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Items: 39


Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk.

Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4140-4145. doi: 10.1073/pnas.1716122115. Epub 2018 Apr 2.


Cell Surface Proteomics of N-Linked Glycoproteins for Typing of Human Lymphocytes.

Haverland NA, Waas M, Ntai I, Keppel T, Gundry RL, Kelleher NL.

Proteomics. 2017 Oct;17(19). doi: 10.1002/pmic.201700156.


Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL.

McDowall JS, Ntai I, Honeychurch KC, Hart JP, Colin P, Schneider BL, Brown DR.

Mol Cell Neurosci. 2017 Dec;85:1-11. doi: 10.1016/j.mcn.2017.08.001. Epub 2017 Aug 12.


TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.

Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW.

Nat Commun. 2017 Aug 10;8(1):233. doi: 10.1038/s41467-017-00307-y.


Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species.

McDowall JS, Ntai I, Hake J, Whitley PR, Mason JM, Pudney CR, Brown DR.

Biochemistry. 2017 May 16;56(19):2497-2505. doi: 10.1021/acs.biochem.7b00257. Epub 2017 May 4.


Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins.

Gan R, Perez JG, Carlson ED, Ntai I, Isaacs FJ, Kelleher NL, Jewett MC.

Biotechnol Bioeng. 2017 May;114(5):1074-1086. doi: 10.1002/bit.26239. Epub 2017 Feb 2.


A Method for Label-Free, Differential Top-Down Proteomics.

Ntai I, Toby TK, LeDuc RD, Kelleher NL.

Methods Mol Biol. 2016;1410:121-33. doi: 10.1007/978-1-4939-3524-6_8.


Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids.

Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, Isaacs FJ.

Nat Biotechnol. 2015 Dec;33(12):1272-1279. doi: 10.1038/nbt.3372. Epub 2015 Nov 16.


Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.

Ntai I, LeDuc RD, Fellers RT, Erdmann-Gilmore P, Davies SR, Rumsey J, Early BP, Thomas PM, Li S, Compton PD, Ellis MJ, Ruggles KV, Fenyö D, Boja ES, Rodriguez H, Townsend RR, Kelleher NL.

Mol Cell Proteomics. 2016 Jan;15(1):45-56. doi: 10.1074/mcp.M114.047480. Epub 2015 Oct 26.


Top Down Proteomics Reveals Mature Proteoforms Expressed in Subcellular Fractions of the Echinococcus granulosus Preadult Stage.

Lorenzatto KR, Kim K, Ntai I, Paludo GP, Camargo de Lima J, Thomas PM, Kelleher NL, Ferreira HB.

J Proteome Res. 2015 Nov 6;14(11):4805-14. doi: 10.1021/acs.jproteome.5b00642. Epub 2015 Oct 28.


Self-Assembly of Temperature-Responsive Protein-Polymer Bioconjugates.

Moatsou D, Li J, Ranji A, Pitto-Barry A, Ntai I, Jewett MC, O'Reilly RK.

Bioconjug Chem. 2015 Sep 16;26(9):1890-9. doi: 10.1021/acs.bioconjchem.5b00264. Epub 2015 Jul 2.


Improving cell-free protein synthesis through genome engineering of Escherichia coli lacking release factor 1.

Hong SH, Kwon YC, Martin RW, Des Soye BJ, de Paz AM, Swonger KN, Ntai I, Kelleher NL, Jewett MC.

Chembiochem. 2015 Mar 23;16(5):844-53. doi: 10.1002/cbic.201402708. Epub 2015 Mar 3.


Deep and quantitative top-down proteomics in clinical and translational research.

Kelleher NL, Thomas PM, Ntai I, Compton PD, LeDuc RD.

Expert Rev Proteomics. 2014 Dec;11(6):649-51. doi: 10.1586/14789450.2014.976559. Epub 2014 Oct 28.


Applying label-free quantitation to top down proteomics.

Ntai I, Kim K, Fellers RT, Skinner OS, Smith AD 4th, Early BP, Savaryn JP, LeDuc RD, Thomas PM, Kelleher NL.

Anal Chem. 2014 May 20;86(10):4961-8. doi: 10.1021/ac500395k. Epub 2014 May 7.


The first pilot project of the consortium for top-down proteomics: a status report.

Dang X, Scotcher J, Wu S, Chu RK, Tolić N, Ntai I, Thomas PM, Fellers RT, Early BP, Zheng Y, Durbin KR, Leduc RD, Wolff JJ, Thompson CJ, Pan J, Han J, Shaw JB, Salisbury JP, Easterling M, Borchers CH, Brodbelt JS, Agar JN, Paša-Tolić L, Kelleher NL, Young NL.

Proteomics. 2014 May;14(10):1130-40. doi: 10.1002/pmic.201300438. Epub 2014 Apr 14.


Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins.

Li Y, Compton PD, Tran JC, Ntai I, Kelleher NL.

Proteomics. 2014 May;14(10):1158-64. doi: 10.1002/pmic.201300381. Epub 2014 Apr 10.


Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins.

Durbin KR, Fellers RT, Ntai I, Kelleher NL, Compton PD.

Anal Chem. 2014 Feb 4;86(3):1485-92. doi: 10.1021/ac402904h. Epub 2014 Jan 23.


Cell-free protein synthesis from a release factor 1 deficient Escherichia coli activates efficient and multiple site-specific nonstandard amino acid incorporation.

Hong SH, Ntai I, Haimovich AD, Kelleher NL, Isaacs FJ, Jewett MC.

ACS Synth Biol. 2014 Jun 20;3(6):398-409. doi: 10.1021/sb400140t. Epub 2014 Jan 2.


Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A.

Rothmann M, Kang M, Villa R, Ntai I, La Clair JJ, Kelleher NL, Chapman E, Burkart MD.

J Am Chem Soc. 2013 Apr 24;135(16):5962-5. doi: 10.1021/ja400795m. Epub 2013 Apr 10.


Gobichelin A and B: Mixed-Ligand Siderophores Discovered Using Proteomics.

Chen Y, Unger M, Ntai I, McClure RA, Albright JC, Thomson RJ, Kelleher NL.

Medchemcomm. 2013 Jan 1;4(1):233-238. Epub 2012 Sep 24.


Mechanism-based small molecule cross-linkers of HECT E3 ubiquitin ligase-substrate pairs.

Park S, Ntai I, Thomas P, Konishcheva E, Kelleher NL, Statsuk AV.

Biochemistry. 2012 Oct 23;51(42):8327-9. doi: 10.1021/bi301231h. Epub 2012 Oct 9.


A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria.

Chen Y, Ntai I, Ju KS, Unger M, Zamdborg L, Robinson SJ, Doroghazi JR, Labeda DP, Metcalf WW, Kelleher NL.

J Proteome Res. 2012 Jan 1;11(1):85-94. doi: 10.1021/pr2009115. Epub 2011 Oct 25.


tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics.

Zhang W, Ntai I, Kelleher NL, Walsh CT.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12249-53. doi: 10.1073/pnas.1109539108. Epub 2011 Jul 11.


Proteomics-based discovery of koranimine, a cyclic imine natural product.

Evans BS, Ntai I, Chen Y, Robinson SJ, Kelleher NL.

J Am Chem Soc. 2011 May 18;133(19):7316-9. doi: 10.1021/ja2015795. Epub 2011 Apr 26.


A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway.

Hollenhorst MA, Ntai I, Badet B, Kelleher NL, Walsh CT.

Biochemistry. 2011 May 17;50(19):3859-61. doi: 10.1021/bi2004735. Epub 2011 Apr 26.


Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics.

Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, Kelleher NL, Walsh CT.

J Am Chem Soc. 2011 Apr 13;133(14):5240-3. doi: 10.1021/ja2011109. Epub 2011 Mar 18.


The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput.

Kellie JF, Tran JC, Lee JE, Ahlf DR, Thomas HM, Ntai I, Catherman AD, Durbin KR, Zamdborg L, Vellaichamy A, Thomas PM, Kelleher NL.

Mol Biosyst. 2010 Sep;6(9):1532-9. doi: 10.1039/c000896f. Epub 2010 Mar 29.


Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster.

Akif M, Ntai I, Sturrock ED, Isaac RE, Bachmann BO, Acharya KR.

Biochem Biophys Res Commun. 2010 Jul 30;398(3):532-6. doi: 10.1016/j.bbrc.2010.06.113. Epub 2010 Jul 1.


A proteomics approach to discovering natural products and their biosynthetic pathways.

Bumpus SB, Evans BS, Thomas PM, Ntai I, Kelleher NL.

Nat Biotechnol. 2009 Oct;27(10):951-6. doi: 10.1038/nbt.1565. Epub 2009 Sep 20.


A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome.

Lee JE, Kellie JF, Tran JC, Tipton JD, Catherman AD, Thomas HM, Ahlf DR, Durbin KR, Vellaichamy A, Ntai I, Marshall AG, Kelleher NL.

J Am Soc Mass Spectrom. 2009 Dec;20(12):2183-91. doi: 10.1016/j.jasms.2009.08.001. Epub 2009 Aug 12.


Combined chemical and biosynthetic route to access a new apoptolidin congener.

Ghidu VP, Ntai I, Wang J, Jacobs AT, Marnett LJ, Bachmann BO, Sulikowski GA.

Org Lett. 2009 Jul 16;11(14):3032-4. doi: 10.1021/ol901045v.


Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26.

Ntai I, Bachmann BO.

Bioorg Med Chem Lett. 2008 May 15;18(10):3068-71. Epub 2007 Dec 5.


Benzodiazepine biosynthesis in Streptomyces refuineus.

Hu Y, Phelan V, Ntai I, Farnet CM, Zazopoulos E, Bachmann BO.

Chem Biol. 2007 Jun;14(6):691-701. Erratum in: Chem Biol. 2007 Jul;14(7):870.


Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis.

Ntai I, Phelan VV, Bachmann BO.

Chem Commun (Camb). 2006 Nov 21;(43):4518-20.


Biosynthetic origins of C-P bond containing tripeptide K-26.

Ntai I, Manier ML, Hachey DL, Bachmann BO.

Org Lett. 2005 Jun 23;7(13):2763-5.


Sweet success: Ionic liquids derived from non-nutritive sweeteners.

Carter EB, Culver SL, Fox PA, Goode RD, Ntai I, Tickell MD, Traylor RK, Hoffman NW, Davis JH Jr.

Chem Commun (Camb). 2004 Mar 21;(6):630-1. Epub 2004 Feb 10.


Novel Brønsted acidic ionic liquids and their use as dual solvent-catalysts.

Cole AC, Jensen JL, Ntai I, Tran KL, Weaver KJ, Forbes DC, Davis JH Jr.

J Am Chem Soc. 2002 May 29;124(21):5962-3.


CO(2) capture by a task-specific ionic liquid.

Bates ED, Mayton RD, Ntai I, Davis JH Jr.

J Am Chem Soc. 2002 Feb 13;124(6):926-7.


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