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A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection.

Zhang W, Yi Z, Keung KL, Shang H, Wei C, Cravedi P, Sun Z, Xi C, Woytovich C, Farouk S, Huang W, Banu K, Gallon L, Magee CN, Najafian N, Samaniego M, Djamali A, Alexander SI, Rosales IA, Smith RN, Xiang J, Lerut E, Kuypers D, Naesens M, O'Connell PJ, Colvin R, Menon MC, Murphy B.

J Am Soc Nephrol. 2019 Aug;30(8):1481-1494. doi: 10.1681/ASN.2018111098. Epub 2019 Jul 5.


Pretransplant transcriptomic signature in peripheral blood predicts early acute rejection.

Zhang W, Yi Z, Wei C, Keung KL, Sun Z, Xi C, Woytovich C, Farouk S, Gallon L, Menon MC, Magee C, Najafian N, Samaniego MD, Djamali A, Alexander SI, Rosales IA, Smith RN, O'Connell PJ, Colvin R, Cravedi P, Murphy B.

JCI Insight. 2019 Jun 6;4(11). pii: 127543. doi: 10.1172/jci.insight.127543. eCollection 2019 Jun 6.


β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes.

Lalwani A, Warren J, Liuwantara D, Hawthorne WJ, O'Connell PJ, Gonzalez FJ, Stokes RA, Chen J, Laybutt DR, Craig ME, Swarbrick MM, King C, Gunton JE.

Cell Rep. 2019 May 21;27(8):2370-2384.e6. doi: 10.1016/j.celrep.2019.04.086.


Standardisation of flow cytometry for whole blood immunophenotyping of islet transplant and transplant clinical trial recipients.

Jimenez Vera E, Chew YV, Nicholson L, Burns H, Anderson P, Chen HT, Williams L, Keung K, Zanjani NT, Dervish S, Patrick E, Wang XM, Yi S, Hawthorne W, Alexander S, O'Connell PJ, Hu M.

PLoS One. 2019 May 22;14(5):e0217163. doi: 10.1371/journal.pone.0217163. eCollection 2019.


Increasing access to integrated ESKD care as part of universal health coverage.

Harris DCH, Davies SJ, Finkelstein FO, Jha V, Donner JA, Abraham G, Bello AK, Caskey FJ, Garcia GG, Harden P, Hemmelgarn B, Johnson DW, Levin NW, Luyckx VA, Martin DE, McCulloch MI, Moosa MR, O'Connell PJ, Okpechi IG, Pecoits Filho R, Shah KD, Sola L, Swanepoel C, Tonelli M, Twahir A, van Biesen W, Varghese C, Yang CW, Zuniga C; Working Groups of the International Society of Nephrology’s 2nd Global Kidney Health Summit.

Kidney Int. 2019 Apr;95(4S):S1-S33. doi: 10.1016/j.kint.2018.12.005. Review.


Mortality in People With Type 1 Diabetes, Severe Hypoglycemia, and Impaired Awareness of Hypoglycemia Referred for Islet Transplantation.

Lee MH, Ward GM, MacIsaac RJ, Howe K, Holmes-Walker DJ, Anderson P, Radford T, Coates PT, Kay TW, O'Connell PJ, Goodman DJ.

Transplant Direct. 2018 Oct 23;4(11):e401. doi: 10.1097/TXD.0000000000000841. eCollection 2018 Nov. No abstract available.


Everolimus and Long-term Clinical Outcomes in Kidney Transplant Recipients: A Registry-based 10-year Follow-up of 5 Randomized Trials.

Ying T, Wong G, Lim WH, Clayton P, Kanellis J, Pilmore H, Campbell S, O'Connell PJ, Russ G, Chadban S.

Transplantation. 2019 Aug;103(8):1705-1713. doi: 10.1097/TP.0000000000002499.


SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts.

Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC.

J Am Soc Nephrol. 2018 Nov;29(11):2641-2657. doi: 10.1681/ASN.2018060573. Epub 2018 Oct 19.


Efficacy and Safety of a Tofacitinib-based Immunosuppressive Regimen After Kidney Transplantation: Results From a Long-term Extension Trial.

Busque S, Vincenti FG, Tedesco Silva H, O'Connell PJ, Yoshida A, Friedewald JJ, Steinberg SM, Budde K, Broeders EN, Kim YS, Hahn CM, Li H, Chan G.

Transplant Direct. 2018 Aug 8;4(9):e380. doi: 10.1097/TXD.0000000000000819. eCollection 2018 Sep.


The causes, significance and consequences of inflammatory fibrosis in kidney transplantation: The Banff i-IFTA lesion.

Nankivell BJ, Shingde M, Keung KL, Fung CL, Borrows RJ, O'Connell PJ, Chapman JR.

Am J Transplant. 2018 Feb;18(2):364-376. doi: 10.1111/ajt.14609. Epub 2018 Jan 3.


Ex vivo-expanded baboon CD39 +  regulatory T cells prevent rejection of porcine islet xenografts in NOD-SCID IL-2rγ-/- mice reconstituted with baboon peripheral blood mononuclear cells.

Huang D, Wang Y, Hawthorne WJ, Hu M, Hawkes J, Burns H, Davies S, Gao F, Chew YV, Yi S, O'Connell PJ.

Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12344. Epub 2017 Sep 30.


Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9.

Nottle MB, Salvaris EJ, Fisicaro N, McIlfatrick S, Vassiliev I, Hawthorne WJ, O'Connell PJ, Brady JL, Lew AM, Cowan PJ.

Sci Rep. 2017 Aug 16;7(1):8383. doi: 10.1038/s41598-017-09030-6.


Transplantation sites for human and murine islets.

Stokes RA, Cheng K, Lalwani A, Swarbrick MM, Thomas HE, Loudovaris T, Kay TW, Hawthorne WJ, O'Connell PJ, Gunton JE.

Diabetologia. 2017 Oct;60(10):1961-1971. doi: 10.1007/s00125-017-4362-8. Epub 2017 Jul 22.


Transplantation sites for porcine islets.

Stokes RA, Simond DM, Burns H, Patel AT, O'Connell PJ, Gunton JE, Hawthorne WJ.

Diabetologia. 2017 Oct;60(10):1972-1976. doi: 10.1007/s00125-017-4363-7. Epub 2017 Jul 21.


Herpes simplex virus-2 transmission following solid organ transplantation: Donor-derived infection and transplantation from prior organ recipients.

Macesic N, Abbott IJ, Kaye M, Druce J, Glanville AR, Gow PJ, Hughes PD, Korman TM, Mulley WR, O'Connell PJ, Opdam H, Paraskeva M, Pitman MC, Setyapranata S, Rawlinson WD, Johnson PDR.

Transpl Infect Dis. 2017 Oct;19(5). doi: 10.1111/tid.12739. Epub 2017 Jul 31.


Clearance of BK Virus Nephropathy by Combination Antiviral Therapy With Intravenous Immunoglobulin.

Kable K, Davies CD, O'connell PJ, Chapman JR, Nankivell BJ.

Transplant Direct. 2017 Mar 10;3(4):e142. doi: 10.1097/TXD.0000000000000641. eCollection 2017 Apr.


BK Virus Nephropathy: Histological Evolution by Sequential Pathology.

Nankivell BJ, Renthawa J, Sharma RN, Kable K, O'Connell PJ, Chapman JR.

Am J Transplant. 2017 Aug;17(8):2065-2077. doi: 10.1111/ajt.14292. Epub 2017 May 5.


Clinical Trials for Immunosuppression in Transplantation: The Case for Reform and Change in Direction.

OʼConnell PJ, Kuypers DR, Mannon RB, Abecassis M, Chadban SJ, Gill JS, Murphy B, Nickerson PW, Schold JD, Stock PG, Seron D, Alloway RR, Bromberg JS, Budde K, Jordan SC, Legendre C, Lefaucheur C, Sarwall M, Segev DL, Stegall MD, Tullius SG, Wong G, Woodle ES, Ascher N, Morris RE.

Transplantation. 2017 Jul;101(7):1527-1534. doi: 10.1097/TP.0000000000001648.


Determinants of regional differences in rates of overeducation in Europe.

Davia MA, McGuinness S, O'Connell PJ.

Soc Sci Res. 2017 Mar;63:67-80. doi: 10.1016/j.ssresearch.2016.09.009. Epub 2016 Oct 4.


Biopsy transcriptome expression profiling: proper validation is key - Authors' reply.

O'Connell PJ, Zhang W, Ge Y, Menon MC, Murphy B.

Lancet. 2017 Feb 11;389(10069):601. doi: 10.1016/S0140-6736(17)30283-0. No abstract available.


Presidential Address: 50 Years of Progress-More Challenges Ahead.

OʼConnell PJ.

Transplantation. 2016 Dec;100(12):2493-2495. No abstract available.


Efficacy and Safety Outcomes of Extended Criteria Donor Kidneys by Subtype: Subgroup Analysis of BENEFIT-EXT at 7 Years After Transplant.

Florman S, Becker T, Bresnahan B, Chevaile-Ramos A, Carvalho D, Grannas G, Muehlbacher F, O'Connell PJ, Meier-Kriesche HU, Larsen CP.

Am J Transplant. 2017 Jan;17(1):180-190. doi: 10.1111/ajt.13886. Epub 2016 Jul 12.


The Transplantation Society Believes a Policy of Engagement Will Facilitate Organ Donation Reform in China.

O'Connell PJ, Ascher N, Delmonico FL.

Am J Transplant. 2016 Nov;16(11):3297-3298. doi: 10.1111/ajt.14050. Epub 2016 Oct 3. No abstract available.


In Vivo Costimulation Blockade-Induced Regulatory T Cells Demonstrate Dominant and Specific Tolerance to Porcine Islet Xenografts.

Wu J, Hu M, Qian YW, Hawthorne WJ, Burns H, Liuwantara D, Alexander SI, Yi S, O'Connell PJ.

Transplantation. 2017 Jul;101(7):1587-1599. doi: 10.1097/TP.0000000000001482.


New solutions to old problems in cell transplantation.

O'Connell PJ.

Curr Opin Organ Transplant. 2016 Oct;21(5):459-60. doi: 10.1097/MOT.0000000000000358. No abstract available.


Characterizing the Mechanistic Pathways of the Instant Blood-Mediated Inflammatory Reaction in Xenogeneic Neonatal Islet Cell Transplantation.

Liuwantara D, Chew YV, Favaloro EJ, Hawkes JM, Burns HL, O'Connell PJ, Hawthorne WJ.

Transplant Direct. 2016 May 19;2(6):e77. doi: 10.1097/TXD.0000000000000590. eCollection 2016 Jun.


Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin Injections.

Holmes-Walker DJ, Gunton JE, Hawthorne W, Payk M, Anderson P, Donath S, Loudovaris T, Ward GM, Kay TW, OʼConnell PJ.

Transplantation. 2017 Jun;101(6):1268-1275. doi: 10.1097/TP.0000000000001381.


Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study.

O'Connell PJ, Zhang W, Menon MC, Yi Z, Schröppel B, Gallon L, Luan Y, Rosales IA, Ge Y, Losic B, Xi C, Woytovich C, Keung KL, Wei C, Greene I, Overbey J, Bagiella E, Najafian N, Samaniego M, Djamali A, Alexander SI, Nankivell BJ, Chapman JR, Smith RN, Colvin R, Murphy B.

Lancet. 2016 Sep 3;388(10048):983-93. doi: 10.1016/S0140-6736(16)30826-1. Epub 2016 Jul 22.


Calcineurin Inhibitor Nephrotoxicity Through the Lens of Longitudinal Histology: Comparison of Cyclosporine and Tacrolimus Eras.

Nankivell BJ, PʼNg CH, OʼConnell PJ, Chapman JR.

Transplantation. 2016 Aug;100(8):1723-31. doi: 10.1097/TP.0000000000001243.


Regulatory T cells in kidney disease and transplantation.

Hu M, Wang YM, Wang Y, Zhang GY, Zheng G, Yi S, O'Connell PJ, Harris DC, Alexander SI.

Kidney Int. 2016 Sep;90(3):502-14. doi: 10.1016/j.kint.2016.03.022. Epub 2016 Jun 3. Review.


Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement.

Markmann JF, Bartlett ST, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, OʼConnell PJ, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Khovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T.

Transplantation. 2016 Jul;100(7):e25-31. doi: 10.1097/TP.0000000000001054. Review.


Erratum. Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes 2012;61:1180-1191.

Yi S, Ji M, Wu J, Ma X, Phillips P, Hawthorne WJ, O'Connell PJ.

Diabetes. 2016 Feb;65(2):534. doi: 10.2337/db16-er02. No abstract available.


Human islet cells are killed by BID-independent mechanisms in response to FAS ligand.

Joglekar MV, Trivedi PM, Kay TW, Hawthorne WJ, O'Connell PJ, Jenkins AJ, Hardikar AA, Thomas HE.

Apoptosis. 2016 Apr;21(4):379-89. doi: 10.1007/s10495-016-1212-y.


Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models.

Stewart JM, Tarantal AF, Hawthorne WJ, Salvaris EJ, O'Connell PJ, Nottle MB, d'Apice AJ, Cowan PJ, Kearns-Jonker M.

Xenotransplantation. 2015 Nov-Dec;22(6):413-26. doi: 10.1111/xen.12199. Epub 2015 Oct 21.


The Use of Genomics and Pathway Analysis in Our Understanding and Prediction of Clinical Renal Transplant Injury.

Menon MC, Keung KL, Murphy B, OʼConnell PJ.

Transplantation. 2016 Jul;100(7):1405-14. doi: 10.1097/TP.0000000000000943. Review.


Clinical Utility of Urinary Cytology to Detect BK Viral Nephropathy.

Nankivell BJ, Renthawa J, Jeoffreys N, Kable K, O'Connell PJ, Chapman JR, Wong G, Sharma RN.

Transplantation. 2015 Aug;99(8):1715-22. doi: 10.1097/TP.0000000000000642.


T lymphocytes possess the machinery for 5-HT synthesis, storage, degradation and release.

Chen Y, Leon-Ponte M, Pingle SC, O'Connell PJ, Ahern GP.

Acta Physiol (Oxf). 2015 Apr;213(4):860-7. doi: 10.1111/apha.12470. Epub 2015 Feb 28.


Long-term cultured neonatal islet cell clusters demonstrate better outcomes for reversal of diabetes: in vivo and molecular profiles.

Jimenez-Vera E, Davies S, Phillips P, O'Connell PJ, Hawthorne WJ.

Xenotransplantation. 2015 Mar-Apr;22(2):114-23. doi: 10.1111/xen.12151. Epub 2015 Feb 10.


Evaluation of the effect of tofacitinib exposure on outcomes in kidney transplant patients.

Vincenti F, Silva HT, Busque S, O'Connell PJ, Russ G, Budde K, Yoshida A, Tortorici MA, Lamba M, Lawendy N, Wang W, Chan G.

Am J Transplant. 2015 Jun;15(6):1644-53. doi: 10.1111/ajt.13181. Epub 2015 Feb 3.


Renal transplantation: better fat than thin.

Chung H, Lam VW, Yuen LP, Ryan BJ, O'Connell PJ, Chapman JR, Hawthorne WJ, Pleass HC.

J Surg Res. 2015 Apr;194(2):644-52. doi: 10.1016/j.jss.2013.12.027. Epub 2014 Jan 3.


Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model.

Brady JL, Harrison LC, Goodman DJ, Cowan PJ, Hawthorne WJ, O'Connell PJ, Sutherland RM, Lew AM.

Clin Transl Immunology. 2014 Dec 19;3(12):e29. doi: 10.1038/cti.2014.28. eCollection 2014 Dec.


Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis.

Menon MC, Chuang PY, Li Z, Wei C, Zhang W, Luan Y, Yi Z, Xiong H, Woytovich C, Greene I, Overbey J, Rosales I, Bagiella E, Chen R, Ma M, Li L, Ding W, Djamali A, Saminego M, O'Connell PJ, Gallon L, Colvin R, Schroppel B, He JC, Murphy B.

J Clin Invest. 2015 Jan;125(1):208-21. doi: 10.1172/JCI76902. Epub 2014 Dec 1.


Islet cell transplantation in Australia: screening, remote transplantation, and incretin hormone secretion in insulin independent patients.

Marathe CS, Drogemuller CJ, Marathe JA, Loudavaris T, Hawthorne WJ, O'Connell PJ, Radford T, Kay TW, Horowitz M, Coates PT, Torpy DJ.

Horm Metab Res. 2015 Jan;47(1):16-23. doi: 10.1055/s-0034-1389941. Epub 2014 Oct 28. Review.


The role of macrophages in the development of human renal allograft fibrosis in the first year after transplantation.

Toki D, Zhang W, Hor KL, Liuwantara D, Alexander SI, Yi Z, Sharma R, Chapman JR, Nankivell BJ, Murphy B, O'Connell PJ.

Am J Transplant. 2014 Sep;14(9):2126-36. doi: 10.1111/ajt.12803. Epub 2014 Aug 6.


Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010.

Balamurugan AN, Naziruddin B, Lockridge A, Tiwari M, Loganathan G, Takita M, Matsumoto S, Papas K, Trieger M, Rainis H, Kin T, Kay TW, Wease S, Messinger S, Ricordi C, Alejandro R, Markmann J, Kerr-Conti J, Rickels MR, Liu C, Zhang X, Witkowski P, Posselt A, Maffi P, Secchi A, Berney T, O'Connell PJ, Hering BJ, Barton FB.

Am J Transplant. 2014 Nov;14(11):2595-606. doi: 10.1111/ajt.12872. Epub 2014 Oct 2.


Professor Bruce Hall and the ABC.

Chapman JR, McCaughan GW, O'Connell PJ.

Med J Aust. 2014 Sep 15;201(6):322. No abstract available.


Organ transplantation in China--not yet a new era.

Delmonico FL, Capron AM, Danovitch GM, Levin A, O'Connell PJ.

Lancet. 2014 Aug 30;384(9945):741. doi: 10.1016/S0140-6736(14)61430-6. No abstract available.


The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation.

Kim MK, Choi HJ, Kwon I, Pierson RN 3rd, Cooper DK, Soulillou JP, O'Connell PJ, Vabres B, Maeda N, Hara H, Scobie L, Gianello P, Takeuchi Y, Yamada K, Hwang ES, Kim SJ, Park CG; International Xenotransplantation Association.

Xenotransplantation. 2014 Sep-Oct;21(5):420-30. doi: 10.1111/xen.12129. Epub 2014 Sep 1.


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