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Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration.

Abo H, Chassaing B, Harusato A, Quiros M, Brazil JC, Ngo VL, Viennois E, Merlin D, Gewirtz AT, Nusrat A, Denning TL.

Nat Commun. 2020 Jan 24;11(1):513. doi: 10.1038/s41467-019-14258-z.


Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration.

Flemming S, Luissint AC, Kusters DHM, Raya-Sandino A, Fan S, Zhou DW, Hasegawa M, Garcia-Hernandez V, García AJ, Parkos CA, Nusrat A.

Mol Biol Cell. 2020 Mar 15;31(6):407-418. doi: 10.1091/mbc.E19-12-0692. Epub 2020 Jan 22.


Integrated Imaging Methodology Detects Claudin-1 Expression in Premalignant Nonpolypoid and Polypoid Colonic Epithelium in Mice.

Wang F, Duan X, Chen J, Gao Z, Zhou J, Wu X, Chang TS, Lee M, Li G, Nusrat A, Kuick R, Appelman HD, Wang TD.

Clin Transl Gastroenterol. 2020 Jan;11(1):e00089. doi: 10.14309/ctg.0000000000000089.


Regulation of neutrophil function by selective targeting of glycan epitopes expressed on the integrin CD11b/CD18.

Kelm M, Lehoux S, Azcutia V, Cummings RD, Nusrat A, Parkos CA, Brazil JC.

FASEB J. 2020 Feb;34(2):2326-2343. doi: 10.1096/fj.201902542R. Epub 2019 Dec 23.


Integrative Medicine Is a Good Prescription for Patients and Planet.

Nusrat AZ, Majd I, Wayne PM.

J Altern Complement Med. 2019 Dec;25(12):1151-1155. doi: 10.1089/acm.2019.0421. No abstract available.


MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State.

Zhang H, Khoa LTP, Mao F, Xu H, Zhou B, Han Y, O'Leary M, Nusrat A, Wang L, Saunders TL, Dou Y.

Cell Rep. 2019 Nov 26;29(9):2659-2671.e6. doi: 10.1016/j.celrep.2019.10.074.


Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo.

Reed M, Luissint AC, Azcutia V, Fan S, O'Leary MN, Quiros M, Brazil J, Nusrat A, Parkos CA.

Nat Commun. 2019 Nov 1;10(1):5004. doi: 10.1038/s41467-019-12968-y.


Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair.

Birkl D, O'Leary MN, Quiros M, Azcutia V, Schaller M, Reed M, Nishio H, Keeney J, Neish AS, Lukacs NW, Parkos CA, Nusrat A.

FASEB J. 2019 Dec;33(12):13632-13643. doi: 10.1096/fj.201901163R. Epub 2019 Oct 4.


IFN-γ-tethered hydrogels enhance mesenchymal stem cell-based immunomodulation and promote tissue repair.

García JR, Quirós M, Han WM, O'Leary MN, Cox GN, Nusrat A, García AJ.

Biomaterials. 2019 Nov;220:119403. doi: 10.1016/j.biomaterials.2019.119403. Epub 2019 Aug 2.


Innate immune cell-epithelial crosstalk during wound repair.

Brazil JC, Quiros M, Nusrat A, Parkos CA.

J Clin Invest. 2019 Jul 22;129(8):2983-2993. doi: 10.1172/JCI124618. eCollection 2019 Jul 22. Review.


A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice.

Caruso R, Mathes T, Martens EC, Kamada N, Nusrat A, Inohara N, Núñez G.

Sci Immunol. 2019 Apr 19;4(34). pii: eaaw4341. doi: 10.1126/sciimmunol.aaw4341.


TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium.

Birkl D, Quiros M, García-Hernández V, Zhou DW, Brazil JC, Hilgarth R, Keeney J, Yulis M, Bruewer M, García AJ, O Leary MN, Parkos CA, Nusrat A.

Mucosal Immunol. 2019 Jul;12(4):909-918. doi: 10.1038/s41385-019-0150-8. Epub 2019 Apr 10.


Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation.

Wang Z, Vaughan TY, Zhu W, Chen Y, Fu G, Medrzycki M, Nishio H, Bunting ST, Hankey-Giblin PA, Nusrat A, Parkos CA, Wang D, Wen R, Bunting KD.

Front Immunol. 2019 Mar 18;10:486. doi: 10.3389/fimmu.2019.00486. eCollection 2019.


Interactions Between Commensal Bacteria and Enteric Neurons, via FPR1 Induction of ROS, Increase Gastrointestinal Motility in Mice.

Chandrasekharan B, Saeedi BJ, Alam A, Houser M, Srinivasan S, Tansey M, Jones R, Nusrat A, Neish AS.

Gastroenterology. 2019 Jul;157(1):179-192.e2. doi: 10.1053/j.gastro.2019.03.045. Epub 2019 Mar 28.


Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice.

Luissint AC, Williams HC, Kim W, Flemming S, Azcutia V, Hilgarth RS, Leary MNO, Denning TL, Nusrat A, Parkos CA.

Mucosal Immunol. 2019 May;12(3):668-678. doi: 10.1038/s41385-019-0143-7. Epub 2019 Feb 11.


IL-10 produced by macrophages regulates epithelial integrity in the small intestine.

Morhardt TL, Hayashi A, Ochi T, Quirós M, Kitamoto S, Nagao-Kitamoto H, Kuffa P, Atarashi K, Honda K, Kao JY, Nusrat A, Kamada N.

Sci Rep. 2019 Feb 4;9(1):1223. doi: 10.1038/s41598-018-38125-x.


Saving Problematic Mucosae: SPMs in Intestinal Mucosal Inflammation and Repair.

Quiros M, Nusrat A.

Trends Mol Med. 2019 Feb;25(2):124-135. doi: 10.1016/j.molmed.2018.12.004. Epub 2019 Jan 11. Review.


Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation.

Fan S, Weight CM, Luissint AC, Hilgarth RS, Brazil JC, Ettel M, Nusrat A, Parkos CA.

Mol Biol Cell. 2019 Mar 1;30(5):566-578. doi: 10.1091/mbc.E18-08-0531. Epub 2019 Jan 9.


Publisher Correction: PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery.

Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ.

Nat Protoc. 2019 Jul;14(7):2258. doi: 10.1038/s41596-018-0079-5.


Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair.

Quirós M, Nusrat A.

Annu Rev Physiol. 2019 Feb 10;81:189-209. doi: 10.1146/annurev-physiol-020518-114504. Epub 2018 Oct 24.


Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model.

Flemming S, Luissint AC, Nusrat A, Parkos CA.

JCI Insight. 2018 Oct 18;3(20). pii: 99722. doi: 10.1172/jci.insight.99722.


PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery.

Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ.

Nat Protoc. 2018 Sep;13(9):2102-2119. doi: 10.1038/s41596-018-0036-3. Erratum in: Nat Protoc. 2018 Oct 24;:.


Fibrous Pseudotumor of Tunica Albuginea Testis Mimicking Testicular Neoplasm in a Young Man.

Nazim SM, Nusrat A, Kazmi Z.

Case Rep Surg. 2018 Jun 20;2018:9315864. doi: 10.1155/2018/9315864. eCollection 2018.


Cadherins: cellular adhesive molecules serving as signalling mediators.

Yulis M, Kusters DHM, Nusrat A.

J Physiol. 2018 Sep;596(17):3883-3898. doi: 10.1113/JP275328. Epub 2018 Aug 8. Review.


A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.

Ngo VL, Abo H, Maxim E, Harusato A, Geem D, Medina-Contreras O, Merlin D, Gewirtz AT, Nusrat A, Denning TL.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5076-E5085. doi: 10.1073/pnas.1718902115. Epub 2018 May 14.


Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines.

Yulis M, Quiros M, Hilgarth R, Parkos CA, Nusrat A.

Cell Death Dis. 2018 Mar 9;9(3):389. doi: 10.1038/s41419-018-0380-9.


Serum Amyloid A1 Is an Epithelial Prorestitutive Factor.

Hinrichs BH, Matthews JD, Siuda D, O'Leary MN, Wolfarth AA, Saeedi BJ, Nusrat A, Neish AS.

Am J Pathol. 2018 Apr;188(4):937-949. doi: 10.1016/j.ajpath.2017.12.013. Epub 2018 Jan 31.


Indian Hedgehog Suppresses Intestinal Inflammation.

Razumilava N, Gumucio DL, Samuelson LC, Shah YM, Nusrat A, Merchant JL.

Cell Mol Gastroenterol Hepatol. 2017 Oct 31;5(1):63-64. doi: 10.1016/j.jcmgh.2017.10.003. eCollection 2018. No abstract available.


Synthetic hydrogels for human intestinal organoid generation and colonic wound repair.

Cruz-Acuña R, Quirós M, Farkas AE, Dedhia PH, Huang S, Siuda D, García-Hernández V, Miller AJ, Spence JR, Nusrat A, García AJ.

Nat Cell Biol. 2017 Nov;19(11):1326-1335. doi: 10.1038/ncb3632. Epub 2017 Oct 23.


Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling.

Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A.

J Clin Invest. 2017 Sep 1;127(9):3510-3520. doi: 10.1172/JCI90229. Epub 2017 Aug 7.


Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation.

Garcia-Hernandez V, Quiros M, Nusrat A.

Ann N Y Acad Sci. 2017 Jun;1397(1):66-79. doi: 10.1111/nyas.13360. Epub 2017 May 10. Review.


IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.

Harusato A, Abo H, Ngo VL, Yi SW, Mitsutake K, Osuka S, Kohlmeier JE, Li JD, Gewirtz AT, Nusrat A, Denning TL.

Mucosal Immunol. 2017 Nov;10(6):1455-1467. doi: 10.1038/mi.2017.21. Epub 2017 Mar 22.


Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk.

Kudelka MR, Hinrichs BH, Darby T, Moreno CS, Nishio H, Cutler CE, Wang J, Wu H, Zeng J, Wang Y, Ju T, Stowell SR, Nusrat A, Jones RM, Neish AS, Cummings RD.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14787-14792. doi: 10.1073/pnas.1612158114. Epub 2016 Dec 7.


Overexpressed Claudin-1 Can Be Visualized Endoscopically in Colonic Adenomas In Vivo.

Rabinsky EF, Joshi BP, Pant A, Zhou J, Duan X, Smith A, Kuick R, Fan S, Nusrat A, Owens SR, Appelman HD, Wang TD.

Cell Mol Gastroenterol Hepatol. 2015 Dec 13;2(2):222-237. eCollection 2016 Mar.


IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL.

Mucosal Immunol. 2017 May;10(3):673-684. doi: 10.1038/mi.2016.80. Epub 2016 Sep 14.


Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades.

Lili LN, Farkas AE, Gerner-Smidt C, Overgaard CE, Moreno CS, Parkos CA, Capaldo CT, Nusrat A.

Tissue Barriers. 2016 Jul 19;4(3):e1214038. doi: 10.1080/21688370.2016.1214038. eCollection 2016 Jul-Sep.


The microenvironment of injured murine gut elicits a local pro-restitutive microbiota.

Alam A, Leoni G, Quiros M, Wu H, Desai C, Nishio H, Jones RM, Nusrat A, Neish AS.

Nat Microbiol. 2016 Jan 27;1:15021. doi: 10.1038/nmicrobiol.2015.21.


Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration.

Butin-Israeli V, Houser MC, Feng M, Thorp EB, Nusrat A, Parkos CA, Sumagin R.

FASEB J. 2016 Dec;30(12):4007-4020. Epub 2016 Aug 23.


Pharmacological Targeting of the Inflamed Intestinal Barrier.

Farkas AE, Nusrat A.

Curr Pharm Des. 2016;22(35):5400-5414. Review.


Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair.

Luissint AC, Parkos CA, Nusrat A.

Gastroenterology. 2016 Oct;151(4):616-32. doi: 10.1053/j.gastro.2016.07.008. Epub 2016 Jul 18. Review.


Redox control of Cas phosphorylation requires Abl kinase in regulation of intestinal epithelial cell spreading and migration.

Matthews JD, Sumagin R, Hinrichs B, Nusrat A, Parkos CA, Neish AS.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G458-65. doi: 10.1152/ajpgi.00189.2016. Epub 2016 Jul 14.


Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol.

Rahman K, Desai C, Iyer SS, Thorn NE, Kumar P, Liu Y, Smith T, Neish AS, Li H, Tan S, Wu P, Liu X, Yu Y, Farris AB, Nusrat A, Parkos CA, Anania FA.

Gastroenterology. 2016 Oct;151(4):733-746.e12. doi: 10.1053/j.gastro.2016.06.022. Epub 2016 Jun 21.


Annexin A1: shifting the balance towards resolution and repair.

Leoni G, Nusrat A.

Biol Chem. 2016 Oct 1;397(10):971-9. doi: 10.1515/hsz-2016-0180. Review.


14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells.

Gómez-Suárez M, Gutiérrez-Martínez IZ, Hernández-Trejo JA, Hernández-Ruiz M, Suárez-Pérez D, Candelario A, Kamekura R, Medina-Contreras O, Schnoor M, Ortiz-Navarrete V, Villegas-Sepúlveda N, Parkos C, Nusrat A, Nava P.

Cell Death Differ. 2016 Jun;23(6):1060-72. doi: 10.1038/cdd.2015.163. Epub 2016 Feb 5.


Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing.

Sumagin R, Brazil JC, Nava P, Nishio H, Alam A, Luissint AC, Weber DA, Neish AS, Nusrat A, Parkos CA.

Mucosal Immunol. 2016 Sep;9(5):1151-62. doi: 10.1038/mi.2015.135. Epub 2016 Jan 6.


Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.

Medina-Contreras O, Harusato A, Nishio H, Flannigan KL, Ngo V, Leoni G, Neumann PA, Geem D, Lili LN, Ramadas RA, Chassaing B, Gewirtz AT, Kohlmeier JE, Parkos CA, Towne JE, Nusrat A, Denning TL.

J Immunol. 2016 Jan 1;196(1):34-8. doi: 10.4049/jimmunol.1501312. Epub 2015 Nov 20.


Cryosectioning Method for Microdissection of Murine Colonic Mucosa.

Farkas AE, Gerner-Smidt C, Lili L, Nusrat A, Capaldo CT.

J Vis Exp. 2015 Jul 12;(101):e53112. doi: 10.3791/53112.


Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier.

Kamekura R, Nava P, Feng M, Quiros M, Nishio H, Weber DA, Parkos CA, Nusrat A.

Mol Biol Cell. 2015 Sep 15;26(18):3165-77. doi: 10.1091/mbc.E15-03-0147. Epub 2015 Jul 29.


HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.

Farkas AE, Hilgarth RS, Capaldo CT, Gerner-Smidt C, Powell DR, Vertino PM, Koval M, Parkos CA, Nusrat A.

Am J Pathol. 2015 Aug;185(8):2206-18. doi: 10.1016/j.ajpath.2015.04.023.


Wound repair: role of immune-epithelial interactions.

Leoni G, Neumann PA, Sumagin R, Denning TL, Nusrat A.

Mucosal Immunol. 2015 Sep;8(5):959-68. doi: 10.1038/mi.2015.63. Epub 2015 Jul 15. Review.

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