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Items: 29

1.

Evaluation of MEDI8852, an Anti-Influenza A Monoclonal Antibody, in Treating Acute Uncomplicated Influenza.

Ali SO, Takas T, Nyborg A, Shoemaker K, Kallewaard NL, Chiong R, Dubovsky F, Mallory RM.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e00694-18. doi: 10.1128/AAC.00694-18. Print 2018 Nov.

2.

A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.

Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB.

J Biol Chem. 2018 Jan 19;293(3):941-952. doi: 10.1074/jbc.M117.813428. Epub 2017 Nov 27.

3.

Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.

Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB.

J Biol Chem. 2017 Sep 1;292(35):14401-14412. doi: 10.1074/jbc.M117.781112. Epub 2017 Jul 13.

4.

Impact of Mutations on the Higher Order Structure and Activity of a Recombinant Uricase.

Gruia F, Parupudi A, Baca M, Ward C, Nyborg A, Remmele RL Jr, Bee JS.

J Pharm Sci. 2017 Apr;106(4):1018-1024. doi: 10.1016/j.xphs.2016.12.028. Epub 2017 Jan 4.

PMID:
28063825
5.

A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.

Nyborg AC, Ward C, Zacco A, Chacko B, Grinberg L, Geoghegan JC, Bean R, Wendeler M, Bartnik F, O'Connor E, Gruia F, Iyer V, Feng H, Roy V, Berge M, Miner JN, Wilson DM, Zhou D, Nicholson S, Wilker C, Wu CY, Wilson S, Jermutus L, Wu H, Owen DA, Osbourn J, Coats S, Baca M.

PLoS One. 2016 Dec 21;11(12):e0167935. doi: 10.1371/journal.pone.0167935. eCollection 2016.

6.

Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells.

Nyborg AC, Zacco A, Ettinger R, Jack Borrok M, Zhu J, Martin T, Woods R, Kiefer C, Bowen MA, Suzanne Cohen E, Herbst R, Wu H, Coats S.

Cell Mol Immunol. 2016 May;13(3):391-400. doi: 10.1038/cmi.2015.19. Epub 2015 Mar 23.

7.

In vivo and ex vivo imaging of amyloid-β cascade aggregates with a Pronucleon™ peptide.

Nyborg AC, Moll JR, Wegrzyn RD, Havas D, Hutter-Paier B, Feuerstein GG, Rudolph AS.

J Alzheimers Dis. 2013;34(4):957-67. doi: 10.3233/JAD-122107.

PMID:
23321523
8.

Targeting the junction of CɛmX and ɛ-migis for the specific depletion of mIgE-expressing B cells.

Chowdhury PS, Chen Y, Yang C, Cook KE, Nyborg AC, Ettinger R, Herbst R, Kiener PA, Wu H.

Mol Immunol. 2012 Oct;52(3-4):279-88. doi: 10.1016/j.molimm.2012.06.004. Epub 2012 Jun 29. Erratum in: Mol Immunol. 2013 Jan;53(1-2):172.

PMID:
22750228
9.

Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.

Nyborg AC, Herl L, Berezovska O, Thomas AV, Ladd TB, Jansen K, Hyman BT, Golde TE.

Mol Neurodegener. 2006 Nov 14;1:16.

10.

Flavodoxin hydroquinone reduces Azotobacter vinelandii Fe protein to the all-ferrous redox state with a S = 0 spin state.

Lowery TJ, Wilson PE, Zhang B, Bunker J, Harrison RG, Nyborg AC, Thiriot D, Watt GD.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17131-6. Epub 2006 Nov 3.

11.

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.

Nyborg AC, Ladd TB, Zwizinski CW, Lah JJ, Golde TE.

Mol Neurodegener. 2006 Jun 12;1:3.

12.

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.

Nyborg AC, Ladd TB, Jansen K, Kukar T, Golde TE.

FASEB J. 2006 Aug;20(10):1671-9.

PMID:
16873890
13.

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.

Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS.

Biochemistry. 2006 Jul 18;45(28):8649-56.

PMID:
16834339
14.

Evidence for a synergistic salt-protein interaction -- complex patterns of activation vs. inhibition of nitrogenase by salt.

Wilson PE, Nyborg AC, Kenealey J, Lowery TJ, Crawford K, King CR, Engan AJ, Johnson JL, Watt GD.

Biophys Chem. 2006 Aug 1;122(3):184-94. Epub 2006 Apr 17.

PMID:
16603308
15.

Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.

Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O.

Biochem Biophys Res Commun. 2006 Feb 10;340(2):668-74. Epub 2005 Dec 20.

PMID:
16376853
16.

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.

Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A.

J Neurochem. 2006 Jan;96(1):218-27. Epub 2005 Nov 23.

18.

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.

Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE.

J Biol Chem. 2004 Apr 9;279(15):15153-60. Epub 2004 Jan 2.

19.

Androgens modulate beta-amyloid levels in male rat brain.

Ramsden M, Nyborg AC, Murphy MP, Chang L, Stanczyk FZ, Golde TE, Pike CJ.

J Neurochem. 2003 Nov;87(4):1052-5.

20.

Overexpression of nicastrin increases Abeta production.

Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE.

FASEB J. 2003 Jun;17(9):1138-40. Epub 2003 Apr 8.

PMID:
12692078
21.

Identification of a novel family of presenilin homologues.

Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE.

Hum Mol Genet. 2002 May 1;11(9):1037-44.

PMID:
11978763
22.

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.

Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE.

Neurobiol Dis. 2002 Feb;9(1):11-23.

PMID:
11848681
24.

Mechanistic interpretation of the dilution effect for Azotobacter vinelandii and Clostridium pasteurianum nitrogenase catalysis.

Johnson JL, Nyborg AC, Wilson PE, Tolley AM, Nordmeyer FR, Watt GD.

Biochim Biophys Acta. 2000 Nov 30;1543(1):36-46.

PMID:
11087939
25.

Analysis of steady state Fe and MoFe protein interactions during nitrogenase catalysis.

Johnson JL, Nyborg AC, Wilson PE, Tolley AM, Nordmeyer FR, Watt GD.

Biochim Biophys Acta. 2000 Nov 30;1543(1):24-35.

PMID:
11087938
26.

Evidence for a two-electron transfer using the all-ferrous Fe protein during nitrogenase catalysis.

Nyborg AC, Johnson JL, Gunn A, Watt GD.

J Biol Chem. 2000 Dec 15;275(50):39307-12.

27.

Reactions of Azotobacter vinelandii nitrogenase using Ti(III) as reductant.

Nyborg AC, Erickson JA, Johnson JL, Gunn A, Truscott SM, Watt GD.

J Inorg Biochem. 2000 Mar;78(4):371-81.

PMID:
10857919
28.

Enhanced efficiency of ATP hydrolysis during nitrogenase catalysis utilizing reductants that form the all-ferrous redox state of the Fe protein.

Erickson JA, Nyborg AC, Johnson JL, Truscott SM, Gunn A, Nordmeyer FR, Watt GD.

Biochemistry. 1999 Oct 26;38(43):14279-85.

PMID:
10572002
29.

Compositional effects in the retention of colloids by thermal field-flow fractionation.

Jeon SJ, Schimpf ME, Nyborg A.

Anal Chem. 1997 Sep 1;69(17):3442-50. doi: 10.1021/ac9613040.

PMID:
21639266

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