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Modeling Down syndrome in cells: From stem cells to organoids.

Gough G, O'Brien NL, Alic I, Goh PA, Yeap YJ, Groet J, Nizetic D, Murray A.

Prog Brain Res. 2020;251:55-90. doi: 10.1016/bs.pbr.2019.10.003. Epub 2019 Nov 20.


Non-invasive estimation of cerebral perfusion pressure using transcranial Doppler ultrasonography in children with severe traumatic brain injury.

O'Brien NF, Lovett ME, Chung M, Maa T.

Childs Nerv Syst. 2020 Jan 30. doi: 10.1007/s00381-020-04524-7. [Epub ahead of print]


Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.

Volta F, Scerbo MJ, Seelig A, Wagner R, O'Brien N, Gerst F, Fritsche A, Häring HU, Zeigerer A, Ullrich S, Gerdes JM.

Nat Commun. 2019 Dec 12;10(1):5686. doi: 10.1038/s41467-019-12953-5.


Transcranial Doppler ultrasound findings in children with moderate-to-severe traumatic brain injury following abusive head trauma.

Lovett ME, Maa T, Moore-Clingenpeel M, O'Brien NF.

Childs Nerv Syst. 2019 Nov 28. doi: 10.1007/s00381-019-04431-6. [Epub ahead of print]


Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home-Based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): a Pilot Study.

Okwose NC, Avery L, O'Brien N, Cassidy S, Charman SJ, Bailey K, Velicki L, Olivotto I, Brennan P, MacGowan GA, Jakovljevic DG.

Sports Med Open. 2019 Nov 27;5(1):45. doi: 10.1186/s40798-019-0216-x.


Development of a dehydrated fortified food base from fermented milk and parboiled wheat, and comparison of its composition and reconstitution behavior with those of commercial dried dairy-cereal blends.

Shevade AV, O'Callaghan YC, O'Brien NM, O'Connor TP, Guinee TP.

Food Sci Nutr. 2019 Oct 15;7(11):3681-3691. doi: 10.1002/fsn3.1226. eCollection 2019 Nov.


Happiness Measurably Propels Human Well-Being & Performance: A Case Report.

Wheaton R, Gassmann J, O'Brien N.

Am J Health Promot. 2019 Nov;33(8):1221-1226. doi: 10.1177/0890117119878277e. No abstract available.


Editor's Desk: The Why and How of Addressing Employee Happiness.

Grossmeier J, Viswanath K, Kubzansky LD, Black H, Greenberg S, Saulsgiver K, Sinar E, Reece A, Carr E, Kellerman G, Heap L, Wheaton R, Gassmann J, O'Brien N.

Am J Health Promot. 2019 Nov;33(8):1209-1226. doi: 10.1177/0890117119878277. No abstract available.


How can we make better health decisions a Best Buy for all?: Commentary based on discussions at iDSI roundtable on 2 nd May 2019 London, UK.

O'Brien N, Li R, Isaranuwatchai W, Dabak SV, Glassman A, Culyer AJ, Chalkidou K.

Gates Open Res. 2019 Sep 20;3:1543. doi: 10.12688/gatesopenres.13063.2. eCollection 2019.


Transcranial Doppler Ultrasound During Critical Illness in Children: Survey of Practices in Pediatric Neurocritical Care Centers.

LaRovere KL, Tasker RC, Wainwright M, Reuter-Rice K, Appavu B, Miles D, Lidsky K, Vittner P, Gundersen D, O'Brien NF; Pediatric Neurocritical Care Research Group (PNCRG).

Pediatr Crit Care Med. 2020 Jan;21(1):67-74. doi: 10.1097/PCC.0000000000002118.


Understanding Alternative Bullying Perspectives Through Research Engagement With Young People.

O'Brien N.

Front Psychol. 2019 Aug 28;10:1984. doi: 10.3389/fpsyg.2019.01984. eCollection 2019.


Fortified Blended Food Base: Effect of Co-Fermentation Time on Composition, Phytic Acid Content and Reconstitution Properties.

Shevade AV, O'Callaghan YC, O'Brien NM, O'Connor TP, Guinee TP.

Foods. 2019 Sep 3;8(9). pii: E388. doi: 10.3390/foods8090388.


Separating the Wheat from the Chaff: Comparative Visual Cues for Transparent Diagnostics of Competing Models.

Dasgupta A, Wang H, O'Brien N, Burrows S.

IEEE Trans Vis Comput Graph. 2020 Jan;26(1):1043-1053. doi: 10.1109/TVCG.2019.2934540. Epub 2019 Aug 26.


Implementation of the uterine fibroids Option Grid patient decision aids across five organizational settings: a randomized stepped-wedge study protocol.

Scalia P, Durand MA, Forcino RC, Schubbe D, Barr PJ, O'Brien N, O'Malley AJ, Foster T, Politi MC, Laughlin-Tommaso S, Banks E, Madden T, Anchan RM, Aarts JWM, Velentgas P, Balls-Berry J, Bacon C, Adams-Foster M, Mulligan CC, Venable S, Cochran NE, Elwyn G.

Implement Sci. 2019 Sep 2;14(1):88. doi: 10.1186/s13012-019-0933-z.


Vascular leiomyosarcoma of the femoral vein: an unusual cause of a femoral triangle mass.

Narayanen N, O'Hanlon D, Murphy M, O'Brien N.

BMJ Case Rep. 2019 Aug 1;12(7). pii: e225967. doi: 10.1136/bcr-2018-225967.


Harnessing new models of care for chronic disease: co-design and sustainable implementation of group clinics into UK clinical practice.

Birrell F, Goff I, Coulson L, Jones T, Baqir W, O'Brien N, Rapley T, Gray K, Flood B, Russell-Westhead M.

Future Healthc J. 2019 Mar;6(Suppl 1):77-78. doi: 10.7861/futurehosp.6-1-s77. No abstract available.


A longitudinal study of associations between HIV-related stigma, recent violence and depression among women living with HIV in a Canadian cohort study.

Logie CH, Marcus N, Wang Y, Kaida A, O'Campo P, Ahmed U, O'Brien N, Nicholson V, Conway T, de Pokomandy A, Fernet M, Loutfy M; CHIWOS Research Team.

J Int AIDS Soc. 2019 Jul;22(7):e25341. doi: 10.1002/jia2.25341.


Hiring, training, and supporting Peer Research Associates: Operationalizing community-based research principles within epidemiological studies by, with, and for women living with HIV.

Kaida A, Carter A, Nicholson V, Lemay J, O'Brien N, Greene S, Tharao W, Proulx-Boucher K, Gormley R, Benoit A, Bernier M, Thomas-Pavanel J, Lewis J, de Pokomandy A, Loutfy M; CHIWOS Research Team.

Harm Reduct J. 2019 Jul 18;16(1):47. doi: 10.1186/s12954-019-0309-3.


Gender-affirming healthcare experiences and medical transition among transgender women living with HIV: a mixed-methods study.

Lacombe-Duncan A, Newman PA, Bauer GR, Logie CH, Persad Y, Shokoohi M, O'Brien N, Kaida A, de Pokomandy A, Loutfy M.

Sex Health. 2019 Jul 9. doi: 10.1071/SH19011. [Epub ahead of print]


The HIV Care Cascade Among Transgender Women with HIV in Canada: A Mixed-Methods Study.

Lacombe-Duncan A, Bauer GR, Logie CH, Newman PA, Shokoohi M, Kay ES, Persad Y, O'Brien N, Kaida A, de Pokomandy A, Loutfy M.

AIDS Patient Care STDS. 2019 Jul;33(7):308-322. doi: 10.1089/apc.2019.0013. Epub 2019 Jun 12.


Characterisation of the in vitro bioactive properties of alkaline and enzyme extracted brewers' spent grain protein hydrolysates.

Connolly A, Cermeño M, Crowley D, O'Callaghan Y, O'Brien NM, FitzGerald RJ.

Food Res Int. 2019 Jul;121:524-532. doi: 10.1016/j.foodres.2018.12.008. Epub 2018 Dec 5.


Role for polo-like kinase 4 in mediation of cytokinesis.

Press MF, Xie B, Davenport S, Zhou Y, Guzman R, Nolan GP, O'Brien N, Palazzolo M, Mak TW, Brugge JS, Slamon DJ.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11309-11318. doi: 10.1073/pnas.1818820116. Epub 2019 May 16.


Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes.

Sghaier R, Zarrouk A, Nury T, Badreddine I, O'Brien N, Mackrill JJ, Vejux A, Samadi M, Nasser B, Caccia C, Leoni V, Moreau T, Cherkaoui-Malki M, Salhedine Masmoudi A, Lizard G.

Free Radic Res. 2019 May;53(5):535-561. doi: 10.1080/10715762.2019.1612891. Erratum in: Free Radic Res. 2019;53(sup1):I.


Factors Associated With Poor Outcome in Pediatric Near-Hanging Injuries.

La Count S, Lovett ME, Zhao S, Kline D, O'Brien NF, Hall MW, Sribnick EA.

J Emerg Med. 2019 Jul;57(1):21-28. doi: 10.1016/j.jemermed.2019.03.013. Epub 2019 Apr 25.


Predictors of cognitive behavioral therapy outcomes for insomnia in veterans with post-traumatic stress disorder.

El-Solh AA, O'Brien N, Akinnusi M, Patel S, Vanguru L, Wijewardena C.

Sleep Breath. 2019 Jun;23(2):635-643. doi: 10.1007/s11325-019-01840-4. Epub 2019 Apr 25.


Cervical cancer screening among women living with HIV: a cross-sectional study using the baseline questionnaire data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS).

de Pokomandy A, Burchell AN, Salters K, Ding E, O'Brien N, Bakombo DM, Proulx-Boucher K, Boucoiran I, Pick N, Ogilvie G, Loutfy M, Kaida A; CHIWOS Research Team.

CMAJ Open. 2019 Apr 12;7(2):E217-E226. doi: 10.9778/cmajo.20180151. Print 2019 Apr-Jun.


Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo.

Zoeller JJ, Vagodny A, Taneja K, Tan BY, O'Brien N, Slamon DJ, Sampath D, Leverson JD, Bronson RT, Dillon DA, Brugge JS.

Mol Cancer Ther. 2019 Jun;18(6):1115-1126. doi: 10.1158/1535-7163.MCT-18-0743. Epub 2019 Apr 8.


Love with HIV: A Latent Class Analysis of Sexual and Intimate Relationship Experiences Among Women Living with HIV in Canada.

Carter A, Greene S, Money D, Sanchez M, Webster K, Nicholson V, Brotto LA, Hankins C, Kestler M, Pick N, Salters K, Proulx-Boucher K, O'Brien N, Patterson S, de Pokomandy A, Loutfy M, Kaida A; CHIWOS Research Team.

Arch Sex Behav. 2019 May;48(4):1015-1040. doi: 10.1007/s10508-019-1418-5. Epub 2019 Mar 19.


Genetic association and functional characterization of MCPH1 gene variation in bipolar disorder and schizophrenia.

Al Eissa MM, Sharp SI, O'Brien NL, Fiorentino A, Bass NJ, Curtis D, McQuillin A.

Am J Med Genet B Neuropsychiatr Genet. 2019 Jun;180(4):258-265. doi: 10.1002/ajmg.b.32722. Epub 2019 Mar 11.


Ranger Athlete Warrior Assessment Performance in a Reserve Officer Training Corps Training Environment.

Meckley DP, Hulbert K, Stewart D, O'Brien N, Barringer N, Hornsby JH.

J Spec Oper Med. Spring 2019;19(1):96-98.


Relationship of Strength and Conditioning Metrics to Success on the Army Ranger Physical Assessment Test.

Barringer ND, McKinnon CJ, OʼBrien NC, Kardouni JR.

J Strength Cond Res. 2019 Apr;33(4):958-964. doi: 10.1519/JSC.0000000000003044.


Evaluating the impact of a community-based social prescribing intervention on people with type 2 diabetes in North East England: mixed-methods study protocol.

Moffatt S, Wildman J, Pollard TM, Penn L, O'Brien N, Pearce MS, Wildman JM.

BMJ Open. 2019 Jan 15;9(1):e026826. doi: 10.1136/bmjopen-2018-026826.


Children With Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure, What Does it Mean? A Review of the Literature.

Lovett ME, O'Brien NF, Leonard JR.

Pediatr Neurol. 2019 May;94:3-20. doi: 10.1016/j.pediatrneurol.2018.12.003. Epub 2019 Jan 11. Review.


HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells.

McDermott MSJ, Conlon N, Browne BC, Szabo A, Synnott NC, O'Brien NA, Duffy MJ, Crown J, O'Donovan N.

Cancers (Basel). 2019 Feb 8;11(2). pii: E197. doi: 10.3390/cancers11020197.


Service-users' perspectives of link worker social prescribing: a qualitative follow-up study.

Wildman JM, Moffatt S, Steer M, Laing K, Penn L, O'Brien N.

BMC Public Health. 2019 Jan 22;19(1):98. doi: 10.1186/s12889-018-6349-x.


Link workers' perspectives on factors enabling and preventing client engagement with social prescribing.

Wildman JM, Moffatt S, Penn L, O'Brien N, Steer M, Hill C.

Health Soc Care Community. 2019 Jul;27(4):991-998. doi: 10.1111/hsc.12716. Epub 2019 Jan 14.


Comparison of the nutritional composition of experimental fermented milk:wheat bulgur blends and commercially available kishk and tarhana products.

O'Callaghan YC, Shevade AV, Guinee TP, O'Connor TP, O'Brien NM.

Food Chem. 2019 Apr 25;278:110-118. doi: 10.1016/j.foodchem.2018.11.026. Epub 2018 Nov 5.


Cereal type significantly affects the composition and reconstitution characteristics of dried fermented milk-cereal composites.

Shevade AV, O'Callaghan YC, Kennedy D, O'Brien NM, O'Connor TP, Guinee TP.

J Sci Food Agric. 2019 Apr;99(6):3097-3105. doi: 10.1002/jsfa.9523. Epub 2019 Jan 17.


Antifungal activity of a de novo synthetic peptide and derivatives against fungal food contaminants.

Thery T, Shwaiki LN, O'Callaghan YC, O'Brien NM, Arendt EK.

J Pept Sci. 2019 Jan;25(1):e3137. doi: 10.1002/psc.3137. Epub 2018 Nov 28.


Extrapontine Myelinolysis and Microhemorrhages: Rare Finding in Pediatric Diabetic Ketoacidosis.

Bline K, Singh D, Poeppelman R, Lo W, O'Brien N.

Pediatr Neurol. 2018 Dec;89:68-70. doi: 10.1016/j.pediatrneurol.2018.09.006. Epub 2018 Sep 19. No abstract available.


Cerebrovascular Physiology During Pediatric Extracorporeal Membrane Oxygenation: A Multicenter Study Using Transcranial Doppler Ultrasonography.

O'Brien NF, Buttram SDW, Maa T, Lovett ME, Reuter-Rice K, LaRovere KL; Pediatric Neurocritical Care Research Group (PNCRG).

Pediatr Crit Care Med. 2019 Feb;20(2):178-186. doi: 10.1097/PCC.0000000000001778.


Proficiency-based progression training: an 'end to end' model for decreasing error applied to achievement of effective epidural analgesia during labour: a randomised control study.

Kallidaikurichi Srinivasan K, Gallagher A, O'Brien N, Sudir V, Barrett N, O'Connor R, Holt F, Lee P, O'Donnell B, Shorten G.

BMJ Open. 2018 Oct 15;8(10):e020099. doi: 10.1136/bmjopen-2017-020099.


Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.

Eustace AJ, Conlon NT, McDermott MSJ, Browne BC, O'Leary P, Holmes FA, Espina V, Liotta LA, O'Shaughnessy J, Gallagher C, O'Driscoll L, Rani S, Madden SF, O'Brien NA, Ginther C, Slamon D, Walsh N, Gallagher WM, Zagozdzon R, Watson WR, O'Donovan N, Crown J.

BMC Cancer. 2018 Oct 11;18(1):965. doi: 10.1186/s12885-018-4852-1.


Transcranial Doppler Ultrasonography Provides Insights into Neurovascular Changes in Children with Cerebral Malaria.

O'Brien NF, Mutatshi Taty T, Moore-Clingenpeel M, Bodi Mabiala J, Mbaka Pongo J, Ambitapio Musungufu D, Uchama M, Yotebieng M.

J Pediatr. 2018 Dec;203:116-124.e3. doi: 10.1016/j.jpeds.2018.07.075. Epub 2018 Sep 14.


HER-targeted tyrosine kinase inhibitors enhance response to trastuzumab and pertuzumab in HER2-positive breast cancer.

Canonici A, Ivers L, Conlon NT, Pedersen K, Gaynor N, Browne BC, O'Brien NA, Gullo G, Collins DM, O'Donovan N, Crown J.

Invest New Drugs. 2019 Jun;37(3):441-451. doi: 10.1007/s10637-018-0649-y. Epub 2018 Jul 30.


Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium.

Felice VD, O'Gorman DM, O'Brien NM, Hyland NP.

Nutrients. 2018 Jul 17;10(7). pii: E912. doi: 10.3390/nu10070912.


Intensive care resources required to care for critically ill children with focal intracranial infections.

Lovett ME, Shah ZS, Moore-Clingenpeel M, Sribnick E, Ostendorf A, Chung MG, Leonard J, O'Brien NF.

J Neurosurg Pediatr. 2018 Oct;22(4):453-461. doi: 10.3171/2018.4.PEDS17715. Epub 2018 Jul 13.


School start times and teenage driver motor vehicle crashes.

Foss RD, Smith RL, O'Brien NP.

Accid Anal Prev. 2019 May;126:54-63. doi: 10.1016/j.aap.2018.03.031. Epub 2018 Apr 26.


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