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Safety and Feasibility of Using Magnetic Resonance Imaging Criteria to Identify Patients With "Good Prognosis" Rectal Cancer Eligible for Primary Surgery: The Phase 2 Nonrandomized QuickSilver Clinical Trial.

Kennedy ED, Simunovic M, Jhaveri K, Kirsch R, Brierley J, Drolet S, Brown C, Vos PM, Xiong W, MacLean T, Kanthan S, Stotland P, Raphael S, Chow G, O'Brien CA, Cho C, Streutker C, Wong R, Schmocker S, Liberman S, Reinhold C, Kopek N, Marcus V, Bouchard A, Lavoie C, Morin S, Périgny M, Wright A, Neumann K, Clarke S, Patil NG, Arnason T, Williams L, McLeod R, Brown G, Mathieson A, Pooni A, Baxter NN.

JAMA Oncol. 2019 Apr 11. doi: 10.1001/jamaoncol.2019.0186. [Epub ahead of print]


Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.

Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA.

Nat Commun. 2019 Mar 29;10(1):1436. doi: 10.1038/s41467-019-09309-4.


IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection.

O'Brien CA, Batista SJ, Still KM, Harris TH.

J Immunol. 2019 Mar 15;202(6):1755-1766. doi: 10.4049/jimmunol.1801229. Epub 2019 Feb 4.


A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations.

Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J.

Sci Rep. 2019 Jan 29;9(1):842. doi: 10.1038/s41598-018-37462-1.


The recently identified flavivirus Bamaga virus is transmitted horizontally by Culex mosquitoes and interferes with West Nile virus replication in vitro and transmission in vivo.

Colmant AMG, Hall-Mendelin S, Ritchie SA, Bielefeldt-Ohmann H, Harrison JJ, Newton ND, O'Brien CA, Cazier C, Johansen CA, Hobson-Peters J, Hall RA, van den Hurk AF.

PLoS Negl Trop Dis. 2018 Oct 24;12(10):e0006886. doi: 10.1371/journal.pntd.0006886. eCollection 2018 Oct.


Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim).

Zimmerman SM, Heard-Lipsmeyer ME, Dimori M, Thostenson JD, Mannen EM, O'Brien CA, Morello R.

Bone Rep. 2018 Jul 2;9:61-73. doi: 10.1016/j.bonr.2018.06.008. eCollection 2018 Dec.


Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss.

Xiong J, Cawley K, Piemontese M, Fujiwara Y, Zhao H, Goellner JJ, O'Brien CA.

Nat Commun. 2018 Jul 25;9(1):2909. doi: 10.1038/s41467-018-05244-y.


Modeling Rare Bone Diseases in Animals.

O'Brien CA, Morello R.

Curr Osteoporos Rep. 2018 Aug;16(4):458-465. doi: 10.1007/s11914-018-0452-x. Review.


Discovery of a novel iflavirus sequence in the eastern paralysis tick Ixodes holocyclus.

O'Brien CA, Hall-Mendelin S, Hobson-Peters J, Deliyannis G, Allen A, Lew-Tabor A, Rodriguez-Valle M, Barker D, Barker SC, Hall RA.

Arch Virol. 2018 Sep;163(9):2451-2457. doi: 10.1007/s00705-018-3868-9. Epub 2018 May 11.


The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation.

Xiong J, Almeida M, O'Brien CA.

Bone. 2018 Jul;112:1-9. doi: 10.1016/j.bone.2018.04.001. Epub 2018 Apr 4.


New genotypes of Liao ning virus (LNV) in Australia exhibit an insect-specific phenotype.

Prow NA, Mah MG, Deerain JM, Warrilow D, Colmant AMG, O'Brien CA, Harrison JJ, McLean BJ, Hewlett EK, Piyasena TBH, Hall-Mendelin S, van den Hurk AF, Watterson D, Huang B, Schulz BL, Webb CE, Johansen CA, Chow WK, Hobson-Peters J, Cazier C, Coffey LL, Faddy HM, Suhrbier A, Bielefeldt-Ohmann H, Hall RA.

J Gen Virol. 2018 Apr;99(4):596-609. doi: 10.1099/jgv.0.001038. Epub 2018 Mar 13.


Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis.

Bauer PV, Duca FA, Waise TMZ, Dranse HJ, Rasmussen BA, Puri A, Rasti M, O'Brien CA, Lam TKT.

Cell Metab. 2018 Mar 6;27(3):572-587.e6. doi: 10.1016/j.cmet.2018.01.013.


Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.

Haynes J, McKee TD, Haller A, Wang Y, Leung C, Gendoo DMA, Lima-Fernandes E, Kreso A, Wolman R, Szentgyorgyi E, Vines DC, Haibe-Kains B, Wouters BG, Metser U, Jaffray DA, Smith M, O'Brien CA.

Clin Cancer Res. 2018 May 1;24(9):2116-2127. doi: 10.1158/1078-0432.CCR-17-1715. Epub 2018 Feb 23.


Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway.

Bauer PV, Duca FA, Waise TMZ, Rasmussen BA, Abraham MA, Dranse HJ, Puri A, O'Brien CA, Lam TKT.

Cell Metab. 2018 Jan 9;27(1):101-117.e5. doi: 10.1016/j.cmet.2017.09.019. Epub 2017 Oct 19.


The Pathophysiological Sequence of Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Male Mice.

Weinstein RS, Hogan EA, Borrelli MJ, Liachenko S, O'Brien CA, Manolagas SC.

Endocrinology. 2017 Nov 1;158(11):3817-3831. doi: 10.1210/en.2017-00662.


Old age causes de novo intracortical bone remodeling and porosity in mice.

Piemontese M, Almeida M, Robling AG, Kim HN, Xiong J, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA, Jilka RL.

JCI Insight. 2017 Sep 7;2(17). pii: 93771. doi: 10.1172/jci.insight.93771. eCollection 2017 Sep 7.


The impact of VDR expression and regulation in vivo.

Lee SM, Meyer MB, Benkusky NA, O'Brien CA, Pike JW.

J Steroid Biochem Mol Biol. 2018 Mar;177:36-45. doi: 10.1016/j.jsbmb.2017.06.002. Epub 2017 Jun 9.


Discovery and Characterisation of Castlerea Virus, a New Species of Negevirus Isolated in Australia.

O'Brien CA, McLean BJ, Colmant AMG, Harrison JJ, Hall-Mendelin S, van den Hurk AF, Johansen CA, Watterson D, Bielefeldt-Ohmann H, Newton ND, Schulz BL, Hall RA, Hobson-Peters J.

Evol Bioinform Online. 2017 Feb 23;13:1176934317691269. doi: 10.1177/1176934317691269. eCollection 2017.


DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.

Kim HN, Chang J, Shao L, Han L, Iyer S, Manolagas SC, O'Brien CA, Jilka RL, Zhou D, Almeida M.

Aging Cell. 2017 Aug;16(4):693-703. doi: 10.1111/acel.12597. Epub 2017 Apr 12.


CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection.

O'Brien CA, Overall C, Konradt C, O'Hara Hall AC, Hayes NW, Wagage S, John B, Christian DA, Hunter CA, Harris TH.

J Immunol. 2017 May 15;198(10):4054-4061. doi: 10.4049/jimmunol.1601581. Epub 2017 Apr 7.


Live Tissue Imaging to Elucidate Mechanical Modulation of Stem Cell Niche Quiescence.

Yu NY, O'Brien CA, Slapetova I, Whan RM, Knothe Tate ML.

Stem Cells Transl Med. 2017 Jan;6(1):285-292. doi: 10.5966/sctm.2015-0306. Epub 2016 Jul 28.


Commensal Viruses of Mosquitoes: Host Restriction, Transmission, and Interaction with Arboviral Pathogens.

Hall RA, Bielefeldt-Ohmann H, McLean BJ, O'Brien CA, Colmant AM, Piyasena TB, Harrison JJ, Newton ND, Barnard RT, Prow NA, Deerain JM, Mah MG, Hobson-Peters J.

Evol Bioinform Online. 2017 Jan 10;12(Suppl 2):35-44. doi: 10.4137/EBO.S40740. eCollection 2016. Review.


Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.

Fil D, DeLoach A, Yadav S, Alkam D, MacNicol M, Singh A, Compadre CM, Goellner JJ, O'Brien CA, Fahmi T, Basnakian AG, Calingasan NY, Klessner JL, Beal FM, Peters OM, Metterville J, Brown RH Jr, Ling KKY, Rigo F, Ozdinler PH, Kiaei M.

Hum Mol Genet. 2017 Feb 15;26(4):686-701. doi: 10.1093/hmg/ddw429.


Estrogens and Androgens in Skeletal Physiology and Pathophysiology.

Almeida M, Laurent MR, Dubois V, Claessens F, O'Brien CA, Bouillon R, Vanderschueren D, Manolagas SC.

Physiol Rev. 2017 Jan;97(1):135-187. Review.


RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice.

Fujiwara Y, Piemontese M, Liu Y, Thostenson JD, Xiong J, O'Brien CA.

J Biol Chem. 2016 Nov 25;291(48):24838-24850. Epub 2016 Oct 12.


Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice.

Piemontese M, Xiong J, Fujiwara Y, Thostenson JD, O'Brien CA.

Am J Physiol Endocrinol Metab. 2016 Sep 1;311(3):E587-93. doi: 10.1152/ajpendo.00219.2016. Epub 2016 Jul 26.


A New Orbivirus Isolated from Mosquitoes in North-Western Australia Shows Antigenic and Genetic Similarity to Corriparta Virus but Does Not Replicate in Vertebrate Cells.

Harrison JJ, Warrilow D, McLean BJ, Watterson D, O'Brien CA, Colmant AM, Johansen CA, Barnard RT, Hall-Mendelin S, Davis SS, Hall RA, Hobson-Peters J.

Viruses. 2016 May 20;8(5). pii: E141. doi: 10.3390/v8050141.


Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage.

Piemontese M, Onal M, Xiong J, Han L, Thostenson JD, Almeida M, O'Brien CA.

Sci Rep. 2016 Apr 11;6:24262. doi: 10.1038/srep24262.


A new virus discovered by immunocapture of double-stranded RNA, a rapid method for virus enrichment in metagenomic studies.

Blouin AG, Ross HA, Hobson-Peters J, O'Brien CA, Warren B, MacDiarmid R.

Mol Ecol Resour. 2016 Sep;16(5):1255-63. doi: 10.1111/1755-0998.12525. Epub 2016 Apr 4.


Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.

Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL.

Am J Physiol Endocrinol Metab. 2016 May 1;310(9):E762-73. doi: 10.1152/ajpendo.00501.2015. Epub 2016 Mar 8.


The Role of Osteocytes in Age-Related Bone Loss.

Jilka RL, O'Brien CA.

Curr Osteoporos Rep. 2016 Feb;14(1):16-25. doi: 10.1007/s11914-016-0297-0. Review.


A newly discovered flavivirus in the yellow fever virus group displays restricted replication in vertebrates.

Colmant AM, Bielefeldt-Ohmann H, Hobson-Peters J, Suen WW, O'Brien CA, van den Hurk AF, Hall RA.

J Gen Virol. 2016 May;97(5):1087-1093. doi: 10.1099/jgv.0.000430. Epub 2016 Feb 15.


Mechanisms of Enhancer-mediated Hormonal Control of Vitamin D Receptor Gene Expression in Target Cells.

Lee SM, Meyer MB, Benkusky NA, O'Brien CA, Pike JW.

J Biol Chem. 2015 Dec 18;290(51):30573-86. doi: 10.1074/jbc.M115.693614. Epub 2015 Oct 25.


Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone.

Xiong J, Piemontese M, Onal M, Campbell J, Goellner JJ, Dusevich V, Bonewald L, Manolagas SC, O'Brien CA.

PLoS One. 2015 Sep 22;10(9):e0138189. doi: 10.1371/journal.pone.0138189. eCollection 2015.


Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs.

Kim HN, Han L, Iyer S, de Cabo R, Zhao H, O'Brien CA, Manolagas SC, Almeida M.

Mol Endocrinol. 2015 Oct;29(10):1498-509. doi: 10.1210/me.2015-1133. Epub 2015 Aug 19.


KIT Signaling Promotes Growth of Colon Xenograft Tumors in Mice and Is Up-Regulated in a Subset of Human Colon Cancers.

Chen EC, Karl TA, Kalisky T, Gupta SK, O'Brien CA, Longacre TA, van de Rijn M, Quake SR, Clarke MF, Rothenberg ME.

Gastroenterology. 2015 Sep;149(3):705-17.e2. doi: 10.1053/j.gastro.2015.05.042. Epub 2015 May 28.


Viral RNA intermediates as targets for detection and discovery of novel and emerging mosquito-borne viruses.

O'Brien CA, Hobson-Peters J, Yam AW, Colmant AM, McLean BJ, Prow NA, Watterson D, Hall-Mendelin S, Warrilow D, Ng ML, Khromykh AA, Hall RA.

PLoS Negl Trop Dis. 2015 Mar 23;9(3):e0003629. doi: 10.1371/journal.pntd.0003629. eCollection 2015 Mar.


The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERα Signaling in Osteoblasts and Osteoclasts.

Ucer S, Iyer S, Bartell SM, Martin-Millan M, Han L, Kim HN, Weinstein RS, Jilka RL, O'Brien CA, Almeida M, Manolagas SC.

J Bone Miner Res. 2015 Jul;30(7):1138-49. doi: 10.1002/jbmr.2485.


Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone.

Piemontese M, Onal M, Xiong J, Wang Y, Almeida M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA.

Bone. 2015 Jun;75:18-26. doi: 10.1016/j.bone.2015.02.005. Epub 2015 Feb 17.


A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse.

Onal M, Bishop KA, St John HC, Danielson AL, Riley EM, Piemontese M, Xiong J, Goellner JJ, O'Brien CA, Pike JW.

J Bone Miner Res. 2015 May;30(5):855-68. doi: 10.1002/jbmr.2417.


Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.

Belmont PJ, Jiang P, McKee TD, Xie T, Isaacson J, Baryla NE, Roper J, Sinnamon MJ, Lee NV, Kan JL, Guicherit O, Wouters BG, O'Brien CA, Shields D, Olson P, VanArsdale T, Weinrich SL, Rejto P, Christensen JG, Fantin VR, Hung KE, Martin ES.

Sci Signal. 2014 Nov 11;7(351):ra107. doi: 10.1126/scisignal.2005516.


A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.

Lee SM, Goellner JJ, O'Brien CA, Pike JW.

Endocrinology. 2014 Nov;155(11):4137-48. doi: 10.1210/en.2014-1417. Epub 2014 Aug 22.


Sirtuin1 (Sirt1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors.

Iyer S, Han L, Bartell SM, Kim HN, Gubrij I, de Cabo R, O'Brien CA, Manolagas SC, Almeida M.

J Biol Chem. 2014 Aug 29;289(35):24069-78. doi: 10.1074/jbc.M114.561803. Epub 2014 Jul 7.


Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency.

Xiong J, Piemontese M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA.

Bone. 2014 Sep;66:146-54. doi: 10.1016/j.bone.2014.06.006. Epub 2014 Jun 14.


FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation.

Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M.

Nat Commun. 2014 Apr 30;5:3773. doi: 10.1038/ncomms4773.


Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype.

Lee SM, Bishop KA, Goellner JJ, O'Brien CA, Pike JW.

Endocrinology. 2014 Jun;155(6):2064-76. doi: 10.1210/en.2014-1107. Epub 2014 Apr 2.


A new species of mesonivirus from the Northern Territory, Australia.

Warrilow D, Watterson D, Hall RA, Davis SS, Weir R, Kurucz N, Whelan P, Allcock R, Hall-Mendelin S, O'Brien CA, Hobson-Peters J.

PLoS One. 2014 Mar 26;9(3):e91103. doi: 10.1371/journal.pone.0091103. eCollection 2014.


Self-renewal as a therapeutic target in human colorectal cancer.

Kreso A, van Galen P, Pedley NM, Lima-Fernandes E, Frelin C, Davis T, Cao L, Baiazitov R, Du W, Sydorenko N, Moon YC, Gibson L, Wang Y, Leung C, Iscove NN, Arrowsmith CH, Szentgyorgyi E, Gallinger S, Dick JE, O'Brien CA.

Nat Med. 2014 Jan;20(1):29-36. doi: 10.1038/nm.3418. Epub 2013 Dec 1.


A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.

Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, Wang Y, Brito GC, Kasimer D, Makhnevych T, Ketela T, Datti A, Babu M, Emili A, Pelletier L, Wrana J, Wainberg Z, Kim PM, Rottapel R, O'Brien CA, Andrews B, Boone C, Moffat J.

Mol Syst Biol. 2013 Oct 8;9:696. doi: 10.1038/msb.2013.54.


The role of estrogen and androgen receptors in bone health and disease.

Manolagas SC, O'Brien CA, Almeida M.

Nat Rev Endocrinol. 2013 Dec;9(12):699-712. doi: 10.1038/nrendo.2013.179. Epub 2013 Sep 17. Review.

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