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Dipeptidyl peptidase-4 inhibitors and sulfonylureas prevent the progressive impairment of the nigrostriatal dopaminergic system induced by diabetes during aging.

Lietzau G, Magni G, Kehr J, Yoshitake T, Candeias E, Duarte AI, Pettersson H, Skogsberg J, Abbracchio MP, Klein T, Nyström T, Ceruti S, Darsalia V, Patrone C.

Neurobiol Aging. 2020 Feb 4. pii: S0197-4580(20)30012-9. doi: 10.1016/j.neurobiolaging.2020.01.004. [Epub ahead of print]


Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.

Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi CJ, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemenčič M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nyström T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, Ståhlberg J, Suárez MF, Thome M, Tuominen H, Van Breusegem F, van der Hoorn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV.

Mol Cell. 2020 Mar 5;77(5):927-929. doi: 10.1016/j.molcel.2019.12.020. No abstract available.


FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism.

Chen X, Ji B, Hao X, Li X, Eisele F, Nyström T, Petranovic D.

Nat Commun. 2020 Feb 13;11(1):867. doi: 10.1038/s41467-020-14525-4.


Heart failure is a common complication after acute myocardial infarction in patients with diabetes: A nationwide study in the SWEDEHEART registry.

Ritsinger V, Nyström T, Saleh N, Lagerqvist B, Norhammar A.

Eur J Prev Cardiol. 2020 Feb 4:2047487319901063. doi: 10.1177/2047487319901063. [Epub ahead of print]


Risk of first stroke in people with type 2 diabetes and its relation to glycaemic control: A nationwide observational study.

Zabala A, Darsalia V, Holzmann MJ, Franzén S, Svensson AM, Eliasson B, Patrone C, Nyström T, Jonsson M.

Diabetes Obes Metab. 2020 Feb;22(2):182-190. doi: 10.1111/dom.13885. Epub 2019 Oct 17.


Oxygen Therapy in Myocardial Infarction Patients With or Without Diabetes: A Predefined Subgroup Analysis From the DETO2X-AMI Trial.

Nyström T, James SK, Lindahl B, Östlund O, Erlinge D, Herlitz J, Omerovic E, Mellbin L, Alfredsson J, Fröbert O, Jernberg T, Hofmann R; DETO2X-SWEDEHEART Investigators.

Diabetes Care. 2019 Nov;42(11):2032-2041. doi: 10.2337/dc19-0590. Epub 2019 Aug 31.


Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress.

Babazadeh R, Ahmadpour D, Jia S, Hao X, Widlund P, Schneider K, Eisele F, Edo LD, Smits GJ, Liu B, Nystrom T.

Cell Rep. 2019 Aug 20;28(8):2096-2110.e8. doi: 10.1016/j.celrep.2019.07.053.


Dapagliflozin vs non-SGLT-2i treatment is associated with lower healthcare costs in type 2 diabetes patients similar to participants in the DECLARE-TIMI 58 trial: A nationwide observational study.

Norhammar A, Bodegard J, Nyström T, Thuresson M, Rikner K, Nathanson D, Eriksson JW.

Diabetes Obes Metab. 2019 Dec;21(12):2651-2659. doi: 10.1111/dom.13852. Epub 2019 Aug 26.


Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons.

Pintana H, Lietzau G, Augestad IL, Chiazza F, Nyström T, Patrone C, Darsalia V.

Clin Sci (Lond). 2019 Jul 1;133(13):1367-1386. doi: 10.1042/CS20190180. Print 2019 Jul 15.


Dipeptidyl Peptidase-4 Inhibitors for the Potential Treatment of Brain Disorders; A Mini-Review With Special Focus on Linagliptin and Stroke.

Darsalia V, Johansen OE, Lietzau G, Nyström T, Klein T, Patrone C.

Front Neurol. 2019 May 8;10:493. doi: 10.3389/fneur.2019.00493. eCollection 2019. Review.


Excess risk of lower extremity amputations in people with type 1 diabetes compared with the general population: amputations and type 1 diabetes.

Ólafsdóttir AF, Svensson AM, Pivodic A, Gudbjörnsdottir S, Nyström T, Wedel H, Rosengren A, Lind M.

BMJ Open Diabetes Res Care. 2019 Apr 14;7(1):e000602. doi: 10.1136/bmjdrc-2018-000602. eCollection 2019.


Glycated Hemoglobin A1c Levels in Type 1 Diabetes Mellitus and Outcomes After Myocardial Infarction.

Nyström T, Sartipy U, Contardi A, Lind M, Bellocco R, Eliasson B, Svensson AM, Holzmann MJ.

Circulation. 2019 May 14;139(20):2380-2382. doi: 10.1161/CIRCULATIONAHA.118.039223. No abstract available.


Heart rate variability in type 2 diabetic subjects randomized to liraglutide or glimepiride treatment, both in combination with metformin: A randomized, open, parallel-group study.

Nyström T, Santos-Pardo I, Fang X, Cao Y, Hedberg F, Jendle J.

Endocrinol Diabetes Metab. 2019 Feb 6;2(2):e00058. doi: 10.1002/edm2.58. eCollection 2019 Apr.


Different patterns of second-line treatment in type 2 diabetes after metformin monotherapy in Denmark, Finland, Norway and Sweden (D360 Nordic): A multinational observational study.

Persson F, Bodegard J, Lahtela JT, Nyström T, Jørgensen ME, Jensen ML, Gulseth HL, Thuresson M, Hoti F, Nathanson D, Norhammar A, Birkeland KI, Eriksson JG, Eriksson JW.

Endocrinol Diabetes Metab. 2018 Aug 31;1(4):e00036. doi: 10.1002/edm2.36. eCollection 2018 Oct.


Dapagliflozin and cardiovascular mortality and disease outcomes in a population with type 2 diabetes similar to that of the DECLARE-TIMI 58 trial: A nationwide observational study.

Norhammar A, Bodegård J, Nyström T, Thuresson M, Nathanson D, Eriksson JW.

Diabetes Obes Metab. 2019 May;21(5):1136-1145. doi: 10.1111/dom.13627. Epub 2019 Feb 6.


Studying Spatial Protein Quality Control, Proteopathies, and Aging Using Different Model Misfolding Proteins in S. cerevisiae.

Schneider KL, Nyström T, Widlund PO.

Front Mol Neurosci. 2018 Jul 23;11:249. doi: 10.3389/fnmol.2018.00249. eCollection 2018. Review.


Comment on Suissa. Lower Risk of Death With SGLT2 Inhibitors in Observational Studies: Real or Bias? Diabetes Care 2018;41:6-10.

Nyström T, Bodegård J, Nathanson D, Thuresson M, Norhammar A, Eriksson JW.

Diabetes Care. 2018 Jun;41(6):e104-e105. doi: 10.2337/dc18-0339. No abstract available.


The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1α/CXCR4 pathway.

Chiazza F, Tammen H, Pintana H, Lietzau G, Collino M, Nyström T, Klein T, Darsalia V, Patrone C.

Cardiovasc Diabetol. 2018 May 19;17(1):60. doi: 10.1186/s12933-018-0702-3.


Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis.

Suhm T, Kaimal JM, Dawitz H, Peselj C, Masser AE, Hanzén S, Ambrožič M, Smialowska A, Björck ML, Brzezinski P, Nyström T, Büttner S, Andréasson C, Ott M.

Cell Metab. 2018 Jun 5;27(6):1309-1322.e6. doi: 10.1016/j.cmet.2018.04.011. Epub 2018 May 10.


Healthcare Cost Development in a Type 2 Diabetes Patient Population on Glucose-Lowering Drug Treatment: A Nationwide Observational Study 2006-2014.

Nathanson D, Sabale U, Eriksson JW, Nyström T, Norhammar A, Olsson U, Bodegård J.

Pharmacoecon Open. 2018 Dec;2(4):393-402. doi: 10.1007/s41669-017-0063-y.


A Randomized Clinical Trial of the Effect of Continuous Glucose Monitoring on Nocturnal Hypoglycemia, Daytime Hypoglycemia, Glycemic Variability, and Hypoglycemia Confidence in Persons with Type 1 Diabetes Treated with Multiple Daily Insulin Injections (GOLD-3).

Ólafsdóttir AF, Polonsky W, Bolinder J, Hirsch IB, Dahlqvist S, Wedel H, Nyström T, Wijkman M, Schwarcz E, Hellman J, Heise T, Lind M.

Diabetes Technol Ther. 2018 Apr;20(4):274-284. doi: 10.1089/dia.2017.0363. Epub 2018 Apr 2.


Effects on repetitive 24-hour ambulatory blood pressure in subjects with type II diabetes randomized to liraglutide or glimepiride treatment both in combination with metformin: a randomized open parallel-group study.

Jendle J, Fang X, Cao Y, Bojö L, Nilsson BK, Hedberg F, Santos-Pardo I, Nyström T.

J Am Soc Hypertens. 2018 May;12(5):346-355. doi: 10.1016/j.jash.2018.02.003. Epub 2018 Feb 16.


Corrigendum: Effects on Subclinical Heart Failure in Type 2 Diabetic Subjects on Liraglutide Treatment vs. Glimepiride Both in Combination with Metformin: A Randomized Open Parallel-Group Study.

Nyström T, Santos-Pardo I, Hedberg F, Wardell J, Witt N, Cao Y, Bojö L, Nilsson B, Jendle J.

Front Endocrinol (Lausanne). 2018 Feb 22;9:50. doi: 10.3389/fendo.2018.00050. eCollection 2018.


Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin.

Lietzau G, Davidsson W, Östenson CG, Chiazza F, Nathanson D, Pintana H, Skogsberg J, Klein T, Nyström T, Darsalia V, Patrone C.

Acta Neuropathol Commun. 2018 Feb 23;6(1):14. doi: 10.1186/s40478-018-0517-1.


Guidelines and recommendations on yeast cell death nomenclature.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.

Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review.


Effects on Subclinical Heart Failure in Type 2 Diabetic Subjects on Liraglutide Treatment vs. Glimepiride Both in Combination with Metformin: A Randomized Open Parallel-Group Study.

Nyström T, Santos-Pardo I, Hedberg F, Wardell J, Witt N, Cao Y, Bojö L, Nilsson B, Jendle J.

Front Endocrinol (Lausanne). 2017 Nov 14;8:325. doi: 10.3389/fendo.2017.00325. eCollection 2017. Erratum in: Front Endocrinol (Lausanne). 2018 Feb 22;9:50.


Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast.

Berglund LL, Hao X, Liu B, Grantham J, Nyström T.

Sci Rep. 2017 Sep 12;7(1):11328. doi: 10.1038/s41598-017-11102-6.


Estimated glucose disposal rate predicts mortality in adults with type 1 diabetes.

Nyström T, Holzmann MJ, Eliasson B, Svensson AM, Sartipy U.

Diabetes Obes Metab. 2018 Mar;20(3):556-563. doi: 10.1111/dom.13110. Epub 2017 Oct 10.


Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1.

Zheng J, Yang J, Choe YJ, Hao X, Cao X, Zhao Q, Zhang Y, Franssens V, Hartl FU, Nyström T, Winderickx J, Liu B.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):708-717. doi: 10.1016/j.bbrc.2017.08.126. Epub 2017 Aug 30.


PCI Versus CABG in Patients With Type 1 Diabetes and Multivessel Disease.

Nyström T, Sartipy U, Franzén S, Eliasson B, Gudbjörnsdottir S, Miftaraj M, Lagerqvist B, Svensson AM, Holzmann MJ.

J Am Coll Cardiol. 2017 Sep 19;70(12):1441-1451. doi: 10.1016/j.jacc.2017.07.744. Epub 2017 Aug 26. Erratum in: J Am Coll Cardiol. 2017 Nov 7;70(19):2462.


Glucagon-like receptor 1 agonists and DPP-4 inhibitors: Anti-diabetic drugs with anti-stroke potential.

Darsalia V, Klein T, Nyström T, Patrone C.

Neuropharmacology. 2018 Jul 1;136(Pt B):280-286. doi: 10.1016/j.neuropharm.2017.08.022. Epub 2017 Aug 18. Review.


Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis.

Birkeland KI, Jørgensen ME, Carstensen B, Persson F, Gulseth HL, Thuresson M, Fenici P, Nathanson D, Nyström T, Eriksson JW, Bodegård J, Norhammar A.

Lancet Diabetes Endocrinol. 2017 Sep;5(9):709-717. doi: 10.1016/S2213-8587(17)30258-9. Epub 2017 Aug 3.


Dapagliflozin is associated with lower risk of cardiovascular events and all-cause mortality in people with type 2 diabetes (CVD-REAL Nordic) when compared with dipeptidyl peptidase-4 inhibitor therapy: A multinational observational study.

Persson F, Nyström T, Jørgensen ME, Carstensen B, Gulseth HL, Thuresson M, Fenici P, Nathanson D, Eriksson JW, Norhammar A, Bodegard J, Birkeland KI.

Diabetes Obes Metab. 2018 Feb;20(2):344-351. doi: 10.1111/dom.13077. Epub 2017 Sep 8.


How and why do toxic conformers of aberrant proteins accumulate during ageing?

Josefson R, Andersson R, Nyström T.

Essays Biochem. 2017 Jul 11;61(3):317-324. doi: 10.1042/EBC20160085. Print 2017 Jul 15. Review.


Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition.

Lietzau G, Darsalia V, Pintana H, Östenson CG, Nyström T, Fisahn A, Patrone C.

Psychoneuroendocrinology. 2017 Aug;82:46-50. doi: 10.1016/j.psyneuen.2017.04.012. Epub 2017 Apr 27.


The Upsides and Downsides of Organelle Interconnectivity.

Gottschling DE, Nyström T.

Cell. 2017 Mar 23;169(1):24-34. doi: 10.1016/j.cell.2017.02.030. Review.


Restricted access: spatial sequestration of damaged proteins during stress and aging.

Hill SM, Hanzén S, Nyström T.

EMBO Rep. 2017 Mar;18(3):377-391. doi: 10.15252/embr.201643458. Epub 2017 Feb 13. Review.


Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections: The GOLD Randomized Clinical Trial.

Lind M, Polonsky W, Hirsch IB, Heise T, Bolinder J, Dahlqvist S, Schwarz E, Ólafsdóttir AF, Frid A, Wedel H, Ahlén E, Nyström T, Hellman J.

JAMA. 2017 Jan 24;317(4):379-387. doi: 10.1001/jama.2016.19976. Erratum in: JAMA. 2017 May 9;317(18):1912.


Novel oral glucose-lowering drugs are associated with lower risk of all-cause mortality, cardiovascular events and severe hypoglycaemia compared with insulin in patients with type 2 diabetes.

Nyström T, Bodegard J, Nathanson D, Thuresson M, Norhammar A, Eriksson JW.

Diabetes Obes Metab. 2017 Jun;19(6):831-841. doi: 10.1111/dom.12889. Epub 2017 Mar 16.


Second line initiation of insulin compared with DPP-4 inhibitors after metformin monotherapy is associated with increased risk of all-cause mortality, cardiovascular events, and severe hypoglycemia.

Nyström T, Bodegard J, Nathanson D, Thuresson M, Norhammar A, Eriksson JW.

Diabetes Res Clin Pract. 2017 Jan;123:199-208. doi: 10.1016/j.diabres.2016.12.004. Epub 2016 Dec 19.


Stimulation of prolactin receptor induces STAT-5 phosphorylation and cellular invasion in glioblastoma multiforme.

Alkharusi A, Yu S, Landázuri N, Zadjali F, Davodi B, Nyström T, Gräslund T, Rahbar A, Norstedt G.

Oncotarget. 2016 Nov 29;7(48):79572-79583. doi: 10.18632/oncotarget.12840.


Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4.

Larsson M, Lietzau G, Nathanson D, Östenson CG, Mallard C, Johansson ME, Nyström T, Patrone C, Darsalia V.

Biosci Rep. 2016 Dec 5;36(6). pii: e00421. doi: 10.1042/BSR20160437. Print 2016 Dec.


A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae.

Zhao L, Yang Q, Zheng J, Zhu X, Hao X, Song J, Lebacq T, Franssens V, Winderickx J, Nystrom T, Liu B.

Sci Rep. 2016 Jul 21;6:30134. doi: 10.1038/srep30134.


Estimated glucose disposal rate and long-term survival in type 2 diabetes after coronary artery bypass grafting.

Nyström T, Holzmann MJ, Eliasson B, Svensson AM, Kuhl J, Sartipy U.

Heart Vessels. 2017 Mar;32(3):269-278. doi: 10.1007/s00380-016-0875-1. Epub 2016 Jul 11.


Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions.

Hill SM, Hao X, Grönvall J, Spikings-Nordby S, Widlund PO, Amen T, Jörhov A, Josefson R, Kaganovich D, Liu B, Nyström T.

Cell Rep. 2016 Jul 19;16(3):826-38. doi: 10.1016/j.celrep.2016.06.016.


Sulphonylurea compared to DPP-4 inhibitors in combination with metformin carries increased risk of severe hypoglycemia, cardiovascular events, and all-cause mortality.

Eriksson JW, Bodegard J, Nathanson D, Thuresson M, Nyström T, Norhammar A.

Diabetes Res Clin Pract. 2016 Jul;117:39-47. doi: 10.1016/j.diabres.2016.04.055. Epub 2016 May 6.


Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu.

Mansouri S, Lietzau G, Lundberg M, Nathanson D, Nyström T, Patrone C.

PLoS One. 2016 Jun 15;11(6):e0156867. doi: 10.1371/journal.pone.0156867. eCollection 2016.


Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins.

Hanzén S, Vielfort K, Yang J, Roger F, Andersson V, Zamarbide-Forés S, Andersson R, Malm L, Palais G, Biteau B, Liu B, Toledano MB, Molin M, Nyström T.

Cell. 2016 Jun 30;166(1):140-51. doi: 10.1016/j.cell.2016.05.006. Epub 2016 Jun 2.


Selective protein degradation ensures cellular longevity.

Malmgren Hill S, Nyström T.

Elife. 2016 Jun 1;5. pii: e17185. doi: 10.7554/eLife.17185.

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