM, Fealy G, Hegarty J, Kennedy C, McNamara M, Nicholson E, O'Connell R, O'Connor L, O'Leary D, O'Reilly P, Stokes D.

J Nurs Manag. 2019 Jun 6. doi: 10.1111/jonm.12804. [Epub ahead of print]


Phase 2 study of anastrozole in recurrent estrogen (ER)/progesterone (PR) positive endometrial cancer: The PARAGON trial - ANZGOG 0903.

Mileshkin L, Edmondson R, O'Connell RL, Sjoquist KM, Andrews J, Jyothirmayi R, Beale P, Bonaventura T, Goh J, Hall M, Clamp A, Green J, Lord R, Amant F, Alexander L, Carty K, Paul J, Scurry J, Millan D, Nottley S, Friedlander M; PARAGON study group.

Gynecol Oncol. 2019 Jul;154(1):29-37. doi: 10.1016/j.ygyno.2019.05.007. Epub 2019 May 23.


Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP.

Saneyoshi T, Matsuno H, Suzuki A, Murakoshi H, Hedrick NG, Agnello E, O'Connell R, Stratton MM, Yasuda R, Hayashi Y.

Neuron. 2019 Jun 19;102(6):1199-1210.e6. doi: 10.1016/j.neuron.2019.04.012. Epub 2019 May 8.


The Least Mating Pathway: Synthetically Refactoring a Familiar Signaling System for New Applications.

O'Connell RW, Bashor CJ.

Cell. 2019 Apr 18;177(3):521-523. doi: 10.1016/j.cell.2019.04.003.


Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial.

Crowell TA, Colby DJ, Pinyakorn S, Sacdalan C, Pagliuzza A, Intasan J, Benjapornpong K, Tangnaree K, Chomchey N, Kroon E, de Souza MS, Tovanabutra S, Rolland M, Eller MA, Paquin-Proulx D, Bolton DL, Tokarev A, Thomas R, Takata H, Trautmann L, Krebs SJ, Modjarrad K, McDermott AB, Bailer RT, Doria-Rose N, Patel B, Gorelick RJ, Fullmer BA, Schuetz A, Grandin PV, O'Connell RJ, Ledgerwood JE, Graham BS, Tressler R, Mascola JR, Chomont N, Michael NL, Robb ML, Phanuphak N, Ananworanich J; RV397 Study Group.

Lancet HIV. 2019 May;6(5):e297-e306. doi: 10.1016/S2352-3018(19)30053-0. Epub 2019 Apr 15.


Reconciling age-related changes in behavioural and neural indices of human perceptual decision-making.

McGovern DP, Hayes A, Kelly SP, O'Connell RG.

Nat Hum Behav. 2018 Dec;2(12):955-966. doi: 10.1038/s41562-018-0465-6. Epub 2018 Nov 12.


Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse.

Reidy PT, McKenzie AI, Mahmassani ZS, Petrocelli JJ, Nelson DB, Lindsay CC, Gardner JE, Morrow VR, Keefe AC, Huffaker TB, Stoddard GJ, Kardon G, O'Connell RM, Drummond MJ.

Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E85-E98. doi: 10.1152/ajpendo.00422.2018. Epub 2019 Apr 9.


H3K4 trimethylation by CclA regulates pathogenicity and the production of three families of terpenoid secondary metabolites in Colletotrichum higginsianum.

Dallery JF, Adelin É, Le Goff G, Pigné S, Auger A, Ouazzani J, O'Connell RJ.

Mol Plant Pathol. 2019 Jun;20(6):831-842. doi: 10.1111/mpp.12795. Epub 2019 Mar 29.


The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study.

O'Connell RL, Rattay T, Dave RV, Trickey A, Skillman J, Barnes NLP, Gardiner M, Harnett A, Potter S, Holcombe C; iBRA-2 Steering Group; Breast Reconstruction Research Collaborative.

Br J Cancer. 2019 Apr;120(9):883-895. doi: 10.1038/s41416-019-0438-1. Epub 2019 Mar 29.


Broad-specificity GH131 β-glucanases are a hallmark of fungi and oomycetes that colonize plants.

Anasontzis GE, Lebrun MH, Haon M, Champion C, Kohler A, Lenfant N, Martin F, O'Connell RJ, Riley R, Grigoriev IV, Henrissat B, Berrin JG, Rosso MN.

Environ Microbiol. 2019 Aug;21(8):2724-2739. doi: 10.1111/1462-2920.14596. Epub 2019 Apr 21.


A randomized placebo-controlled trial of vitamin D supplementation for reduction of mortality and cancer: Statistical analysis plan for the D-Health Trial.

Waterhouse M, English DR, Armstrong BK, Baxter C, Duarte Romero B, Ebeling PR, Hartel G, Kimlin MG, McLeod DSA, O'Connell RL, van der Pols JC, Venn AJ, Webb PM, Whiteman DC, Neale RE.

Contemp Clin Trials Commun. 2019 Feb 20;14:100333. doi: 10.1016/j.conctc.2019.100333. eCollection 2019 Jun.


Catecholamine Modulation of Evidence Accumulation during Perceptual Decision Formation: A Randomized Trial.

Loughnane GM, Brosnan MB, Barnes JJM, Dean A, Nandam SL, O'Connell RG, Bellgrove MA.

J Cogn Neurosci. 2019 Jul;31(7):1044-1053. doi: 10.1162/jocn_a_01393. Epub 2019 Mar 18.


Behavioural and neural signatures of perceptual decision-making are modulated by pupil-linked arousal.

van Kempen J, Loughnane GM, Newman DP, Kelly SP, Thiele A, O'Connell RG, Bellgrove MA.

Elife. 2019 Mar 18;8. pii: e42541. doi: 10.7554/eLife.42541.


Nonproteinaceous effectors: the terra incognita of plant-fungal interactions.

Collemare J, O'Connell R, Lebrun MH.

New Phytol. 2019 Jul;223(2):590-596. doi: 10.1111/nph.15785. Epub 2019 Apr 3. Review.


Associations of depression and anxiety symptoms with sexual behaviour in women and heterosexual men attending sexual health clinics: a cross-sectional study.

Coyle RM, Lampe FC, Miltz AR, Sewell J, Anderson J FRCP, Apea V, Collins S, Dhairyawan R, Johnson AM, Lascar M, Mann S, O'Connell R, Sherr L, Speakman A, Tang A, Phillips AN, Rodger A; AURAH Study Group.

Sex Transm Infect. 2019 Jun;95(4):254-261. doi: 10.1136/sextrans-2018-053689. Epub 2019 Feb 27.


Deleting a Chromatin Remodeling Gene Increases the Diversity of Secondary Metabolites Produced by Colletotrichum higginsianum.

Dallery JF, Le Goff G, Adelin E, Iorga BI, Pigné S, O'Connell RJ, Ouazzani J.

J Nat Prod. 2019 Apr 26;82(4):813-822. doi: 10.1021/acs.jnatprod.8b00796. Epub 2019 Feb 18.


Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.

Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM.

PLoS Genet. 2019 Feb 15;15(2):e1007970. doi: 10.1371/journal.pgen.1007970. eCollection 2019 Feb.


Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.

Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round JL.

Cell Host Microbe. 2019 Feb 13;25(2):285-299.e8. doi: 10.1016/j.chom.2019.01.008.


MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers.

Ekiz HA, Huffaker TB, Grossmann AH, Stephens WZ, Williams MA, Round JL, O'Connell RM.

JCI Insight. 2019 Mar 21;4(6). pii: 126543. doi: 10.1172/jci.insight.126543. eCollection 2019 Mar 21.


Molecular epidemiology of a primarily MSM acute HIV-1 cohort in Bangkok, Thailand and connections within networks of transmission in Asia.

Chang D, Sanders-Buell E, Bose M, O'Sullivan AM, Pham P, Kroon E, Colby DJ, Sirijatuphat R, Billings E, Pinyakorn S, Chomchey N, Rutvisuttinunt W, Kijak G, de Souza M, Excler JL, Phanuphak P, Phanuphak N, O'Connell RJ, Kim JH, Robb ML, Michael NL, Ananworanich J, Tovanabutra S; RV254/SEARCH 010 Study Group.

J Int AIDS Soc. 2018 Nov;21(11):e25204. doi: 10.1002/jia2.25204.


Dexamethasone and postoperative hyperglycemia in diabetics undergoing elective hip or knee arthroplasty: a case control study in 238 patients.

O'Connell RS, Clinger BN, Donahue EE, Celi FS, Golladay GJ.

Patient Saf Surg. 2018 Nov 5;12:30. doi: 10.1186/s13037-018-0178-9. eCollection 2018.


Biomechanical Evaluation of Osteoporotic Proximal Periprosthetic Femur Fractures With Proximal Bicortical Fixation and Allograft Struts.

OʼConnell RS, Owen JR, Hansen EJ, Bashir AS, Wayne JS, Satpathy J, Kates SL.

J Orthop Trauma. 2018 Oct;32(10):508-514. doi: 10.1097/BOT.0000000000001261.


Decisions are expedited through multiple neural adjustments spanning the sensorimotor hierarchy.

Steinemann NA, O'Connell RG, Kelly SP.

Nat Commun. 2018 Sep 7;9(1):3627. doi: 10.1038/s41467-018-06117-0.


Development and psychometric testing of the clinical leadership needs analysis (CLeeNA) instrument for nurses and midwives.

Mc Carthy VJC, Murphy A, Savage E, Hegarty J, Coffey A, Leahy-Warren P, Horgan A, O'Connell R, Marsh L, Drennan J.

J Nurs Manag. 2019 Mar;27(2):245-255. doi: 10.1111/jonm.12672. Epub 2018 Aug 31.


Child food poverty requires radical long term solutions.

O'Connell R, Brannen J, Knight A.

BMJ. 2018 Aug 28;362:k3608. doi: 10.1136/bmj.k3608. No abstract available.


Current practice and short-term outcomes of therapeutic mammaplasty in the international TeaM multicentre prospective cohort study.

O'Connell RL, Baker E, Trickey A, Rattay T, Whisker L, Macmillan RD, Potter S; TeaM Steering Group; Mammary Fold Academic and Research Collaborative.

Br J Surg. 2018 Dec;105(13):1778-1792. doi: 10.1002/bjs.10959. Epub 2018 Aug 22.


Bridging Neural and Computational Viewpoints on Perceptual Decision-Making.

O'Connell RG, Shadlen MN, Wong-Lin K, Kelly SP.

Trends Neurosci. 2018 Nov;41(11):838-852. doi: 10.1016/j.tins.2018.06.005. Epub 2018 Jul 12. Review.


Prefrontal Modulation of Visual Processing and Sustained Attention in Aging, a tDCS-EEG Coregistration Approach.

Brosnan MB, Arvaneh M, Harty S, Maguire T, O'Connell R, Robertson IH, Dockree PM.

J Cogn Neurosci. 2018 Nov;30(11):1630-1645. doi: 10.1162/jocn_a_01307. Epub 2018 Jul 13.


The US Military Commitment to Vaccine Development: A Century of Successes and Challenges.

Ratto-Kim S, Yoon IK, Paris RM, Excler JL, Kim JH, O'Connell RJ.

Front Immunol. 2018 Jun 21;9:1397. doi: 10.3389/fimmu.2018.01397. eCollection 2018. Review.


Establishing a Europe-wide foundation for high quality midwifery education: The role of the European Midwives Association (EMA).

Vermeulen J, Luyben A, Jokinen M, Matintupa E, O'Connell R, Bick D.

Midwifery. 2018 Sep;64:128-131. doi: 10.1016/j.midw.2018.06.009. Epub 2018 Jun 19.


Specific-IgE to galactose-α-1,3-galactose (alpha-gal) has limited utility in diagnosing meat allergy in a tick-endemic population.

Li J, Fulton RB, O'Connell R, Jang HS, Fernando SL.

Ann Allergy Asthma Immunol. 2018 Oct;121(4):509-511. doi: 10.1016/j.anai.2018.06.025. Epub 2018 Jun 30. No abstract available.


Comparison of Immediate versus Delayed DIEP Flap Reconstruction in Women Who Require Postmastectomy Radiotherapy.

O'Connell RL, Di Micco R, Khabra K, Kirby AM, Harris PA, James SE, Power K, Ramsey KWD, Rusby JE.

Plast Reconstr Surg. 2018 Sep;142(3):594-605. doi: 10.1097/PRS.0000000000004676.


Association of rapidly destructive osteoarthritis of the hip with intra-articular steroid injections.

Hess SR, O'Connell RS, Bednarz CP, Waligora AC 4th, Golladay GJ, Jiranek WA.

Arthroplast Today. 2018 May 7;4(2):205-209. doi: 10.1016/j.artd.2017.12.002. eCollection 2018 Jun.


Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.

Colby DJ, Trautmann L, Pinyakorn S, Leyre L, Pagliuzza A, Kroon E, Rolland M, Takata H, Buranapraditkun S, Intasan J, Chomchey N, Muir R, Haddad EK, Tovanabutra S, Ubolyam S, Bolton DL, Fullmer BA, Gorelick RJ, Fox L, Crowell TA, Trichavaroj R, O'Connell R, Chomont N, Kim JH, Michael NL, Robb ML, Phanuphak N, Ananworanich J; RV411 study group.

Nat Med. 2018 Jul;24(7):923-926. doi: 10.1038/s41591-018-0026-6. Epub 2018 Jun 11.


Validation of the Vectra XT three-dimensional imaging system for measuring breast volume and symmetry following oncological reconstruction.

O'Connell RL, Khabra K, Bamber JC, deSouza N, Meybodi F, Barry PA, Rusby JE.

Breast Cancer Res Treat. 2018 Sep;171(2):391-398. doi: 10.1007/s10549-018-4843-6. Epub 2018 Jun 5.


Red cell distribution width and neutrophil to lymphocyte ratio as predictors of outcomes in acute pancreatitis: A retrospective cohort study.

O'Connell RM, Boland MR, O'Driscoll J, Salih A, Arumugasamy M, Walsh TN, Allen MJ, Beddy DJ.

Int J Surg. 2018 Jul;55:124-127. doi: 10.1016/j.ijsu.2018.05.028. Epub 2018 May 25.


Discursive constructions of professional identity in policy and regulatory discourse.

Fealy G, Hegarty JM, McNamara M, Casey M, O'Leary D, Kennedy C, O'Reilly P, O'Connell R, Brady AM, Nicholson E.

J Adv Nurs. 2018 May 23. doi: 10.1111/jan.13723. [Epub ahead of print]


Subcellular Localization Screening of Colletotrichum higginsianum Effector Candidates Identifies Fungal Proteins Targeted to Plant Peroxisomes, Golgi Bodies, and Microtubules.

Robin GP, Kleemann J, Neumann U, Cabre L, Dallery JF, Lapalu N, O'Connell RJ.

Front Plant Sci. 2018 May 2;9:562. doi: 10.3389/fpls.2018.00562. eCollection 2018.


Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations.

Akapirat S, Karnasuta C, Vasan S, Rerks-Ngarm S, Pitisuttithum P, Madnote S, Savadsuk H, Rittiroongrad S, Puangkaew J, Phogat S, Tartaglia J, Sinangil F, de Souza MS, Excler JL, Kim JH, Robb ML, Michael NL, Ngauy V, O'Connell RJ, Karasavvas N; RV305 Study Group.

PLoS One. 2018 Apr 27;13(4):e0196397. doi: 10.1371/journal.pone.0196397. eCollection 2018.


Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant.

Wen Y, Trinh HV, Linton CE, Tani C, Norais N, Martinez-Guzman D, Ramesh P, Sun Y, Situ F, Karaca-Griffin S, Hamlin C, Onkar S, Tian S, Hilt S, Malyala P, Lodaya R, Li N, Otten G, Palladino G, Friedrich K, Aggarwal Y, LaBranche C, Duffy R, Shen X, Tomaras GD, Montefiori DC, Fulp W, Gottardo R, Burke B, Ulmer JB, Zolla-Pazner S, Liao HX, Haynes BF, Michael NL, Kim JH, Rao M, O'Connell RJ, Carfi A, Barnett SW.

PLoS One. 2018 Apr 26;13(4):e0194266. doi: 10.1371/journal.pone.0194266. eCollection 2018.


Coupling of respiration and attention via the locus coeruleus: Effects of meditation and pranayama.

Melnychuk MC, Dockree PM, O'Connell RG, Murphy PR, Balsters JH, Robertson IH.

Psychophysiology. 2018 Sep;55(9):e13091. doi: 10.1111/psyp.13091. Epub 2018 Apr 22.


Pattern of care and survival of anaplastic lymphoma kinase rearranged non-small cell lung cancer (ALK+ NSCLC) in an Australian Metropolitan Tertiary Referral Centre: A retrospective cohort analysis.

Itchins M, Hayes SA, Gill AJ, Cooper W, O'Connell R, Howell VM, Clarke SJ, Pavlakis N.

Asia Pac J Clin Oncol. 2018 Oct;14(5):e275-e282. doi: 10.1111/ajco.12877. Epub 2018 Apr 19.


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