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Items: 25


TRPC Channels in Cardiac Plasticity.

Numaga-Tomita T, Nishida M.

Cells. 2020 Feb 17;9(2). pii: E454. doi: 10.3390/cells9020454. Review.


TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.

Sudi SB, Tanaka T, Oda S, Nishiyama K, Nishimura A, Sunggip C, Mangmool S, Numaga-Tomita T, Nishida M.

Sci Rep. 2019 Jul 5;9(1):9785. doi: 10.1038/s41598-019-46252-2.


Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.

Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M.

Br J Pharmacol. 2019 Sep;176(18):3723-3738. doi: 10.1111/bph.14777. Epub 2019 Aug 6.


Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.

Nishimura A, Shimoda K, Tanaka T, Toyama T, Nishiyama K, Shinkai Y, Numaga-Tomita T, Yamazaki D, Kanda Y, Akaike T, Kumagai Y, Nishida M.

Sci Signal. 2019 Jun 25;12(587). pii: eaaw1920. doi: 10.1126/scisignal.aaw1920.


TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.

Numaga-Tomita T, Shimauchi T, Oda S, Tanaka T, Nishiyama K, Nishimura A, Birnbaumer L, Mori Y, Nishida M.

FASEB J. 2019 Sep;33(9):9785-9796. doi: 10.1096/fj.201802811R. Epub 2019 Jun 4.


Mitochondrial dynamics in exercise physiology.

Tanaka T, Nishimura A, Nishiyama K, Goto T, Numaga-Tomita T, Nishida M.

Pflugers Arch. 2020 Feb;472(2):137-153. doi: 10.1007/s00424-019-02258-3. Epub 2019 Feb 1. Review.


Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.

Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.

Sci Signal. 2018 Nov 13;11(556). pii: eaat5185. doi: 10.1126/scisignal.aat5185.


TRPC channels in exercise-mimetic therapy.

Numaga-Tomita T, Oda S, Nishiyama K, Tanaka T, Nishimura A, Nishida M.

Pflugers Arch. 2019 Mar;471(3):507-517. doi: 10.1007/s00424-018-2211-3. Epub 2018 Oct 8. Review.


[New Strategies for Exercise-Mimetic Medication].

Oda S, Numaga-Tomita T, Nishida M.

Yakugaku Zasshi. 2018;138(10):1257-1262. doi: 10.1248/yakushi.18-00091-1. Review. Japanese.


TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.

Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, Nishimura A, Numaga-Tomita T, Nishida M.

Front Pharmacol. 2018 May 22;9:523. doi: 10.3389/fphar.2018.00523. eCollection 2018.


TRPC3 Channels in Cardiac Fibrosis.

Numaga-Tomita T, Oda S, Shimauchi T, Nishimura A, Mangmool S, Nishida M.

Front Cardiovasc Med. 2017 Sep 7;4:56. doi: 10.3389/fcvm.2017.00056. eCollection 2017. Review.


TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.

Oda S, Numaga-Tomita T, Kitajima N, Toyama T, Harada E, Shimauchi T, Nishimura A, Ishikawa T, Kumagai Y, Birnbaumer L, Nishida M.

Sci Rep. 2017 Aug 8;7(1):7511. doi: 10.1038/s41598-017-07903-4.


TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.

Shimauchi T, Numaga-Tomita T, Ito T, Nishimura A, Matsukane R, Oda S, Hoka S, Ide T, Koitabashi N, Uchida K, Sumimoto H, Mori Y, Nishida M.

JCI Insight. 2017 Aug 3;2(15). pii: 93358. doi: 10.1172/jci.insight.93358. eCollection 2017 Aug 3.


Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases.

Nishimura A, Sunggip C, Oda S, Numaga-Tomita T, Tsuda M, Nishida M.

Pharmacol Ther. 2017 Dec;180:113-128. doi: 10.1016/j.pharmthera.2017.06.010. Epub 2017 Jun 23. Review.


Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension.

Sunggip C, Nishimura A, Shimoda K, Numaga-Tomita T, Tsuda M, Nishida M.

Pharmacol Res. 2017 Jun;120:51-59. doi: 10.1016/j.phrs.2017.03.013. Epub 2017 Mar 20. Review.


TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes.

Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K.

J Physiol Sci. 2018 Mar;68(2):153-164. doi: 10.1007/s12576-016-0519-3. Epub 2017 Jan 19.


TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.

Numaga-Tomita T, Kitajima N, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.

Sci Rep. 2016 Dec 19;6:39383. doi: 10.1038/srep39383.


The functions of store-operated calcium channels.

Putney JW, Steinckwich-Besançon N, Numaga-Tomita T, Davis FM, Desai PN, D'Agostin DM, Wu S, Bird GS.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):900-906. doi: 10.1016/j.bbamcr.2016.11.028. Epub 2016 Nov 30. Review.


TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.

Kitajima N, Numaga-Tomita T, Watanabe M, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.

Sci Rep. 2016 Nov 11;6:37001. doi: 10.1038/srep37001.


Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.

Nishimura A, Sunggip C, Tozaki-Saitoh H, Shimauchi T, Numaga-Tomita T, Hirano K, Ide T, Boeynaems JM, Kurose H, Tsuda M, Robaye B, Inoue K, Nishida M.

Sci Signal. 2016 Jan 19;9(411):ra7. doi: 10.1126/scisignal.aac9187.


TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation.

Numaga-Tomita T, Nishida M, Putney JW Jr, Mori Y.

Biochem J. 2016 Jan 15;473(2):201-10. doi: 10.1042/BJ20150596. Epub 2015 Nov 9.


Role of STIM1- and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation.

Numaga-Tomita T, Putney JW.

J Cell Sci. 2013 Jan 15;126(Pt 2):605-12. doi: 10.1242/jcs.115980. Epub 2012 Nov 30.


Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation.

Hwang SY, Foley J, Numaga-Tomita T, Petranka JG, Bird GS, Putney JW Jr.

Cell Calcium. 2012 Dec;52(6):488-500. doi: 10.1016/j.ceca.2012.10.001. Epub 2012 Oct 31.


Direct observation of protein microcrystals in crystallization buffer by atmospheric scanning electron microscopy.

Maruyama Y, Ebihara T, Nishiyama H, Konyuba Y, Senda M, Numaga-Tomita T, Senda T, Suga M, Sato C.

Int J Mol Sci. 2012;13(8):10553-67. doi: 10.3390/ijms130810553. Epub 2012 Aug 22.

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