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Items: 43


New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord.

Andrews MG, Kong J, Novitch BG, Butler SJ.

Curr Top Dev Biol. 2019;132:417-450. doi: 10.1016/bs.ctdb.2018.12.010. Epub 2018 Dec 26.


Molecular specification of facial branchial motor neurons in vertebrates.

Han AY, Gupta S, Novitch BG.

Dev Biol. 2018 Apr 1;436(1):5-13. doi: 10.1016/j.ydbio.2018.01.019. Epub 2018 Jan 31. Review.


Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.

Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG.

PLoS Biol. 2018 Feb 1;16(2):e2003127. doi: 10.1371/journal.pbio.2003127. eCollection 2018 Feb.


Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.

Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG.

Cell Rep. 2017 Oct 10;21(2):517-532. doi: 10.1016/j.celrep.2017.09.047.


Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).

Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8770-8775. doi: 10.1073/pnas.1705091114. Epub 2017 Jul 31.


Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord.

Varadarajan SG, Kong JH, Phan KD, Kao TJ, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ.

Neuron. 2017 May 17;94(4):790-799.e3. doi: 10.1016/j.neuron.2017.03.007. Epub 2017 Apr 21.


25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.

Li C, Deng YQ, Wang S, Ma F, Aliyari R, Huang XY, Zhang NN, Watanabe M, Dong HL, Liu P, Li XF, Ye Q, Tian M, Hong S, Fan J, Zhao H, Li L, Vishlaghi N, Buth JE, Au C, Liu Y, Lu N, Du P, Qin FX, Zhang B, Gong D, Dai X, Sun R, Novitch BG, Xu Z, Qin CF, Cheng G.

Immunity. 2017 Mar 21;46(3):446-456. doi: 10.1016/j.immuni.2017.02.012. Epub 2017 Mar 14.


Cbx3 maintains lineage specificity during neural differentiation.

Huang C, Su T, Xue Y, Cheng C, Lay FD, McKee RA, Li M, Vashisht A, Wohlschlegel J, Novitch BG, Plath K, Kurdistani SK, Carey M.

Genes Dev. 2017 Feb 1;31(3):241-246. doi: 10.1101/gad.292169.116.


The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation.

Linares AJ, Lin CH, Damianov A, Adams KL, Novitch BG, Black DL.

Elife. 2015 Dec 24;4:e09268. doi: 10.7554/eLife.09268.


Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling.

Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG.

Dev Cell. 2015 May 26;33(4):373-87. doi: 10.1016/j.devcel.2015.03.005. Epub 2015 Apr 30.


Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.

Adams KL, Rousso DL, Umbach JA, Novitch BG.

Nat Commun. 2015 Apr 14;6:6778. doi: 10.1038/ncomms7778.


Neuronal organization: unsticking the cadherin code.

Pearson CA, Butler SJ, Novitch BG.

Curr Biol. 2014 Dec 1;24(23):R1127-9. doi: 10.1016/j.cub.2014.10.034. Epub 2014 Dec 1.


Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling.

Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R.

Cell Rep. 2014 Jan 16;6(1):168-181. doi: 10.1016/j.celrep.2013.12.003. Epub 2013 Dec 27.


Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.

Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19438-43. doi: 10.1073/pnas.1315075110. Epub 2013 Nov 11.


PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors.

Gaber ZB, Butler SJ, Novitch BG.

PLoS Biol. 2013 Oct;11(10):e1001676. doi: 10.1371/journal.pbio.1001676. Epub 2013 Oct 8.


My brain told me to do it.

Kong JH, Butler SJ, Novitch BG.

Dev Cell. 2013 Jun 10;25(5):436-8. doi: 10.1016/j.devcel.2013.05.019.


Retinoid acid specifies neuronal identity through graded expression of Ascl1.

Jacob J, Kong J, Moore S, Milton C, Sasai N, Gonzalez-Quevedo R, Terriente J, Imayoshi I, Kageyama R, Wilkinson DG, Novitch BG, Briscoe J.

Curr Biol. 2013 Mar 4;23(5):412-8. doi: 10.1016/j.cub.2013.01.046. Epub 2013 Feb 14. Erratum in: Curr Biol. 2013 Apr 8;23(7):632. Kageyama, Ryoichoro [corrected to Kageyama, Ryoichiro].


ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities.

Wang Y, Kim E, Wang X, Novitch BG, Yoshikawa K, Chang LS, Zhu Y.

Cell. 2012 Aug 17;150(4):816-30. doi: 10.1016/j.cell.2012.06.034.


Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification.

Roy A, Francius C, Rousso DL, Seuntjens E, Debruyn J, Luxenhofer G, Huber AB, Huylebroeck D, Novitch BG, Clotman F.

Development. 2012 Sep;139(17):3109-19. doi: 10.1242/dev.078501. Epub 2012 Jul 25.


Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons.

Umbach JA, Adams KL, Gundersen CB, Novitch BG.

PLoS One. 2012;7(5):e36049. doi: 10.1371/journal.pone.0036049. Epub 2012 May 4.


Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.

Rousso DL, Pearson CA, Gaber ZB, Miquelajauregui A, Li S, Portera-Cailliau C, Morrisey EE, Novitch BG.

Neuron. 2012 Apr 26;74(2):314-30. doi: 10.1016/j.neuron.2012.02.024.


Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis.

Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B.

Neuron. 2012 Apr 12;74(1):79-94. doi: 10.1016/j.neuron.2012.01.024.


Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling.

Skaggs K, Martin DM, Novitch BG.

Development. 2011 Aug;138(15):3199-211. doi: 10.1242/dev.057281.


All the embryo's a stage, and Olig2 in its time plays many parts.

Gaber ZB, Novitch BG.

Neuron. 2011 Mar 10;69(5):833-5. doi: 10.1016/j.neuron.2011.02.037.


Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb.

Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB.

PLoS Biol. 2011 Feb;9(2):e1001020. doi: 10.1371/journal.pbio.1001020. Epub 2011 Feb 22.


Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.

Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A.

PLoS Biol. 2010 Aug 10;8(8):e1000446. doi: 10.1371/journal.pbio.1000446.


Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.

Dessaud E, Ribes V, Balaskas N, Yang LL, Pierani A, Kicheva A, Novitch BG, Briscoe J, Sasai N.

PLoS Biol. 2010 Jun 1;8(6):e1000382. doi: 10.1371/journal.pbio.1000382.


Reducing the mystery of neuronal differentiation.

Novitch BG, Butler SJ.

Cell. 2009 Sep 18;138(6):1062-4. doi: 10.1016/j.cell.2009.09.001.


Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.

Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE.

Stem Cells. 2009 Apr;27(4):806-11. doi: 10.1002/stem.31.


Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons.

Rousso DL, Gaber ZB, Wellik D, Morrisey EE, Novitch BG.

Neuron. 2008 Jul 31;59(2):226-40. doi: 10.1016/j.neuron.2008.06.025.


Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism.

Dessaud E, Yang LL, Hill K, Cox B, Ulloa F, Ribeiro A, Mynett A, Novitch BG, Briscoe J.

Nature. 2007 Nov 29;450(7170):717-20.


Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube.

Briscoe J, Novitch BG.

Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):57-70. Review.


Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.

Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1551-6. Epub 2006 Jan 23.


Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells.

Marshall CA, Novitch BG, Goldman JE.

J Neurosci. 2005 Aug 10;25(32):7289-98.


Vertebrate neurogenesis is counteracted by Sox1-3 activity.

Bylund M, Andersson E, Novitch BG, Muhr J.

Nat Neurosci. 2003 Nov;6(11):1162-8. Epub 2003 Sep 28.


PAK4 kinase is essential for embryonic viability and for proper neuronal development.

Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A.

Mol Cell Biol. 2003 Oct;23(20):7122-33.


pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation.

Novitch BG, Spicer DB, Kim PS, Cheung WL, Lassar AB.

Curr Biol. 1999 May 6;9(9):449-59.


Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth.

Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB, Kaelin WG Jr.

Genes Dev. 1998 Jan 1;12(1):95-106.


Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation.

Skapek SX, Rhee J, Kim PS, Novitch BG, Lassar AB.

Mol Cell Biol. 1996 Dec;16(12):7043-53.


Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB.

Science. 1995 Feb 17;267(5200):1018-21.


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