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Items: 40

1.

Female sex and brain-selective estrogen benefit α-synuclein tetramerization and the PD-like motor syndrome in 3K transgenic mice.

Rajsombath MM, Nam AY, Ericsson M, Nuber S.

J Neurosci. 2019 Aug 12. pii: 0313-19. doi: 10.1523/JNEUROSCI.0313-19.2019. [Epub ahead of print]

PMID:
31405930
2.

[Three-point buttressing with internal fixator for minimally invasive stabilization of the anterior pelvic ring : Operative technique and first clinical results].

Nuber S, Ovalle D, Förch S, Plath J, Nuber M, Mayr E.

Unfallchirurg. 2019 Jan 7. doi: 10.1007/s00113-018-0599-z. [Epub ahead of print] German.

PMID:
30617539
3.

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D.

Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4.

PMID:
30527540
4.

Attenuated impression of irony created by the mismatch of verbal and nonverbal cues in patients with autism spectrum disorder.

Nuber S, Jacob H, Kreifelts B, Martinelli A, Wildgruber D.

PLoS One. 2018 Oct 15;13(10):e0205750. doi: 10.1371/journal.pone.0205750. eCollection 2018.

5.

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.

Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ.

Neuron. 2018 Oct 10;100(1):75-90.e5. doi: 10.1016/j.neuron.2018.09.014.

PMID:
30308173
6.

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.

Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D.

Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227.

7.

FRET Studies of Quinolone-Based Bitopic Ligands and Their Structural Analogues at the Muscarinic M1 Receptor.

Messerer R, Kauk M, Volpato D, Alonso Canizal MC, Klöckner J, Zabel U, Nuber S, Hoffmann C, Holzgrabe U.

ACS Chem Biol. 2017 Mar 17;12(3):833-843. doi: 10.1021/acschembio.6b00828. Epub 2017 Feb 6.

PMID:
28117571
8.

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.

Casadei N, Sood P, Ulrich T, Fallier-Becker P, Kieper N, Helling S, May C, Glaab E, Chen J, Nuber S, Wolburg H, Marcus K, Rapaport D, Ott T, Riess O, Krüger R, Fitzgerald JC.

Hum Mol Genet. 2016 Dec 15;25(24):5513. doi: 10.1093/hmg/ddw353. No abstract available.

PMID:
28031291
9.

Caspase-1 clipping causes complications for α-synuclein.

Nuber S, Selkoe DJ.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9958-60. doi: 10.1073/pnas.1610993113. Epub 2016 Aug 22. No abstract available.

10.

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.

Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C.

Nature. 2016 Mar 31;531(7596):661-4. doi: 10.1038/nature17198. Epub 2016 Mar 23.

11.

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.

Casadei N, Sood P, Ulrich T, Fallier-Becker P, Kieper N, Helling S, May C, Glaab E, Chen J, Nuber S, Wolburg H, Marcus K, Rapaport D, Ott T, Riess O, Krüger R, Fitzgerald JC.

Hum Mol Genet. 2016 Feb 1;25(3):459-71. doi: 10.1093/hmg/ddv485. Epub 2015 Nov 24. Erratum in: Hum Mol Genet. 2016 Dec 15;25(24):5513.

PMID:
26604148
12.

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease.

Kohl Z, Ben Abdallah N, Vogelgsang J, Tischer L, Deusser J, Amato D, Anderson S, Müller CP, Riess O, Masliah E, Nuber S, Winkler J.

Neurobiol Dis. 2016 Jan;85:206-217. doi: 10.1016/j.nbd.2015.10.021. Epub 2015 Oct 30.

13.

Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein.

Schlachetzki JC, Grimm T, Schlachetzki Z, Ben Abdallah NM, Ettle B, Vöhringer P, Ferger B, Winner B, Nuber S, Winkler J.

J Neurosci Res. 2016 Jan;94(1):62-73. doi: 10.1002/jnr.23677. Epub 2015 Oct 9.

PMID:
26451750
14.

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.

Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D'Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2015 Mar;36(3):1543-58. doi: 10.1016/j.neurobiolaging.2014.11.015. Epub 2014 Dec 17.

PMID:
25599874
15.

Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.

Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E.

J Neurosci. 2014 Jul 9;34(28):9441-54. doi: 10.1523/JNEUROSCI.5314-13.2014.

16.

α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.

May VE, Ettle B, Poehler AM, Nuber S, Ubhi K, Rockenstein E, Winner B, Wegner M, Masliah E, Winkler J.

Neurobiol Aging. 2014 Oct;35(10):2357-68. doi: 10.1016/j.neurobiolaging.2014.02.028. Epub 2014 Mar 4.

17.

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.

Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E.

Brain. 2014 May;137(Pt 5):1496-513. doi: 10.1093/brain/awu057. Epub 2014 Mar 24.

18.

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.

Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S.

Hum Mol Genet. 2014 Aug 1;23(15):3975-89. doi: 10.1093/hmg/ddu112. Epub 2014 Mar 11.

19.

Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.

Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E.

Acta Neuropathol. 2014 Apr;127(4):477-94. doi: 10.1007/s00401-014-1255-5. Epub 2014 Feb 8.

20.

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.

Oliveras-Salvá M, Van der Perren A, Casadei N, Stroobants S, Nuber S, D'Hooge R, Van den Haute C, Baekelandt V.

Mol Neurodegener. 2013 Nov 25;8:44. doi: 10.1186/1750-1326-8-44.

21.

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.

Casadei N, Pöhler AM, Tomás-Zapico C, Torres-Peraza J, Schwedhelm I, Witz A, Zamolo I, De Heer R, Spruijt B, Noldus LP, Klucken J, Lucas JJ, Kahle PJ, Krüger R, Riess O, Nuber S.

Hum Mol Genet. 2014 Feb 1;23(3):767-81. doi: 10.1093/hmg/ddt467. Epub 2013 Sep 24.

PMID:
24064336
22.

Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.

Marxreiter F, Ettle B, May VE, Esmer H, Patrick C, Kragh CL, Klucken J, Winner B, Riess O, Winkler J, Masliah E, Nuber S.

Neurobiol Dis. 2013 Nov;59:38-51. doi: 10.1016/j.nbd.2013.07.004. Epub 2013 Jul 16.

23.

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.

Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahashi R, Winkler J, Masliah E, Riess O.

Brain. 2013 Feb;136(Pt 2):412-32. doi: 10.1093/brain/aws358.

24.

Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.

Games D, Seubert P, Rockenstein E, Patrick C, Trejo M, Ubhi K, Ettle B, Ghassemiam M, Barbour R, Schenk D, Nuber S, Masliah E.

Am J Pathol. 2013 Mar;182(3):940-53. doi: 10.1016/j.ajpath.2012.11.018. Epub 2013 Jan 9.

25.

Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein.

May VE, Nuber S, Marxreiter F, Riess O, Winner B, Winkler J.

Neuroscience. 2012 Oct 11;222:343-55. doi: 10.1016/j.neuroscience.2012.07.001. Epub 2012 Jul 17.

PMID:
22814000
26.

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlötzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J.

Autophagy. 2012 May 1;8(5):754-66. doi: 10.4161/auto.19371. Epub 2012 May 1.

27.

Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells.

Hoffmann C, Nuber S, Zabel U, Ziegler N, Winkler C, Hein P, Berlot CH, Bünemann M, Lohse MJ.

Mol Pharmacol. 2012 Aug;82(2):236-45. doi: 10.1124/mol.112.077578. Epub 2012 May 7.

PMID:
22564786
28.

Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling.

Lohse MJ, Nuber S, Hoffmann C.

Pharmacol Rev. 2012 Apr;64(2):299-336. doi: 10.1124/pr.110.004309. Epub 2012 Mar 8. Review.

PMID:
22407612
29.

Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.

Nuber S, Petrasch-Parwez E, Arias-Carrión O, Koch L, Kohl Z, Schneider J, Calaminus C, Dermietzel R, Samarina A, Boy J, Nguyen HP, Teismann P, Velavan TP, Kahle PJ, von Hörsten S, Fendt M, Krüger R, Riess O.

Neurobiol Dis. 2011 Nov;44(2):192-204. doi: 10.1016/j.nbd.2011.06.017. Epub 2011 Jul 5.

PMID:
21767644
30.

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice.

Kurz A, Double KL, Lastres-Becker I, Tozzi A, Tantucci M, Bockhart V, Bonin M, García-Arencibia M, Nuber S, Schlaudraff F, Liss B, Fernández-Ruiz J, Gerlach M, Wüllner U, Lüddens H, Calabresi P, Auburger G, Gispert S.

PLoS One. 2010 Jul 7;5(7):e11464. doi: 10.1371/journal.pone.0011464.

31.

First appraisal of brain pathology owing to A30P mutant alpha-synuclein.

Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WF, Deller T, Rüb U, Krüger R.

Ann Neurol. 2010 May;67(5):684-9. doi: 10.1002/ana.21966. Erratum in: Ann Neurol. 2010 Jun;67(6):841.

PMID:
20437567
32.

Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.

Nuber S, Franck T, Wolburg H, Schumann U, Casadei N, Fischer K, Calaminus C, Pichler BJ, Chanarat S, Teismann P, Schulz JB, Luft AR, Tomiuk J, Wilbertz J, Bornemann A, Krüger R, Riess O.

Neurogenetics. 2010 Feb;11(1):107-20. doi: 10.1007/s10048-009-0212-2.

PMID:
19760259
33.

Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3.

Boy J, Schmidt T, Wolburg H, Mack A, Nuber S, Böttcher M, Schmitt I, Holzmann C, Zimmermann F, Servadio A, Riess O.

Hum Mol Genet. 2009 Nov 15;18(22):4282-95. doi: 10.1093/hmg/ddp381. Epub 2009 Aug 10.

PMID:
19666958
34.

Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.

Marxreiter F, Nuber S, Kandasamy M, Klucken J, Aigner R, Burgmayer R, Couillard-Despres S, Riess O, Winkler J, Winner B.

Eur J Neurosci. 2009 Mar;29(5):879-90. doi: 10.1111/j.1460-9568.2009.06641.x.

PMID:
19291219
35.

Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease.

Nuber S, Petrasch-Parwez E, Winner B, Winkler J, von Hörsten S, Schmidt T, Boy J, Kuhn M, Nguyen HP, Teismann P, Schulz JB, Neumann M, Pichler BJ, Reischl G, Holzmann C, Schmitt I, Bornemann A, Kuhn W, Zimmermann F, Servadio A, Riess O.

J Neurosci. 2008 Mar 5;28(10):2471-84. doi: 10.1523/JNEUROSCI.3040-07.2008.

36.

Genetic causes of Parkinson's disease: extending the pathway.

Riess O, Krüger R, Hochstrasser H, Soehn AS, Nuber S, Franck T, Berg D.

J Neural Transm Suppl. 2006;(70):181-9. Review.

PMID:
17017528
37.

Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models.

Boy J, Leergaard TB, Schmidt T, Odeh F, Bichelmeier U, Nuber S, Holzmann C, Wree A, Prusiner SB, Bujard H, Riess O, Bjaalie JG.

Neuroimage. 2006 Nov 1;33(2):449-62. Epub 2006 Aug 23.

PMID:
16931059
38.
39.

Index of suspicion. Case 1. Diagnosis: vascular ring.

Nuber SM.

Pediatr Rev. 1997 May;18(5):175-6. No abstract available.

PMID:
9114718
40.

Perioperative complications of neck dissection.

Nuber SM, Wiegand DA.

Trans Pa Acad Ophthalmol Otolaryngol. 1987;39(1):634-40. No abstract available.

PMID:
3451403

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