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Items: 24


A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation.

Shen Y, Zeng L, Novosyadlyy R, Forest A, Zhu A, Korytko A, Zhang H, Eastman SW, Topper M, Hindi S, Covino N, Persaud K, Kang Y, Burtrum D, Surguladze D, Prewett M, Chintharlapalli S, Wroblewski VJ, Shen J, Balderes P, Zhu Z, Snavely M, Ludwig DL.

MAbs. 2015;7(5):931-45. doi: 10.1080/19420862.2015.1055442.


Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance--implications for IGF-II and IGF-IR-targeted therapy.

Li B, Tsao SW, Chan KW, Ludwig DL, Novosyadlyy R, Li YY, He QY, Cheung AL.

Clin Cancer Res. 2014 May 15;20(10):2651-62. doi: 10.1158/1078-0432.CCR-13-2735. Epub 2014 Mar 5.


Insulin and IGFs in obesity-related breast cancer.

Belardi V, Gallagher EJ, Novosyadlyy R, LeRoith D.

J Mammary Gland Biol Neoplasia. 2013 Dec;18(3-4):277-89. doi: 10.1007/s10911-013-9303-7. Epub 2013 Oct 24. Review.


Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer.

Ferguson RD, Gallagher EJ, Cohen D, Tobin-Hess A, Alikhani N, Novosyadlyy R, Haddad N, Yakar S, LeRoith D.

Endocr Relat Cancer. 2013 May 21;20(3):391-401. doi: 10.1530/ERC-12-0333. Print 2013 Jun.


Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model.

Alikhani N, Ferguson RD, Novosyadlyy R, Gallagher EJ, Scheinman EJ, Yakar S, LeRoith D.

Oncogene. 2013 Feb 21;32(8):961-7. doi: 10.1038/onc.2012.113. Epub 2012 Apr 2.


Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.

Novosyadlyy R, Leroith D.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):640-51. doi: 10.1093/gerona/gls065. Epub 2012 Mar 15. Review.


Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes.

Ferguson RD, Novosyadlyy R, Fierz Y, Alikhani N, Sun H, Yakar S, Leroith D.

Breast Cancer Res. 2012 Jan 7;14(1):R8.


Blockade of insulin-like growth factor type-1 receptor with cixutumumab (IMC-A12): a novel approach to treatment for multiple cancers.

Rowinsky EK, Schwartz JD, Zojwalla N, Youssoufian H, Fox F, Pultar P, Novosyadlyy R, Cosaert J, Ludwig DL.

Curr Drug Targets. 2011 Dec;12(14):2016-33. Review.


Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes.

Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D.

Endocr Relat Cancer. 2010 Oct 5;17(4):941-51. doi: 10.1677/ERC-10-0091. Print 2010 Dec.


Hyperinsulinemia and type 2 diabetes: impact on cancer.

Novosyadlyy R, LeRoith D.

Cell Cycle. 2010 Apr 15;9(8):1449-50. Epub 2010 Apr 15. No abstract available.


Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes.

Novosyadlyy R, Lann DE, Vijayakumar A, Rowzee A, Lazzarino DA, Fierz Y, Carboni JM, Gottardis MM, Pennisi PA, Molinolo AA, Kurshan N, Mejia W, Santopietro S, Yakar S, Wood TL, LeRoith D.

Cancer Res. 2010 Jan 15;70(2):741-51. doi: 10.1158/0008-5472.CAN-09-2141. Epub 2010 Jan 12.


Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.

Wu Y, Brodt P, Sun H, Mejia W, Novosyadlyy R, Nunez N, Chen X, Mendoza A, Hong SH, Khanna C, Yakar S.

Cancer Res. 2010 Jan 1;70(1):57-67. doi: 10.1158/0008-5472.CAN-09-2472.


Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression.

Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D.

Diabetes. 2010 Mar;59(3):686-93. doi: 10.2337/db09-1291. Epub 2009 Dec 3.


Biological effects of growth hormone on carbohydrate and lipid metabolism.

Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, LeRoith D.

Growth Horm IGF Res. 2010 Feb;20(1):1-7. doi: 10.1016/j.ghir.2009.09.002. Epub 2009 Oct 1. Review.


Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.

Novosyadlyy R, Vijayakumar A, Lann D, Fierz Y, Kurshan N, LeRoith D.

Oncogene. 2009 Oct 1;28(39):3477-86. doi: 10.1038/onc.2009.209. Epub 2009 Jul 20.


Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence.

LeRoith D, Novosyadlyy R, Gallagher EJ, Lann D, Vijayakumar A, Yakar S.

Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S4-6. doi: 10.1055/s-2008-1081488. Epub 2008 Sep 5. Review.


Temporal and spatial expression of IGF-I and IGFBP-1 during acute-phase response induced by localized inflammation in rats.

Novosyadlyy R, Lelbach A, Sheikh N, Tron K, Pannem R, Ramadori G, Scharf JG.

Growth Horm IGF Res. 2009 Feb;19(1):51-60. doi: 10.1016/j.ghir.2008.05.004. Epub 2008 Jul 15.


Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.

Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, LeRoith D.

Cell Death Differ. 2008 Aug;15(8):1304-17. doi: 10.1038/cdd.2008.52. Epub 2008 Apr 25.


Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.

Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N, Stannard B, East-Palmer J, Smith NC, Perkins SN, Fuchs-Young R, Barrett JC, Hursting SD, LeRoith D.

Endocrinology. 2006 Dec;147(12):5826-34. Epub 2006 Sep 7.


Crosstalk between PDGF and IGF-I receptors in rat liver myofibroblasts: implication for liver fibrogenesis.

Novosyadlyy R, Dudas J, Pannem R, Ramadori G, Scharf JG.

Lab Invest. 2006 Jul;86(7):710-23. Epub 2006 May 8.


Upregulation of heme oxygenase-1 gene by turpentine oil-induced localized inflammation: involvement of interleukin-6.

Tron K, Novosyadlyy R, Dudas J, Samoylenko A, Kietzmann T, Ramadori G.

Lab Invest. 2005 Mar;85(3):376-87.


Expression and regulation of the insulin-like growth factor axis components in rat liver myofibroblasts.

Novosyadlyy R, Tron K, Dudas J, Ramadori G, Scharf JG.

J Cell Physiol. 2004 Jun;199(3):388-98.


Insulin-like growth factor (IGF)-binding protein-1 is highly induced during acute carbon tetrachloride liver injury and potentiates the IGF-I-stimulated activation of rat hepatic stellate cells.

Scharf JG, Dombrowski F, Novosyadlyy R, Eisenbach C, Demori I, K├╝bler B, Braulke T.

Endocrinology. 2004 Jul;145(7):3463-72. Epub 2004 Apr 7.


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