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Items: 7


Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain.

Nwosu LN, Gowler PRW, Burston JJ, Rizoska B, Tunblad K, Lindström E, Grabowska U, Li L, McWilliams DF, Walsh DA, Chapman V.

Pain Rep. 2018 Oct 5;3(6):e685. doi: 10.1097/PR9.0000000000000685. eCollection 2018 Nov.


Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.

Wyatt LA, Nwosu LN, Wilson D, Hill R, Spendlove I, Bennett AJ, Scammell BE, Walsh DA.

Osteoarthritis Cartilage. 2019 Apr;27(4):667-675. doi: 10.1016/j.joca.2018.12.012. Epub 2018 Dec 28.


Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

Nwosu LN, Allen M, Wyatt L, Huebner JL, Chapman V, Walsh DA, Kraus VB.

Osteoarthritis Cartilage. 2017 Jun;25(6):858-865. doi: 10.1016/j.joca.2017.01.002. Epub 2017 Jan 10.


Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

Nwosu LN, Mapp PI, Chapman V, Walsh DA.

Osteoarthritis Cartilage. 2016 Nov;24(11):1910-1917. doi: 10.1016/j.joca.2016.06.012. Epub 2016 Jun 24.


The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.

Xu L, Nwosu LN, Burston JJ, Millns PJ, Sagar DR, Mapp PI, Meesawatsom P, Li L, Bennett AJ, Walsh DA, Chapman V.

Osteoarthritis Cartilage. 2016 Sep;24(9):1587-95. doi: 10.1016/j.joca.2016.05.015. Epub 2016 May 18.


Response to: 'Role of nerve growth factor (NGF) and tropomyosin receptor kinase A (TrkA) in the pathogenesis of osteoarthritis. Might NGF be the link interwinding obesity and OA?' by Iannone et al.

Nwosu LN, Walsh DA.

Ann Rheum Dis. 2015 Dec;74(12):e71. doi: 10.1136/annrheumdis-2015-208523. Epub 2015 Sep 29. No abstract available.


Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.

Nwosu LN, Mapp PI, Chapman V, Walsh DA.

Ann Rheum Dis. 2016 Jun;75(6):1246-54. doi: 10.1136/annrheumdis-2014-207203. Epub 2015 Aug 18.

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