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Items: 1 to 50 of 278

1.

Crystal structure of heliorhodopsin.

Shihoya W, Inoue K, Singh M, Konno M, Hososhima S, Yamashita K, Ikeda K, Higuchi A, Izume T, Okazaki S, Hashimoto M, Mizutori R, Tomida S, Yamauchi Y, Abe-Yoshizumi R, Katayama K, Tsunoda SP, Shibata M, Furutani Y, Pushkarev A, Béjà O, Uchihashi T, Kandori H, Nureki O.

Nature. 2019 Oct;574(7776):132-136. doi: 10.1038/s41586-019-1604-6. Epub 2019 Sep 25.

PMID:
31554965
2.

Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.

Hiraizumi M, Yamashita K, Nishizawa T, Nureki O.

Science. 2019 Sep 13;365(6458):1149-1155. doi: 10.1126/science.aay3353. Epub 2019 Aug 15.

PMID:
31416931
3.

Crystal structure of human endothelin ETB receptor in complex with peptide inverse agonist IRL2500.

Nagiri C, Shihoya W, Inoue A, Kadji FMN, Aoki J, Nureki O.

Commun Biol. 2019 Jun 21;2:236. doi: 10.1038/s42003-019-0482-7. eCollection 2019.

4.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.

Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O.

Nat Struct Mol Biol. 2019 Jun;26(6):510-517. doi: 10.1038/s41594-019-0237-7. Epub 2019 Jun 3.

PMID:
31160781
5.

Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2.

Nagamura R, Fukuda M, Kawamoto A, Matoba K, Dohmae N, Ishitani R, Takagi J, Nureki O.

Acta Crystallogr F Struct Biol Commun. 2019 May 1;75(Pt 5):348-358. doi: 10.1107/S2053230X19003546. Epub 2019 Apr 24.

6.

Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9.

Hirano S, Abudayyeh OO, Gootenberg JS, Horii T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O.

Nat Commun. 2019 Apr 29;10(1):1968. doi: 10.1038/s41467-019-09741-6.

7.

Crystallization of the human tetraspanin protein CD9.

Umeda R, Nishizawa T, Nureki O.

Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):254-259. doi: 10.1107/S2053230X1801840X. Epub 2019 Apr 2.

8.

Ultrafast Dynamics of Heliorhodopsins.

Tahara S, Singh M, Kuramochi H, Shihoya W, Inoue K, Nureki O, Béjà O, Mizutani Y, Kandori H, Tahara T.

J Phys Chem B. 2019 Mar 21;123(11):2507-2512. doi: 10.1021/acs.jpcb.9b00887. Epub 2019 Mar 8.

PMID:
30742768
9.

Crystal structure of plant vacuolar iron transporter VIT1.

Kato T, Kumazaki K, Wada M, Taniguchi R, Nakane T, Yamashita K, Hirata K, Ishitani R, Ito K, Nishizawa T, Nureki O.

Nat Plants. 2019 Mar;5(3):308-315. doi: 10.1038/s41477-019-0367-2. Epub 2019 Feb 11.

PMID:
30742036
10.

Spectroscopic study of the transmembrane domain of a rhodopsin-phosphodiesterase fusion protein from a unicellular eukaryote.

Watari M, Ikuta T, Yamada D, Shihoya W, Yoshida K, Tsunoda SP, Nureki O, Kandori H.

J Biol Chem. 2019 Mar 8;294(10):3432-3443. doi: 10.1074/jbc.RA118.006277. Epub 2019 Jan 8.

PMID:
30622140
11.

Genome editing in plants by engineered CRISPR-Cas9 recognizing NG PAM.

Endo M, Mikami M, Endo A, Kaya H, Itoh T, Nishimasu H, Nureki O, Toki S.

Nat Plants. 2019 Jan;5(1):14-17. doi: 10.1038/s41477-018-0321-8. Epub 2018 Dec 10.

PMID:
30531939
12.

Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.

Fukuhara S, Nakane T, Yamashita K, Ishii R, Ishitani R, Nureki O.

Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):810-816. doi: 10.1107/S2053230X18016369. Epub 2018 Nov 30.

13.

Cap-specific terminal N 6-methylation of RNA by an RNA polymerase II-associated methyltransferase.

Akichika S, Hirano S, Shichino Y, Suzuki T, Nishimasu H, Ishitani R, Sugita A, Hirose Y, Iwasaki S, Nureki O, Suzuki T.

Science. 2019 Jan 11;363(6423). pii: eaav0080. doi: 10.1126/science.aav0080. Epub 2018 Nov 22.

PMID:
30467178
14.

Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter.

Kusakizako T, Claxton DP, Tanaka Y, Maturana AD, Kuroda T, Ishitani R, Mchaourab HS, Nureki O.

Structure. 2019 Feb 5;27(2):293-301.e3. doi: 10.1016/j.str.2018.10.004. Epub 2018 Nov 15.

PMID:
30449688
15.

Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation.

Shihoya W, Izume T, Inoue A, Yamashita K, Kadji FMN, Hirata K, Aoki J, Nishizawa T, Nureki O.

Nat Commun. 2018 Nov 9;9(1):4711. doi: 10.1038/s41467-018-07094-0.

16.

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.

Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O.

Nat Commun. 2018 Oct 24;9(1):4424. doi: 10.1038/s41467-018-06922-7.

17.

Resonance Raman Investigation of the Chromophore Structure of Heliorhodopsins.

Otomo A, Mizuno M, Singh M, Shihoya W, Inoue K, Nureki O, Béjà O, Kandori H, Mizutani Y.

J Phys Chem Lett. 2018 Nov 15;9(22):6431-6436. doi: 10.1021/acs.jpclett.8b02741. Epub 2018 Oct 29.

PMID:
30351947
18.

DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells.

Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou HK, Nakajima T, Kanno T, Ouchi Y, Uematsu S, Nishimasu H, Nureki O, Tumes DJ, Shimojo N, Nakayama T.

Nat Commun. 2018 Oct 12;9(1):4231. doi: 10.1038/s41467-018-06468-8.

19.

Crystal structure of the red light-activated channelrhodopsin Chrimson.

Oda K, Vierock J, Oishi S, Rodriguez-Rozada S, Taniguchi R, Yamashita K, Wiegert JS, Nishizawa T, Hegemann P, Nureki O.

Nat Commun. 2018 Sep 26;9(1):3949. doi: 10.1038/s41467-018-06421-9.

20.

Vibrational and Molecular Properties of Mg2+ Binding and Ion Selectivity in the Magnesium Channel MgtE.

Kimura T, Lorenz-Fonfria VA, Douki S, Motoki H, Ishitani R, Nureki O, Higashi M, Furutani Y.

J Phys Chem B. 2018 Oct 25;122(42):9681-9696. doi: 10.1021/acs.jpcb.8b07967. Epub 2018 Oct 10.

PMID:
30252477
21.

An Atomistic Model of a Precursor State of Light-Induced Channel Opening of Channelrhodopsin.

Cheng C, Kamiya M, Takemoto M, Ishitani R, Nureki O, Yoshida N, Hayashi S.

Biophys J. 2018 Oct 2;115(7):1281-1291. doi: 10.1016/j.bpj.2018.08.024. Epub 2018 Aug 27.

22.

Free Energy Landscape for the Entire Transport Cycle of Triose-Phosphate/Phosphate Translocator.

Takemoto M, Lee Y, Ishitani R, Nureki O.

Structure. 2018 Sep 4;26(9):1284-1296.e4. doi: 10.1016/j.str.2018.05.012. Epub 2018 Jun 28.

23.

Engineered CRISPR-Cas9 nuclease with expanded targeting space.

Nishimasu H, Shi X, Ishiguro S, Gao L, Hirano S, Okazaki S, Noda T, Abudayyeh OO, Gootenberg JS, Mori H, Oura S, Holmes B, Tanaka M, Seki M, Hirano H, Aburatani H, Ishitani R, Ikawa M, Yachie N, Zhang F, Nureki O.

Science. 2018 Sep 21;361(6408):1259-1262. doi: 10.1126/science.aas9129. Epub 2018 Aug 30.

24.

Cryo-EM structures of the human volume-regulated anion channel LRRC8.

Kasuya G, Nakane T, Yokoyama T, Jia Y, Inoue M, Watanabe K, Nakamura R, Nishizawa T, Kusakizako T, Tsutsumi A, Yanagisawa H, Dohmae N, Hattori M, Ichijo H, Yan Z, Kikkawa M, Shirouzu M, Ishitani R, Nureki O.

Nat Struct Mol Biol. 2018 Sep;25(9):797-804. doi: 10.1038/s41594-018-0109-6. Epub 2018 Aug 20.

PMID:
30127360
25.

Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation.

Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N.

J Cell Biol. 2018 Nov 5;217(11):3817-3828. doi: 10.1083/jcb.201804132. Epub 2018 Aug 9.

26.

Real-time observation of flexible domain movements in CRISPR-Cas9.

Osuka S, Isomura K, Kajimoto S, Komori T, Nishimasu H, Shima T, Nureki O, Uemura S.

EMBO J. 2018 May 15;37(10). pii: e96941. doi: 10.15252/embj.201796941. Epub 2018 Apr 12.

27.

PIK3CA and KRAS mutations in cell free circulating DNA are useful markers for monitoring ovarian clear cell carcinoma.

Morikawa A, Hayashi T, Shimizu N, Kobayashi M, Taniue K, Takahashi A, Tachibana K, Saito M, Kawabata A, Iida Y, Ueda K, Saito M, Yanaihara N, Tanabe H, Yamada K, Takano H, Nureki O, Okamoto A, Akiyama T.

Oncotarget. 2018 Feb 22;9(20):15266-15274. doi: 10.18632/oncotarget.24555. eCollection 2018 Mar 16.

28.

Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing.

Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S.

Int Immunol. 2018 Apr 3;30(4):141-154. doi: 10.1093/intimm/dxy006.

PMID:
29617862
29.

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR.

Maruyama T, Imai S, Kusakizako T, Hattori M, Ishitani R, Nureki O, Ito K, Maturana AD, Shimada I, Osawa M.

Elife. 2018 Apr 3;7. pii: e31596. doi: 10.7554/eLife.31596.

30.

Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors.

Kusakizako T, Tanaka Y, Hipolito CJ, Suga H, Nureki O.

Methods Mol Biol. 2018;1700:37-57. doi: 10.1007/978-1-4939-7454-2_3.

PMID:
29177824
31.

Production and rearing of germ-free X-SCID pigs.

Hara H, Shibata H, Nakano K, Abe T, Uosaki H, Ohnuki T, Hishikawa S, Kunita S, Watanabe M, Nureki O, Nagashima H, Hanazono Y.

Exp Anim. 2018 May 10;67(2):139-146. doi: 10.1538/expanim.17-0095. Epub 2017 Nov 21.

32.

Structural basis for xenobiotic extrusion by eukaryotic MATE transporter.

Miyauchi H, Moriyama S, Kusakizako T, Kumazaki K, Nakane T, Yamashita K, Hirata K, Dohmae N, Nishizawa T, Ito K, Miyaji T, Moriyama Y, Ishitani R, Nureki O.

Nat Commun. 2017 Nov 21;8(1):1633. doi: 10.1038/s41467-017-01541-0.

33.

Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate.

Tosha T, Nomura T, Nishida T, Saeki N, Okubayashi K, Yamagiwa R, Sugahara M, Nakane T, Yamashita K, Hirata K, Ueno G, Kimura T, Hisano T, Muramoto K, Sawai H, Takeda H, Mizohata E, Yamashita A, Kanematsu Y, Takano Y, Nango E, Tanaka R, Nureki O, Shoji O, Ikemoto Y, Murakami H, Owada S, Tono K, Yabashi M, Yamamoto M, Ago H, Iwata S, Sugimoto H, Shiro Y, Kubo M.

Nat Commun. 2017 Nov 17;8(1):1585. doi: 10.1038/s41467-017-01702-1.

34.

Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy.

Shibata M, Nishimasu H, Kodera N, Hirano S, Ando T, Uchihashi T, Nureki O.

Nat Commun. 2017 Nov 10;8(1):1430. doi: 10.1038/s41467-017-01466-8.

35.

Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.

Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T, Yoshimitsu M, Shiraishi Y, Sato-Otsubo A, Sanada M, Chiba K, Tanaka H, Ochi Y, Aoki K, Suzuki H, Shiozawa Y, Yoshizato T, Sato Y, Yoshida K, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Shide K, Kubuki Y, Hidaka T, Nakamaki T, Ishiyama K, Miyawaki S, Ishii R, Nureki O, Tobinai K, Miyazaki Y, Takaori-Kondo A, Shibata T, Miyano S, Ishitsuka K, Utsunomiya A, Shimoda K, Matsuoka M, Watanabe T, Ogawa S.

Blood. 2018 Jan 11;131(2):215-225. doi: 10.1182/blood-2017-01-761874. Epub 2017 Oct 30.

36.

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel.

Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O, Hattori M, Nureki O.

Nat Commun. 2017 Oct 12;8(1):876. doi: 10.1038/s41467-017-00887-9.

37.

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity.

Lee Y, Nishizawa T, Takemoto M, Kumazaki K, Yamashita K, Hirata K, Minoda A, Nagatoishi S, Tsumoto K, Ishitani R, Nureki O.

Nat Plants. 2017 Oct;3(10):825-832. doi: 10.1038/s41477-017-0022-8. Epub 2017 Oct 2.

PMID:
28970497
38.

XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction.

Thomaston JL, Woldeyes RA, Nakane T, Yamashita A, Tanaka T, Koiwai K, Brewster AS, Barad BA, Chen Y, Lemmin T, Uervirojnangkoorn M, Arima T, Kobayashi J, Masuda T, Suzuki M, Sugahara M, Sauter NK, Tanaka R, Nureki O, Tono K, Joti Y, Nango E, Iwata S, Yumoto F, Fraser JS, DeGrado WF.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13357-13362. doi: 10.1073/pnas.1705624114. Epub 2017 Aug 23.

39.

SecY-SecA fusion protein retains the ability to mediate protein transport.

Sugano Y, Furukawa A, Nureki O, Tanaka Y, Tsukazaki T.

PLoS One. 2017 Aug 18;12(8):e0183434. doi: 10.1371/journal.pone.0183434. eCollection 2017.

40.

X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog.

Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O.

Nat Struct Mol Biol. 2017 Sep;24(9):758-764. doi: 10.1038/nsmb.3450. Epub 2017 Aug 14.

PMID:
28805809
41.

Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6.

Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O.

Nature. 2017 Aug 17;548(7667):356-360. doi: 10.1038/nature23448. Epub 2017 Aug 9.

PMID:
28792932
42.

Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1.

Yamano T, Zetsche B, Ishitani R, Zhang F, Nishimasu H, Nureki O.

Mol Cell. 2017 Aug 17;67(4):633-645.e3. doi: 10.1016/j.molcel.2017.06.035. Epub 2017 Aug 3.

43.

ATP-dependent modulation of MgtE in Mg2+ homeostasis.

Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z, Hattori M, Nureki O.

Nat Commun. 2017 Jul 27;8(1):148. doi: 10.1038/s41467-017-00082-w.

44.

Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature.

Andersson R, Safari C, Dods R, Nango E, Tanaka R, Yamashita A, Nakane T, Tono K, Joti Y, Båth P, Dunevall E, Bosman R, Nureki O, Iwata S, Neutze R, Brändén G.

Sci Rep. 2017 Jul 3;7(1):4518. doi: 10.1038/s41598-017-04817-z.

45.

CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice.

Ohmori T, Nagao Y, Mizukami H, Sakata A, Muramatsu SI, Ozawa K, Tominaga SI, Hanazono Y, Nishimura S, Nureki O, Sakata Y.

Sci Rep. 2017 Jun 23;7(1):4159. doi: 10.1038/s41598-017-04625-5.

46.

Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1.

Nishimasu H, Yamano T, Gao L, Zhang F, Ishitani R, Nureki O.

Mol Cell. 2017 Jul 6;67(1):139-147.e2. doi: 10.1016/j.molcel.2017.04.019. Epub 2017 Jun 6.

47.

Engineered Cpf1 variants with altered PAM specificities.

Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, Yamano T, Nishimasu H, Nureki O, Crosetto N, Zhang F.

Nat Biotechnol. 2017 Aug;35(8):789-792. doi: 10.1038/nbt.3900. Epub 2017 Jun 5.

48.

Applications of the CRISPR-Cas9 system in kidney research.

Higashijima Y, Hirano S, Nangaku M, Nureki O.

Kidney Int. 2017 Aug;92(2):324-335. doi: 10.1016/j.kint.2017.01.037. Epub 2017 Apr 20. Review.

PMID:
28433382
49.

Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.

Kato K, Omura H, Ishitani R, Nureki O.

Annu Rev Biochem. 2017 Jun 20;86:541-566. doi: 10.1146/annurev-biochem-061516-044813. Epub 2017 Apr 7. Review.

PMID:
28399655
50.

Hydroxyethyl cellulose matrix applied to serial crystallography.

Sugahara M, Nakane T, Masuda T, Suzuki M, Inoue S, Song C, Tanaka R, Nakatsu T, Mizohata E, Yumoto F, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Numata K, Nango E, Iwata S.

Sci Rep. 2017 Apr 6;7(1):703. doi: 10.1038/s41598-017-00761-0.

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