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Perspectives on the role of Wnt biology in cancer.

Mirabelli CK, Nusse R, Tuveson DA, Williams BO.

Sci Signal. 2019 Jul 9;12(589). pii: eaay4494. doi: 10.1126/scisignal.aay4494. Review.


Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/β-Catenin Signaling.

Zhao L, Jin Y, Donahue K, Tsui M, Fish M, Logan CY, Wang B, Nusse R.

Hepatology. 2019 Jun;69(6):2623-2635. doi: 10.1002/hep.30563. Epub 2019 Apr 9.


A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.

Basham KJ, Rodriguez S, Turcu AF, Lerario AM, Logan CY, Rysztak MR, Gomez-Sanchez CE, Breault DT, Koo BK, Clevers H, Nusse R, Val P, Hammer GD.

Genes Dev. 2019 Feb 1;33(3-4):209-220. doi: 10.1101/gad.317412.118. Epub 2019 Jan 28.


Honey bee Royalactin unlocks conserved pluripotency pathway in mammals.

Wan DC, Morgan SL, Spencley AL, Mariano N, Chang EY, Shankar G, Luo Y, Li TH, Huh D, Huynh SK, Garcia JM, Dovey CM, Lumb J, Liu L, Brown KV, Bermudez A, Luong R, Zeng H, Mascetti VL, Pitteri SJ, Wang J, Tu H, Quarta M, Sebastiano V, Nusse R, Rando TA, Carette JE, Bazan JF, Wang KC.

Nat Commun. 2018 Dec 4;9(1):5078. doi: 10.1038/s41467-018-06256-4.


Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.

Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Álvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R.

Cell. 2018 Nov 29;175(6):1607-1619.e15. doi: 10.1016/j.cell.2018.11.012.


Wnt signalling: conquering complexity.

Wiese KE, Nusse R, van Amerongen R.

Development. 2018 Jun 26;145(12). pii: dev165902. doi: 10.1242/dev.165902. Review.


Wnt/β-catenin signaling regulates ependymal cell development and adult homeostasis.

Xing L, Anbarchian T, Tsai JM, Plant GW, Nusse R.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5954-E5962. doi: 10.1073/pnas.1803297115. Epub 2018 Jun 11.


Gene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway.

Przybyl J, Kidzinski L, Hastie T, Debiec-Rychter M, Nusse R, van de Rijn M.

Gynecol Oncol. 2018 May;149(2):388-393. doi: 10.1016/j.ygyno.2018.03.007. Epub 2018 Mar 12.


Single-Molecule Imaging of Wnt3A Protein Diffusion on Living Cell Membranes.

Lippert A, Janeczek AA, Fürstenberg A, Ponjavic A, Moerner WE, Nusse R, Helms JA, Evans ND, Lee SF.

Biophys J. 2017 Dec 19;113(12):2762-2767. doi: 10.1016/j.bpj.2017.08.060.


Live Imaging Reveals that the First Division of Differentiating Human Embryonic Stem Cells Often Yields Asymmetric Fates.

Brown K, Loh KM, Nusse R.

Cell Rep. 2017 Oct 10;21(2):301-307. doi: 10.1016/j.celrep.2017.09.044.


In vivo lineage tracing reveals Axin2-expressing, long-lived cortical thymic epithelial progenitors in the postnatal thymus.

Tan SH, Nusse R.

PLoS One. 2017 Sep 8;12(9):e0184582. doi: 10.1371/journal.pone.0184582. eCollection 2017.


Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF.

Nature. 2017 Aug 24;548(7668):451-455. doi: 10.1038/nature23642. Epub 2017 Aug 16.


Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Nusse R, Clevers H.

Cell. 2017 Jun 1;169(6):985-999. doi: 10.1016/j.cell.2017.05.016. Review.


Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals.

Loh KM, van Amerongen R, Nusse R.

Dev Cell. 2016 Sep 26;38(6):643-55. doi: 10.1016/j.devcel.2016.08.011. Review.


Fibrosis of the Neonatal Mouse Heart After Cryoinjury Is Accompanied by Wnt Signaling Activation and Epicardial-to-Mesenchymal Transition.

Mizutani M, Wu JC, Nusse R.

J Am Heart Assoc. 2016 Mar 15;5(3):e002457. doi: 10.1161/JAHA.115.002457.


Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis.

Takase HM, Nusse R.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1489-97. doi: 10.1073/pnas.1601461113. Epub 2016 Feb 29.


Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling.

Lim X, Tan SH, Yu KL, Lim SB, Nusse R.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1498-505. doi: 10.1073/pnas.1601599113. Epub 2016 Feb 22.


Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver.

Wang B, Zhao L, Fish M, Logan CY, Nusse R.

Nature. 2015 Aug 13;524(7564):180-5. doi: 10.1038/nature14863. Epub 2015 Aug 5.


Wnt/β-Catenin-Responsive Cells in Prostatic Development and Regeneration.

Lee SH, Johnson DT, Luong R, Yu EJ, Cunha GR, Nusse R, Sun Z.

Stem Cells. 2015 Nov;33(11):3356-67. doi: 10.1002/stem.2096. Epub 2015 Jul 29.


A distinct regulatory region of the Bmp5 locus activates gene expression following adult bone fracture or soft tissue injury.

Guenther CA, Wang Z, Li E, Tran MC, Logan CY, Nusse R, Pantalena-Filho L, Yang GP, Kingsley DM.

Bone. 2015 Aug;77:31-41. doi: 10.1016/j.bone.2015.04.010. Epub 2015 Apr 14.


Cell signalling: Disarming Wnt.

Nusse R.

Nature. 2015 Mar 12;519(7542):163-4. doi: 10.1038/nature14208. Epub 2015 Feb 25. No abstract available.


Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands.

Sigal M, Rothenberg ME, Logan CY, Lee JY, Honaker RW, Cooper RL, Passarelli B, Camorlinga M, Bouley DM, Alvarez G, Nusse R, Torres J, Amieva MR.

Gastroenterology. 2015 Jun;148(7):1392-404.e21. doi: 10.1053/j.gastro.2015.02.049. Epub 2015 Feb 26.


Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.

Tan SH, Senarath-Yapa K, Chung MT, Longaker MT, Wu JY, Nusse R.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5262-71. doi: 10.1073/pnas.1420463111. Epub 2014 Nov 24.


Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control.

Clevers H, Loh KM, Nusse R.

Science. 2014 Oct 3;346(6205):1248012. doi: 10.1126/science.1248012. Epub 2014 Oct 2. Review.


In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.

Rinkevich Y, Montoro DT, Contreras-Trujillo H, Harari-Steinberg O, Newman AM, Tsai JM, Lim X, Van-Amerongen R, Bowman A, Januszyk M, Pleniceanu O, Nusse R, Longaker MT, Weissman IL, Dekel B.

Cell Rep. 2014 May 22;7(4):1270-83. doi: 10.1016/j.celrep.2014.04.018. Epub 2014 May 15.


The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction.

Green J, Nusse R, van Amerongen R.

Cold Spring Harb Perspect Biol. 2014 Feb 1;6(2). pii: a009175. doi: 10.1101/cshperspect.a009175. Review.


Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling.

Lim X, Tan SH, Koh WL, Chau RM, Yan KS, Kuo CJ, van Amerongen R, Klein AM, Nusse R.

Science. 2013 Dec 6;342(6163):1226-30. doi: 10.1126/science.1239730.


Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.

Sugiyama T, Benitez CM, Ghodasara A, Liu L, McLean GW, Lee J, Blauwkamp TA, Nusse R, Wright CV, Gu G, Kim SK.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12691-6. doi: 10.1073/pnas.1304507110. Epub 2013 Jul 12.


structural Studies of Wnts and identification of an LRP6 binding site.

Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI.

Structure. 2013 Jul 2;21(7):1235-42. doi: 10.1016/j.str.2013.05.006. Epub 2013 Jun 20.


Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells.

Bowman AN, van Amerongen R, Palmer TD, Nusse R.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7324-9. doi: 10.1073/pnas.1305411110. Epub 2013 Apr 15.


Paracrine Wnt signaling both promotes and inhibits human breast tumor growth.

Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl GM.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6991-6. doi: 10.1073/pnas.1303671110. Epub 2013 Apr 4.


A localized Wnt signal orients asymmetric stem cell division in vitro.

Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R.

Science. 2013 Mar 22;339(6126):1445-8. doi: 10.1126/science.1231077. Erratum in: Science. 2013 May 24;340(6135):924.


Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells.

Jan TA, Chai R, Sayyid ZN, van Amerongen R, Xia A, Wang T, Sinkkonen ST, Zeng YA, Levin JR, Heller S, Nusse R, Cheng AG.

Development. 2013 Mar;140(6):1196-206. doi: 10.1242/dev.087528.


Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue.

Ardehali R, Ali SR, Inlay MA, Abilez OJ, Chen MQ, Blauwkamp TA, Yazawa M, Gong Y, Nusse R, Drukker M, Weissman IL.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3405-10. doi: 10.1073/pnas.1220832110. Epub 2013 Feb 7.


Wnt signaling in skin development, homeostasis, and disease.

Lim X, Nusse R.

Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a008029. doi: 10.1101/cshperspect.a008029. Review.


Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.

Blauwkamp TA, Nigam S, Ardehali R, Weissman IL, Nusse R.

Nat Commun. 2012;3:1070. doi: 10.1038/ncomms2064.


Wnt proteins.

Willert K, Nusse R.

Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a007864. doi: 10.1101/cshperspect.a007864. Review.


Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland.

van Amerongen R, Bowman AN, Nusse R.

Cell Stem Cell. 2012 Sep 7;11(3):387-400. doi: 10.1016/j.stem.2012.05.023. Epub 2012 Aug 2.


Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development.

van Amerongen R, Fuerer C, Mizutani M, Nusse R.

Dev Biol. 2012 Sep 1;369(1):101-14. doi: 10.1016/j.ydbio.2012.06.020. Epub 2012 Jul 4.


Wnt/β-catenin signaling and disease.

Clevers H, Nusse R.

Cell. 2012 Jun 8;149(6):1192-205. doi: 10.1016/j.cell.2012.05.012. Review.


Three decades of Wnts: a personal perspective on how a scientific field developed.

Nusse R, Varmus H.

EMBO J. 2012 Jun 13;31(12):2670-84. doi: 10.1038/emboj.2012.146. Epub 2012 May 22. Review.


Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea.

Chai R, Kuo B, Wang T, Liaw EJ, Xia A, Jan TA, Liu Z, Taketo MM, Oghalai JS, Nusse R, Zuo J, Cheng AG.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8167-72. doi: 10.1073/pnas.1202774109. Epub 2012 May 4.


Wnt signaling.

Nusse R.

Cold Spring Harb Perspect Biol. 2012 May 1;4(5). pii: a011163. doi: 10.1101/cshperspect.a011163. Review. No abstract available.


ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour.

Edris B, Espinosa I, Mühlenberg T, Mikels A, Lee CH, Steigen SE, Zhu S, Montgomery KD, Lazar AJ, Lev D, Fletcher JA, Beck AH, West RB, Nusse R, van de Rijn M.

J Pathol. 2012 Jun;227(2):223-33. doi: 10.1002/path.3986. Epub 2012 Feb 17.


Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility.

Mulligan KA, Fuerer C, Ching W, Fish M, Willert K, Nusse R.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):370-7. doi: 10.1073/pnas.1119197109. Epub 2011 Dec 27.


A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.

McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba JD, Nusse R.

PLoS One. 2011;6(11):e26993. doi: 10.1371/journal.pone.0026993. Epub 2011 Nov 1.


Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis.

Bowman A, Nusse R.

Cancer Cell. 2011 Oct 18;20(4):415-6. doi: 10.1016/j.ccr.2011.10.003.


Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells.

ten Berge D, Kurek D, Blauwkamp T, Koole W, Maas A, Eroglu E, Siu RK, Nusse R.

Nat Cell Biol. 2011 Aug 14;13(9):1070-5. doi: 10.1038/ncb2314.


Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.

Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH.

Nat Neurosci. 2011 Jun 26;14(8):1009-16. doi: 10.1038/nn.2855.


Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture.

Zeng YA, Nusse R.

Cell Stem Cell. 2010 Jun 4;6(6):568-77. doi: 10.1016/j.stem.2010.03.020.

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