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Prime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge.

de Camargo TM, de Freitas EO, Gimenez AM, Lima LC, de Almeida Caramico K, Françoso KS, Bruna-Romero O, Andolina C, Nosten F, Rénia L, Ertl HCJ, Nussenzweig RS, Nussenzweig V, Rodrigues MM, Reyes-Sandoval A, Soares IS.

Sci Rep. 2018 Jan 18;8(1):1118. doi: 10.1038/s41598-017-19063-6.


Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency.

Zhang M, Gallego-Delgado J, Fernandez-Arias C, Waters NC, Rodriguez A, Tsuji M, Wek RC, Nussenzweig V, Sullivan WJ Jr.

Cell Host Microbe. 2017 Dec 13;22(6):766-776.e4. doi: 10.1016/j.chom.2017.11.005.


Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite.

Gimenez AM, Lima LC, Françoso KS, Denapoli PMA, Panatieri R, Bargieri DY, Thiberge JM, Andolina C, Nosten F, Renia L, Nussenzweig RS, Nussenzweig V, Amino R, Rodrigues MM, Soares IS.

Front Immunol. 2017 Oct 11;8:1275. doi: 10.3389/fimmu.2017.01275. eCollection 2017.


Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice.

Li X, Huang J, Zhang M, Funakoshi R, Sheetij D, Spaccapelo R, Crisanti A, Nussenzweig V, Nussenzweig RS, Tsuji M.

Vaccine. 2016 Aug 31;34(38):4501-4506. doi: 10.1016/j.vaccine.2016.08.006. Epub 2016 Aug 5.


UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages.

Zhang M, Mishra S, Sakthivel R, Fontoura BM, Nussenzweig V.

PLoS Pathog. 2016 Jan 6;12(1):e1005370. doi: 10.1371/journal.ppat.1005370. eCollection 2016 Jan.


Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria.

Huang J, Li X, Coelho-dos-Reis JG, Zhang M, Mitchell R, Nogueira RT, Tsao T, Noe AR, Ayala R, Sahi V, Gutierrez GM, Nussenzweig V, Wilson JM, Nardin EH, Nussenzweig RS, Tsuji M.

J Immunol Methods. 2015 Dec;427:42-50. doi: 10.1016/j.jim.2015.09.005. Epub 2015 Sep 26.


Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.

Nemetski SM, Cardozo TJ, Bosch G, Weltzer R, O'Malley K, Ejigiri I, Kumar KA, Buscaglia CA, Nussenzweig V, Sinnis P, Levitskaya J, Bosch J.

Malar J. 2015 Aug 20;14:324. doi: 10.1186/s12936-015-0834-9.


Immunogenicity of a prime-boost vaccine containing the circumsporozoite proteins of Plasmodium vivax in rodents.

Teixeira LH, Tararam CA, Lasaro MO, Camacho AG, Ersching J, Leal MT, Herrera S, Bruna-Romero O, Soares IS, Nussenzweig RS, Ertl HC, Nussenzweig V, Rodrigues MM.

Infect Immun. 2014 Feb;82(2):793-807. doi: 10.1128/IAI.01410-13. Epub 2013 Dec 9.


Translational control in Plasmodium and toxoplasma parasites.

Zhang M, Joyce BR, Sullivan WJ Jr, Nussenzweig V.

Eukaryot Cell. 2013 Feb;12(2):161-7. doi: 10.1128/EC.00296-12. Epub 2012 Dec 14. Review.


Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope.

Rudra JS, Mishra S, Chong AS, Mitchell RA, Nardin EH, Nussenzweig V, Collier JH.

Biomaterials. 2012 Sep;33(27):6476-84. doi: 10.1016/j.biomaterials.2012.05.041. Epub 2012 Jun 12.


PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium.

Zhang M, Mishra S, Sakthivel R, Rojas M, Ranjan R, Sullivan WJ Jr, Fontoura BM, Ménard R, Dever TE, Nussenzweig V.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3956-61. doi: 10.1073/pnas.1121567109. Epub 2012 Feb 21.


Antibodies to Plasmodium circumsporozoite protein (CSP) inhibit sporozoite's cell traversal activity.

Mishra S, Nussenzweig RS, Nussenzweig V.

J Immunol Methods. 2012 Mar 30;377(1-2):47-52. doi: 10.1016/j.jim.2012.01.009. Epub 2012 Jan 28.


Mixed results for a malaria vaccine.

Nussenzweig V, Good MF, Hill AV.

Nat Med. 2011 Dec 6;17(12):1560-1. doi: 10.1038/nm1211-1560. No abstract available.


TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium.

Camacho AG, Teixeira LH, Bargieri DY, Boscardin SB, Soares IS, Nussenzweig RS, Nussenzweig V, Rodrigues MM.

Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:167-71.


Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites.

Mishra S, Rai U, Shiratsuchi T, Li X, Vanloubbeeck Y, Cohen J, Nussenzweig RS, Winzeler EA, Tsuji M, Nussenzweig V.

Vaccine. 2011 Oct 6;29(43):7335-42. doi: 10.1016/j.vaccine.2011.07.081. Epub 2011 Jul 30.


The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands.

Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ Jr, Roos DS, Fontoura BM, Ménard R, Winzeler EA, Nussenzweig V.

J Exp Med. 2010 Jul 5;207(7):1465-74. doi: 10.1084/jem.20091975. Epub 2010 Jun 28.


Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.

Singh AP, Zhang Y, No JH, Docampo R, Nussenzweig V, Oldfield E.

Antimicrob Agents Chemother. 2010 Jul;54(7):2987-93. doi: 10.1128/AAC.00198-10. Epub 2010 May 10.


A bicomponent Plasmodium falciparum investigational vaccine composed of protein-peptide conjugates.

Kubler-Kielb J, Majadly F, Biesova Z, Mocca CP, Guo C, Nussenzweig R, Nussenzweig V, Mishra S, Wu Y, Miller LH, Keith JM, Liu TY, Robbins JB, Schneerson R.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1172-7. doi: 10.1073/pnas.0913374107. Epub 2009 Dec 28.


From the circumsporozoite protein to the RTS, S/AS candidate vaccine.

Cohen J, Nussenzweig V, Nussenzweig R, Vekemans J, Leach A.

Hum Vaccin. 2010 Jan;6(1):90-6. Epub 2010 Jan 30. Review.


Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites.

Kumar KA, Baxter P, Tarun AS, Kappe SH, Nussenzweig V.

PLoS One. 2009;4(2):e4480. doi: 10.1371/journal.pone.0004480. Epub 2009 Feb 13.


Plasmodium pre-erythrocytic stages: what's new?

Ménard R, Heussler V, Yuda M, Nussenzweig V.

Trends Parasitol. 2008 Dec;24(12):564-9. doi: 10.1016/ Epub 2008 Oct 17. Review.


Evidence-based annotation of the malaria parasite's genome using comparative expression profiling.

Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler EA.

PLoS One. 2008 Feb 13;3(2):e1570. doi: 10.1371/journal.pone.0001570.


Class II-restricted protective immunity induced by malaria sporozoites.

Oliveira GA, Kumar KA, Calvo-Calle JM, Othoro C, Altszuler D, Nussenzweig V, Nardin EH.

Infect Immun. 2008 Mar;76(3):1200-6. Epub 2007 Dec 26.


Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite.

Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler EA, Fujii H, Fontoura BM, Nussenzweig V.

Cell. 2007 Nov 2;131(3):492-504. Erratum in: Cell. 2008 Apr 18;133(2):375.


Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity.

Kumar KA, Garcia CR, Chandran VR, Van Rooijen N, Zhou Y, Winzeler E, Nussenzweig V.

Mol Biochem Parasitol. 2007 Nov;156(1):32-40. Epub 2007 Jul 13.


Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.

Bosch J, Buscaglia CA, Krumm B, Ingason BP, Lucas R, Roach C, Cardozo T, Nussenzweig V, Hol WG.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7015-20. Epub 2007 Apr 10.


The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites.

Kumar KA, Sano G, Boscardin S, Nussenzweig RS, Nussenzweig MC, Zavala F, Nussenzweig V.

Nature. 2006 Dec 14;444(7121):937-40. Epub 2006 Dec 6.


Characterization of an aldolase-binding site in the Wiskott-Aldrich syndrome protein.

Buscaglia CA, Penesetti D, Tao M, Nussenzweig V.

J Biol Chem. 2006 Jan 20;281(3):1324-31. Epub 2005 Nov 8.


Mutational analysis of the GPI-anchor addition sequence from the circumsporozoite protein of Plasmodium.

Wang Q, Fujioka H, Nussenzweig V.

Cell Microbiol. 2005 Nov;7(11):1616-26.


Exit of Plasmodium sporozoites from oocysts is an active process that involves the circumsporozoite protein.

Wang Q, Fujioka H, Nussenzweig V.

PLoS Pathog. 2005 Sep;1(1):e9. Epub 2005 Sep 30.


Yellow fever 17D as a vaccine vector for microbial CTL epitopes: protection in a rodent malaria model.

Tao D, Barba-Spaeth G, Rai U, Nussenzweig V, Rice CM, Nussenzweig RS.

J Exp Med. 2005 Jan 17;201(2):201-9.


A surface phospholipase is involved in the migration of plasmodium sporozoites through cells.

Bhanot P, Schauer K, Coppens I, Nussenzweig V.

J Biol Chem. 2005 Feb 25;280(8):6752-60. Epub 2004 Dec 8.


Plasmodium sporozoite molecular cell biology.

Kappe SH, Buscaglia CA, Nussenzweig V.

Annu Rev Cell Dev Biol. 2004;20:29-59. Review.


Quantitative Plasmodium sporozoite neutralization assay (TSNA).

Kumar KA, Oliveira GA, Edelman R, Nardin E, Nussenzweig V.

J Immunol Methods. 2004 Sep;292(1-2):157-64.


Transcriptome of axenic liver stages of Plasmodium yoelii.

Wang Q, Brown S, Roos DS, Nussenzweig V, Bhanot P.

Mol Biochem Parasitol. 2004 Sep;137(1):161-8.


Apicomplexan gliding motility and host cell invasion: overhauling the motor model.

Kappe SH, Buscaglia CA, Bergman LW, Coppens I, Nussenzweig V.

Trends Parasitol. 2004 Jan;20(1):13-6. Review. No abstract available.


Sites of interaction between aldolase and thrombospondin-related anonymous protein in plasmodium.

Buscaglia CA, Coppens I, Hol WG, Nussenzweig V.

Mol Biol Cell. 2003 Dec;14(12):4947-57. Epub 2003 Oct 31.


Defective sorting of the thrombospondin-related anonymous protein (TRAP) inhibits Plasmodium infectivity.

Bhanot P, Frevert U, Nussenzweig V, Persson C.

Mol Biochem Parasitol. 2003 Feb;126(2):263-73.


Myosin A tail domain interacting protein (MTIP) localizes to the inner membrane complex of Plasmodium sporozoites.

Bergman LW, Kaiser K, Fujioka H, Coppens I, Daly TM, Fox S, Matuschewski K, Nussenzweig V, Kappe SH.

J Cell Sci. 2003 Jan 1;116(Pt 1):39-49.


Plasmodium yoelii sporozoites infect Syndecan-1 deficient mice.

Bhanot P, Nussenzweig V.

Mol Biochem Parasitol. 2002 Aug 28;123(2):143-4. No abstract available.


Infectivity-associated changes in the transcriptional repertoire of the malaria parasite sporozoite stage.

Matuschewski K, Ross J, Brown SM, Kaiser K, Nussenzweig V, Kappe SH.

J Biol Chem. 2002 Nov 1;277(44):41948-53. Epub 2002 Aug 12.


Plasmodium sporozoite invasion into insect and mammalian cells is directed by the same dual binding system.

Matuschewski K, Nunes AC, Nussenzweig V, Ménard R.

EMBO J. 2002 Apr 2;21(7):1597-606.


Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology.

Thathy V, Fujioka H, Gantt S, Nussenzweig R, Nussenzweig V, Ménard R.

EMBO J. 2002 Apr 2;21(7):1586-96.


Exploring the transcriptome of the malaria sporozoite stage.

Kappe SH, Gardner MJ, Brown SM, Ross J, Matuschewski K, Ribeiro JM, Adams JH, Quackenbush J, Cho J, Carucci DJ, Hoffman SL, Nussenzweig V.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9895-900. Epub 2001 Aug 7.


Gene targeting in the rodent malaria parasite Plasmodium yoelii.

Mota MM, Thathy V, Nussenzweig RS, Nussenzweig V.

Mol Biochem Parasitol. 2001 Apr 6;113(2):271-8.


Complementation of Plasmodium berghei TRAP knockout parasites using human dihydrofolate reductase gene as a selectable marker.

Sultan AA, Thathy V, de Koning-Ward TF, Nussenzweig V.

Mol Biochem Parasitol. 2001 Mar;113(1):151-6.


Phosphatidylinositol-specific phospholipase C (PI-PLC) cleavage of GPI-anchored surface molecules of Trypanosoma cruzi triggers in vitro morphological reorganization of trypomastigotes.

Mortara RA, Minelli LM, Vandekerckhove F, Nussenzweig V, Ramalho-Pinto FJ.

J Eukaryot Microbiol. 2001 Jan-Feb;48(1):27-37.


The ubiquitin-proteasome pathway plays an essential role in proteolysis during Trypanosoma cruzi remodeling.

de Diego JL, Katz JM, Marshall P, Gutiérrez B, Manning JE, Nussenzweig V, González J.

Biochemistry. 2001 Jan 30;40(4):1053-62.


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