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Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases.

Yap ML, McFadyen JD, Wang X, Ziegler M, Chen YC, Willcox A, Nowell CJ, Scott AM, Sloan EK, Hogarth PM, Pietersz GA, Peter K.

Theranostics. 2019 Feb 7;9(4):1154-1169. doi: 10.7150/thno.29146. eCollection 2019.


Direct Comparison of Standard Transmission Electron Microscopy and Cryogenic-TEM in Imaging Nanocrystals Inside Liposomes.

Li T, Nowell CJ, Cipolla D, Rades T, Boyd BJ.

Mol Pharm. 2019 Apr 1;16(4):1775-1781. doi: 10.1021/acs.molpharmaceut.8b01308. Epub 2019 Feb 27.


Cell quiescence correlates with enhanced glioblastoma cell invasion and cytotoxic resistance.

Atkins RJ, Stylli SS, Kurganovs N, Mangiola S, Nowell CJ, Ware TM, Corcoran NM, Brown DV, Kaye AH, Morokoff A, Luwor RB, Hovens CM, Mantamadiotis T.

Exp Cell Res. 2019 Jan 15;374(2):353-364. doi: 10.1016/j.yexcr.2018.12.010. Epub 2018 Dec 15.


A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL.

Suys EJA, Warren DB, Pham AC, Nowell CJ, Clulow AJ, Benameur H, Porter CJH, Pouton CW, Chalmers DK.

J Pharm Sci. 2019 Jan;108(1):193-204. doi: 10.1016/j.xphs.2018.11.028. Epub 2018 Nov 28.


Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function.

Kim TH, Ly C, Christodoulides A, Nowell CJ, Gunning PW, Sloan EK, Rowat AC.

FASEB J. 2019 Mar;33(3):3997-4006. doi: 10.1096/fj.201801429RR. Epub 2018 Dec 3.


Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment.

Dandrieux JR, Martinez Lopez LM, Stent A, Jergens A, Allenspach K, Nowell CJ, Firestone SM, Kimpton W, Mansfield CS.

Innate Immun. 2018 Oct;24(7):400-410. doi: 10.1177/1753425918799865. Epub 2018 Sep 17.


Inflammation-associated changes in DOR expression and function in the mouse colon.

DiCello JJ, Saito A, Rajasekhar P, Eriksson EM, McQuade RM, Nowell CJ, Sebastian BW, Fichna J, Veldhuis NA, Canals M, Bunnett NW, Carbone SE, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G544-G559. doi: 10.1152/ajpgi.00025.2018. Epub 2018 Jun 21.


Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice.

Yun B, Zhang T, Azad MAK, Wang J, Nowell CJ, Kalitsis P, Velkov T, Hudson DF, Li J.

Arch Toxicol. 2018 Jul;92(7):2273-2274. doi: 10.1007/s00204-018-2233-9.


Rosiglitazone and a β3-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture.

Merlin J, Sato M, Chia LY, Fahey R, Pakzad M, Nowell CJ, Summers RJ, Bengtsson T, Evans BA, Hutchinson DS.

Front Endocrinol (Lausanne). 2018 May 30;9:249. doi: 10.3389/fendo.2018.00249. eCollection 2018.


MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.

Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B, Liu S, Palmieri M, Love C, Jorissen RN, Li S, Whitehead L, Putoczki TL, Preaudet A, Tsui C, Nowell CJ, Ward RL, Hawkins NJ, Desai J, Gibbs P, Ernst M, Street I, Buchert M, Sieber OM.

Cancer Discov. 2018 Aug;8(8):988-1005. doi: 10.1158/2159-8290.CD-17-0909. Epub 2018 Jun 7.


Polymyxin B causes DNA damage in HK-2 cells and mice.

Yun B, Zhang T, Azad MAK, Wang J, Nowell CJ, Kalitsis P, Velkov T, Hudson DF, Li J.

Arch Toxicol. 2018 Jul;92(7):2259-2271. doi: 10.1007/s00204-018-2192-1. Epub 2018 Mar 20. Erratum in: Arch Toxicol. 2018 Jun 18;:.


Biologically active constituents of the secretome of human W8B2+ cardiac stem cells.

Nie S, Wang X, Sivakumaran P, Chong MMW, Liu X, Karnezis T, Bandara N, Takov K, Nowell CJ, Wilcox S, Shambrook M, Hill AF, Harris NC, Newcomb AE, Strappe P, Shayan R, Hernández D, Clarke J, Hanssen E, Davidson SM, Dusting GJ, Pébay A, Ho JWK, Williamson N, Lim SY.

Sci Rep. 2018 Jan 25;8(1):1579. doi: 10.1038/s41598-018-19855-4.


Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery.

Yadav P, McLeod VM, Nowell CJ, Selby LI, Johnston APR, Kaminskas LM, Trevaskis NL.

J Control Release. 2018 Feb 28;272:17-28. doi: 10.1016/j.jconrel.2017.12.031. Epub 2018 Jan 3.


Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide.

Xing Y, Pilkington EH, Wang M, Nowell CJ, Kakinen A, Sun Y, Wang B, Davis TP, Ding F, Ke PC.

Phys Chem Chem Phys. 2017 Nov 22;19(45):30627-30635. doi: 10.1039/c7cp06670h.


Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion.

Duivenvoorden HM, Rautela J, Edgington-Mitchell LE, Spurling A, Greening DW, Nowell CJ, Molloy TJ, Robbins E, Brockwell NK, Lee CS, Chen M, Holliday A, Selinger CI, Hu M, Britt KL, Stroud DA, Bogyo M, Möller A, Polyak K, Sloane BF, O'Toole SA, Parker BS.

J Pathol. 2017 Dec;243(4):496-509. doi: 10.1002/path.4990. Epub 2017 Oct 31.


Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling.

Williams SP, Odell AF, Karnezis T, Farnsworth RH, Gould CM, Li J, Paquet-Fifield S, Harris NC, Walter A, Gregory JL, Lamont SF, Liu R, Takano EA, Nowell CJ, Bower NI, Resnick D, Smyth GK, Coultas L, Hogan BM, Fox SB, Mueller SN, Simpson KJ, Achen MG, Stacker SA.

Sci Signal. 2017 Oct 3;10(499). pii: eaal2987. doi: 10.1126/scisignal.aal2987.


Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia.

McArthur K, D'Cruz AA, Segal D, Lackovic K, Wilks AF, O'Donnell JA, Nowell CJ, Gerlic M, Huang DCS, Burns CJ, Croker BA.

Oncotarget. 2017 Jul 28;8(35):57948-57963. doi: 10.18632/oncotarget.19678. eCollection 2017 Aug 29.


Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages.

Sadek MM, Barzegar Amiri Olia M, Nowell CJ, Barlow Ν, Schiesser CH, Nicholson SE, Norton RS.

Bioorg Med Chem. 2017 Oct 15;25(20):5743-5748. doi: 10.1016/j.bmc.2017.08.054. Epub 2017 Sep 5.


Potential Toxicity of Polymyxins in Human Lung Epithelial Cells.

Ahmed MU, Velkov T, Lin YW, Yun B, Nowell CJ, Zhou F, Zhou QT, Chan K, Azad MAK, Li J.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02690-16. doi: 10.1128/AAC.02690-16. Print 2017 Jun.


Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology.

Williams SP, Gould CM, Nowell CJ, Karnezis T, Achen MG, Simpson KJ, Stacker SA.

Sci Data. 2017 Mar 1;4:170009. doi: 10.1038/sdata.2017.9.


A Three-Dimensional Lymphatic Endothelial Cell Tube Formation Assay to Identify Novel Kinases Involved in Lymphatic Vessel Remodeling.

Gambino TJ, Williams SP, Caesar C, Resnick D, Nowell CJ, Farnsworth RH, Achen MG, Stacker SA, Karnezis T.

Assay Drug Dev Technol. 2017 Jan;15(1):30-43. doi: 10.1089/adt.2016.764.


Inhibition of the KCa3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model.

Organ L, Bacci B, Koumoundouros E, Kimpton WG, Samuel CS, Nowell CJ, Bradding P, Roach KM, Westall G, Jaffar J, Snibson KJ.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):539-550. doi: 10.1165/rcmb.2016-0092OC.


High throughput, quantitative analysis of human osteoclast differentiation and activity.

Diepenhorst NA, Nowell CJ, Rueda P, Henriksen K, Pierce T, Cook AE, Pastoureau P, Sabatini M, Charman WN, Christopoulos A, Summers RJ, Sexton PM, Langmead CJ.

Anal Biochem. 2017 Feb 15;519:51-56. doi: 10.1016/j.ab.2016.12.010. Epub 2016 Dec 14.


Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling.

Kim TH, Gill NK, Nyberg KD, Nguyen AV, Hohlbauch SV, Geisse NA, Nowell CJ, Sloan EK, Rowat AC.

J Cell Sci. 2016 Dec 15;129(24):4563-4575. Epub 2016 Nov 14.


Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.

Furness SGB, Liang YL, Nowell CJ, Halls ML, Wookey PJ, Dal Maso E, Inoue A, Christopoulos A, Wootten D, Sexton PM.

Cell. 2016 Oct 20;167(3):739-749.e11. doi: 10.1016/j.cell.2016.09.021. Epub 2016 Oct 6.


Differences in the cellular composition of small versus large uterine fibroids.

Holdsworth-Carson SJ, Zhao D, Cann L, Bittinger S, Nowell CJ, Rogers PA.

Reproduction. 2016 Nov;152(5):467-80. doi: 10.1530/REP-16-0216. Epub 2016 Aug 15.


Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts.

Müllner M, Mehta D, Nowell CJ, Porter CJ.

Chem Commun (Camb). 2016 Jul 12;52(58):9121-4. doi: 10.1039/c6cc00447d.


Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination.

Le CP, Nowell CJ, Kim-Fuchs C, Botteri E, Hiller JG, Ismail H, Pimentel MA, Chai MG, Karnezis T, Rotmensz N, Renne G, Gandini S, Pouton CW, Ferrari D, Möller A, Stacker SA, Sloan EK.

Nat Commun. 2016 Mar 1;7:10634. doi: 10.1038/ncomms10634.


Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling.

Halls ML, Yeatman HR, Nowell CJ, Thompson GL, Gondin AB, Civciristov S, Bunnett NW, Lambert NA, Poole DP, Canals M.

Sci Signal. 2016 Feb 9;9(414):ra16. doi: 10.1126/scisignal.aac9177.


The Wiggle Index: An Open Source Bioassay to Assess Sub-Lethal Insecticide Response in Drosophila melanogaster.

Denecke S, Nowell CJ, Fournier-Level A, Perry T, Batterham P.

PLoS One. 2015 Dec 18;10(12):e0145051. doi: 10.1371/journal.pone.0145051. eCollection 2015.


β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.

Creed SJ, Le CP, Hassan M, Pon CK, Albold S, Chan KT, Berginski ME, Huang Z, Bear JE, Lane JR, Halls ML, Ferrari D, Nowell CJ, Sloan EK.

Breast Cancer Res. 2015 Nov 25;17(1):145. doi: 10.1186/s13058-015-0655-3.


In Vivo Formation of Cubic Phase in Situ after Oral Administration of Cubic Phase Precursor Formulation Provides Long Duration Gastric Retention and Absorption for Poorly Water-Soluble Drugs.

Pham AC, Hong L, Montagnat O, Nowell CJ, Nguyen TH, Boyd BJ.

Mol Pharm. 2016 Jan 4;13(1):280-6. doi: 10.1021/acs.molpharmaceut.5b00784. Epub 2015 Dec 4.


Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes.

Yun B, Azad MA, Nowell CJ, Nation RL, Thompson PE, Roberts KD, Velkov T, Li J.

Antimicrob Agents Chemother. 2015 Dec;59(12):7489-96. doi: 10.1128/AAC.01216-15. Epub 2015 Sep 21.


Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging.

Pham AC, Nguyen TH, Nowell CJ, Graham B, Boyd BJ.

Drug Deliv Transl Res. 2015 Dec;5(6):566-74. doi: 10.1007/s13346-015-0253-z.


Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging.

Halls ML, Poole DP, Ellisdon AM, Nowell CJ, Canals M.

Methods Mol Biol. 2015;1335:131-61. doi: 10.1007/978-1-4939-2914-6_10.


Combination of agrin and laminin increase acetylcholine receptor clustering and enhance functional neuromuscular junction formation In vitro.

Zhang BG, Quigley AF, Bourke JL, Nowell CJ, Myers DE, Choong PF, Kapsa RM.

Dev Neurobiol. 2016 May;76(5):551-65. doi: 10.1002/dneu.22331. Epub 2015 Aug 21.


Differential use of autophagy by primary dendritic cells specialized in cross-presentation.

Mintern JD, Macri C, Chin WJ, Panozza SE, Segura E, Patterson NL, Zeller P, Bourges D, Bedoui S, McMillan PJ, Idris A, Nowell CJ, Brown A, Radford KJ, Johnston AP, Villadangos JA.

Autophagy. 2015;11(6):906-17. doi: 10.1080/15548627.2015.1045178.


Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E.

Stem Cell Reports. 2015 May 12;4(5):759-67. doi: 10.1016/j.stemcr.2015.03.003. Epub 2015 Apr 16.


A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep.

Organ L, Bacci B, Koumoundouros E, Barcham G, Kimpton W, Nowell CJ, Samuel C, Snibson K.

Exp Lung Res. 2015 Apr;41(3):115-34. doi: 10.3109/01902148.2014.985806. Epub 2014 Dec 22.


Fas regulates neutrophil lifespan during viral and bacterial infection.

O'Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Zhang JG, O'Reilly LA, Cengia L, Dias S, Masters SL, Hartland EL, Roberts AW, Gerlic M, Croker BA.

J Leukoc Biol. 2015 Feb;97(2):321-6. doi: 10.1189/jlb.3AB1113-594RR. Epub 2014 Dec 3.


Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M.

Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411.


IDH1 mutation is associated with seizures and protoplasmic subtype in patients with low-grade gliomas.

Liubinas SV, D'Abaco GM, Moffat BM, Gonzales M, Feleppa F, Nowell CJ, Gorelik A, Drummond KJ, O'Brien TJ, Kaye AH, Morokoff AP.

Epilepsia. 2014 Sep;55(9):1438-43. doi: 10.1111/epi.12662. Epub 2014 Jun 5.


Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus.

Holdsworth-Carson SJ, Craythorn RG, Winnall WR, Dhaliwal K, Genovese R, Nowell CJ, Rogers PA, de Kretser DM, Hedger MP, Girling JE.

Reprod Fertil Dev. 2015 Sep;27(7):985-99. doi: 10.1071/RD13372.


Vascular endothelial growth factor-d modulates caliber and function of initial lymphatics in the dermis.

Paquet-Fifield S, Levy SM, Sato T, Shayan R, Karnezis T, Davydova N, Nowell CJ, Roufail S, Ma GZ, Zhang YF, Stacker SA, Achen MG.

J Invest Dermatol. 2013 Aug;133(8):2074-84. doi: 10.1038/jid.2013.83. Epub 2013 Feb 25.


NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.

Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O'Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker BA.

Immunity. 2012 Dec 14;37(6):1009-23. doi: 10.1016/j.immuni.2012.08.027. Epub 2012 Dec 6.


Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.

Samson AL, Knaupp AS, Sashindranath M, Borg RJ, Au AE, Cops EJ, Saunders HM, Cody SH, McLean CA, Nowell CJ, Hughes VA, Bottomley SP, Medcalf RL.

Cell Rep. 2012 Oct 25;2(4):889-901. doi: 10.1016/j.celrep.2012.08.026. Epub 2012 Oct 4.


Divergent lymphocyte signalling revealed by a powerful new tool for analysis of time-lapse microscopy.

Pham K, Shimoni R, Ludford-Menting MJ, Nowell CJ, Lobachevsky P, Bomzon Z, Gu M, Speed TP, McGlade CJ, Russell SM.

Immunol Cell Biol. 2013 Jan;91(1):70-81. doi: 10.1038/icb.2012.49. Epub 2012 Oct 2.


Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish.

Pase L, Layton JE, Wittmann C, Ellett F, Nowell CJ, Reyes-Aldasoro CC, Varma S, Rogers KL, Hall CJ, Keightley MC, Crosier PS, Grabher C, Heath JK, Renshaw SA, Lieschke GJ.

Curr Biol. 2012 Oct 9;22(19):1818-24. doi: 10.1016/j.cub.2012.07.060. Epub 2012 Aug 30.


In vivo real-time visualization of leukocytes and intracellular hydrogen peroxide levels during a zebrafish acute inflammation assay.

Pase L, Nowell CJ, Lieschke GJ.

Methods Enzymol. 2012;506:135-56. doi: 10.1016/B978-0-12-391856-7.00032-9.


A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growth.

Farnsworth RH, Karnezis T, Shayan R, Matsumoto M, Nowell CJ, Achen MG, Stacker SA.

Cancer Res. 2011 Oct 15;71(20):6547-57. doi: 10.1158/0008-5472.CAN-11-0200. Epub 2011 Aug 25.

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