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Items: 1 to 50 of 92

1.

GATA-2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in human subjects.

Desai A, Sowerwine K, Liu Y, Lawrence MG, Chovanec J, Hsu AP, O'Connell MP, Kim J, Boris L, Jones N, Wisch L, Eisch RR, Carter MC, Komarow HD, Zerbe C, Milner JD, Maric I, Sun X, Lee CR, Tunc I, Pirooznia M, Stone KD, Holland SM, Metcalfe DD, Lyons JJ.

J Allergy Clin Immunol. 2019 Aug;144(2):613-617.e14. doi: 10.1016/j.jaci.2019.05.007. Epub 2019 May 15. No abstract available.

PMID:
31102699
2.

Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production.

Tobío A, Bandara G, Morris DA, Kim DK, O'Connell MP, Komarow HD, Carter MC, Smrz D, Metcalfe DD, Olivera A.

Haematologica. 2020 Jan;105(1):124-135. doi: 10.3324/haematol.2018.212126. Epub 2019 Apr 4.

3.

PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.

Zhang Y, Ma CA, Lawrence MG, Break TJ, O'Connell MP, Lyons JJ, López DB, Barber JS, Zhao Y, Barber DL, Freeman AF, Holland SM, Lionakis MS, Milner JD.

J Exp Med. 2017 Sep 4;214(9):2523-2533. doi: 10.1084/jem.20161427. Epub 2017 Jul 14.

4.

Correction: ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

Lyons JJ, Liu Y, Ma CA, Yu X, O'Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegel AM, Stone KD, Nelson C, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD.

J Exp Med. 2017 Apr 3;214(4):1201. doi: 10.1084/jem.2016143503082017c. Epub 2017 Mar 13. No abstract available.

5.

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

Lyons JJ, Liu Y, Ma CA, Yu X, O'Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegel AM, Stone KD, Nelson C, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD.

J Exp Med. 2017 Mar 6;214(3):669-680. doi: 10.1084/jem.20161435. Epub 2017 Jan 26. Erratum in: J Exp Med. 2017 Apr 3;214(4):1201.

6.

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.

Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD.

Nat Genet. 2016 Dec;48(12):1564-1569. doi: 10.1038/ng.3696. Epub 2016 Oct 17.

7.

Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT.

Nature. 2016 Sep 8;537(7619):254. doi: 10.1038/nature18939. Epub 2016 Jul 6. No abstract available.

PMID:
27383789
8.

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT.

Nature. 2016 Apr 14;532(7598):250-4. doi: 10.1038/nature17392. Epub 2016 Apr 4.

9.

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.

Hox V, O'Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD.

J Allergy Clin Immunol. 2016 Jul;138(1):187-199. doi: 10.1016/j.jaci.2015.11.024. Epub 2016 Mar 2. Erratum in: J Allergy Clin Immunol. 2017 Jul;140(1):320.

10.

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.

Webster MR, Xu M, Kinzler KA, Kaur A, Appleton J, O'Connell MP, Marchbank K, Valiga A, Dang VM, Perego M, Zhang G, Slipicevic A, Keeney F, Lehrmann E, Wood W 3rd, Becker KG, Kossenkov AV, Frederick DT, Flaherty KT, Xu X, Herlyn M, Murphy ME, Weeraratna AT.

Pigment Cell Melanoma Res. 2015 Mar;28(2):184-95. doi: 10.1111/pcmr.12330. Epub 2014 Dec 29.

11.

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.

Milner JD, Vogel TP, Forbes L, Ma CA, Stray-Pedersen A, Niemela JE, Lyons JJ, Engelhardt KR, Zhang Y, Topcagic N, Roberson ED, Matthews H, Verbsky JW, Dasu T, Vargas-Hernandez A, Varghese N, McClain KL, Karam LB, Nahmod K, Makedonas G, Mace EM, Sorte HS, Perminow G, Rao VK, O'Connell MP, Price S, Su HC, Butrick M, McElwee J, Hughes JD, Willet J, Swan D, Xu Y, Santibanez-Koref M, Slowik V, Dinwiddie DL, Ciaccio CE, Saunders CJ, Septer S, Kingsmore SF, White AJ, Cant AJ, Hambleton S, Cooper MA.

Blood. 2015 Jan 22;125(4):591-9. doi: 10.1182/blood-2014-09-602763. Epub 2014 Oct 30.

12.

Lean methodology: an evidence-based practice approach for healthcare improvement.

Johnson PM, Patterson CJ, OʼConnell MP.

Nurse Pract. 2013 Dec 10;38(12):1-7. doi: 10.1097/01.NPR.0000437576.14143.b9.

PMID:
24253524
13.

Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.

O'Connell MP, Marchbank K, Webster MR, Valiga AA, Kaur A, Vultur A, Li L, Herlyn M, Villanueva J, Liu Q, Yin X, Widura S, Nelson J, Ruiz N, Camilli TC, Indig FE, Flaherty KT, Wargo JA, Frederick DT, Cooper ZA, Nair S, Amaravadi RK, Schuchter LM, Karakousis GC, Xu W, Xu X, Weeraratna AT.

Cancer Discov. 2013 Dec;3(12):1378-93. doi: 10.1158/2159-8290.CD-13-0005. Epub 2013 Oct 8.

14.

Change is in the air: the hypoxic induction of phenotype switching in melanoma.

O'Connell MP, Weeraratna AT.

J Invest Dermatol. 2013 Oct;133(10):2316-2317. doi: 10.1038/jid.2013.208.

15.

An unusual case of post-operative pain following caesarean section.

Geisler ME, O'Connell MP.

Ir Med J. 2012 Nov-Dec;105(10):348-9. No abstract available.

PMID:
23495553
16.

Methadone dosing and prescribed medication use in a prospective cohort of opioid-dependent pregnant women.

Cleary BJ, Reynolds K, Eogan M, O'Connell MP, Fahey T, Gallagher PJ, Clarke T, White MJ, McDermott C, O'Sullivan A, Carmody D, Gleeson J, Murphy DJ.

Addiction. 2013 Apr;108(4):762-70. doi: 10.1111/add.12078. Epub 2013 Feb 11.

PMID:
23216809
17.

Methadone and perinatal outcomes: a prospective cohort study.

Cleary BJ, Eogan M, O'Connell MP, Fahey T, Gallagher PJ, Clarke T, White MJ, McDermott C, O'Sullivan A, Carmody D, Gleeson J, Murphy DJ.

Addiction. 2012 Aug;107(8):1482-92. doi: 10.1111/j.1360-0443.2012.03844.x. Epub 2012 May 8.

PMID:
22340442
18.

Piriformis pyomyositis, an unusual presentation of leg pain post partum--case report and review of literature.

Wong LF, Mullers S, McGuinness E, Meaney J, O'Connell MP, Fitzpatrick C.

J Matern Fetal Neonatal Med. 2012 Aug;25(8):1505-7. doi: 10.3109/14767058.2011.636098. Epub 2011 Dec 6. Review.

PMID:
22082187
19.

A spoonful of sugar makes the melanoma go: the role of heparan sulfate proteoglycans in melanoma metastasis.

O'Connell MP, Weeraratna AT.

Pigment Cell Melanoma Res. 2011 Dec;24(6):1133-47. doi: 10.1111/j.1755-148X.2011.00918.x. Epub 2011 Nov 2. Review.

PMID:
21978367
20.

The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein.

Fiori JL, Sanghvi M, O'Connell MP, Krzysik-Walker SM, Moaddel R, Bernier M.

Br J Pharmacol. 2011 Oct;164(3):1026-40. doi: 10.1111/j.1476-5381.2011.01384.x.

21.

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.

Camilli TC, Xu M, O'Connell MP, Chien B, Frank BP, Subaran S, Indig FE, Morin PJ, Hewitt SM, Weeraratna AT.

Pigment Cell Melanoma Res. 2011 Feb;24(1):175-86. doi: 10.1111/j.1755-148X.2010.00792.x. Epub 2010 Dec 1.

22.

How effective is amniotomy as a means of induction of labour?

Cooley SM, Geary MP, O'Connell MP, McQuillan K, McParland P, Keane D.

Ir J Med Sci. 2010 Sep;179(3):381-3. doi: 10.1007/s11845-010-0502-6. Epub 2010 May 28.

PMID:
20509002
23.

Lack of Wnt5A expression in Merkel cell carcinoma.

Weeraratna AT, Houben R, O'Connell MP, Becker JC.

Arch Dermatol. 2010 Jan;146(1):88-9. doi: 10.1001/archdermatol.2009.348. No abstract available.

24.

The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma.

O'Connell MP, Fiori JL, Xu M, Carter AD, Frank BP, Camilli TC, French AD, Dissanayake SK, Indig FE, Bernier M, Taub DD, Hewitt SM, Weeraratna AT.

Oncogene. 2010 Jan 7;29(1):34-44. doi: 10.1038/onc.2009.305. Epub 2009 Oct 5.

25.

Conservative management of placenta accreta.

Russell NE, Gleeson V, Robson M, McAuliffe FM, O'Connell MP.

Ir Med J. 2009 Jul-Aug;102(7):232-3.

PMID:
19772011
26.

Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt.

O'Connell MP, Weeraratna AT.

Pigment Cell Melanoma Res. 2009 Dec;22(6):724-39. doi: 10.1111/j.1755-148X.2009.00627.x. Epub 2009 Aug 25. Review.

27.

Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells.

O'Connell MP, Fiori JL, Kershner EK, Frank BP, Indig FE, Taub DD, Hoek KS, Weeraratna AT.

J Biol Chem. 2009 Oct 16;284(42):28704-12. doi: 10.1074/jbc.M109.028498. Epub 2009 Aug 20.

28.

Resuscitation at the limits of viability--an Irish perspective.

Khan RA, Burgoyne L, O'Connell MP, Dempsey EM.

Acta Paediatr. 2009 Sep;98(9):1456-60. doi: 10.1111/j.1651-2227.2009.01400.x.

PMID:
19673731
29.

Aplastic anaemia: uncomplicated pregnancy following allogeneic bone marrow transplantation.

Martyn F, O'Connell MP.

J Obstet Gynaecol. 2009 Jul;29(5):441. doi: 10.1080/01443610902952547. No abstract available.

PMID:
19603329
30.

Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration.

Ghosh MC, Collins GD, Vandanmagsar B, Patel K, Brill M, Carter A, Lustig A, Becker KG, Wood WW 3rd, Emeche CD, French AD, O'Connell MP, Xu M, Weeraratna AT, Taub DD.

Blood. 2009 Aug 13;114(7):1366-73. doi: 10.1182/blood-2008-08-175869. Epub 2009 Jun 11.

31.

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.

Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y.

Nat Genet. 2009 May;41(5):518-20. doi: 10.1038/ng.340. Epub 2009 Mar 29.

32.

PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells.

French AD, Fiori JL, Camilli TC, Leotlela PD, O'Connell MP, Frank BP, Subaran S, Indig FE, Taub DD, Weeraratna AT.

Int J Med Sci. 2009;6(2):93-101. Epub 2009 Mar 12.

33.

Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells.

Fiori JL, Zhu TN, O'Connell MP, Hoek KS, Indig FE, Frank BP, Morris C, Kole S, Hasskamp J, Elias G, Weeraratna AT, Bernier M.

Endocrinology. 2009 Jun;150(6):2551-60. doi: 10.1210/en.2008-1344. Epub 2009 Feb 12.

34.

Wnt5A activates the calpain-mediated cleavage of filamin A.

O'Connell MP, Fiori JL, Baugher KM, Indig FE, French AD, Camilli TC, Frank BP, Earley R, Hoek KS, Hasskamp JH, Elias EG, Taub DD, Bernier M, Weeraratna AT.

J Invest Dermatol. 2009 Jul;129(7):1782-9. doi: 10.1038/jid.2008.433. Epub 2009 Jan 29.

35.

Assaying Wnt5A-mediated invasion in melanoma cells.

O'Connell MP, French AD, Leotlela PD, Weeraratna AT.

Methods Mol Biol. 2008;468:243-53. doi: 10.1007/978-1-59745-249-6_19.

36.

Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.

Dissanayake SK, Olkhanud PB, O'Connell MP, Carter A, French AD, Camilli TC, Emeche CD, Hewitt KJ, Rosenthal DT, Leotlela PD, Wade MS, Yang SW, Brant L, Nickoloff BJ, Messina JL, Biragyn A, Hoek KS, Taub DD, Longo DL, Sondak VK, Hewitt SM, Weeraratna AT.

Cancer Res. 2008 Dec 15;68(24):10205-14. doi: 10.1158/0008-5472.CAN-08-2149.

37.

Comparative study on the outcome of obstetric cholestasis.

Wong LF, Shallow H, O'Connell MP.

J Matern Fetal Neonatal Med. 2008 May;21(5):327-30. doi: 10.1080/14767050802034446.

PMID:
18446660
38.

Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP).

Billings PC, Fiori JL, Bentwood JL, O'Connell MP, Jiao X, Nussbaum B, Caron RJ, Shore EM, Kaplan FS.

J Bone Miner Res. 2008 Mar;23(3):305-13.

39.

HSPG modulation of BMP signaling in fibrodysplasia ossificans progressiva cells.

O'Connell MP, Billings PC, Fiori JL, Deirmengian G, Roach HI, Shore EM, Kaplan FS.

J Cell Biochem. 2007 Dec 15;102(6):1493-503.

PMID:
17516498
40.

The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.

Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT.

J Biol Chem. 2007 Jun 8;282(23):17259-71. Epub 2007 Apr 10.

41.

Heparan sulfate proteoglycans (HSPGs) modulate BMP2 osteogenic bioactivity in C2C12 cells.

Jiao X, Billings PC, O'Connell MP, Kaplan FS, Shore EM, Glaser DL.

J Biol Chem. 2007 Jan 12;282(2):1080-6. Epub 2006 Oct 3.

42.

Knowledge and usage of seat belts in an Irish pregnant population.

O'Connell MP, Potter H.

Ir Med J. 2006 May;99(5):156-7. No abstract available.

PMID:
16892925
43.

Positioning impact on the surgical patient.

O'Connell MP.

Nurs Clin North Am. 2006 Jun;41(2):173-92, v. Review.

PMID:
16698337
44.

Spontaneous uterine artery rupture: a rare cause of abdominal pain in pregnancy.

O'Connell MP, Prendiville W.

J Obstet Gynaecol. 2005 Jul;25(5):511-2. No abstract available.

PMID:
16183596
45.

Helminth communities of the lesser sandeel Ammodytes tobianus L. off the west coast of Ireland.

O'Connell MP, Fives JM.

J Parasitol. 2004 Oct;90(5):1058-61.

PMID:
15562606
46.

Trends in obstetric care in the United Kingdom.

O'Connell MP, Lindow SW.

J Obstet Gynaecol. 2000 Nov;20(6):592-3.

PMID:
15512671
47.

Chronic hypokalaemia in pregnancy secondary to hyperemesis gravidarum.

O'Connell MP, Poon P, Lindow SW, Robinson DW.

J Obstet Gynaecol. 1999 Sep;19(5):532. No abstract available.

PMID:
15512384
48.

Incarcerated retroverted uterus--a non recurring complication of pregnancy.

O'Connell MP, Ivory CM, Hunter RW.

J Obstet Gynaecol. 1999 Jan;19(1):84-5. No abstract available.

PMID:
15512235
49.

Solvent-detergent plasma as replacement therapy in a pregnant patient with factor V deficiency.

O'Connell MP, Eogan M, Murphy KM, White B, Keane DP, O'Donnell J.

J Matern Fetal Neonatal Med. 2004 Jul;16(1):69-70.

PMID:
15370088
50.

Is the monitoring of anti-Xa activity necessary in pregnant women undergoing thromboprophylaxis?

O'Connell MP, O'Leary M, MacKeogh L, Murphy K, Keane DP.

Eur J Obstet Gynecol Reprod Biol. 2004 May 10;114(1):12-4.

PMID:
15099863

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