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Items: 1 to 50 of 262

1.

Is the mysterious platelet receptor GPV an unsuspected major target for platelet autoantibodies?

Nurden P, Nurden AT.

Haematologica. 2019 Jun;104(6):1103-1105. doi: 10.3324/haematol.2018.214908. No abstract available.

2.

Acquired Glanzmann thrombasthenia: From antibodies to anti-platelet drugs.

Nurden AT.

Blood Rev. 2019 Jul;36:10-22. doi: 10.1016/j.blre.2019.03.004. Epub 2019 Mar 20. Review.

PMID:
31010659
3.

Autologous fibrin scaffolds: When platelet- and plasma-derived biomolecules meet fibrin.

Anitua E, Nurden P, Prado R, Nurden AT, Padilla S.

Biomaterials. 2019 Feb;192:440-460. doi: 10.1016/j.biomaterials.2018.11.029. Epub 2018 Nov 21. Review.

PMID:
30500725
4.

A mutation of the human EPHB2 gene leads to a major platelet functional defect.

Berrou E, Soukaseum C, Favier R, Adam F, Elaib Z, Kauskot A, Bordet JC, Ballerini P, Loyau S, Feng M, Dias K, Muheidli A, Girault S, Nurden AT, Turro E, Ouwehand WH, Denis CV, Jandrot-Perrus M, Rosa JP, Nurden P, Bryckaert M.

Blood. 2018 Nov 8;132(19):2067-2077. doi: 10.1182/blood-2018-04-845644. Epub 2018 Sep 13.

PMID:
30213874
5.

Personal reflections on the early contributions of Gus Born to platelet research.

Nurden AT.

Platelets. 2018 Sep 5:1-5. doi: 10.1080/09537104.2018.1513477. [Epub ahead of print]

PMID:
30183446
6.

Phenotype analysis and clinical management in a large family with a novel truncating mutation in RASGRP2, the CalDAG-GEFI encoding gene.

Desai A, Bergmeier W, Canault M, Alessi MC, Paul DS, Nurden P, Pillois X, Jy W, Ahn YS, Nurden AT.

Res Pract Thromb Haemost. 2017 Jun 20;1(1):128-133. doi: 10.1002/rth2.12019. eCollection 2017 Jul.

7.

Acquired Antibodies to αIIbβ3 in Glanzmann Thrombasthenia: From Transfusion and Pregnancy to Bone Marrow Transplants and Beyond.

Nurden AT.

Transfus Med Rev. 2018 May 23. pii: S0887-7963(18)30037-3. doi: 10.1016/j.tmrv.2018.05.002. [Epub ahead of print] Review.

PMID:
29884513
8.

Professor Gustav Victor Rudolph Born (29 July 1921 - 16 April 2018).

Nurden AT.

J Thromb Haemost. 2018 Jun;16(6):1250-1251. doi: 10.1111/jth.14152. Epub 2018 May 24. No abstract available.

PMID:
29799167
9.

A novel variant Glanzmann thrombasthenia due to co-inheritance of a loss- and a gain-of-function mutation of ITGB3: evidence of a dominant effect of gain-of-function mutations.

Bury L, Zetterberg E, Leinøe EB, Falcinelli E, Marturano A, Manni G, Nurden AT, Gresele P.

Haematologica. 2018 Jun;103(6):e259-e263. doi: 10.3324/haematol.2017.180927. Epub 2018 Feb 8. No abstract available.

10.

In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia.

Pillois X, Peters P, Segers K, Nurden AT.

Mol Genet Genomic Med. 2018 Mar;6(2):249-260. doi: 10.1002/mgg3.365. Epub 2018 Jan 31.

11.

An intracytoplasmic β3 Leu718 deletion in a patient with a novel platelet phenotype.

Nurden P, Bordet JC, Pillois X, Nurden AT.

Blood Adv. 2017 Mar 10;1(8):494-499. doi: 10.1182/bloodadvances.2016002808. eCollection 2017 Mar 14.

12.

High-throughput sequencing for rapid diagnosis of inherited platelet disorders: a case for a European consensus.

Nurden AT, Nurden P.

Haematologica. 2018 Jan;103(1):6-8. doi: 10.3324/haematol.2017.182295. No abstract available.

13.

ITGA2B and ITGB3 gene mutations associated with Glanzmann thrombasthenia.

Nurden AT, Pillois X.

Platelets. 2018 Jan;29(1):98-101. doi: 10.1080/09537104.2017.1371291. Epub 2017 Nov 10. Review. No abstract available.

PMID:
29125375
14.

Peripartum bleeding management in a patient with CalDAG-GEFI deficiency.

Canault M, Saultier P, Fauré S, Poggi M, Nurden AT, Nurden P, Morange PE, Alessi MC, Gris JC.

Haemophilia. 2017 Nov;23(6):e533-e535. doi: 10.1111/hae.13352. Epub 2017 Oct 4. No abstract available.

PMID:
28976076
15.

The biology of the platelet with special reference to inflammation, wound healing and immunity.

Nurden AT.

Front Biosci (Landmark Ed). 2018 Jan 1;23:726-751. Review.

PMID:
28930569
16.

Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).

Bermejo E, Alberto MF, Paul DS, Cook AA, Nurden P, Sanchez Luceros A, Nurden AT, Bergmeier W.

Platelets. 2018 Jan;29(1):84-86. doi: 10.1080/09537104.2017.1332759. Epub 2017 Jul 20.

17.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B.

Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

18.

Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?

Nurden AT.

Blood Rev. 2017 Sep;31(5):287-299. doi: 10.1016/j.blre.2017.03.005. Epub 2017 Apr 4. Review.

PMID:
28395882
19.

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.

Poggi M, Canault M, Favier M, Turro E, Saultier P, Ghalloussi D, Baccini V, Vidal L, Mezzapesa A, Chelghoum N, Mohand-Oumoussa B, Falaise C, Favier R, Ouwehand WH, Fiore M, Peiretti F, Morange PE, Saut N, Bernot D, Greinacher A, BioResource N, Nurden AT, Nurden P, Freson K, Trégouët DA, Raslova H, Alessi MC.

Haematologica. 2017 Feb;102(2):282-294. doi: 10.3324/haematol.2016.147694. Epub 2016 Sep 23.

20.

Linkage disequilibrium amongst ITGA2B and ITGB3 gene variants in patients with Glanzmann thrombasthenia confirms that most disease-causing mutations are recent.

Pillois X, Nurden AT.

Br J Haematol. 2016 Nov;175(4):686-695. doi: 10.1111/bjh.14283. Epub 2016 Jul 29.

PMID:
27469266
21.

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, López JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E.

Blood. 2016 Jun 9;127(23):2791-803. doi: 10.1182/blood-2015-12-688267. Epub 2016 Apr 15.

22.

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.

Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A.

Nat Commun. 2016 Mar 29;7:11097. doi: 10.1038/ncomms11097.

23.

Should any genetic defect affecting α-granules in platelets be classified as gray platelet syndrome?

Nurden AT, Nurden P.

Am J Hematol. 2016 Jul;91(7):714-8. doi: 10.1002/ajh.24359. Epub 2016 Apr 26. Review.

24.

A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.

Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C; BRIDGE-BPD Consortium, Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD.

Blood. 2016 Jun 9;127(23):2903-14. doi: 10.1182/blood-2015-10-675629. Epub 2016 Feb 24.

25.

Inherited disorders of platelet function: selected updates.

Nurden AT, Nurden P.

J Thromb Haemost. 2015 Jun;13 Suppl 1:S2-9. doi: 10.1111/jth.12898. Review.

26.

Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders.

Westbury SK, Turro E, Greene D, Lentaigne C, Kelly AM, Bariana TK, Simeoni I, Pillois X, Attwood A, Austin S, Jansen SB, Bakchoul T, Crisp-Hihn A, Erber WN, Favier R, Foad N, Gattens M, Jolley JD, Liesner R, Meacham S, Millar CM, Nurden AT, Peerlinck K, Perry DJ, Poudel P, Schulman S, Schulze H, Stephens JC, Furie B, Robinson PN, van Geet C, Rendon A, Gomez K, Laffan MA, Lambert MP, Nurden P, Ouwehand WH, Richardson S, Mumford AD, Freson K; BRIDGE-BPD Consortium.

Genome Med. 2015 Apr 9;7(1):36. doi: 10.1186/s13073-015-0151-5. eCollection 2015.

27.

Platelets: 25 years under the editorship of Stan Heptinstall.

Nurden AT.

Platelets. 2015;26(5):378-81. doi: 10.3109/09537104.2015.1037825. Epub 2015 Apr 30. No abstract available.

PMID:
25928030
28.

Expanding the Mutation Spectrum Affecting αIIbβ3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort.

Nurden AT, Pillois X, Fiore M, Alessi MC, Bonduel M, Dreyfus M, Goudemand J, Gruel Y, Benabdallah-Guerida S, Latger-Cannard V, Négrier C, Nugent D, Oiron RD, Rand ML, Sié P, Trossaert M, Alberio L, Martins N, Sirvain-Trukniewicz P, Couloux A, Canault M, Fronthroth JP, Fretigny M, Nurden P, Heilig R, Vinciguerra C.

Hum Mutat. 2015 May;36(5):548-61. doi: 10.1002/humu.22776.

29.

Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey.

Gresele P, Harrison P, Bury L, Falcinelli E, Gachet C, Hayward CP, Kenny D, Mezzano D, Mumford AD, Nugent D, Nurden AT, Orsini S, Cattaneo M.

J Thromb Haemost. 2014 Sep;12(9):1562-9. doi: 10.1111/jth.12650. Epub 2014 Jul 25.

30.

Platelet membrane glycoproteins: a historical review.

Nurden AT.

Semin Thromb Hemost. 2014 Jul;40(5):577-84. doi: 10.1055/s-0034-1383826. Epub 2014 Jun 26.

PMID:
24967889
31.

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.

Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange PE, Saut N, Pillois X, Nurden AT, Cambien F, Pierres A, van den Berg TK, Kuijpers TW, Alessi MC, Tregouet DA.

J Exp Med. 2014 Jun 30;211(7):1349-62. doi: 10.1084/jem.20130477. Epub 2014 Jun 23.

32.

[Glycoproteins, inherited diseases of platelets, and the role of platelets in wound healing].

Nurden AT, Nurden P.

Bull Acad Natl Med. 2013 Feb;197(2):349-58; discussion 358-9. French.

PMID:
24919365
33.

Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets.

Wang H, Bang KW, Blanchette VS, Nurden AT, Rand ML.

Thromb Haemost. 2014 Jun;111(6):1184-6. doi: 10.1160/TH13-08-0704. Epub 2014 Jan 30. No abstract available.

PMID:
24477274
34.

Congenital platelet disorders and understanding of platelet function.

Nurden AT, Nurden P.

Br J Haematol. 2014 Apr;165(2):165-78. doi: 10.1111/bjh.12662. Epub 2013 Nov 29. Review.

PMID:
24286193
35.

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.

Du LM, Nurden P, Nurden AT, Nichols TC, Bellinger DA, Jensen ES, Haberichter SL, Merricks E, Raymer RA, Fang J, Koukouritaki SB, Jacobi PM, Hawkins TB, Cornetta K, Shi Q, Wilcox DA.

Nat Commun. 2013;4:2773. doi: 10.1038/ncomms3773.

36.

Molecular dynamics analysis of a novel β3 Pro189Ser mutation in a patient with glanzmann thrombasthenia differentially affecting αIIbβ3 and αvβ3 expression.

Laguerre M, Sabi E, Daly M, Stockley J, Nurden P, Pillois X, Nurden AT.

PLoS One. 2013 Nov 13;8(11):e78683. doi: 10.1371/journal.pone.0078683. eCollection 2013.

37.

Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates.

Abaeva AA, Canault M, Kotova YN, Obydennyy SI, Yakimenko AO, Podoplelova NA, Kolyadko VN, Chambost H, Mazurov AV, Ataullakhanov FI, Nurden AT, Alessi MC, Panteleev MA.

J Biol Chem. 2013 Oct 11;288(41):29621-32. doi: 10.1074/jbc.M113.474163. Epub 2013 Aug 30.

38.

Glanzmann thrombasthenia: state of the art and future directions.

Nurden AT, Pillois X, Wilcox DA.

Semin Thromb Hemost. 2013 Sep;39(6):642-55. doi: 10.1055/s-0033-1353393. Epub 2013 Aug 8. Review.

39.

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B.

J Clin Invest. 2013 Jul 1. pii: 69210. doi: 10.1172/JCI69210. [Epub ahead of print]

40.

An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families.

Matus V, Valenzuela G, Sáez CG, Hidalgo P, Lagos M, Aranda E, Panes O, Pereira J, Pillois X, Nurden AT, Mezzano D.

J Thromb Haemost. 2013 Sep;11(9):1751-9. doi: 10.1111/jth.12334.

41.

C560Rβ3 caused platelet integrin αII b β3 to bind fibrinogen continuously, but resulted in a severe bleeding syndrome and increased murine mortality.

Fang J, Nurden P, North P, Nurden AT, Du LM, Valentin N, Wilcox DA.

J Thromb Haemost. 2013 Jun;11(6):1163-71. doi: 10.1111/jth.12209.

42.

The Nbeal2(-/-) mouse as a model for the gray platelet syndrome.

Deppermann C, Nurden P, Nurden AT, Nieswandt B, Stegner D.

Rare Dis. 2013 Sep 26;1:e26561. doi: 10.4161/rdis.26561. eCollection 2013.

43.

Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment.

Nurden AT, Pillois X, Nurden P.

Expert Rev Hematol. 2012 Oct;5(5):487-503. doi: 10.1586/ehm.12.46. Review.

PMID:
23146053
44.

Two types of procoagulant platelets are formed upon physiological activation and are controlled by integrin α(IIb)β(3).

Topalov NN, Yakimenko AO, Canault M, Artemenko EO, Zakharova NV, Abaeva AA, Loosveld M, Ataullakhanov FI, Nurden AT, Alessi MC, Panteleev MA.

Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2475-83. doi: 10.1161/ATVBAHA.112.253765. Epub 2012 Jul 26.

PMID:
22837472
45.

Clinical utility gene card for: Glanzmann thrombasthenia.

Fiore M, Nurden AT, Nurden P, Seligsohn U.

Eur J Hum Genet. 2012 Oct;20(10). doi: 10.1038/ejhg.2012.151. Epub 2012 Jul 11. No abstract available. Erratum in: Eur J Hum Genet. 2012 Oct;20(10):1102.

46.

Is there a redundancy of β3 and other platelet receptors in the brain and central nervous system?

Nurden AT.

Platelets. 2013;24(2):170-2. doi: 10.3109/09537104.2012.678427. Epub 2012 Jul 3. No abstract available.

PMID:
22757689
47.

Inherited platelet disorders.

Nurden AT, Freson K, Seligsohn U.

Haemophilia. 2012 Jul;18 Suppl 4:154-60. doi: 10.1111/j.1365-2516.2012.02856.x. Review.

PMID:
22726100
48.

A novel amino acid substitution of integrin αIIb in Glanzmann thrombasthenia confirms that the N-terminal region of the receptor plays a role in maintaining β-propeller structure.

Pillois X, Fiore M, Heilig R, Pico M, Nurden AT.

Platelets. 2013;24(1):77-80. doi: 10.3109/09537104.2012.665278. Epub 2012 Mar 6.

PMID:
22394243
49.

Natural history of platelet antibody formation against αIIbβ3 in a French cohort of Glanzmann thrombasthenia patients.

Fiore M, Firah N, Pillois X, Nurden P, Heilig R, Nurden AT.

Haemophilia. 2012 May;18(3):e201-9. doi: 10.1111/j.1365-2516.2011.02744.x. Epub 2012 Jan 18.

PMID:
22250950
50.

Glanzmann thrombasthenia-like syndromes associated with Macrothrombocytopenias and mutations in the genes encoding the αIIbβ3 integrin.

Nurden AT, Pillois X, Fiore M, Heilig R, Nurden P.

Semin Thromb Hemost. 2011 Sep;37(6):698-706. doi: 10.1055/s-0031-1291380. Epub 2011 Nov 18. Review.

PMID:
22102273

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