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Items: 1 to 50 of 73

1.

Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation.

Nzila A, Razzak SA, Sankara S, Nazal MK, Al-Momani M, Kang GU, Ibal JC, Shin JH.

PLoS One. 2019 Nov 8;14(11):e0224989. doi: 10.1371/journal.pone.0224989. eCollection 2019.

2.

Current Status of the Degradation of Aliphatic and Aromatic Petroleum Hydrocarbons by Thermophilic Microbes and Future Perspectives.

Nzila A.

Int J Environ Res Public Health. 2018 Dec 7;15(12). pii: E2782. doi: 10.3390/ijerph15122782. Review.

3.

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters.

Ndung'u L, Langat B, Magiri E, Ng'ang'a J, Irungu B, Nzila A, Kiboi D.

Wellcome Open Res. 2017 Jun 20;2:44. doi: 10.12688/wellcomeopenres.11768.2. eCollection 2017.

4.

Biodegradation of high-molecular-weight polycyclic aromatic hydrocarbons under anaerobic conditions: Overview of studies, proposed pathways and future perspectives.

Nzila A.

Environ Pollut. 2018 Aug;239:788-802. doi: 10.1016/j.envpol.2018.04.074. Epub 2018 May 8. Review.

PMID:
29751337
5.

Mini review: Update on bioaugmentation in anaerobic processes for biogas production.

Nzila A.

Anaerobe. 2017 Aug;46:3-12. doi: 10.1016/j.anaerobe.2016.11.007. Epub 2016 Nov 23. Review.

PMID:
27887952
6.

Bioaugmentation: An Emerging Strategy of Industrial Wastewater Treatment for Reuse and Discharge.

Nzila A, Razzak SA, Zhu J.

Int J Environ Res Public Health. 2016 Aug 25;13(9). pii: E846. doi: 10.3390/ijerph13090846. Review.

7.

Characterization of aerobic oil and grease-degrading bacteria in wastewater.

Nzila A, Thukair A, Sankara S, Abdur Razzak S.

Environ Technol. 2017 Mar;38(6):661-670. doi: 10.1080/09593330.2016.1207712. Epub 2016 Jul 18.

PMID:
27426954
8.

Malaria in the Era of Food Fortification With Folic Acid.

Nzila A, Okombo J, Hyde J.

Food Nutr Bull. 2016 Jun;37(2):153-63. doi: 10.1177/0379572116634511. Epub 2016 Mar 4. Review.

PMID:
26944505
9.

The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya.

Ochola-Oyier LI, Okombo J, Mwai L, Kiara SM, Pole L, Tetteh KK, Nzila A, Marsh K.

Antimicrob Agents Chemother. 2015 Mar;59(3):1770-5. doi: 10.1128/AAC.03522-14. Epub 2014 Dec 22.

10.

Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes.

Kiboi D, Irungu B, Orwa J, Kamau L, Ochola-Oyier LI, Ngángá J, Nzila A.

Exp Parasitol. 2014 Dec;147:23-32. doi: 10.1016/j.exppara.2014.10.008. Epub 2014 Oct 18.

11.

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine.

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Davis TME, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Björkman A, Borrmann S, Checchi F, Desai M, Dhorda M, Djimdé AA, El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher JF, Fröberg G, Grivoyannis A, Hamour S, Houzé S, Johnson J, Kamugisha E, Kariuki S, Kiechel JR, Kironde F, Kofoed PE, LeBras J, Malmberg M, Mwai L, Ngasala B, Nosten F, Nsobya SL, Nzila A, Oguike M, Otienoburu SD, Ogutu B, Ouédraogo JB, Piola P, Rombo L, Schramm B, Somé AF, Thwing J, Ursing J, Wong RPM, Zeynudin A, Zongo I, Plowe CV, Sibley CH, Asaq Molecular Marker Study Group.

Am J Trop Med Hyg. 2014 Oct;91(4):833-843. doi: 10.4269/ajtmh.14-0031. Epub 2014 Jul 21. Erratum in: Am J Trop Med Hyg. 2015 May;92(5):1084. Am J Trop Med Hyg. 2019 Mar;100(3):766.

12.

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.

Ocholla H, Preston MD, Mipando M, Jensen AT, Campino S, MacInnis B, Alcock D, Terlouw A, Zongo I, Oudraogo JB, Djimde AA, Assefa S, Doumbo OK, Borrmann S, Nzila A, Marsh K, Fairhurst RM, Nosten F, Anderson TJ, Kwiatkowski DP, Craig A, Clark TG, Montgomery J.

J Infect Dis. 2014 Dec 15;210(12):1991-2000. doi: 10.1093/infdis/jiu349. Epub 2014 Jun 19.

13.

A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya.

Wendler JP, Okombo J, Amato R, Miotto O, Kiara SM, Mwai L, Pole L, O'Brien J, Manske M, Alcock D, Drury E, Sanders M, Oyola SO, Malangone C, Jyothi D, Miles A, Rockett KA, MacInnis BL, Marsh K, Bejon P, Nzila A, Kwiatkowski DP.

PLoS One. 2014 May 8;9(5):e96486. doi: 10.1371/journal.pone.0096486. eCollection 2014.

14.

PlasmoView: a web-based resource to visualise global Plasmodium falciparum genomic variation.

Preston MD, Assefa SA, Ocholla H, Sutherland CJ, Borrmann S, Nzila A, Michon P, Hien TT, Bousema T, Drakeley CJ, Zongo I, Ouédraogo JB, Djimde AA, Doumbo OK, Nosten F, Fairhurst RM, Conway DJ, Roper C, Clark TG.

J Infect Dis. 2014 Jun 1;209(11):1808-15. doi: 10.1093/infdis/jit812. Epub 2013 Dec 12.

15.

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya.

Borrmann S, Straimer J, Mwai L, Abdi A, Rippert A, Okombo J, Muriithi S, Sasi P, Kortok MM, Lowe B, Campino S, Assefa S, Auburn S, Manske M, Maslen G, Peshu N, Kwiatkowski DP, Marsh K, Nzila A, Clark TG.

Sci Rep. 2013 Nov 25;3:3318. doi: 10.1038/srep03318.

16.

Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.

Nzila A, Okombo J, Molloy AM.

J Antimicrob Chemother. 2014 Feb;69(2):323-30. doi: 10.1093/jac/dkt394. Epub 2013 Oct 14. Review.

PMID:
24126794
17.

Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.

Okombo J, Abdi AI, Kiara SM, Mwai L, Pole L, Sutherland CJ, Nzila A, Ochola-Oyier LI.

Antimicrob Agents Chemother. 2013 Dec;57(12):6196-204. doi: 10.1128/AAC.01465-13. Epub 2013 Sep 30.

18.

Drugs for the treatment of malaria in the Kingdom of Saudi Arabia.

Nzila A, Al-Zahrani I.

Saudi Med J. 2013 Jun;34(6):569-78. Review.

PMID:
23756920
19.

Update on the cometabolism of organic pollutants by bacteria.

Nzila A.

Environ Pollut. 2013 Jul;178:474-82. doi: 10.1016/j.envpol.2013.03.042. Epub 2013 Apr 6. Review.

PMID:
23570949
20.

Preclinical drug evaluation system in the Plasmodium knowlesi baboon model of malaria: the methotrexate study.

Ichagichu M, Ngotho M, Karanja SM, Kokwaro G, Kariuki T, Nzila A, Ozwara H.

J Med Primatol. 2013 Apr;42(2):62-70. doi: 10.1111/jmp.12034. Epub 2013 Jan 7.

PMID:
23294369
21.

Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials.

Chigorimbo-Murefu NT, Njoroge M, Nzila A, Louw S, Masimirembwa C, Chibale K.

Future Med Chem. 2012 Dec;4(18):2325-36. doi: 10.4155/fmc.12.173. Review.

PMID:
23234554
22.

Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes.

Okombo J, Kiara SM, Abdirahman A, Mwai L, Ohuma E, Borrmann S, Nzila A, Ward S.

J Antimicrob Chemother. 2013 Apr;68(4):786-8. doi: 10.1093/jac/dks471. Epub 2012 Nov 20.

PMID:
23169890
23.

Update on the in vivo tolerance and in vitro reduced susceptibility to the antimalarial lumefantrine.

Nzila A, Okombo J, Ohuma E, Al-Thukair A.

J Antimicrob Chemother. 2012 Oct;67(10):2309-15. doi: 10.1093/jac/dks252. Epub 2012 Jul 2. Review.

PMID:
22761327
24.

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O'Brien J, Djimde A, Doumbo O, Zongo I, Ouedraogo JB, Michon P, Mueller I, Siba P, Nzila A, Borrmann S, Kiara SM, Marsh K, Jiang H, Su XZ, Amaratunga C, Fairhurst R, Socheat D, Nosten F, Imwong M, White NJ, Sanders M, Anastasi E, Alcock D, Drury E, Oyola S, Quail MA, Turner DJ, Ruano-Rubio V, Jyothi D, Amenga-Etego L, Hubbart C, Jeffreys A, Rowlands K, Sutherland C, Roper C, Mangano V, Modiano D, Tan JC, Ferdig MT, Amambua-Ngwa A, Conway DJ, Takala-Harrison S, Plowe CV, Rayner JC, Rockett KA, Clark TG, Newbold CI, Berriman M, MacInnis B, Kwiatkowski DP.

Nature. 2012 Jul 19;487(7407):375-9. doi: 10.1038/nature11174.

25.

Genome wide adaptations of Plasmodium falciparum in response to lumefantrine selective drug pressure.

Mwai L, Diriye A, Masseno V, Muriithi S, Feltwell T, Musyoki J, Lemieux J, Feller A, Mair GR, Marsh K, Newbold C, Nzila A, Carret CK.

PLoS One. 2012;7(2):e31623. doi: 10.1371/journal.pone.0031623. Epub 2012 Feb 27.

26.

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy.

Gutman J, Kachur SP, Slutsker L, Nzila A, Mutabingwa T.

Malar J. 2012 Feb 9;11:39. doi: 10.1186/1475-2875-11-39. Review.

27.

Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.

Okombo J, Kiara SM, Mwai L, Pole L, Ohuma E, Ochola LI, Nzila A.

Antimicrob Agents Chemother. 2012 Feb;56(2):1105-7. doi: 10.1128/AAC.05454-11. Epub 2011 Nov 28.

28.

Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast.

Borrmann S, Sasi P, Mwai L, Bashraheil M, Abdallah A, Muriithi S, Frühauf H, Schaub B, Pfeil J, Peshu J, Hanpithakpong W, Rippert A, Juma E, Tsofa B, Mosobo M, Lowe B, Osier F, Fegan G, Lindegårdh N, Nzila A, Peshu N, Mackinnon M, Marsh K.

PLoS One. 2011;6(11):e26005. doi: 10.1371/journal.pone.0026005. Epub 2011 Nov 10.

29.

The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters.

Salcedo-Sora JE, Ochong E, Beveridge S, Johnson D, Nzila A, Biagini GA, Stocks PA, O'Neill PM, Krishna S, Bray PG, Ward SA.

J Biol Chem. 2011 Dec 30;286(52):44659-68. doi: 10.1074/jbc.M111.286054. Epub 2011 Oct 13.

30.

Drug repositioning in the treatment of malaria and TB.

Nzila A, Ma Z, Chibale K.

Future Med Chem. 2011 Sep;3(11):1413-26. doi: 10.4155/fmc.11.95. Review.

PMID:
21879845
31.

Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay.

Campino S, Auburn S, Kivinen K, Zongo I, Ouedraogo JB, Mangano V, Djimde A, Doumbo OK, Kiara SM, Nzila A, Borrmann S, Marsh K, Michon P, Mueller I, Siba P, Jiang H, Su XZ, Amaratunga C, Socheat D, Fairhurst RM, Imwong M, Anderson T, Nosten F, White NJ, Gwilliam R, Deloukas P, MacInnis B, Newbold CI, Rockett K, Clark TG, Kwiatkowski DP.

PLoS One. 2011;6(6):e20251. doi: 10.1371/journal.pone.0020251. Epub 2011 Jun 6.

32.

A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers.

Chilengi R, Juma R, Abdallah AM, Bashraheil M, Lodenyo H, Nyakundi P, Anabwani E, Salim A, Mwambingu G, Wenwa E, Jemutai J, Kipkeu C, Oyoo GO, Muchohi SN, Kokwaro G, Niehues T, Lang T, Nzila A.

Malar J. 2011 Mar 16;10:63. doi: 10.1186/1475-2875-10-63.

33.

Update on genetic markers of quinine resistance in Plasmodium falciparum.

Okombo J, Ohuma E, Picot S, Nzila A.

Mol Biochem Parasitol. 2011 Jun;177(2):77-82. doi: 10.1016/j.molbiopara.2011.01.012. Epub 2011 Feb 1. Review.

PMID:
21295079
34.

Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax.

Imwong M, Russell B, Suwanarusk R, Nzila A, Leimanis ML, Sriprawat K, Kaewpongsri S, Phyo AP, Snounou G, Nosten F, Renia L.

J Infect Dis. 2011 Jan 15;203(2):207-10. doi: 10.1093/infdis/jiq024. Epub 2010 Dec 9.

35.

In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.

Okombo J, Kiara SM, Rono J, Mwai L, Pole L, Ohuma E, Borrmann S, Ochola LI, Nzila A.

Antimicrob Agents Chemother. 2010 Aug;54(8):3302-7. doi: 10.1128/AAC.00325-10. Epub 2010 Jun 1.

36.

Modulators of the efficacy and toxicity of drugs in malaria treatment.

Nzila A, Chilengi R.

Trends Pharmacol Sci. 2010 Jun;31(6):277-83. doi: 10.1016/j.tips.2010.03.002. Epub 2010 Apr 9. Review.

PMID:
20381886
37.

Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT.

Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. doi: 10.1128/AAC.01526-09. Epub 2010 Mar 29.

38.

Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition.

Wang P, Wang Q, Yang Y, Coward JK, Nzila A, Sims PF, Hyde JE.

Mol Biochem Parasitol. 2010 Jul;172(1):41-51. doi: 10.1016/j.molbiopara.2010.03.012. Epub 2010 Mar 27.

39.

Anticancer agents against malaria: time to revisit?

Nzila A, Okombo J, Becker RP, Chilengi R, Lang T, Niehues T.

Trends Parasitol. 2010 Mar;26(3):125-9. doi: 10.1016/j.pt.2009.12.002. Epub 2010 Jan 6.

40.

In vitro selection of Plasmodium falciparum drug-resistant parasite lines.

Nzila A, Mwai L.

J Antimicrob Chemother. 2010 Mar;65(3):390-8. doi: 10.1093/jac/dkp449. Epub 2009 Dec 18. Review.

41.

In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

Mwai L, Kiara SM, Abdirahman A, Pole L, Rippert A, Diriye A, Bull P, Marsh K, Borrmann S, Nzila A.

Antimicrob Agents Chemother. 2009 Dec;53(12):5069-73. doi: 10.1128/AAC.00638-09. Epub 2009 Sep 21.

42.

In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.

Kiara SM, Okombo J, Masseno V, Mwai L, Ochola I, Borrmann S, Nzila A.

Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. doi: 10.1128/AAC.00308-09. Epub 2009 Jun 15.

43.

Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species.

Irungu B, Kiboi D, Langat B, Rukunga G, Wittlin S, Nzila A.

Exp Parasitol. 2009 Oct;123(2):118-21. doi: 10.1016/j.exppara.2009.06.007. Epub 2009 Jun 13.

PMID:
19527714
44.

Chloroquine resistance before and after its withdrawal in Kenya.

Mwai L, Ochong E, Abdirahman A, Kiara SM, Ward S, Kokwaro G, Sasi P, Marsh K, Borrmann S, Mackinnon M, Nzila A.

Malar J. 2009 May 18;8:106. doi: 10.1186/1475-2875-8-106.

45.

In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa.

Sasi P, Abdulrahaman A, Mwai L, Muriithi S, Straimer J, Schieck E, Rippert A, Bashraheil M, Salim A, Peshu J, Awuondo K, Lowe B, Pirmohamed M, Winstanley P, Ward S, Nzila A, Borrmann S.

J Infect Dis. 2009 Jun 1;199(11):1575-82. doi: 10.1086/598862.

PMID:
19405863
46.

In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.

Masseno V, Muriithi S, Nzila A.

Antimicrob Agents Chemother. 2009 Jul;53(7):3131-4. doi: 10.1128/AAC.01689-08. Epub 2009 Apr 13.

47.

Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.

Kiboi DM, Irungu BN, Langat B, Wittlin S, Brun R, Chollet J, Abiodun O, Nganga JK, Nyambati VC, Rukunga GM, Bell A, Nzila A.

Exp Parasitol. 2009 Jul;122(3):196-202. doi: 10.1016/j.exppara.2009.03.010. Epub 2009 Mar 24.

48.

Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987--2006.

Certain LK, Briceño M, Kiara SM, Nzila AM, Watkins WM, Sibley CH.

J Infect Dis. 2008 Jun 15;197(12):1743-51. doi: 10.1086/588198.

49.

Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.

Nduati E, Diriye A, Ommeh S, Mwai L, Kiara S, Masseno V, Kokwaro G, Nzila A.

Parasitol Res. 2008 May;102(6):1227-34. doi: 10.1007/s00436-008-0897-4. Epub 2008 Feb 9.

50.

Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria.

Kokwaro G, Mwai L, Nzila A.

Expert Opin Pharmacother. 2007 Jan;8(1):75-94. Review.

PMID:
17163809

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