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Items: 9


Polyisoprenylated cysteinyl amide inhibitors deplete K-Ras and induce caspase-dependent apoptosis in lung cancer cells.

Nkembo AT, Amissah F, Ntantie E, Poku RA, Salako OO, Ikpatt OF, Lamango NS.

Curr Cancer Drug Targets. 2019 Mar 25. doi: 10.2174/1568009619666190325144636. [Epub ahead of print]


7,8-Dihydroxy-3-arylcoumarin Induces Cell Death Through S-Phase Arrest in MDA-MB-231 Breast Cancer Cells.

Musa MA, Badisa VLD, Latinwo LM, Ntantie E.

Anticancer Res. 2018 Nov;38(11):6091-6098. doi: 10.21873/anticanres.12959.


Suppression of focal adhesion formation may account for the suppression of cell migration, invasion and growth of non-small cell lung cancer cells following treatment with polyisoprenylated cysteinyl amide inhibitors.

Ntantie E, Allen MJ, Fletcher J, Nkembo AT, Lamango NS, Ikpatt OF.

Oncotarget. 2018 May 25;9(40):25781-25795. doi: 10.18632/oncotarget.25372. eCollection 2018 May 25.


Polyisoprenylated cysteinyl amide inhibitors induce caspase 3/7- and 8-mediated apoptosis and inhibit migration and invasion of metastatic prostate cancer cells.

Poku RA, Salako OO, Amissah F, Nkembo AT, Ntantie E, Lamango NS.

Am J Cancer Res. 2017 Jul 1;7(7):1515-1527. eCollection 2017.


Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer.

Ntantie E, Fletcher J, Amissah F, Salako OO, Nkembo AT, Poku RA, Ikpatt FO, Lamango NS.

Oncotarget. 2017 May 9;8(19):31726-31744. doi: 10.18632/oncotarget.15956.


Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides.

Nkembo AT, Salako O, Poku RA, Amissah F, Ntantie E, Flores-Rozas H, Lamango NS.

Am J Cancer Res. 2016 Nov 1;6(11):2532-2546. eCollection 2016.


Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B.

Wilson JM, Prokop JW, Lorimer E, Ntantie E, Williams CL.

J Mol Biol. 2016 Dec 4;428(24 Pt B):4929-4945. doi: 10.1016/j.jmb.2016.10.016. Epub 2016 Oct 17.


The antiangiogenic effects of polyisoprenylated cysteinyl amide inhibitors in HUVEC, chick embryo and zebrafish is dependent on the polyisoprenyl moiety.

Nkembo AT, Ntantie E, Salako OO, Amissah F, Poku RA, Latinwo LM, Lamango NS.

Oncotarget. 2016 Oct 18;7(42):68194-68205. doi: 10.18632/oncotarget.11908.


An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.

Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL.

Sci Signal. 2013 May 28;6(277):ra39. doi: 10.1126/scisignal.2003374.

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