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Items: 1 to 50 of 206

1.

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system.

Bruno L, Ramlall V, Studer RA, Sauer S, Bradley D, Dharmalingam G, Carroll T, Ghoneim M, Chopin M, Nutt SL, Elderkin S, Rueda DS, Fisher AG, Siggers T, Beltrao P, Merkenschlager M.

Nat Immunol. 2019 Oct;20(10):1372-1380. doi: 10.1038/s41590-019-0471-5. Epub 2019 Aug 26.

PMID:
31451789
2.

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection.

Sheikh AA, Cooper L, Feng M, Souza-Fonseca-Guimaraes F, Lafouresse F, Duckworth BC, Huntington ND, Moon JJ, Pellegrini M, Nutt SL, Belz GT, Good-Jacobson KL, Groom JR.

Cell Rep. 2019 Aug 13;28(7):1758-1772.e4. doi: 10.1016/j.celrep.2019.07.034.

3.

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.

McKenzie MD, Ghisi M, Oxley EP, Ngo S, Cimmino L, Esnault C, Liu R, Salmon JM, Bell CC, Ahmed N, Erlichster M, Witkowski MT, Liu GJ, Chopin M, Dakic A, Simankowicz E, Pomilio G, Vu T, Krsmanovic P, Su S, Tian L, Baldwin TM, Zalcenstein DA, DiRago L, Wang S, Metcalf D, Johnstone RW, Croker BA, Lancaster GI, Murphy AJ, Naik SH, Nutt SL, Pospisil V, Schroeder T, Wall M, Dawson MA, Wei AH, de Thé H, Ritchie ME, Zuber J, Dickins RA.

Cell Stem Cell. 2019 Aug 1;25(2):258-272.e9. doi: 10.1016/j.stem.2019.07.001.

PMID:
31374198
4.

New players in the gene regulatory network controlling late B cell differentiation.

Willis SN, Nutt SL.

Curr Opin Immunol. 2019 Jun;58:68-74. doi: 10.1016/j.coi.2019.04.007. Epub 2019 May 24. Review.

PMID:
31132512
5.

Polycomb repressive complex 2 is a critical mediator of allergic inflammation.

Keenan CR, Iannarella N, Garnham AL, Brown AC, Kim RY, Horvat JC, Hansbro PM, Nutt SL, Allan RS.

JCI Insight. 2019 May 16;4(10). pii: 127745. doi: 10.1172/jci.insight.127745. eCollection 2019 May 16.

6.

Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.

Wang H, Jain S, Li P, Lin JX, Oh J, Qi C, Gao Y, Sun J, Sakai T, Naghashfar Z, Abbasi S, Kovalchuk AL, Bolland S, Nutt SL, Leonard WJ, Morse HC 3rd.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9511-9520. doi: 10.1073/pnas.1901258116. Epub 2019 Apr 18.

7.

A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation.

Roy K, Mitchell S, Liu Y, Ohta S, Lin YS, Metzig MO, Nutt SL, Hoffmann A.

Immunity. 2019 Mar 19;50(3):616-628.e6. doi: 10.1016/j.immuni.2019.02.004. Epub 2019 Mar 5.

PMID:
30850343
8.

Directing the conductor: TNF regulation of HSCs.

Nutt SL.

Blood. 2019 Feb 21;133(8):771-773. doi: 10.1182/blood-2018-10-880815. No abstract available.

PMID:
30792221
9.

PU.1 controls fibroblast polarization and tissue fibrosis.

Wohlfahrt T, Rauber S, Uebe S, Luber M, Soare A, Ekici A, Weber S, Matei AE, Chen CW, Maier C, Karouzakis E, Kiener HP, Pachera E, Dees C, Beyer C, Daniel C, Gelse K, Kremer AE, Naschberger E, Stürzl M, Butter F, Sticherling M, Finotto S, Kreuter A, Kaplan MH, Jüngel A, Gay S, Nutt SL, Boykin DW, Poon GMK, Distler O, Schett G, Distler JHW, Ramming A.

Nature. 2019 Feb;566(7744):344-349. doi: 10.1038/s41586-019-0896-x. Epub 2019 Jan 30.

10.

The cis-Regulatory Atlas of the Mouse Immune System.

Yoshida H, Lareau CA, Ramirez RN, Rose SA, Maier B, Wroblewska A, Desland F, Chudnovskiy A, Mortha A, Dominguez C, Tellier J, Kim E, Dwyer D, Shinton S, Nabekura T, Qi Y, Yu B, Robinette M, Kim KW, Wagers A, Rhoads A, Nutt SL, Brown BD, Mostafavi S, Buenrostro JD, Benoist C; Immunological Genome Project.

Cell. 2019 Feb 7;176(4):897-912.e20. doi: 10.1016/j.cell.2018.12.036. Epub 2019 Jan 24.

PMID:
30686579
11.

Viral Replicative Capacity, Antigen Availability via Hematogenous Spread, and High TFH:TFR Ratios Drive Induction of Potent Neutralizing Antibody Responses.

Eldi P, Chaudhri G, Nutt SL, Newsome TP, Karupiah G.

J Virol. 2019 Mar 5;93(6). pii: e01795-18. doi: 10.1128/JVI.01795-18. Print 2019 Mar 15.

12.

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT.

Chopin M, Lun AT, Zhan Y, Schreuder J, Coughlan H, D'Amico A, Mielke LA, Almeida FF, Kueh AJ, Dickins RA, Belz GT, Naik SH, Lew AM, Bouillet P, Herold MJ, Smyth GK, Corcoran LM, Nutt SL.

Immunity. 2019 Jan 15;50(1):77-90.e5. doi: 10.1016/j.immuni.2018.11.010. Epub 2019 Jan 2.

PMID:
30611612
13.

CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells.

Zhan Y, Wang N, Vasanthakumar A, Zhang Y, Chopin M, Nutt SL, Kallies A, Lew AM.

Cell Mol Immunol. 2018 Dec 11. doi: 10.1038/s41423-018-0187-8. [Epub ahead of print]

PMID:
30538272
14.

Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity.

Bagherzadeh Yazdchi S, Witalis M, Meli AP, Leung J, Li X, Panneton V, Chang J, Li J, Nutt SL, Johnson RL, Lim DS, Gu H, King IL, Suh WK.

J Immunol. 2019 Jan 1;202(1):69-78. doi: 10.4049/jimmunol.1701407. Epub 2018 Nov 26.

PMID:
30478091
15.

Transcription-factor-mediated supervision of global genome architecture maintains B cell identity.

Johanson TM, Lun ATL, Coughlan HD, Tan T, Smyth GK, Nutt SL, Allan RS.

Nat Immunol. 2018 Nov;19(11):1257-1264. doi: 10.1038/s41590-018-0234-8. Epub 2018 Oct 15.

PMID:
30323344
16.

Plasma cells: The programming of an antibody-secreting machine.

Tellier J, Nutt SL.

Eur J Immunol. 2019 Jan;49(1):30-37. doi: 10.1002/eji.201847517. Epub 2018 Oct 15. Review.

PMID:
30273443
17.

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.

Andreani V, Ramamoorthy S, Pandey A, Lupar E, Nutt SL, Lämmermann T, Grosschedl R.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9630-E9639. doi: 10.1073/pnas.1809739115. Epub 2018 Sep 26.

18.

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos.

Fedele PL, Willis SN, Liao Y, Low MS, Rautela J, Segal DH, Gong JN, Huntington ND, Shi W, Huang DCS, Grigoriadis G, Tellier J, Nutt SL.

Blood. 2018 Nov 15;132(20):2166-2178. doi: 10.1182/blood-2018-05-850727. Epub 2018 Sep 18.

PMID:
30228232
19.

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins.

Trezise S, Karnowski A, Fedele PL, Mithraprabhu S, Liao Y, D'Costa K, Kueh AJ, Hardy MP, Owczarek CM, Herold MJ, Spencer A, Shi W, Willis SN, Nutt SL, Corcoran LM.

Int J Mol Sci. 2018 Jul 24;19(8). pii: E2161. doi: 10.3390/ijms19082161.

20.

PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors.

Pang SHM, de Graaf CA, Hilton DJ, Huntington ND, Carotta S, Wu L, Nutt SL.

Front Immunol. 2018 Jun 11;9:1264. doi: 10.3389/fimmu.2018.01264. eCollection 2018.

21.

Transcription Factor Theft-PU.1 Caught Red-Handed.

Kallies A, Nutt SL.

Immunity. 2018 Jun 19;48(6):1063-1065. doi: 10.1016/j.immuni.2018.05.007.

22.

Editorial overview: Lymphocyte development and activation.

Nutt SL, Groom JR.

Curr Opin Immunol. 2018 Apr;51:iv-vi. doi: 10.1016/j.coi.2018.04.017. No abstract available.

PMID:
29739545
23.

LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins.

Zanker D, Pang K, Oveissi S, Lu C, Faou P, Nowell C, Mbogo GW, Carotta S, Quillici C, Karupiah G, Hibbs ML, Nutt SL, Neeson P, Puthalakath H, Chen W.

Immunol Cell Biol. 2018 Oct;96(9):981-993. doi: 10.1111/imcb.12163. Epub 2018 Jun 3.

PMID:
29738610
24.

Characterization of Blimp-1 function in effector regulatory T cells.

Cretney E, Leung PS, Trezise S, Newman DM, Rankin LC, Teh CE, Putoczki TL, Gray DH, Belz GT, Mielke LA, Dias S, Nutt SL.

J Autoimmun. 2018 Jul;91:73-82. doi: 10.1016/j.jaut.2018.04.003. Epub 2018 Apr 30.

PMID:
29724515
25.

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model.

Sheean RK, McKay FC, Cretney E, Bye CR, Perera ND, Tomas D, Weston RA, Scheller KJ, Djouma E, Menon P, Schibeci SD, Marmash N, Yerbury JJ, Nutt SL, Booth DR, Stewart GJ, Kiernan MC, Vucic S, Turner BJ.

JAMA Neurol. 2018 Jun 1;75(6):681-689. doi: 10.1001/jamaneurol.2018.0035.

26.

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB.

Willis SN, Tellier J, Liao Y, Trezise S, Light A, O'Donnell K, Garrett-Sinha LA, Shi W, Tarlinton DM, Nutt SL.

Nat Commun. 2017 Nov 10;8(1):1426. doi: 10.1038/s41467-017-01605-1.

27.

Interleukin-12 from CD103+ Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis.

Mittal D, Vijayan D, Putz EM, Aguilera AR, Markey KA, Straube J, Kazakoff S, Nutt SL, Takeda K, Hill GR, Waddell N, Smyth MJ.

Cancer Immunol Res. 2017 Dec;5(12):1098-1108. doi: 10.1158/2326-6066.CIR-17-0341. Epub 2017 Oct 25.

28.

Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells.

Kerdiles YM, Almeida FF, Thompson T, Chopin M, Vienne M, Bruhns P, Huntington ND, Raulet DH, Nutt SL, Belz GT, Vivier E.

Immunity. 2017 Aug 15;47(2):199-200. doi: 10.1016/j.immuni.2017.07.026. No abstract available.

29.

Standing out from the crowd: How to identify plasma cells.

Tellier J, Nutt SL.

Eur J Immunol. 2017 Aug;47(8):1276-1279. doi: 10.1002/eji.201747168.

30.

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J.

Elife. 2017 Jun 27;6. pii: e29849. doi: 10.7554/eLife.29849. No abstract available.

31.

IL-17-producing γδ T cells switch migratory patterns between resting and activated states.

McKenzie DR, Kara EE, Bastow CR, Tyllis TS, Fenix KA, Gregor CE, Wilson JJ, Babb R, Paton JC, Kallies A, Nutt SL, Brüstle A, Mack M, Comerford I, McColl SR.

Nat Commun. 2017 Jun 5;8:15632. doi: 10.1038/ncomms15632.

32.

Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor Ets1.

Saelee P, Kearly A, Nutt SL, Garrett-Sinha LA.

Front Immunol. 2017 Apr 7;8:383. doi: 10.3389/fimmu.2017.00383. eCollection 2017.

33.

The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.

Keightley MC, Carradice DP, Layton JE, Pase L, Bertrand JY, Wittig JG, Dakic A, Badrock AP, Cole NJ, Traver D, Nutt SL, McCoey J, Buckle AM, Heath JK, Lieschke GJ.

Nat Commun. 2017 Apr 6;8:14911. doi: 10.1038/ncomms14911.

34.

A non-canonical function of Ezh2 preserves immune homeostasis.

Vasanthakumar A, Xu D, Lun AT, Kueh AJ, van Gisbergen KP, Iannarella N, Li X, Yu L, Wang D, Williams BR, Lee SC, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS.

EMBO Rep. 2017 Apr;18(4):619-631. doi: 10.15252/embr.201643237. Epub 2017 Feb 21.

35.

Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb.

Dias S, D'Amico A, Cretney E, Liao Y, Tellier J, Bruggeman C, Almeida FF, Leahy J, Belz GT, Smyth GK, Shi W, Nutt SL.

Immunity. 2017 Jan 17;46(1):78-91. doi: 10.1016/j.immuni.2016.12.017.

36.

NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.

Marshall NB, Vong AM, Devarajan P, Brauner MD, Kuang Y, Nayar R, Schutten EA, Castonguay CH, Berg LJ, Nutt SL, Swain SL.

J Immunol. 2017 Feb 1;198(3):1142-1155. doi: 10.4049/jimmunol.1601297. Epub 2016 Dec 28.

37.

Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge.

Blanc P, Moro-Sibilot L, Barthly L, Jagot F, This S, de Bernard S, Buffat L, Dussurgey S, Colisson R, Hobeika E, Fest T, Taillardet M, Thaunat O, Sicard A, Mondière P, Genestier L, Nutt SL, Defrance T.

Nat Commun. 2016 Dec 7;7:13600. doi: 10.1038/ncomms13600.

38.

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.

Donnarumma T, Young GR, Merkenschlager J, Eksmond U, Bongard N, Nutt SL, Boyer C, Dittmer U, Le-Trilling VT, Trilling M, Bayer W, Kassiotis G.

Cell Rep. 2016 Nov 1;17(6):1571-1583. doi: 10.1016/j.celrep.2016.10.013.

39.

Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity.

Newman DM, Sakaguchi S, Lun A, Preston S, Pellegrini M, Khamina K, Bergthaler A, Nutt SL, Smyth GK, Voss AK, Thomas T, Ellmeier W, Belz GT, Allan RS.

Cell Rep. 2016 Sep 20;16(12):3311-3321. doi: 10.1016/j.celrep.2016.08.056.

40.

Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.

Achuthan A, Cook AD, Lee MC, Saleh R, Khiew HW, Chang MW, Louis C, Fleetwood AJ, Lacey DC, Christensen AD, Frye AT, Lam PY, Kusano H, Nomura K, Steiner N, Förster I, Nutt SL, Olshansky M, Turner SJ, Hamilton JA.

J Clin Invest. 2016 Sep 1;126(9):3453-66. doi: 10.1172/JCI87828. Epub 2016 Aug 15.

41.

Long-Lived Plasma Cells Have a Sweet Tooth.

Corcoran LM, Nutt SL.

Immunity. 2016 Jul 19;45(1):3-5. doi: 10.1016/j.immuni.2016.07.003.

42.

Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development.

Gloury R, Zotos D, Zuidscherwoude M, Masson F, Liao Y, Hasbold J, Corcoran LM, Hodgkin PD, Belz GT, Shi W, Nutt SL, Tarlinton DM, Kallies A.

J Exp Med. 2016 May 30;213(6):1095-111. doi: 10.1084/jem.20152003. Epub 2016 May 23.

43.

RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity.

Chopin M, Preston SP, Lun ATL, Tellier J, Smyth GK, Pellegrini M, Belz GT, Corcoran LM, Visvader JE, Wu L, Nutt SL.

Cell Rep. 2016 Apr 26;15(4):866-878. doi: 10.1016/j.celrep.2016.03.066. Epub 2016 Apr 14.

44.

Th17 cell differentiation proceeds independently of IRF8.

Newman DM, Leung PS, Putoczki TL, Nutt SL, Cretney E.

Immunol Cell Biol. 2016 Sep;94(8):796-801. doi: 10.1038/icb.2016.33. Epub 2016 May 3.

PMID:
27140932
45.

A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.

Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A.

Nat Immunol. 2016 Apr;17(4):422-32. doi: 10.1038/ni.3410. Epub 2016 Mar 7.

46.

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.

Pang SH, Minnich M, Gangatirkar P, Zheng Z, Ebert A, Song G, Dickins RA, Corcoran LM, Mullighan CG, Busslinger M, Huntington ND, Nutt SL, Carotta S.

Leukemia. 2016 Jun;30(6):1375-87. doi: 10.1038/leu.2016.27. Epub 2016 Mar 2.

47.

Correction: Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.

Montes de Oca M, Kumar R, de Labastida Rivera F, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Muller W, Cretney E, Nutt SL, Smyth MJ, Haque A, Hill GR, Sundar S, Kallies A, Engwerda CR.

PLoS Pathog. 2016 Feb 12;12(2):e1005460. doi: 10.1371/journal.ppat.1005460. eCollection 2016 Feb. No abstract available.

48.

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Delconte RB, Shi W, Sathe P, Ushiki T, Seillet C, Minnich M, Kolesnik TB, Rankin LC, Mielke LA, Zhang JG, Busslinger M, Smyth MJ, Hutchinson DS, Nutt SL, Nicholson SE, Alexander WS, Corcoran LM, Vivier E, Belz GT, Carotta S, Huntington ND.

Immunity. 2016 Jan 19;44(1):103-115. doi: 10.1016/j.immuni.2015.12.007. Epub 2016 Jan 12.

49.

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.

Minnich M, Tagoh H, Bönelt P, Axelsson E, Fischer M, Cebolla B, Tarakhovsky A, Nutt SL, Jaritz M, Busslinger M.

Nat Immunol. 2016 Mar;17(3):331-43. doi: 10.1038/ni.3349. Epub 2016 Jan 18.

50.

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.

Tellier J, Shi W, Minnich M, Liao Y, Crawford S, Smyth GK, Kallies A, Busslinger M, Nutt SL.

Nat Immunol. 2016 Mar;17(3):323-30. doi: 10.1038/ni.3348. Epub 2016 Jan 18.

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