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BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes.

O'Brien SL, Johnstone EKM, Devost D, Conroy J, Reichelt ME, Purdue BW, Ayoub MA, Kawai T, Inoue A, Eguchi S, Hébert TE, Pfleger KDG, Thomas WG.

Biochem Pharmacol. 2018 Oct 19. pii: S0006-2952(18)30438-6. doi: 10.1016/j.bcp.2018.10.017. [Epub ahead of print]


Control of norovirus infection.

O'Brien SJ, Sanderson RA, Rushton SP.

Curr Opin Gastroenterol. 2018 Oct 20. doi: 10.1097/MOG.0000000000000491. [Epub ahead of print]


Prolymphocytic transformation of Lymphoplasmacytic lymphoma; an extremely unusual event.

Zhang K, Farrell D, Jeyakumar D, O'Brien S, Zhao X, Rezk SA.

Hum Pathol. 2018 Oct 17. pii: S0046-8177(18)30385-X. doi: 10.1016/j.humpath.2018.09.021. [Epub ahead of print]


Inpatient Health Care Utilization in Children With Hemophilia Before and After the Joint Outcome Study Publication.

Drayton Jackson M, O'Brien SH, Stanek J, Dunn AL, Kerlin BA.

J Pediatr Hematol Oncol. 2018 Oct 18. doi: 10.1097/MPH.0000000000001329. [Epub ahead of print]


A prospective analysis of symptom burden for patients with chronic myeloid leukemia in chronic phase treated with frontline second- and third-generation tyrosine kinase inhibitors.

Zulbaran-Rojas A, Lin HK, Shi Q, Williams LA, George B, Garcia-Manero G, Jabbour E, O'Brien S, Ravandi F, Wierda W, Estrov Z, Borthakur G, Kadia T, Cleeland C, Cortes JE, Kantarjian H.

Cancer Med. 2018 Oct 14. doi: 10.1002/cam4.1808. [Epub ahead of print]


Total Knee Arthroplasty in Severe Valgus Deformity Using a Modified Technique-A 10-Year Follow-Up Study.

Tucker A, O'Brien S, Doran E, Gallagher N, Beverland DE.

J Arthroplasty. 2018 Sep 18. pii: S0883-5403(18)30767-8. doi: 10.1016/j.arth.2018.09.002. [Epub ahead of print]


Chemoimmunotherapy with inotuzumab ozogamicin combined with mini-hyper-CVD, with or without blinatumomab, is highly effective in patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first salvage.

Jabbour E, Sasaki K, Ravandi F, Huang X, Short NJ, Khouri M, Kebriaei P, Burger J, Khoury J, Jorgensen J, Jain N, Konopleva M, Garcia-Manero G, Kadia T, Cortes J, Jacob J, Montalbano K, Garris R, O'Brien S, Kantarjian H.

Cancer. 2018 Oct 11. doi: 10.1002/cncr.31720. [Epub ahead of print]


Variation in Platelet Delta Granules Over Time in Young Women Undergoing Evaluation for Heavy Menstrual Bleeding.

Woods GM, Pillay Smiley N, Stanek J, Kahwash S, Kerlin BA, O'Brien SH.

Pediatr Dev Pathol. 2018 Oct 9:1093526618803838. doi: 10.1177/1093526618803838. [Epub ahead of print]


Clinical implications of the 2018 iwCLL Guidelines update.

O'Brien SM.

Clin Adv Hematol Oncol. 2018 Aug;16 Suppl 15(8):1-16. No abstract available.


Sarcopenia and Post-Operative Morbidity and Mortality in Patients with Gastric Cancer.

O'Brien S, Twomey M, Moloney F, Kavanagh RG, Carey BW, Power D, Maher MM, O'Connor OJ, Ó'Súilleabháin C.

J Gastric Cancer. 2018 Sep;18(3):242-252. doi: 10.5230/jgc.2018.18.e25. Epub 2018 Sep 5.


Intravenous Immunoglobulin Versus Anti-D Immunoglobulin: When Better Treatment May Not Be the Best Treatment.

O'Brien SH, Despotovic JM, Neunert CE.

J Pediatr. 2018 Sep 28. pii: S0022-3476(18)31236-8. doi: 10.1016/j.jpeds.2018.08.062. [Epub ahead of print] No abstract available.


Social patterning of telephone health-advice for diarrhoea and vomiting: analysis of 24 million telehealth calls in England.

Adams NL, Rose TC, Elliot AJ, Smith G, Morbey R, Loveridge P, Lewis J, Studdard G, Violato M, O'Brien SJ, Whitehead M, Taylor-Robinson DC, Hawker JI, Barr B.

J Infect. 2018 Sep 26. pii: S0163-4453(18)30281-0. doi: 10.1016/j.jinf.2018.09.008. [Epub ahead of print]


Interest in Learning about Fertility Status Among Male Adolescent and Young Adult Survivors of Childhood Cancer.

Ferrante AC, Gerhardt CA, Yeager ND, Rausch JR, Lehmann V, O'Brien S, Quinn GP, Nahata L.

J Adolesc Young Adult Oncol. 2018 Sep 27. doi: 10.1089/jayao.2018.0094. [Epub ahead of print]


Two-year follow-up of donors in a large national study of ferritin testing.

Goldman M, Uzicanin S, Osmond L, Yi QL, Scalia V, O'Brien SF.

Transfusion. 2018 Sep 27. doi: 10.1111/trf.14941. [Epub ahead of print]


Improvement in Parameters of Hematologic and Immunologic Function and Patient Well-being in the Phase III RESONATE Study of Ibrutinib Versus Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

Barrientos JC, O'Brien S, Brown JR, Kay NE, Reddy NM, Coutre S, Tam C, Mulligan S, Jaeger U, Devereux S, Pocock C, Robak T, Schuster SJ, Schuh A, Gill D, Bloor A, Dearden C, Moreno C, Cull G, Hamblin M, Jones JA, Eckert K, Solman IG, Suzuki S, Hsu E, James DF, Byrd JC, Hillmen P.

Clin Lymphoma Myeloma Leuk. 2018 Aug 18. pii: S2152-2650(18)30574-3. doi: 10.1016/j.clml.2018.08.007. [Epub ahead of print]


Highlights in chronic lymphocytic leukemia from the 2018 American Society of Clinical Oncology Annual Meeting: commentary.

O'Brien SM.

Clin Adv Hematol Oncol. 2018 Jul;16 Suppl 12(7):14-15. No abstract available.


Approaches to Chronic Lymphocytic Leukemia Therapy in the Era of New Agents: The Conundrum of Many Options.

Jain N, Thompson P, Ferrajoli A, Nabhan C, Mato AR, O'Brien S.

Am Soc Clin Oncol Educ Book. 2018 May 23;(38):580-591. doi: 10.1200/EDBK_200691.


Development of a Congenital Heart Surgery Composite Quality Metric: Part 2 - Analytic Methods.

O'Brien SM, Jacobs JP, Shahian DM, Jacobs ML, Gaynor JW, Romano JC, Gaies MG, Hill KD, Mayer JE, Pasquali SK.

Ann Thorac Surg. 2018 Sep 15. pii: S0003-4975(18)31257-8. doi: 10.1016/j.athoracsur.2018.07.036. [Epub ahead of print]


Development of a Congenital Heart Surgery Composite Quality Metric: Part 1 - Conceptual Framework.

Pasquali SK, Shahian DM, O'Brien SM, Jacobs ML, Gaynor JW, Romano JC, Gaies MG, Hill KD, Mayer JE, Jacobs JP.

Ann Thorac Surg. 2018 Sep 15. pii: S0003-4975(18)31258-X. doi: 10.1016/j.athoracsur.2018.07.037. [Epub ahead of print]


Utility of a screening tool for haemostatic defects in a multicentre cohort of adolescents with heavy menstrual bleeding.

Zia A, Stanek J, Christian-Rancy M, Ahuja SP, Savelli S, O'Brien SH.

Haemophilia. 2018 Sep 12. doi: 10.1111/hae.13609. [Epub ahead of print]


A pilot study of hormonal contraceptive use and bone mineral density in young women with sickle cell disease.

Harrell KJ, Stanek J, Bonny AE, Christian-Rancy M, Creary SE, Desai P, O'Brien SH.

Pediatr Blood Cancer. 2018 Dec;65(12):e27398. doi: 10.1002/pbc.27398. Epub 2018 Sep 11. No abstract available.


Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.

Toofan P, Busch C, Morrison H, O'Brien S, Jørgensen H, Copland M, Wheadon H.

Cell Death Dis. 2018 Sep 11;9(9):927. doi: 10.1038/s41419-018-0905-2.


A spatial and temporal analysis of risk factors associated with sporadic Shiga toxin-producing Escherichia coli O157 infection in England between 2009 and 2015.

Elson R, Grace K, Vivancos R, Jenkins C, Adak GK, O'Brien SJ, Lake IR.

Epidemiol Infect. 2018 Nov;146(15):1928-1939. doi: 10.1017/S095026881800256X. Epub 2018 Sep 12.


Radiology: Imaging Trauma Patients in a Deployed Setting.

Ritter J, O'Brien S, Rivet D, Gibb I, Grimes J, Hinds S, Jessinger R, May T, Wirt M, Shackelford S, Adam O, York G, Ritchie B, Flores R, Stockinger Z.

Mil Med. 2018 Sep 1;183(suppl_2):60-64. doi: 10.1093/milmed/usy063.


Multi-drug resistant Escherichia coli in diarrhoeagenic foals: Pulsotyping, phylotyping, serotyping, antibiotic resistance and virulence profiling.

Kennedy CA, Walsh C, Karczmarczyk M, O'Brien S, Akasheh N, Quirke M, Farrell-Ward S, Buckley T, Fogherty U, Kavanagh K, Parker CT, Sweeney T, Fanning S.

Vet Microbiol. 2018 Sep;223:144-152. doi: 10.1016/j.vetmic.2018.08.009. Epub 2018 Aug 7.


International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design.

Bangalore S, Maron DJ, Fleg JL, O'Brien SM, Herzog CA, Stone GW, Mark DB, Spertus JA, Alexander KP, Sidhu MS, Chertow GM, Boden WE, Hochman JS; ISCHEMIA-CKD Research Group.

Am Heart J. 2018 Aug 1;205:42-52. doi: 10.1016/j.ahj.2018.07.023. [Epub ahead of print]


Recurring Genomic Structural Variation Leads to Clonal Instability and Loss of Productivity.

Bandyopadhyay AA, O'Brien SA, Zhao L, Fu HY, Vishwanathan N, Hu WS.

Biotechnol Bioeng. 2018 Aug 25. doi: 10.1002/bit.26823. [Epub ahead of print]


Incidence of household transmission of acute gastroenteritis (AGE) in a primary care sentinel network (1992-2017): cross-sectional and retrospective cohort study protocol.

de Lusignan S, Konstantara E, Joy M, Sherlock J, Hoang U, Coyle R, Ferreira F, Jones S, O'Brien SJ.

BMJ Open. 2018 Aug 23;8(8):e022524. doi: 10.1136/bmjopen-2018-022524.


A systematic review of methods to measure menstrual blood loss.

Magnay JL, O'Brien S, Gerlinger C, Seitz C.

BMC Womens Health. 2018 Aug 22;18(1):142. doi: 10.1186/s12905-018-0627-8.


Cladribine and low-dose cytarabine alternating with decitabine as front-line therapy for elderly patients with acute myeloid leukaemia: a phase 2 single-arm trial.

Kadia TM, Cortes J, Ravandi F, Jabbour E, Konopleva M, Benton CB, Burger J, Sasaki K, Borthakur G, DiNardo CD, Pemmaraju N, Daver N, Ferrajoli A, Wang X, Patel K, Jorgensen JL, Wang S, O'Brien S, Pierce S, Tuttle C, Estrov Z, Verstovsek S, Garcia-Manero G, Kantarjian H.

Lancet Haematol. 2018 Sep;5(9):e411-e421. doi: 10.1016/S2352-3026(18)30132-7. Epub 2018 Aug 13.


Foodborne and Food-Handler Norovirus Outbreaks: A Systematic Review.

Hardstaff JL, Clough HE, Lutje V, McIntyre KM, Harris JP, Garner P, O'Brien SJ.

Foodborne Pathog Dis. 2018 Oct;15(10):589-597. doi: 10.1089/fpd.2018.2452. Epub 2018 Aug 15.


Author Correction: Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.

Kukekova AV, Johnson JL, Xiang X, Feng S, Liu S, Rando HM, Kharlamova AV, Herbeck Y, Serdyukova NA, Xiong Z, Beklemischeva V, Koepfli KP, Gulevich RG, Vladimirova AV, Hekman JP, Perelman PL, Graphodatsky AS, O'Brien SJ, Wang X, Clark AG, Acland GM, Trut LN, Zhang G.

Nat Ecol Evol. 2018 Sep;2(9):1514. doi: 10.1038/s41559-018-0664-6.


Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya.

Carron M, Chang YM, Momanyi K, Akoko J, Kiiru J, Bettridge J, Chaloner G, Rushton J, O'Brien S, Williams N, Fèvre EM, Häsler B.

PLoS Negl Trop Dis. 2018 Aug 13;12(8):e0006658. doi: 10.1371/journal.pntd.0006658. eCollection 2018 Aug.


Duvelisib, an oral dual PI3K-δ,γ inhibitor, shows clinical and pharmacodynamic activity in chronic lymphocytic leukemia and small lymphocytic lymphoma in a phase 1 study.

O'Brien S, Patel M, Kahl BS, Horwitz SM, Foss FM, Porcu P, Jones J, Burger J, Jain N, Allen K, Faia K, Douglas M, Stern HM, Sweeney J, Kelly P, Kelly V, Flinn I.

Am J Hematol. 2018 Nov;93(11):1318-1326. doi: 10.1002/ajh.25243. Epub 2018 Oct 20.


Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.

Kukekova AV, Johnson JL, Xiang X, Feng S, Liu S, Rando HM, Kharlamova AV, Herbeck Y, Serdyukova NA, Xiong Z, Beklemischeva V, Koepfli KP, Gulevich RG, Vladimirova AV, Hekman JP, Perelman PL, Graphodatsky AS, O'Brien SJ, Wang X, Clark AG, Acland GM, Trut LN, Zhang G.

Nat Ecol Evol. 2018 Sep;2(9):1479-1491. doi: 10.1038/s41559-018-0611-6. Epub 2018 Aug 6. Erratum in: Nat Ecol Evol. 2018 Aug 13;:.


Temporal expression of circulating miRNA after severe injury.

Galbraith NJ, O'Brien SJ, Walker SP, Gardner SA, Polk HC Jr, Barnes SL.

Surgery. 2018 Oct;164(4):665-672. doi: 10.1016/j.surg.2018.05.042. Epub 2018 Aug 1.


The impact of psychiatric comorbidities on patient-reported surgical outcomes in adults treated for the median arcuate ligament syndrome.

Skelly CL, Stiles-Shields C, Mak GZ, Speaker CR, Lorenz J, Anitescu M, Dickerson DM, Boyd H, O'Brien S, Drossos T.

J Vasc Surg. 2018 Jul 28. pii: S0741-5214(18)30278-7. doi: 10.1016/j.jvs.2017.12.078. [Epub ahead of print]


Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma.

O'Brien S, Hillmen P, Coutre S, Barr PM, Fraser G, Tedeschi A, Burger JA, Dilhuydy MS, Hess G, Moreno C, Cramer P, Liu E, Chang S, Vermeulen J, Styles L, Howes A, James DF, Patel K, Graef T, Valentino R.

Clin Lymphoma Myeloma Leuk. 2018 Oct;18(10):648-657.e15. doi: 10.1016/j.clml.2018.06.016. Epub 2018 Jun 28.


The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2018 Update on Research.

Jacobs ML, Jacobs JP, Hill KD, O'Brien SM, Pasquali SK, Vener D, Kumar SR, Chiswell K, Habib RH, Shahian DM, Fernandez FG.

Ann Thorac Surg. 2018 Sep;106(3):654-663. doi: 10.1016/j.athoracsur.2018.06.032. Epub 2018 Jul 25.


Barium titanate perovskite nanoparticles as a photoreactive medium for chemical warfare agent detoxification.

Giannakoudakis DA, Pearsall F, Florent M, Lombardi J, O'Brien S, Bandosz TJ.

J Colloid Interface Sci. 2018 Dec 1;531:233-244. doi: 10.1016/j.jcis.2018.07.053. Epub 2018 Jul 19.


Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis.

O'Brien SA, Lee K, Fu HY, Lee Z, Le TS, Stach CS, McCann MG, Zhang AQ, Smanski MJ, Somia NV, Hu WS.

Biotechnol J. 2018 Oct;13(10):e1800226. doi: 10.1002/biot.201800226. Epub 2018 Jul 30.


Direct oral anticoagulants: What will be their role in children?

Male C, Thom K, O'Brien SH.

Thromb Res. 2018 Jun 28. pii: S0049-3848(18)30405-5. doi: 10.1016/j.thromres.2018.06.021. [Epub ahead of print] Review.


Australasian bronchiolitis guideline.

O'Brien S, Borland ML, Cotterell E, Armstrong D, Babl F, Bauert P, Brabyn C, Garside L, Haskell L, Levitt D, McKay N, Neutze J, Schibler A, Sinn K, Spencer J, Stevens H, Thomas D, Zhang M, Oakley E, Dalziel SR; Paediatric Research in Emergency Departments International Collaborative (PREDICT) Network, Australasia.

J Paediatr Child Health. 2018 Jul 15. doi: 10.1111/jpc.14104. [Epub ahead of print]


Analytical "bake-off" of whole genome sequencing quality for the Genome Russia project using a small cohort for autoimmune hepatitis.

Zhernakova DV, Kliver S, Cherkasov N, Tamazian G, Rotkevich M, Krasheninnikova K, Evsyukov I, Sidorov S, Dobrynin P, Yurchenko AA, Shimansky V, Shcherbakova IV, Glotov AS, Valle DL, Tang M, Shin E, Schwarz KB, O'Brien SJ.

PLoS One. 2018 Jul 11;13(7):e0200423. doi: 10.1371/journal.pone.0200423. eCollection 2018.


Implementing evidence-based practices in the care of infants with bronchiolitis in Australasian acute care settings: study protocol for a cluster randomised controlled study.

Haskell L, Tavender EJ, Wilson C, O'Brien S, Babl FE, Borland ML, Cotterell L, Schuster T, Orsini F, Sheridan N, Johnson D, Oakley E, Dalziel SR; PREDICT.

BMC Pediatr. 2018 Jul 6;18(1):218. doi: 10.1186/s12887-018-1187-7.


McMaster RARE-Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome.

Legault K, Schunemann H, Hillis C, Yeung C, Akl EA, Carrier M, Cervera R, Crowther M, Dentali F, Erkan D, Espinosa G, Khamashta M, Meerpohl JJ, Moffat K, O'Brien S, Pengo V, Rand JH, Rodriguez Pinto I, Thom L, Iorio A.

J Thromb Haemost. 2018 Jun 7. doi: 10.1111/jth.14192. [Epub ahead of print]


A prospective evaluation of a largely cementless total knee arthroplasty cohort without patellar resurfacing: 10-year outcomes and survivorship.

Napier RJ, O'Neill C, O'Brien S, Doran E, Mockford B, Boldt J, Beverland DE.

BMC Musculoskelet Disord. 2018 Jun 26;19(1):205. doi: 10.1186/s12891-018-2128-1.


Hematologic Considerations and Management of Adolescent Girls with Heavy Menstrual Bleeding and Anemia in US Children's Hospitals.

Powers JM, Stanek JR, Srivaths L, Haamid FW, O'Brien SH.

J Pediatr Adolesc Gynecol. 2018 Oct;31(5):446-450. doi: 10.1016/j.jpag.2018.06.008. Epub 2018 Jun 22.


National Benchmarks for Proportions of Patients Receiving Blood Transfusions During Pediatric and Congenital Heart Surgery: An Analysis of the STS Congenital Heart Surgery Database.

Kartha VM, Jacobs JP, Vener DF, Hill KD, Goldenberg NA, Pasquali SK, Meza JM, O'Brien SM, Feng L, Chiswell K, Eghtesady P, Badhwar V, Rehman M, Jacobs ML.

Ann Thorac Surg. 2018 Oct;106(4):1197-1203. doi: 10.1016/j.athoracsur.2018.04.088. Epub 2018 Jun 11.


Statins enhance efficacy of venetoclax in blood cancers.

Lee JS, Roberts A, Juarez D, Vo TT, Bhatt S, Herzog LO, Mallya S, Bellin RJ, Agarwal SK, Salem AH, Xu T, Jia J, Li L, Hanna JR, Davids MS, Fleischman AG, O'Brien S, Lam LT, Leverson JD, Letai A, Schatz JH, Fruman DA.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaaq1240. doi: 10.1126/scitranslmed.aaq1240.


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