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Items: 34


A Protein E-PilA fusion protein shows vaccine potential against nontypeable Haemophilus influenzae in mice and chinchillas.

Ysebaert C, Denoël P, Weynants V, Bakaletz LO, Novotny LA, Godfroid F, Hermand P.

Infect Immun. 2019 May 20. pii: IAI.00345-19. doi: 10.1128/IAI.00345-19. [Epub ahead of print]


Biofilm biology and vaccine strategies for otitis media due to nontypeable Haemophilus influenzae.

Novotny LA, Brockman KL, Mokrzan EM, Jurcisek JA, Bakaletz LO.

J Pediatr Infect Dis. 2019 Feb;14(2):69-77. doi: 10.1055/s-0038-1660818. Epub 2018 Jul 6.


Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm.

Mokrzan EM, Novotny LA, Brockman KL, Bakaletz LO.

MBio. 2018 Dec 11;9(6). pii: e02423-18. doi: 10.1128/mBio.02423-18.


Nontypeable Haemophilus influenzae (NTHi).

Bakaletz LO, Novotny LA.

Trends Microbiol. 2018 Aug;26(8):727-728. doi: 10.1016/j.tim.2018.05.001. Epub 2018 May 21.


Nontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.

Jurcisek JA, Brockman KL, Novotny LA, Goodman SD, Bakaletz LO.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6632-E6641. doi: 10.1073/pnas.1705508114. Epub 2017 Jul 10.


Transcutaneous Immunization with a Band-Aid Prevents Experimental Otitis Media in a Polymicrobial Model.

Novotny LA, Clements JD, Goodman SD, Bakaletz LO.

Clin Vaccine Immunol. 2017 Jun 5;24(6). pii: e00563-16. doi: 10.1128/CVI.00563-16. Print 2017 Jun.


Panel 4: Report of the Microbiology Panel.

Barenkamp SJ, Chonmaitree T, Hakansson AP, Heikkinen T, King S, Nokso-Koivisto J, Novotny LA, Patel JA, Pettigrew M, Swords WE.

Otolaryngol Head Neck Surg. 2017 Apr;156(4_suppl):S51-S62. doi: 10.1177/0194599816639028. Review.


Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo.

Novotny LA, Jurcisek JA, Goodman SD, Bakaletz LO.

EBioMedicine. 2016 Aug;10:33-44. doi: 10.1016/j.ebiom.2016.06.022. Epub 2016 Jun 16.


Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.

Novotny LA, Bakaletz LO.

Cell Microbiol. 2016 Aug;18(8):1043-55. doi: 10.1111/cmi.12575. Epub 2016 Feb 26.


Therapeutic Transcutaneous Immunization with a Band-Aid Vaccine Resolves Experimental Otitis Media.

Novotny LA, Clements JD, Bakaletz LO.

Clin Vaccine Immunol. 2015 Aug;22(8):867-74. doi: 10.1128/CVI.00090-15. Epub 2015 May 27.


Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media.

Novotny LA, Jurcisek JA, Ward MO Jr, Jordan ZB, Goodman SD, Bakaletz LO.

Mol Microbiol. 2015 Apr;96(2):276-92. doi: 10.1111/mmi.12934. Epub 2015 Feb 15.


Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms.

Brockson ME, Novotny LA, Mokrzan EM, Malhotra S, Jurcisek JA, Akbar R, Devaraj A, Goodman SD, Bakaletz LO.

Mol Microbiol. 2014 Sep;93(6):1246-58. doi: 10.1111/mmi.12735. Epub 2014 Aug 19.


Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients.

Fox KL, Atack JM, Srikhanta YN, Eckert A, Novotny LA, Bakaletz LO, Jennings MP.

PLoS One. 2014 Feb 28;9(2):e90505. doi: 10.1371/journal.pone.0090505. eCollection 2014.


Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis.

Das S, Rosas LE, Jurcisek JA, Novotny LA, Green KB, Bakaletz LO.

Laryngoscope. 2014 Mar;124(3):608-15. doi: 10.1002/lary.24333. Epub 2013 Oct 2.


Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein.

Novotny LA, Amer AO, Brockson ME, Goodman SD, Bakaletz LO.

PLoS One. 2013 Jun 14;8(6):e67629. doi: 10.1371/journal.pone.0067629. Print 2013.


Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.

Abu Khweek A, Fernández Dávila NS, Caution K, Akhter A, Abdulrahman BA, Tazi M, Hassan H, Novotny LA, Bakaletz LO, Amer AO.

Front Cell Infect Microbiol. 2013 May 27;3:18. doi: 10.3389/fcimb.2013.00018. eCollection 2013.


Epitope-specific immune recognition of the nontypeable Haemophilus influenzae outer membrane protein 26.

Kunthalert D, Novotny LA, Massa HM, Ulett GC, Bakaletz LO, Kyd JM, Cripps AW.

Hum Vaccin Immunother. 2013 Mar;9(3):625-35. Epub 2013 Jan 4.


Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media.

Brockson ME, Novotny LA, Jurcisek JA, McGillivary G, Bowers MR, Bakaletz LO.

PLoS One. 2012;7(6):e40088. doi: 10.1371/journal.pone.0040088. Epub 2012 Jun 29.


Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins.

Goodman SD, Obergfell KP, Jurcisek JA, Novotny LA, Downey JS, Ayala EA, Tjokro N, Li B, Justice SS, Bakaletz LO.

Mucosal Immunol. 2011 Nov;4(6):625-37. doi: 10.1038/mi.2011.27. Epub 2011 Jun 29.


Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae.

Novotny LA, Clements JD, Bakaletz LO.

Mucosal Immunol. 2011 Jul;4(4):456-67. doi: 10.1038/mi.2011.6. Epub 2011 Feb 16. Erratum in: Mucosal Immunol. 2012 Jan;5(1):110.


Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates.

Novotny LA, Adams LD, Kang DR, Wiet GJ, Cai X, Sethi S, Murphy TF, Bakaletz LO.

Vaccine. 2009 Dec 10;28(1):279-89. doi: 10.1016/j.vaccine.2009.08.017. Epub 2009 Aug 22.


Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.

Novotny LA, Partida-Sánchez S, Munson RS Jr, Bakaletz LO.

Infect Immun. 2008 Mar;76(3):967-77. Epub 2007 Dec 26.


The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract.

Jurcisek JA, Bookwalter JE, Baker BD, Fernandez S, Novotny LA, Munson RS Jr, Bakaletz LO.

Mol Microbiol. 2007 Sep;65(5):1288-99. Epub 2007 Jul 23.


Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae.

Bakaletz LO, Baker BD, Jurcisek JA, Harrison A, Novotny LA, Bookwalter JE, Mungur R, Munson RS Jr.

Infect Immun. 2005 Mar;73(3):1635-43.


Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media.

Novotny LA, Pichichero ME, Denoël PA, Neyt C, Vanderschrick S, Dequesne G, Bakaletz LO.

Vaccine. 2002 Oct 4;20(29-30):3590-7.


Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention.

Visweswaraiah A, Novotny LA, Hjemdahl-Monsen EJ, Bakaletz LO, Thanavala Y.

Vaccine. 2002 Aug 19;20(25-26):3209-20.


Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae.

Novotny LA, Jurcisek JA, Pichichero ME, Bakaletz LO.

Infect Immun. 2000 Apr;68(4):2119-28.


Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection.

Bakaletz LO, Kennedy BJ, Novotny LA, Duquesne G, Cohen J, Lobet Y.

Infect Immun. 1999 Jun;67(6):2746-62. Erratum in: Infect Immun 1999 Oct;67(10):5545.

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