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Items: 1 to 50 of 137

1.

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ.

Heidari Z, Chrisman IM, Nemetchek MD, Novick SJ, Blayo AL, Patton T, Mendes DE, Diaz P, Kamenecka TM, Griffin PR, Hughes TS.

Nat Commun. 2019 Dec 20;10(1):5825. doi: 10.1038/s41467-019-13768-0.

2.

Design of an in vitro biocatalytic cascade for the manufacture of islatravir.

Huffman MA, Fryszkowska A, Alvizo O, Borra-Garske M, Campos KR, Canada KA, Devine PN, Duan D, Forstater JH, Grosser ST, Halsey HM, Hughes GJ, Jo J, Joyce LA, Kolev JN, Liang J, Maloney KM, Mann BF, Marshall NM, McLaughlin M, Moore JC, Murphy GS, Nawrat CC, Nazor J, Novick S, Patel NR, Rodriguez-Granillo A, Robaire SA, Sherer EC, Truppo MD, Whittaker AM, Verma D, Xiao L, Xu Y, Yang H.

Science. 2019 Dec 6;366(6470):1255-1259. doi: 10.1126/science.aay8484.

PMID:
31806816
3.

Comparisons of outlier tests for potency bioassays.

Sondag P, Zeng L, Yu B, Yang H, Novick S.

Pharm Stat. 2019 Nov 24. doi: 10.1002/pst.1984. [Epub ahead of print]

PMID:
31762118
4.

Correction: HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists.

Strutzenberg TS, Garcia-Ordonez RD, Novick SJ, Park H, Chang MR, Doebellin C, He Y, Patouret R, Kamenecka TM, Griffin PR.

Elife. 2019 Oct 18;8. pii: e52847. doi: 10.7554/eLife.52847.

5.

Population Pharmacokinetics of an Anti-PD-L1 Antibody, Durvalumab in Patients with Hematologic Malignancies.

Ogasawara K, Newhall K, Maxwell SE, Dell'Aringa J, Komashko V, Kilavuz N, Delarue R, Czuczman M, Sternas L, Rose S, Beach CL, Novick S, Zhou S, Palmisano M, Li Y.

Clin Pharmacokinet. 2020 Feb;59(2):217-227. doi: 10.1007/s40262-019-00804-x.

6.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM.

Cell. 2019 Jul 11;178(2):507-508. doi: 10.1016/j.cell.2019.06.028. No abstract available.

7.

Structure and Dynamics of the Methane-Propane van der Waals Complex.

Peterson KI, Pullman DP, Lin W, Minei AJ, Arsenault EA, Novick SE.

J Phys Chem A. 2019 Jun 27;123(25):5274-5282. doi: 10.1021/acs.jpca.9b02486. Epub 2019 Jun 12.

PMID:
31188586
8.

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists.

Strutzenberg TS, Garcia-Ordonez RD, Novick SJ, Park H, Chang MR, Doebellin C, He Y, Patouret R, Kamenecka TM, Griffin PR.

Elife. 2019 Jun 7;8. pii: e47172. doi: 10.7554/eLife.47172. Erratum in: Elife. 2019 Oct 18;8:.

9.

Detecting bliss synergy in in vivo combination studies with a tumor kinetic model.

Zhao W, Vicini P, Novick S, Anderton J, Davies G, DAngelo G, O'Day T, Yu B, Harper J, Narwal R, Roskos L, Yang H.

Pharm Stat. 2019 Nov;18(6):688-699. doi: 10.1002/pst.1952. Epub 2019 May 29.

PMID:
31140720
10.

Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways.

Chang MR, Ciesla A, Strutzenberg TS, Novick SJ, He Y, Garcia-Ordonez RD, Frkic RL, Bruning JB, Kamenecka TM, Griffin PR.

ACS Chem Biol. 2019 May 17;14(5):1051-1062. doi: 10.1021/acschembio.9b00236. Epub 2019 Apr 15.

PMID:
30951276
11.

A fast and reliable test for parallelism in bioassay.

Novick S, Yang H.

J Biopharm Stat. 2019;29(6):1011-1023. doi: 10.1080/10543406.2019.1572615. Epub 2019 Feb 4.

PMID:
30712462
12.

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.

Zheng J, Wang C, Chang MR, Devarkar SC, Schweibenz B, Crynen GC, Garcia-Ordonez RD, Pascal BD, Novick SJ, Patel SS, Marcotrigiano J, Griffin PR.

Nat Commun. 2018 Dec 18;9(1):5366. doi: 10.1038/s41467-018-07780-z.

13.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM.

Cell. 2018 Dec 13;175(7):1756-1768.e17. doi: 10.1016/j.cell.2018.10.025. Erratum in: Cell. 2019 Jul 11;178(2):507-508.

14.

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.

Patil DN, Rangarajan ES, Novick SJ, Pascal BD, Kojetin DJ, Griffin PR, Izard T, Martemyanov KA.

Elife. 2018 Dec 12;7. pii: e42150. doi: 10.7554/eLife.42150.

15.

Expectations for Phase-Appropriate Drug Substance and Drug Product Specifications for Early-Stage Protein Therapeutics.

Kretsinger J, Frantz N, Hart SA, Kelley WP, Kitchen B, Novick S, Rellahan B, Stranges D, Stroop CJM, Yin P, Gastens MH.

J Pharm Sci. 2019 Apr;108(4):1442-1452. doi: 10.1016/j.xphs.2018.11.042. Epub 2018 Dec 6.

PMID:
30528942
16.

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.

Yan Y, Zhou XE, Novick SJ, Shaw SJ, Li Y, Brunzelle JS, Hitoshi Y, Griffin PR, Xu HE, Melcher K.

J Biol Chem. 2019 Jan 18;294(3):953-967. doi: 10.1074/jbc.RA118.004883. Epub 2018 Nov 26.

17.

Torsional splitting and the four-fold barrier to internal rotation: The rotational spectra of vinylsulfur pentafluoride.

Orellana W, Stephens SL, Pringle WC, Groner P, Novick SE, Cooke SA.

J Chem Phys. 2018 Oct 14;149(14):144304. doi: 10.1063/1.5050021.

PMID:
30316255
18.

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.

Zhang C, Konermann S, Brideau NJ, Lotfy P, Wu X, Novick SJ, Strutzenberg T, Griffin PR, Hsu PD, Lyumkis D.

Cell. 2018 Sep 20;175(1):212-223.e17. doi: 10.1016/j.cell.2018.09.001.

19.

Identification of potent RORβ modulators: Scaffold variation.

Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Novick S, Ciesla A, Campbell S, Solt LA, Griffin PR, Kamenecka TM.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3210-3215. doi: 10.1016/j.bmcl.2018.08.017. Epub 2018 Aug 16.

20.

Effect of a statistical outlier in potency bioassays.

Sondag P, Zeng L, Yu B, Rousseau R, Boulanger B, Yang H, Novick S.

Pharm Stat. 2018 Nov;17(6):701-709. doi: 10.1002/pst.1893. Epub 2018 Aug 15.

PMID:
30112804
21.

Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration.

Lin H, Long JZ, Roche AM, Svensson KJ, Dou FY, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM.

J Med Chem. 2018 Apr 12;61(7):3224-3230. doi: 10.1021/acs.jmedchem.8b00029. Epub 2018 Mar 22.

22.

A Novel Method for Qualification of a Potency Assay through Partial Computer Simulation.

Novick S, Sondag P, Schofield T, Miller K.

PDA J Pharm Sci Technol. 2018 May-Jun;72(3):249-263. doi: 10.5731/pdajpst.2017.008094. Epub 2018 Feb 14.

PMID:
29444993
23.

Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988.

Frkic RL, Chua BS, Shin Y, Pascal BD, Novick SJ, Kamenecka TM, Griffin PR, Bruning JB.

Nucl Receptor Res. 2018;5. pii: 101350. doi: 10.11131/2018/101350.

24.

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.

Zheng J, Chang MR, Stites RE, Wang Y, Bruning JB, Pascal BD, Novick SJ, Garcia-Ordonez RD, Stayrook KR, Chalmers MJ, Dodge JA, Griffin PR.

Nat Commun. 2017 Oct 13;8(1):923. doi: 10.1038/s41467-017-00978-7.

25.

Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.

Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA.

J Mol Biol. 2017 Nov 24;429(23):3696-3716. doi: 10.1016/j.jmb.2017.09.016. Epub 2017 Sep 29.

26.

Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA.

de Vera IMS, Zheng J, Novick S, Shang J, Hughes TS, Brust R, Munoz-Tello P, Gardner WJ Jr, Marciano DP, Kong X, Griffin PR, Kojetin DJ.

Structure. 2017 Oct 3;25(10):1506-1518.e4. doi: 10.1016/j.str.2017.07.019. Epub 2017 Sep 7.

27.

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing.

Gu X, Yan Y, Novick SJ, Kovach A, Goswami D, Ke J, Tan MHE, Wang L, Li X, de Waal PW, Webb MR, Griffin PR, Xu HE, Melcher K.

J Biol Chem. 2017 Jul 28;292(30):12653-12666. doi: 10.1074/jbc.M117.793018. Epub 2017 Jun 14.

28.

The covalent interaction between dihydrogen and gold: A rotational spectroscopic study of H2-AuCl.

Obenchain DA, Frank DS, Grubbs GS 2nd, Pickett HM, Novick SE.

J Chem Phys. 2017 May 28;146(20):204302. doi: 10.1063/1.4983042.

29.

Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691c. No abstract available.

PMID:
28514424
30.

Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 May 17;13(6):691. doi: 10.1038/nchembio0617-691b. No abstract available.

PMID:
28514419
31.

Content uniformity testing for stratified samples via parametric tolerance interval testing.

Novick S, Hudson-Curtis B.

J Biopharm Stat. 2018;28(3):463-474. doi: 10.1080/10543406.2017.1321005. Epub 2017 May 8.

PMID:
28422566
32.

Efficacy and safety of nilotinib in patients with KIT-mutated metastatic or inoperable melanoma: final results from the global, single-arm, phase II TEAM trial.

Guo J, Carvajal RD, Dummer R, Hauschild A, Daud A, Bastian BC, Markovic SN, Queirolo P, Arance A, Berking C, Camargo V, Herchenhorn D, Petrella TM, Schadendorf D, Sharfman W, Testori A, Novick S, Hertle S, Nourry C, Chen Q, Hodi FS.

Ann Oncol. 2017 Jun 1;28(6):1380-1387. doi: 10.1093/annonc/mdx079.

33.

Adhesion and invasion of Streptococcus pneumoniae to primary and secondary respiratory epithelial cells.

Novick S, Shagan M, Blau K, Lifshitz S, Givon-Lavi N, Grossman N, Bodner L, Dagan R, Mizrachi Nebenzahl Y.

Mol Med Rep. 2017 Jan;15(1):65-74. doi: 10.3892/mmr.2016.5996. Epub 2016 Dec 6.

34.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists.

Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Kuruvilla DS, Novick SJ, Lin L, Cameron MD, Griffin PR, Kamenecka TM.

ChemMedChem. 2016 Dec 6;11(23):2607-2620. doi: 10.1002/cmdc.201600491. Epub 2016 Nov 23.

35.

Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW.

Nat Chem Biol. 2017 Jan;13(1):111-118. doi: 10.1038/nchembio.2236. Epub 2016 Nov 21. Erratum in: Nat Chem Biol. 2017 May 17;13(6):691. Nat Chem Biol. 2017 May 17;13(6):691.

36.

A Study of 2-Iodobutane by Rotational Spectroscopy.

Arsenault EA, Obenchain DA, Choi YJ, Blake TA, Cooke SA, Novick SE.

J Phys Chem A. 2016 Sep 15;120(36):7145-51. doi: 10.1021/acs.jpca.6b06938. Epub 2016 Sep 1.

PMID:
27556339
37.

Setting Alert and Action Limits in the Presence of Significant Amount of Censoring in Data.

Novick SJ, Zhao W, Yang H.

PDA J Pharm Sci Technol. 2017 1/2;71(1):20-32. doi: 10.5731/pdajpst.2016.006684. Epub 2016 Aug 11.

PMID:
27516490
38.

On Statistical Approaches for Demonstrating Analytical Similarity in the Presence of Correlation.

Yang H, Novick S, Burdick RK.

PDA J Pharm Sci Technol. 2016 11/12;70(6):547-559. Epub 2016 Jun 20.

PMID:
27325594
39.

Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform.

Cummins DJ, Espada A, Novick SJ, Molina-Martin M, Stites RE, Espinosa JF, Broughton H, Goswami D, Pascal BD, Dodge JA, Chalmers MJ, Griffin PR.

Anal Chem. 2016 Jun 21;88(12):6607-14. doi: 10.1021/acs.analchem.6b01650. Epub 2016 Jun 13.

PMID:
27224086
40.

A new PK equivalence test for a bridging study.

Novick SJ, Zhang X, Yang H.

J Biopharm Stat. 2016;26(5):992-1002. doi: 10.1080/10543406.2016.1148712. Epub 2016 Feb 16.

PMID:
26882145
41.

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL.

Elife. 2016 Feb 2;5. pii: e12792. doi: 10.7554/eLife.12792.

42.

Synthetic RORγt Agonists Enhance Protective Immunity.

Chang MR, Dharmarajan V, Doebelin C, Garcia-Ordonez RD, Novick SJ, Kuruvilla DS, Kamenecka TM, Griffin PR.

ACS Chem Biol. 2016 Apr 15;11(4):1012-8. doi: 10.1021/acschembio.5b00899. Epub 2016 Jan 25.

43.

Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection.

Hoover J, Lewandowski T, Straub RJ, Novick SJ, DeMarsh P, Aubart K, Rittenhouse S, Zalacain M.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):180-9. doi: 10.1128/AAC.01842-15. Print 2016 Jan.

44.

A Study of the Monohydrate and Dihydrate Complexes of Perfluoropropionic Acid Using Chirped-Pulse Fourier Transform Microwave (CP-FTMW) Spectroscopy.

Grubbs GS 2nd, Obenchain DA, Frank DS, Novick SE, Cooke SA, Serrato A 3rd, Lin W.

J Phys Chem A. 2015 Oct 22;119(42):10475-80. doi: 10.1021/acs.jpca.5b08347. Epub 2015 Oct 8.

PMID:
26421936
45.

The position of deuterium in HOD-NNO as determined by structural and nuclear quadrupole coupling constants.

Obenchain DA, Frank DS, Novick SE, Klemperer W.

J Chem Phys. 2015 Aug 28;143(8):084301. doi: 10.1063/1.4928687.

PMID:
26328837
46.

A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions.

Peng Y, Zeng W, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA.

Chem Biol. 2015 Aug 20;22(8):1134-43. doi: 10.1016/j.chembiol.2015.07.011. Epub 2015 Aug 13.

47.

Erratum: "H2-AgCl: A spectroscopic study of a dihydrogen complex" [J. Chem. Phys. 141, 114306 (2014)].

Grubbs GS 2nd, Obenchain DA, Pickett HM, Novick SE.

J Chem Phys. 2015 Jul 14;143(2):029901. doi: 10.1063/1.4926540. No abstract available.

PMID:
26178133
48.

Nilotinib versus imatinib for GIST - Authors' reply.

Blay JY, Hurh E, Green S, Novick S.

Lancet Oncol. 2015 Jul;16(7):e311-2. doi: 10.1016/S1470-2045(15)00016-9. No abstract available.

PMID:
26149878
49.

Internal dynamics in the molecular complex of CF3CN and H2O.

Lin W, Wu A, Lu X, Tang X, Obenchain DA, Novick SE.

Phys Chem Chem Phys. 2015 Jul 14;17(26):17266-70. doi: 10.1039/c5cp01550b.

PMID:
26073642
50.

Pharmacological repression of PPARγ promotes osteogenesis.

Marciano DP, Kuruvilla DS, Boregowda SV, Asteian A, Hughes TS, Garcia-Ordonez R, Corzo CA, Khan TM, Novick SJ, Park H, Kojetin DJ, Phinney DG, Bruning JB, Kamenecka TM, Griffin PR.

Nat Commun. 2015 Jun 12;6:7443. doi: 10.1038/ncomms8443.

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