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Items: 1 to 50 of 198

1.

Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice.

Luissint AC, Williams HC, Kim W, Flemming S, Azcutia V, Hilgarth RS, Leary MNO, Denning TL, Nusrat A, Parkos CA.

Mucosal Immunol. 2019 Feb 11. doi: 10.1038/s41385-019-0143-7. [Epub ahead of print]

PMID:
30745566
2.

IL-10 produced by macrophages regulates epithelial integrity in the small intestine.

Morhardt TL, Hayashi A, Ochi T, Quirós M, Kitamoto S, Nagao-Kitamoto H, Kuffa P, Atarashi K, Honda K, Kao JY, Nusrat A, Kamada N.

Sci Rep. 2019 Feb 4;9(1):1223. doi: 10.1038/s41598-018-38125-x.

3.

Saving Problematic Mucosae: SPMs in Intestinal Mucosal Inflammation and Repair.

Quiros M, Nusrat A.

Trends Mol Med. 2019 Feb;25(2):124-135. doi: 10.1016/j.molmed.2018.12.004. Epub 2019 Jan 11. Review.

PMID:
30642681
4.

Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation.

Fan S, Weight CM, Luissint AC, Hilgarth RS, Brazil JC, Ettel M, Nusrat A, Parkos CA.

Mol Biol Cell. 2019 Jan 9:mbcE18080531. doi: 10.1091/mbc.E18-08-0531. [Epub ahead of print]

PMID:
30625033
5.

Publisher Correction: PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery.

Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ.

Nat Protoc. 2018 Oct 24. doi: 10.1038/s41596-018-0079-5. [Epub ahead of print]

PMID:
30356140
6.

Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair.

Quirós M, Nusrat A.

Annu Rev Physiol. 2019 Feb 10;81:189-209. doi: 10.1146/annurev-physiol-020518-114504. Epub 2018 Oct 24.

PMID:
30354933
7.

Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model.

Flemming S, Luissint AC, Nusrat A, Parkos CA.

JCI Insight. 2018 Oct 18;3(20). pii: 99722. doi: 10.1172/jci.insight.99722. [Epub ahead of print]

8.

PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery.

Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ.

Nat Protoc. 2018 Sep;13(9):2102-2119. doi: 10.1038/s41596-018-0036-3. Erratum in: Nat Protoc. 2018 Oct 24;:.

PMID:
30190557
9.

Fibrous Pseudotumor of Tunica Albuginea Testis Mimicking Testicular Neoplasm in a Young Man.

Nazim SM, Nusrat A, Kazmi Z.

Case Rep Surg. 2018 Jun 20;2018:9315864. doi: 10.1155/2018/9315864. eCollection 2018.

10.

Cadherins: cellular adhesive molecules serving as signalling mediators.

Yulis M, Kusters DHM, Nusrat A.

J Physiol. 2018 Sep;596(17):3883-3898. doi: 10.1113/JP275328. Epub 2018 Aug 8.

PMID:
29968384
11.

A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.

Ngo VL, Abo H, Maxim E, Harusato A, Geem D, Medina-Contreras O, Merlin D, Gewirtz AT, Nusrat A, Denning TL.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5076-E5085. doi: 10.1073/pnas.1718902115. Epub 2018 May 14.

12.

Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines.

Yulis M, Quiros M, Hilgarth R, Parkos CA, Nusrat A.

Cell Death Dis. 2018 Mar 9;9(3):389. doi: 10.1038/s41419-018-0380-9.

13.

Serum Amyloid A1 Is an Epithelial Prorestitutive Factor.

Hinrichs BH, Matthews JD, Siuda D, O'Leary MN, Wolfarth AA, Saeedi BJ, Nusrat A, Neish AS.

Am J Pathol. 2018 Apr;188(4):937-949. doi: 10.1016/j.ajpath.2017.12.013. Epub 2018 Jan 31.

PMID:
29366677
14.

Indian Hedgehog Suppresses Intestinal Inflammation.

Razumilava N, Gumucio DL, Samuelson LC, Shah YM, Nusrat A, Merchant JL.

Cell Mol Gastroenterol Hepatol. 2017 Oct 31;5(1):63-64. doi: 10.1016/j.jcmgh.2017.10.003. eCollection 2018. No abstract available.

15.

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair.

Cruz-Acuña R, Quirós M, Farkas AE, Dedhia PH, Huang S, Siuda D, García-Hernández V, Miller AJ, Spence JR, Nusrat A, García AJ.

Nat Cell Biol. 2017 Nov;19(11):1326-1335. doi: 10.1038/ncb3632. Epub 2017 Oct 23.

16.

Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling.

Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A.

J Clin Invest. 2017 Sep 1;127(9):3510-3520. doi: 10.1172/JCI90229. Epub 2017 Aug 7.

17.

Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation.

Garcia-Hernandez V, Quiros M, Nusrat A.

Ann N Y Acad Sci. 2017 Jun;1397(1):66-79. doi: 10.1111/nyas.13360. Epub 2017 May 10. Review.

18.

IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.

Harusato A, Abo H, Ngo VL, Yi SW, Mitsutake K, Osuka S, Kohlmeier JE, Li JD, Gewirtz AT, Nusrat A, Denning TL.

Mucosal Immunol. 2017 Nov;10(6):1455-1467. doi: 10.1038/mi.2017.21. Epub 2017 Mar 22.

19.

Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk.

Kudelka MR, Hinrichs BH, Darby T, Moreno CS, Nishio H, Cutler CE, Wang J, Wu H, Zeng J, Wang Y, Ju T, Stowell SR, Nusrat A, Jones RM, Neish AS, Cummings RD.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14787-14792. doi: 10.1073/pnas.1612158114. Epub 2016 Dec 7.

20.

Overexpressed Claudin-1 Can Be Visualized Endoscopically in Colonic Adenomas In Vivo.

Rabinsky EF, Joshi BP, Pant A, Zhou J, Duan X, Smith A, Kuick R, Fan S, Nusrat A, Owens SR, Appelman HD, Wang TD.

Cell Mol Gastroenterol Hepatol. 2015 Dec 13;2(2):222-237. eCollection 2016 Mar.

21.

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL.

Mucosal Immunol. 2017 May;10(3):673-684. doi: 10.1038/mi.2016.80. Epub 2016 Sep 14.

22.

Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades.

Lili LN, Farkas AE, Gerner-Smidt C, Overgaard CE, Moreno CS, Parkos CA, Capaldo CT, Nusrat A.

Tissue Barriers. 2016 Jul 19;4(3):e1214038. doi: 10.1080/21688370.2016.1214038. eCollection 2016 Jul-Sep.

23.

The microenvironment of injured murine gut elicits a local pro-restitutive microbiota.

Alam A, Leoni G, Quiros M, Wu H, Desai C, Nishio H, Jones RM, Nusrat A, Neish AS.

Nat Microbiol. 2016 Jan 27;1:15021. doi: 10.1038/nmicrobiol.2015.21.

24.

Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration.

Butin-Israeli V, Houser MC, Feng M, Thorp EB, Nusrat A, Parkos CA, Sumagin R.

FASEB J. 2016 Dec;30(12):4007-4020. Epub 2016 Aug 23.

25.

Pharmacological Targeting of the Inflamed Intestinal Barrier.

Farkas AE, Nusrat A.

Curr Pharm Des. 2016;22(35):5400-5414. Review.

PMID:
27464718
26.

Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair.

Luissint AC, Parkos CA, Nusrat A.

Gastroenterology. 2016 Oct;151(4):616-32. doi: 10.1053/j.gastro.2016.07.008. Epub 2016 Jul 18. Review.

27.

Redox control of Cas phosphorylation requires Abl kinase in regulation of intestinal epithelial cell spreading and migration.

Matthews JD, Sumagin R, Hinrichs B, Nusrat A, Parkos CA, Neish AS.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G458-65. doi: 10.1152/ajpgi.00189.2016. Epub 2016 Jul 14.

28.

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol.

Rahman K, Desai C, Iyer SS, Thorn NE, Kumar P, Liu Y, Smith T, Neish AS, Li H, Tan S, Wu P, Liu X, Yu Y, Farris AB, Nusrat A, Parkos CA, Anania FA.

Gastroenterology. 2016 Oct;151(4):733-746.e12. doi: 10.1053/j.gastro.2016.06.022. Epub 2016 Jun 21.

29.

Annexin A1: shifting the balance towards resolution and repair.

Leoni G, Nusrat A.

Biol Chem. 2016 Oct 1;397(10):971-9. doi: 10.1515/hsz-2016-0180. Review.

30.

14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells.

Gómez-Suárez M, Gutiérrez-Martínez IZ, Hernández-Trejo JA, Hernández-Ruiz M, Suárez-Pérez D, Candelario A, Kamekura R, Medina-Contreras O, Schnoor M, Ortiz-Navarrete V, Villegas-Sepúlveda N, Parkos C, Nusrat A, Nava P.

Cell Death Differ. 2016 Jun;23(6):1060-72. doi: 10.1038/cdd.2015.163. Epub 2016 Feb 5.

31.

Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing.

Sumagin R, Brazil JC, Nava P, Nishio H, Alam A, Luissint AC, Weber DA, Neish AS, Nusrat A, Parkos CA.

Mucosal Immunol. 2016 Sep;9(5):1151-62. doi: 10.1038/mi.2015.135. Epub 2016 Jan 6.

32.

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.

Medina-Contreras O, Harusato A, Nishio H, Flannigan KL, Ngo V, Leoni G, Neumann PA, Geem D, Lili LN, Ramadas RA, Chassaing B, Gewirtz AT, Kohlmeier JE, Parkos CA, Towne JE, Nusrat A, Denning TL.

J Immunol. 2016 Jan 1;196(1):34-8. doi: 10.4049/jimmunol.1501312. Epub 2015 Nov 20.

33.

Cryosectioning Method for Microdissection of Murine Colonic Mucosa.

Farkas AE, Gerner-Smidt C, Lili L, Nusrat A, Capaldo CT.

J Vis Exp. 2015 Jul 12;(101):e53112. doi: 10.3791/53112.

34.

Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier.

Kamekura R, Nava P, Feng M, Quiros M, Nishio H, Weber DA, Parkos CA, Nusrat A.

Mol Biol Cell. 2015 Sep 15;26(18):3165-77. doi: 10.1091/mbc.E15-03-0147. Epub 2015 Jul 29.

35.

HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.

Farkas AE, Hilgarth RS, Capaldo CT, Gerner-Smidt C, Powell DR, Vertino PM, Koval M, Parkos CA, Nusrat A.

Am J Pathol. 2015 Aug;185(8):2206-18. doi: 10.1016/j.ajpath.2015.04.023.

36.

Wound repair: role of immune-epithelial interactions.

Leoni G, Neumann PA, Sumagin R, Denning TL, Nusrat A.

Mucosal Immunol. 2015 Sep;8(5):959-68. doi: 10.1038/mi.2015.63. Epub 2015 Jul 15. Review.

37.

Claudin switching: Physiological plasticity of the Tight Junction.

Capaldo CT, Nusrat A.

Semin Cell Dev Biol. 2015 Jun;42:22-9. doi: 10.1016/j.semcdb.2015.04.003. Epub 2015 May 7. Review.

PMID:
25957515
38.

Introduction for the special issue on "Tissue Barriers in Inflammation".

Luscinskas FW, Leick M, Newton G, Nusrat A.

Tissue Barriers. 2015 Feb 25;3(1-2):e1015825. doi: 10.1080/21688370.2015.1015825. eCollection 2015.

39.

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.

Leoni G, Neumann PA, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS, Nusrat A.

J Clin Invest. 2015 Mar 2;125(3):1215-27. doi: 10.1172/JCI76693. Epub 2015 Feb 9.

40.

Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function.

Mitchell LA, Ward C, Kwon M, Mitchell PO, Quintero DA, Nusrat A, Parkos CA, Koval M.

Am J Pathol. 2015 Feb;185(2):372-86. doi: 10.1016/j.ajpath.2014.10.010. Epub 2014 Nov 28.

41.

Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response.

Leoni G, Gripentrog J, Lord C, Riesselman M, Sumagin R, Parkos CA, Nusrat A, Jesaitis AJ.

J Leukoc Biol. 2015 Jan;97(1):87-101. doi: 10.1189/jlb.4A0314-153R. Epub 2014 Nov 13.

42.

RhoGTPases, actomyosin signaling and regulation of the epithelial Apical Junctional Complex.

Quiros M, Nusrat A.

Semin Cell Dev Biol. 2014 Dec;36:194-203. doi: 10.1016/j.semcdb.2014.09.003. Epub 2014 Sep 16. Review.

43.

Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine.

Gumber S, Nusrat A, Villinger F.

Exp Toxicol Pathol. 2014 Dec;66(9-10):437-44. doi: 10.1016/j.etp.2014.07.004. Epub 2014 Aug 19.

44.

IFNγ-induced suppression of β-catenin signaling: evidence for roles of Akt and 14.3.3ζ.

Nava P, Kamekura R, Quirós M, Medina-Contreras O, Hamilton RW, Kolegraff KN, Koch S, Candelario A, Romo-Parra H, Laur O, Hilgarth RS, Denning TL, Parkos CA, Nusrat A.

Mol Biol Cell. 2014 Oct 1;25(19):2894-904. doi: 10.1091/mbc.E13-09-0512. Epub 2014 Jul 30.

45.

Periostin and receptor activator of nuclear factor κ-B ligand expression in allergic fungal rhinosinusitis.

Laury AM, Hilgarth R, Nusrat A, Wise SK.

Int Forum Allergy Rhinol. 2014 Sep;4(9):716-24. doi: 10.1002/alr.21367. Epub 2014 Jul 24.

PMID:
25060295
46.

Glutathione administration reduces mitochondrial damage and shifts cell death from necrosis to apoptosis in ageing diabetic mice hearts during exercise.

Golbidi S, Botta A, Gottfred S, Nusrat A, Laher I, Ghosh S.

Br J Pharmacol. 2014 Dec;171(23):5345-60. doi: 10.1111/bph.12847.

47.

Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins.

Capaldo CT, Farkas AE, Hilgarth RS, Krug SM, Wolf MF, Benedik JK, Fromm M, Koval M, Parkos C, Nusrat A.

Mol Biol Cell. 2014 Sep 15;25(18):2710-9. doi: 10.1091/mbc.E14-02-0773. Epub 2014 Jul 16.

48.

Crohn's disease-associated Escherichia coli survive in macrophages by suppressing NFκB signaling.

Rahman K, Sasaki M, Nusrat A, Klapproth JM.

Inflamm Bowel Dis. 2014 Aug;20(8):1419-25. doi: 10.1097/MIB.0000000000000096.

49.

Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface.

Monteiro AC, Luissint AC, Sumagin R, Lai C, Vielmuth F, Wolf MF, Laur O, Reiss K, Spindler V, Stehle T, Dermody TS, Nusrat A, Parkos CA.

Mol Biol Cell. 2014 May;25(10):1574-85. doi: 10.1091/mbc.E14-01-0018. Epub 2014 Mar 26.

50.

JAM-related proteins in mucosal homeostasis and inflammation.

Luissint AC, Nusrat A, Parkos CA.

Semin Immunopathol. 2014 Mar;36(2):211-26. doi: 10.1007/s00281-014-0421-0. Epub 2014 Mar 26. Review.

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