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Items: 1 to 50 of 107

1.

Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice.

Oseghale AR, Zhu X, Li B, Peterson KR, Nudelman A, Rephaeli A, Xu H, Pace BS.

Blood Cells Mol Dis. 2019 Nov;79:102345. doi: 10.1016/j.bcmd.2019.102345. Epub 2019 Jul 9.

PMID:
31351219
2.

The HIV gp41 Fusion Protein Inhibits T-Cell Activation through the Lentiviral Lytic Peptide 2 Motif.

Klug YA, Schwarzer R, Rotem E, Charni M, Nudelman A, Gramatica A, Zarmi B, Rotter V, Shai Y.

Biochemistry. 2019 Feb 12;58(6):818-832. doi: 10.1021/acs.biochem.8b01175. Epub 2019 Jan 15.

PMID:
30602116
3.

The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice.

Rotem E, Faingold O, Charni M, Klug YA, Harari D, Shmuel-Galia L, Nudelman A, Rotter V, Shai Y.

PLoS Pathog. 2018 May 4;14(5):e1007044. doi: 10.1371/journal.ppat.1007044. eCollection 2018 May.

4.

Synthesis and Biological Evaluation of Derivatives of Indoline as Highly Potent Antioxidant and Anti-inflammatory Agents.

Zeeli S, Weill T, Finkin-Groner E, Bejar C, Melamed M, Furman S, Zhenin M, Nudelman A, Weinstock M.

J Med Chem. 2018 May 10;61(9):4004-4019. doi: 10.1021/acs.jmedchem.8b00001. Epub 2018 Apr 27.

PMID:
29681148
5.

Comparison of the anticancer properties of a novel valproic acid prodrug to leading histone deacetylase inhibitors.

Tarasenko N, Chekroun-Setti H, Nudelman A, Rephaeli A.

J Cell Biochem. 2018 Apr;119(4):3417-3428. doi: 10.1002/jcb.26512. Epub 2017 Dec 26.

PMID:
29135083
6.

AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair.

Moyal L, Goldfeiz N, Gorovitz B, Rephaeli A, Tal E, Tarasenko N, Nudelman A, Ziv Y, Hodak E.

Invest New Drugs. 2018 Feb;36(1):1-9. doi: 10.1007/s10637-017-0500-x. Epub 2017 Sep 8.

PMID:
28884410
7.

Effect of Histone Deacetylase Inhibitor, Butyroyloxymethyl-Diethyl Phosphate (AN-7), on Corneal Neovascularization in a Mouse Model.

Schaap-Fogler M, Bahar I, Rephaeli A, Dahbash M, Nudelman A, Livny E, Barliya T, Nisgav Y, Livnat T.

J Ocul Pharmacol Ther. 2017 Jul/Aug;33(6):480-486. doi: 10.1089/jop.2016.0017. Epub 2017 Mar 24.

PMID:
28338404
8.

Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft.

Tarasenko N, Nudelman A, Rozic G, Cutts SM, Rephaeli A.

Invest New Drugs. 2017 Aug;35(4):412-426. doi: 10.1007/s10637-017-0448-x. Epub 2017 Mar 17.

PMID:
28315153
9.

Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin-independent manner.

Rephaeli A, Tarasenko N, Fibach E, Rozic G, Lubin I, Lipovetsky J, Furman S, Malik Z, Nudelman A.

Eur J Pharm Sci. 2016 Aug 25;91:91-7. doi: 10.1016/j.ejps.2016.06.004. Epub 2016 Jun 7.

PMID:
27283485
10.

The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin.

Moyal L, Feldbaum N, Goldfeiz N, Rephaeli A, Nudelman A, Weitman M, Tarasenko N, Gorovitz B, Maron L, Yehezkel S, Amitay-Laish I, Lubin I, Hodak E.

PLoS One. 2016 Jan 11;11(1):e0146115. doi: 10.1371/journal.pone.0146115. eCollection 2016.

11.

Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent.

Cutts SM, Rephaeli A, Nudelman A, Ugarenko M, Phillips DR.

Curr Top Med Chem. 2015;15(14):1409-22. Review.

PMID:
25866273
12.

Indoline-3-propionate and 3-aminopropyl carbamates reduce lung injury and pro-inflammatory cytokines induced in mice by LPS.

Finkin-Groner E, Moradov D, Shifrin H, Bejar C, Nudelman A, Weinstock M.

Br J Pharmacol. 2015 Feb;172(4):1101-13. doi: 10.1111/bph.12982. Epub 2015 Jan 12.

13.

Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.

Furman S, Nissim-Bardugo E, Zeeli S, Weitman M, Nudelman A, Finkin-Groner E, Moradov D, Shifrin H, Schorer-Apelbaum D, Weinstock M.

Bioorg Med Chem Lett. 2014 May 15;24(10):2283-7. doi: 10.1016/j.bmcl.2014.03.081. Epub 2014 Apr 2.

PMID:
24731278
14.

A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo.

Tarasenko N, Cutts SM, Phillips DR, Berkovitch-Luria G, Bardugo-Nissim E, Weitman M, Nudelman A, Rephaeli A.

Biochem Pharmacol. 2014 Mar 15;88(2):158-68. doi: 10.1016/j.bcp.2014.01.023. Epub 2014 Jan 24.

PMID:
24463168
15.

Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer.

Burford B, Gentry-Maharaj A, Graham R, Allen D, Pedersen JW, Nudelman AS, Blixt O, Fourkala EO, Bueti D, Dawnay A, Ford J, Desai R, David L, Trinder P, Acres B, Schwientek T, Gammerman A, Reis CA, Silva L, Osório H, Hallett R, Wandall HH, Mandel U, Hollingsworth MA, Jacobs I, Fentiman I, Clausen H, Taylor-Papadimitriou J, Menon U, Burchell JM.

Br J Cancer. 2013 May 28;108(10):2045-55. doi: 10.1038/bjc.2013.214. Epub 2013 May 7.

16.

The hydroxyl epimer of doxorubicin controls the rate of formation of cytotoxic anthracycline-DNA adducts.

Forrest RA, Swift LP, Evison BJ, Rephaeli A, Nudelman A, Phillips DR, Cutts SM.

Cancer Chemother Pharmacol. 2013 Mar;71(3):809-16. doi: 10.1007/s00280-012-2049-x. Epub 2012 Dec 23.

PMID:
23263186
17.

Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.

Yanovsky I, Finkin-Groner E, Zaikin A, Lerman L, Shalom H, Zeeli S, Weill T, Ginsburg I, Nudelman A, Weinstock M.

J Med Chem. 2012 Dec 13;55(23):10700-15. doi: 10.1021/jm301411g. Epub 2012 Nov 28.

PMID:
23151013
18.

A multifunctional 5-aminolevulinic acid derivative induces erythroid differentiation of K562 human erythroleukemic cells.

Berkovitch-Luria G, Yakobovitch S, Weitman M, Nudelman A, Rozic G, Rephaeli A, Malik Z.

Eur J Pharm Sci. 2012 Aug 30;47(1):206-14. doi: 10.1016/j.ejps.2012.05.017. Epub 2012 Jun 13.

PMID:
22705251
19.

Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.

Schjoldager KT, Vakhrushev SY, Kong Y, Steentoft C, Nudelman AS, Pedersen NB, Wandall HH, Mandel U, Bennett EP, Levery SB, Clausen H.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9893-8. doi: 10.1073/pnas.1203563109. Epub 2012 May 7.

20.

Characterization of the viral O-glycopeptidome: a novel tool of relevance for vaccine design and serodiagnosis.

Cló E, Kracun SK, Nudelman AS, Jensen KJ, Liljeqvist JÅ, Olofsson S, Bergström T, Blixt O.

J Virol. 2012 Jun;86(11):6268-78. doi: 10.1128/JVI.00392-12. Epub 2012 Apr 4.

21.

Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation.

Forrest RA, Swift LP, Rephaeli A, Nudelman A, Kimura K, Phillips DR, Cutts SM.

Biochem Pharmacol. 2012 Jun 15;83(12):1602-12. doi: 10.1016/j.bcp.2012.02.026. Epub 2012 Mar 5.

PMID:
22414726
22.

Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor.

Tarasenko N, Cutts SM, Phillips DR, Inbal A, Nudelman A, Kessler-Icekson G, Rephaeli A.

PLoS One. 2012;7(2):e31393. doi: 10.1371/journal.pone.0031393. Epub 2012 Feb 23.

23.

A histone deacetylase inhibitory prodrug - butyroyloxymethyl diethyl phosphate - protects the heart and cardiomyocytes against ischemia injury.

Kessler-Icekson G, Hochhauser E, Sinai T, Kremer A, Dick J, Tarasenko N, Nudelman V, Schlesinger H, Abraham S, Nudelman A, Rephaeli A.

Eur J Pharm Sci. 2012 Apr 11;45(5):592-9. doi: 10.1016/j.ejps.2011.12.013. Epub 2012 Jan 3.

PMID:
22234377
24.

Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates.

Yoshimura Y, Nudelman AS, Levery SB, Wandall HH, Bennett EP, Hindsgaul O, Clausen H, Nishimura S.

Glycobiology. 2012 Mar;22(3):429-38. doi: 10.1093/glycob/cwr159. Epub 2011 Oct 31.

PMID:
22042768
25.

Modulating ALA-PDT efficacy of mutlidrug resistant MCF-7 breast cancer cells using ALA prodrug.

Feuerstein T, Berkovitch-Luria G, Nudelman A, Rephaeli A, Malik Z.

Photochem Photobiol Sci. 2011 Dec;10(12):1926-33. doi: 10.1039/c1pp05205e. Epub 2011 Oct 24.

PMID:
22020364
26.

Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways.

Berkovitch-Luria G, Weitman M, Nudelman A, Rephaeli A, Malik Z.

Invest New Drugs. 2012 Jun;30(3):1028-38. doi: 10.1007/s10637-011-9669-6. Epub 2011 Apr 21.

PMID:
21509470
27.

Structure--activity relationship studies of 1-(4-chloro-2,5-dimethoxyphenyl)-3-(3-propoxypropyl)thiourea, a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type-1.

Weitman M, Lerman K, Nudelman A, Major DT, Hizi A, Herschhorn A.

Eur J Med Chem. 2011 Feb;46(2):447-67. doi: 10.1016/j.ejmech.2010.11.003. Epub 2010 Nov 10.

PMID:
21159409
28.

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity.

Tarasenko N, Kessler-Icekson G, Boer P, Inbal A, Schlesinger H, Phillips DR, Cutts SM, Nudelman A, Rephaeli A.

Invest New Drugs. 2012 Feb;30(1):130-43. doi: 10.1007/s10637-010-9542-z. Epub 2010 Sep 23.

PMID:
20862515
29.

New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.

Mansour OC, Evison BJ, Sleebs BE, Watson KG, Nudelman A, Rephaeli A, Buck DP, Collins JG, Bilardi RA, Phillips DR, Cutts SM.

J Med Chem. 2010 Oct 14;53(19):6851-66. doi: 10.1021/jm901894c.

PMID:
20860366
30.

A high-throughput O-glycopeptide discovery platform for seromic profiling.

Blixt O, Cló E, Nudelman AS, Sørensen KK, Clausen T, Wandall HH, Livingston PO, Clausen H, Jensen KJ.

J Proteome Res. 2010 Oct 1;9(10):5250-61. doi: 10.1021/pr1005229. Erratum in: J Proteome Res. 2011 Mar 4;10(3):1436.

31.

Monitoring of progestins: development of immunochemical methods for purification and detection of levonorgestrel.

Shalev M, Bardugo M, Nudelman A, Krol A, Schlesinger H, Bronshtein A, Altstein M.

Anal Chim Acta. 2010 Apr 30;665(2):176-84. doi: 10.1016/j.aca.2010.03.029. Epub 2010 Mar 23.

PMID:
20417328
32.

Adult type 3 adenylyl cyclase-deficient mice are obese.

Wang Z, Li V, Chan GC, Phan T, Nudelman AS, Xia Z, Storm DR.

PLoS One. 2009 Sep 11;4(9):e6979. doi: 10.1371/journal.pone.0006979.

33.

ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin-DNA adducts.

Ugarenko M, Nudelman A, Rephaeli A, Kimura K, Phillips DR, Cutts SM.

Biochem Pharmacol. 2010 Feb 1;79(3):339-49. doi: 10.1016/j.bcp.2009.09.004. Epub 2009 Sep 6.

PMID:
19737541
34.

Carbon nanotubes based electrochemical biosensor for detection of formaldehyde released from a cancer cell line treated with formaldehyde-releasing anticancer prodrugs.

Bareket L, Rephaeli A, Berkovitch G, Nudelman A, Rishpon J.

Bioelectrochemistry. 2010 Feb;77(2):94-9. doi: 10.1016/j.bioelechem.2009.06.016. Epub 2009 Jul 8.

PMID:
19643682
35.

Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo.

Nudelman AS, DiRocco DP, Lambert TJ, Garelick MG, Le J, Nathanson NM, Storm DR.

Hippocampus. 2010 Apr;20(4):492-8. doi: 10.1002/hipo.20646.

36.

Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity.

Rephaeli A, Gil-Ad I, Aharoni A, Tarasenko I, Tarasenko N, Geffen Y, Halbfinger E, Nisemblat Y, Weizman A, Nudelman A.

J Med Chem. 2009 May 14;52(9):3010-7. doi: 10.1021/jm900143u.

PMID:
19378992
37.

Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation.

Berkovitch G, Doron D, Nudelman A, Malik Z, Rephaeli A.

J Med Chem. 2008 Dec 11;51(23):7356-69. doi: 10.1021/jm8008794.

PMID:
19007111
38.

BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia.

Geffen Y, Nudelman A, Gil-Ad I, Rephaeli A, Huang M, Savitsky K, Klapper L, Winkler I, Meltzer HY, Weizman A.

Eur Neuropsychopharmacol. 2009 Jan;19(1):1-13. doi: 10.1016/j.euroneuro.2008.07.002. Epub 2008 Aug 30.

PMID:
18757185
39.

Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex).

Tarasenko N, Nudelman A, Tarasenko I, Entin-Meer M, Hass-Kogan D, Inbal A, Rephaeli A.

Clin Exp Metastasis. 2008;25(7):703-16. doi: 10.1007/s10585-008-9179-x. Epub 2008 May 28.

PMID:
18506586
40.

Electrochemical lab on a chip for high-throughput analysis of anticancer drugs efficiency.

Popovtzer R, Neufeld T, Popovtzer A, Rivkin I, Margalit R, Engel D, Nudelman A, Rephaeli A, Rishpon J, Shacham-Diamand Y.

Nanomedicine. 2008 Jun;4(2):121-6. doi: 10.1016/j.nano.2008.03.002. Epub 2008 May 14.

PMID:
18482873
41.

A mutual prodrug ester of GABA and perphenazine exhibits antischizophrenic efficacy with diminished extrapyramidal effects.

Nudelman A, Gil-Ad I, Shpaisman N, Terasenko I, Ron H, Savitsky K, Geffen Y, Weizman A, Rephaeli A.

J Med Chem. 2008 May 8;51(9):2858-62. doi: 10.1021/jm7012453. Epub 2008 Mar 26.

PMID:
18363346
42.

Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties.

Engel D, Nudelman A, Tarasenko N, Levovich I, Makarovsky I, Sochotnikov S, Tarasenko I, Rephaeli A.

J Med Chem. 2008 Jan 24;51(2):314-23. doi: 10.1021/jm7009827. Epub 2007 Dec 29.

PMID:
18163551
43.

Development of pluronic micelle-encapsulated doxorubicin and formaldehyde-releasing prodrugs for localized anticancer chemotherapy.

Ugarenko M, Chan CK, Nudelman A, Rephaeli A, Cutts SM, Phillips DR.

Oncol Res. 2009;17(7):283-99.

PMID:
19408574
44.

Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species.

Levovich I, Nudelman A, Berkovitch G, Swift LP, Cutts SM, Phillips DR, Rephaeli A.

Cancer Chemother Pharmacol. 2008 Aug;62(3):471-82. Epub 2007 Nov 21.

PMID:
18030472
45.

Are pheromones detected through the main olfactory epithelium?

Wang Z, Nudelman A, Storm DR.

Mol Neurobiol. 2007 Jun;35(3):317-23. Review.

PMID:
17917120
46.

Formaldehyde-releasing prodrugs in combination with adriamycin can overcome cellular drug resistance.

Cutts SM, Nudelman A, Pillay V, Spencer DM, Levovich I, Rephaeli A, Phillips DR.

Oncol Res. 2005;15(4):199-213.

PMID:
17822280
47.

Aryl chain analogues of the biotin vitamers as potential herbicides. Part 3.

Ashkenazi T, Pinkert D, Nudelman A, Widberg A, Wexler B, Wittenbach V, Flint D, Nudelman A.

Pest Manag Sci. 2007 Oct;63(10):974-1001.

PMID:
17665367
48.

The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties.

Blank-Porat D, Gruss-Fischer T, Tarasenko N, Malik Z, Nudelman A, Rephaeli A.

Cancer Lett. 2007 Oct 18;256(1):39-48. Epub 2007 Jul 3.

PMID:
17611019
49.

The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity.

Swift LP, Cutts SM, Nudelman A, Levovich I, Rephaeli A, Phillips DR.

Cancer Chemother Pharmacol. 2008 Apr;61(5):739-49. Epub 2007 Jun 27.

PMID:
17594094
50.

Anticancer prodrugs of butyric acid and formaldehyde protect against doxorubicin-induced cardiotoxicity.

Rephaeli A, Waks-Yona S, Nudelman A, Tarasenko I, Tarasenko N, Phillips DR, Cutts SM, Kessler-Icekson G.

Br J Cancer. 2007 Jun 4;96(11):1667-74. Epub 2007 May 1.

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