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Items: 1 to 50 of 53

1.

Intact pancreatic islets and dispersed beta-cells both generate intracellular calcium oscillations but differ in their responsiveness to glucose.

Scarl RT, Corbin KL, Vann NW, Smith HM, Satin LS, Sherman A, Nunemaker CS.

Cell Calcium. 2019 Nov;83:102081. doi: 10.1016/j.ceca.2019.102081. Epub 2019 Sep 16.

PMID:
31563790
2.

Comparing methods to normalize insulin secretion shows the process may not be needed.

Slepchenko KG, Corbin KL, Nunemaker CS.

J Endocrinol. 2019 Mar 1. pii: JOE-18-0542.R2. doi: 10.1530/JOE-18-0542. [Epub ahead of print]

PMID:
30870813
3.

Reducing Glucokinase Activity Restores Endogenous Pulsatility and Enhances Insulin Secretion in Islets From db/db Mice.

Jahan I, Corbin KL, Bogart AM, Whitticar NB, Waters CD, Schildmeyer C, Vann NW, West HL, Law NC, Wiseman JS, Nunemaker CS.

Endocrinology. 2018 Nov 1;159(11):3747-3760. doi: 10.1210/en.2018-00589.

4.

Metformin Inhibits Mouse Islet Insulin Secretion and Alters Intracellular Calcium in a Concentration-Dependent and Duration-Dependent Manner near the Circulating Range.

Gelin L, Li J, Corbin KL, Jahan I, Nunemaker CS.

J Diabetes Res. 2018 Mar 18;2018:9163052. doi: 10.1155/2018/9163052. eCollection 2018.

5.

Can NMDA Receptors Get β-Cells Toxically Excited?

Nunemaker CS, Li C.

Endocrinology. 2017 Nov 1;158(11):3709-3710. doi: 10.1210/en.2017-00832. No abstract available.

6.

STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.

Scarl RT, Lawrence CM, Gordon HM, Nunemaker CS.

J Endocrinol. 2017 Sep;234(3):R123-R134. doi: 10.1530/JOE-16-0594. Epub 2017 Jun 2. Review.

7.

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

Gordon HM, Majithia N, MacDonald PE, Fox JEM, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS.

Endocrine. 2017 Jun;56(3):528-537. doi: 10.1007/s12020-017-1297-2. Epub 2017 Apr 12.

8.
9.

An Automated Perifusion System for Modifying Cell Culture Conditions over Time.

Whitticar NB, Strahler EW, Rajan P, Kaya S, Nunemaker CS.

Biol Proced Online. 2016 Nov 21;18:19. doi: 10.1186/s12575-016-0049-7. eCollection 2016.

11.

Islet Hypersensitivity to Glucose Is Associated With Disrupted Oscillations and Increased Impact of Proinflammatory Cytokines in Islets From Diabetes-Prone Male Mice.

Corbin KL, Waters CD, Shaffer BK, Verrilli GM, Nunemaker CS.

Endocrinology. 2016 May;157(5):1826-38. doi: 10.1210/en.2015-1879. Epub 2016 Mar 4.

12.

An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.

Sharma PR, Mackey AJ, Dejene EA, Ramadan JW, Langefeld CD, Palmer ND, Taylor KD, Wagenknecht LE, Watanabe RM, Rich SS, Nunemaker CS.

Endocrinology. 2015 Sep;156(9):3147-56. doi: 10.1210/en.2015-1203. Epub 2015 May 27.

13.

Stress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic islets.

Qureshi FM, Dejene EA, Corbin KL, Nunemaker CS.

Cell Calcium. 2015 May;57(5-6):366-375. doi: 10.1016/j.ceca.2015.03.002. Epub 2015 Mar 23.

14.

Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function.

Nunemaker CS, Chung HG, Verrilli GM, Corbin KL, Upadhye A, Sharma PR.

J Endocrinol. 2014 Aug;222(2):267-76. doi: 10.1530/JOE-14-0126. Epub 2014 Jun 13.

15.

Episodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH.

Nunemaker CS, Satin LS.

Endocrine. 2014 Sep;47(1):49-63. doi: 10.1007/s12020-014-0212-3. Epub 2014 Mar 8. Review.

16.

Slow oscillations of KATP conductance in mouse pancreatic islets provide support for electrical bursting driven by metabolic oscillations.

Ren J, Sherman A, Bertram R, Goforth PB, Nunemaker CS, Waters CD, Satin LS.

Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E805-17. doi: 10.1152/ajpendo.00046.2013. Epub 2013 Aug 6.

17.

Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice.

O'Neill CM, Lu C, Corbin KL, Sharma PR, Dula SB, Carter JD, Ramadan JW, Xin W, Lee JK, Nunemaker CS.

Endocrinology. 2013 Sep;154(9):3077-88. doi: 10.1210/en.2012-2138. Epub 2013 Jul 8.

18.

Vesicular nucleotide transporter-mediated ATP release regulates insulin secretion.

Geisler JC, Corbin KL, Li Q, Feranchak AP, Nunemaker CS, Li C.

Endocrinology. 2013 Feb;154(2):675-84. doi: 10.1210/en.2012-1818. Epub 2012 Dec 19.

19.

Manganese-enhanced magnetic resonance imaging detects declining pancreatic β-cell mass in a cyclophosphamide-accelerated mouse model of type 1 diabetes.

Antkowiak PF, Stevens BK, Nunemaker CS, McDuffie M, Epstein FH.

Diabetes. 2013 Jan;62(1):44-8. doi: 10.2337/db12-0153. Epub 2012 Aug 29.

20.

Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling.

Nandula SR, Dey P, Corbin KL, Nunemaker CS, Bagavant H, Deshmukh US.

J Oral Pathol Med. 2013 Jan;42(1):66-72. doi: 10.1111/j.1600-0714.2012.01181.x. Epub 2012 Jun 5.

21.

Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion.

Wang F, Kohan AB, Kindel TL, Corbin KL, Nunemaker CS, Obici S, Woods SC, Davidson WS, Tso P.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9641-6. doi: 10.1073/pnas.1201433109. Epub 2012 May 22.

22.

Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse.

Head WS, Orseth ML, Nunemaker CS, Satin LS, Piston DW, Benninger RK.

Diabetes. 2012 Jul;61(7):1700-7. doi: 10.2337/db11-1312. Epub 2012 Apr 17.

23.

The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes.

Ramadan JW, Steiner SR, O'Neill CM, Nunemaker CS.

Cell Calcium. 2011 Dec;50(6):481-90. doi: 10.1016/j.ceca.2011.08.005. Epub 2011 Sep 23. Review.

24.

A novel fluorescence imaging approach for comparative measurements of pancreatic islet function in vitro.

Corbin KL, Hall TE, Haile R, Nunemaker CS.

Islets. 2011 Jan-Feb;3(1):14-20. Epub 2011 Jan 1.

25.

Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling.

Dula SB, Jecmenica M, Wu R, Jahanshahi P, Verrilli GM, Carter JD, Brayman KL, Nunemaker CS.

Cell Calcium. 2010 Aug-Sep;48(2-3):133-42. doi: 10.1016/j.ceca.2010.07.007. Epub 2010 Aug 25.

26.

Prenatal androgen exposure programs metabolic dysfunction in female mice.

Roland AV, Nunemaker CS, Keller SR, Moenter SM.

J Endocrinol. 2010 Nov;207(2):213-23. doi: 10.1677/JOE-10-0217. Epub 2010 Aug 16.

27.

The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.

Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG.

J Clin Invest. 2010 Jun;120(6):2156-70. doi: 10.1172/JCI38924. Epub 2010 May 24.

28.

AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.

Crim WS, Wu R, Carter JD, Cole BK, Trace AP, Mirmira RG, Kunsch C, Nadler JL, Nunemaker CS.

Mol Cell Endocrinol. 2010 Jul 29;323(2):246-55. doi: 10.1016/j.mce.2010.02.041. Epub 2010 Mar 6.

29.

Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice.

Cole BK, Keller SR, Wu R, Carter JD, Nadler JL, Nunemaker CS.

Hypertension. 2010 Mar;55(3):715-21. doi: 10.1161/HYPERTENSIONAHA.109.148049. Epub 2010 Jan 25.

30.

12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets.

Ma K, Nunemaker CS, Wu R, Chakrabarti SK, Taylor-Fishwick DA, Nadler JL.

J Clin Endocrinol Metab. 2010 Feb;95(2):887-93. doi: 10.1210/jc.2009-1102. Epub 2010 Jan 20.

31.

Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.

Nunemaker CS, Dishinger JF, Dula SB, Wu R, Merrins MJ, Reid KR, Sherman A, Kennedy RT, Satin LS.

PLoS One. 2009 Dec 23;4(12):e8428. doi: 10.1371/journal.pone.0008428.

32.

A practical guide to rodent islet isolation and assessment.

Carter JD, Dula SB, Corbin KL, Wu R, Nunemaker CS.

Biol Proced Online. 2009 Dec 3;11:3-31. doi: 10.1007/s12575-009-9021-0.

33.

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.

Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG.

Mol Cell Biol. 2009 Apr;29(8):2053-67. doi: 10.1128/MCB.01179-08. Epub 2009 Feb 23.

34.

Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets.

Jahanshahi P, Wu R, Carter JD, Nunemaker CS.

Endocrinology. 2009 Feb;150(2):607-15. doi: 10.1210/en.2008-0773. Epub 2008 Sep 25.

35.

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.

Nunemaker CS, Chen M, Pei H, Kimble SD, Keller SR, Carter JD, Yang Z, Smith KM, Wu R, Bevard MH, Garmey JC, Nadler JL.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1065-75. doi: 10.1152/ajpendo.90371.2008. Epub 2008 Sep 9.

36.

Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.

Huang X, Moore DJ, Ketchum RJ, Nunemaker CS, Kovatchev B, McCall AL, Brayman KL.

Endocr Rev. 2008 Aug;29(5):603-30. doi: 10.1210/er.2008-0006. Epub 2008 Jul 29. Review.

37.

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.

McDuffie M, Maybee NA, Keller SR, Stevens BK, Garmey JC, Morris MA, Kropf E, Rival C, Ma K, Carter JD, Tersey SA, Nunemaker CS, Nadler JL.

Diabetes. 2008 Jan;57(1):199-208. Epub 2007 Oct 16.

38.

Glucose-induced release of nitric oxide from mouse pancreatic islets as detected with nitric oxide-selective glass microelectrodes.

Nunemaker CS, Buerk DG, Zhang M, Satin LS.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E907-12. Epub 2006 Nov 22.

39.

Glucose modulates [Ca2+]i oscillations in pancreatic islets via ionic and glycolytic mechanisms.

Nunemaker CS, Bertram R, Sherman A, Tsaneva-Atanasova K, Daniel CR, Satin LS.

Biophys J. 2006 Sep 15;91(6):2082-96. Epub 2006 Jun 30.

40.

Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes.

Yang Z, Chen M, Carter JD, Nunemaker CS, Garmey JC, Kimble SD, Nadler JL.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):1017-22. Epub 2006 Apr 5.

PMID:
16643856
41.

Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?

Nunemaker CS, Zhang M, Wasserman DH, McGuinness OP, Powers AC, Bertram R, Sherman A, Satin LS.

Diabetes. 2005 Dec;54(12):3517-22.

42.

Insulin secretion in the conscious mouse is biphasic and pulsatile.

Nunemaker CS, Wasserman DH, McGuinness OP, Sweet IR, Teague JC, Satin LS.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E523-9. Epub 2005 Oct 25.

43.

Comparison of metabolic oscillations from mouse pancreatic beta cells and islets.

Nunemaker CS, Satin LS.

Endocrine. 2004 Oct;25(1):61-7.

PMID:
15545708
45.

Steroid regulation of GnRH neurons.

Moenter SM, Defazio RA, Straume M, Nunemaker CS.

Ann N Y Acad Sci. 2003 Dec;1007:143-52. Review.

PMID:
14993048
46.

Dose-dependent switch in response of gonadotropin-releasing hormone (GnRH) neurons to GnRH mediated through the type I GnRH receptor.

Xu C, Xu XZ, Nunemaker CS, Moenter SM.

Endocrinology. 2004 Feb;145(2):728-35. Epub 2003 Oct 23.

PMID:
14576189
47.

Calcium current subtypes in GnRH neurons.

Nunemaker CS, DeFazio RA, Moenter SM.

Biol Reprod. 2003 Dec;69(6):1914-22. Epub 2003 Aug 6.

PMID:
12904316
48.

Mechanisms underlying episodic gonadotropin-releasing hormone secretion.

Moenter SM, DeFazio AR, Pitts GR, Nunemaker CS.

Front Neuroendocrinol. 2003 Apr;24(2):79-93. Review.

PMID:
12762999
49.

A targeted extracellular approach for recording long-term firing patterns of excitable cells: a practical guide.

Nunemaker CS, DeFazio RA, Moenter SM.

Biol Proced Online. 2003;5:53-62. Epub 2003 Feb 17.

50.

Gonadotropin-releasing hormone neurons generate interacting rhythms in multiple time domains.

Nunemaker CS, Straume M, DeFazio RA, Moenter SM.

Endocrinology. 2003 Mar;144(3):823-31.

PMID:
12586758

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