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Items: 1 to 50 of 76

1.

Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation.

Lu J, Cao Q, Wang C, Zheng J, Luo F, Xie J, Li Y, Ma X, He L, Eisenberg D, Nowick J, Jiang L, Li D.

Front Mol Neurosci. 2019 Mar 4;12:54. doi: 10.3389/fnmol.2019.00054. eCollection 2019.

2.

Correction to "Repurposing Triphenylmethane Dyes To Bind to Trimers Derived from Aβ".

Salveson PJ, Haerianardakani S, Thuy-Boun A, Yoo S, Kreutzer AG, Demeler B, Nowick JS.

J Am Chem Soc. 2018 Nov 14;140(45):15546. doi: 10.1021/jacs.8b11195. Epub 2018 Nov 5. No abstract available.

PMID:
30394740
3.

Structural Polymorphs Suggest Competing Pathways for the Formation of Amyloid Fibrils That Diverge from a Common Intermediate Species.

Buchanan LE, Maj M, Dunkelberger EB, Cheng PN, Nowick JS, Zanni MT.

Biochemistry. 2018 Nov 20;57(46):6470-6478. doi: 10.1021/acs.biochem.8b00997. Epub 2018 Nov 6.

4.

X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly.

Yang H, Wierzbicki M, Du Bois DR, Nowick JS.

J Am Chem Soc. 2018 Oct 31;140(43):14028-14032. doi: 10.1021/jacs.8b07709. Epub 2018 Oct 12.

PMID:
30296063
5.

Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from Aβ.

Salveson PJ, Haerianardakani S, Thuy-Boun A, Yoo S, Kreutzer AG, Demeler B, Nowick JS.

J Am Chem Soc. 2018 Sep 19;140(37):11745-11754. doi: 10.1021/jacs.8b06568. Epub 2018 Sep 6. Erratum in: J Am Chem Soc. 2018 Nov 14;140(45):15546.

6.

An Efficient Method for the Expression and Purification of Aβ(M1-42).

Yoo S, Zhang S, Kreutzer AG, Nowick JS.

Biochemistry. 2018 Jul 3;57(26):3861-3866. doi: 10.1021/acs.biochem.8b00393. Epub 2018 May 24.

7.

Controlling the Oligomerization State of Aβ-Derived Peptides with Light.

Salveson PJ, Haerianardakani S, Thuy-Boun A, Kreutzer AG, Nowick JS.

J Am Chem Soc. 2018 May 2;140(17):5842-5852. doi: 10.1021/jacs.8b02658. Epub 2018 Apr 20.

8.

Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer's Disease and Other Amyloid Diseases.

Kreutzer AG, Nowick JS.

Acc Chem Res. 2018 Mar 20;51(3):706-718. doi: 10.1021/acs.accounts.7b00554. Epub 2018 Mar 6. Review.

9.

Effects of charge and hydrophobicity on the oligomerization of peptides derived from IAPP.

Wang Y, Truex NL, Vo NDP, Nowick JS.

Bioorg Med Chem. 2018 Mar 15;26(6):1151-1156. doi: 10.1016/j.bmc.2017.10.001. Epub 2017 Oct 5.

PMID:
29074350
10.

A Hexamer of a Peptide Derived from Aβ16-36.

Kreutzer AG, Spencer RK, McKnelly KJ, Yoo S, Hamza IL, Salveson PJ, Nowick JS.

Biochemistry. 2017 Nov 14;56(45):6061-6071. doi: 10.1021/acs.biochem.7b00831. Epub 2017 Oct 27.

11.

Alanine scan reveals modifiable residues in teixobactin.

Chen KH, Le SP, Han X, Frias JM, Nowick JS.

Chem Commun (Camb). 2017 Oct 12;53(82):11357-11359. doi: 10.1039/c7cc03415f.

12.

Transmembrane Proteins: Amyloids Hidden in Plain Sight?

Truex NL, Nowick JS.

Biochemistry. 2017 Sep 12;56(36):4735-4736. doi: 10.1021/acs.biochem.7b00758. Epub 2017 Aug 30. No abstract available.

PMID:
28853555
13.

X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16-36.

Salveson PJ, Spencer RK, Kreutzer AG, Nowick JS.

Org Lett. 2017 Jul 7;19(13):3462-3465. doi: 10.1021/acs.orglett.7b01445. Epub 2017 Jun 15.

14.

A Tetramer Derived from Islet Amyloid Polypeptide.

Wang Y, Kreutzer AG, Truex NL, Nowick JS.

J Org Chem. 2017 Aug 4;82(15):7905-7912. doi: 10.1021/acs.joc.7b01116. Epub 2017 Jul 14.

PMID:
28661686
15.

X-ray Crystallographic Structure of a Giant Double-Walled Peptide Nanotube Formed by a Macrocyclic β-Sheet Containing Aβ16-22.

Chen KH, Corro KA, Le SP, Nowick JS.

J Am Chem Soc. 2017 Jun 21;139(24):8102-8105. doi: 10.1021/jacs.7b03890. Epub 2017 Jun 13.

PMID:
28598147
16.

Square channels formed by a peptide derived from transthyretin.

Yoo S, Kreutzer AG, Truex NL, Nowick JS.

Chem Sci. 2016 Dec 1;7(12):6946-6951. doi: 10.1039/c6sc01927g. Epub 2016 Aug 1.

17.

X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.

Yang H, Du Bois DR, Ziller JW, Nowick JS.

Chem Commun (Camb). 2017 Feb 28;53(18):2772-2775. doi: 10.1039/c7cc00783c.

18.

Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ.

Kreutzer AG, Yoo S, Spencer RK, Nowick JS.

J Am Chem Soc. 2017 Jan 18;139(2):966-975. doi: 10.1021/jacs.6b11748. Epub 2017 Jan 10.

19.

Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid.

Truex NL, Nowick JS.

J Am Chem Soc. 2016 Oct 26;138(42):13891-13900. Epub 2016 Oct 14.

20.

Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid.

Truex NL, Wang Y, Nowick JS.

J Am Chem Soc. 2016 Oct 26;138(42):13882-13890. Epub 2016 Oct 14.

21.

Elucidation of the Teixobactin Pharmacophore.

Yang H, Chen KH, Nowick JS.

ACS Chem Biol. 2016 Jul 15;11(7):1823-6. doi: 10.1021/acschembio.6b00295. Epub 2016 Jun 3.

22.

X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17-36 β-Hairpin.

Kreutzer AG, Hamza IL, Spencer RK, Nowick JS.

J Am Chem Soc. 2016 Apr 6;138(13):4634-42. doi: 10.1021/jacs.6b01332. Epub 2016 Mar 29.

23.

X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers.

Salveson PJ, Spencer RK, Nowick JS.

J Am Chem Soc. 2016 Apr 6;138(13):4458-67. doi: 10.1021/jacs.5b13261. Epub 2016 Mar 23.

24.

Diversification of β-Augmentation Interactions between CDI Toxin/Immunity Proteins.

Morse RP, Willett JL, Johnson PM, Zheng J, Credali A, Iniguez A, Nowick JS, Hayes CS, Goulding CW.

J Mol Biol. 2015 Nov 20;427(23):3766-84. doi: 10.1016/j.jmb.2015.09.020. Epub 2015 Oct 9.

25.

A Newcomer's Guide to Peptide Crystallography.

Spencer RK, Nowick JS.

Isr J Chem. 2015 Jun 1;55(6-7):698-710.

26.

X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin.

Spencer RK, Kreutzer AG, Salveson PJ, Li H, Nowick JS.

J Am Chem Soc. 2015 May 20;137(19):6304-11. doi: 10.1021/jacs.5b01673. Epub 2015 May 12.

27.

A fibril-like assembly of oligomers of a peptide derived from β-amyloid.

Pham JD, Spencer RK, Chen KH, Nowick JS.

J Am Chem Soc. 2014 Sep 10;136(36):12682-90. doi: 10.1021/ja505713y. Epub 2014 Aug 26.

28.

X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from Aβ(17-36).

Spencer RK, Li H, Nowick JS.

J Am Chem Soc. 2014 Apr 16;136(15):5595-8. doi: 10.1021/ja5017409. Epub 2014 Apr 3.

29.

Polymorphism of oligomers of a peptide from β-amyloid.

Pham JD, Demeler B, Nowick JS.

J Am Chem Soc. 2014 Apr 9;136(14):5432-42. doi: 10.1021/ja500996d. Epub 2014 Mar 26.

30.

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet.

Buchanan LE, Dunkelberger EB, Tran HQ, Cheng PN, Chiu CC, Cao P, Raleigh DP, de Pablo JJ, Nowick JS, Zanni MT.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19285-90. doi: 10.1073/pnas.1314481110. Epub 2013 Nov 11.

31.

Structures of oligomers of a peptide from β-amyloid.

Pham JD, Chim N, Goulding CW, Nowick JS.

J Am Chem Soc. 2013 Aug 21;135(33):12460-7. doi: 10.1021/ja4068854. Epub 2013 Aug 8. Erratum in: J Am Chem Soc. 2014 Mar 19;136(11):4446.

32.

A hydrophobic surface is essential to inhibit the aggregation of a tau-protein-derived hexapeptide.

Zheng J, Baghkhanian AM, Nowick JS.

J Am Chem Soc. 2013 May 8;135(18):6846-52. doi: 10.1021/ja310817d. Epub 2013 Apr 29.

PMID:
23627648
33.

The supramolecular chemistry of β-sheets.

Cheng PN, Pham JD, Nowick JS.

J Am Chem Soc. 2013 Apr 17;135(15):5477-92. doi: 10.1021/ja3088407. Epub 2013 Apr 2. Review.

34.

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.

Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20913-8. doi: 10.1073/pnas.1218792109. Epub 2012 Dec 3.

35.

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity.

Cheng PN, Liu C, Zhao M, Eisenberg D, Nowick JS.

Nat Chem. 2012 Nov;4(11):927-33. doi: 10.1038/nchem.1433. Epub 2012 Sep 9.

36.

Heterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one.

Cheng PN, Spencer R, Woods RJ, Glabe CG, Nowick JS.

J Am Chem Soc. 2012 Aug 29;134(34):14179-84. doi: 10.1021/ja305416a. Epub 2012 Aug 17.

37.

Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics.

Liu C, Sawaya MR, Cheng PN, Zheng J, Nowick JS, Eisenberg D.

J Am Chem Soc. 2011 May 4;133(17):6736-44. doi: 10.1021/ja200222n. Epub 2011 Apr 7.

38.

Giant macrolactams based on β-sheet peptides.

Cheng PN, Nowick JS.

J Org Chem. 2011 May 6;76(9):3166-73. doi: 10.1021/jo102598n. Epub 2011 Apr 15.

39.

Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide.

Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ, Nowick JS.

J Am Chem Soc. 2011 Mar 9;133(9):3144-57. doi: 10.1021/ja110545h. Epub 2011 Feb 14. Erratum in: J Am Chem Soc. 2012 Oct 24;134(42):17832.

40.

X-ray crystallographic structure of an artificial beta-sheet dimer.

Khakshoor O, Lin AJ, Korman TP, Sawaya MR, Tsai SC, Eisenberg D, Nowick JS.

J Am Chem Soc. 2010 Aug 25;132(33):11622-8. doi: 10.1021/ja103438w.

41.

Selective heteronuclear Hartmann-Hahn: a multiple-pulse sequence for selective magnetization transfer in the structural elucidation of "isotagged" oligosaccharides.

Meng X, Nguyen WH, Nowick JS, Shaka AJ.

J Magn Reson. 2010 Mar;203(1):73-80. doi: 10.1016/j.jmr.2009.12.003. Epub 2009 Dec 30.

PMID:
20044287
42.

Nanometer-scale water-soluble macrocycles from nanometer-sized amino acids.

Gothard CM, Nowick JS.

J Org Chem. 2010 Mar 19;75(6):1822-30. doi: 10.1021/jo902268x.

43.

Use of disulfide "staples" to stabilize beta-sheet quaternary structure.

Khakshoor O, Nowick JS.

Org Lett. 2009 Jul 16;11(14):3000-3. doi: 10.1021/ol901015a.

44.

A new artificial beta-sheet that dimerizes through parallel beta-sheet interactions.

Levin S, Nowick JS.

Org Lett. 2009 Feb 19;11(4):1003-6. doi: 10.1021/ol802993v.

45.

Functionalized analogues of an unnatural amino acid that mimics a tripeptide beta-strand.

Khasanova TV, Khakshoor O, Nowick JS.

Org Lett. 2008 Nov 20;10(22):5293-6. doi: 10.1021/ol8021897. Epub 2008 Oct 21.

46.

Exploring beta-sheet structure and interactions with chemical model systems.

Nowick JS.

Acc Chem Res. 2008 Oct;41(10):1319-30. doi: 10.1021/ar800064f. Epub 2008 Sep 18.

47.

Artificial beta-sheets: chemical models of beta-sheets.

Khakshoor O, Nowick JS.

Curr Opin Chem Biol. 2008 Dec;12(6):722-9. doi: 10.1016/j.cbpa.2008.08.009. Epub 2008 Sep 5. Review.

48.

An artificial beta-sheet that dimerizes through parallel beta-sheet interactions.

Levin S, Nowick JS.

J Am Chem Soc. 2007 Oct 31;129(43):13043-8. Epub 2007 Oct 6.

49.

Nanometer-sized amino acids for the synthesis of nanometer-scale water-soluble molecular rods of precise length.

Gothard CM, Rao NA, Nowick JS.

J Am Chem Soc. 2007 Jun 13;129(23):7272-3. Epub 2007 May 16. No abstract available.

50.

Macrocyclic beta-sheet peptides that mimic protein quaternary structure through intermolecular beta-sheet interactions.

Khakshoor O, Demeler B, Nowick JS.

J Am Chem Soc. 2007 May 2;129(17):5558-69. Epub 2007 Apr 10.

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