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Pathogenicity Islands and Their Role in Staphylococcal Biology.

Novick RP.

Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.GPP3-0062-2019.


Identification of a Molecular Latch that Regulates Staphylococcal Virulence.

Xie Q, Zhao A, Jeffrey PD, Kim MK, Bassler BL, Stone HA, Novick RP, Muir TW.

Cell Chem Biol. 2019 Apr 18;26(4):548-558.e4. doi: 10.1016/j.chembiol.2019.01.006. Epub 2019 Feb 14.


Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure infections in mice.

Ram G, Ross HF, Novick RP, Rodriguez-Pagan I, Jiang D.

Nat Biotechnol. 2018 Nov;36(10):971-976. doi: 10.1038/nbt.4203. Epub 2018 Sep 24.


Staphylococcal pathogenicity islands-movers and shakers in the genomic firmament.

Novick RP, Ram G.

Curr Opin Microbiol. 2017 Aug;38:197-204. doi: 10.1016/j.mib.2017.08.001. Epub 2017 Nov 1. Review.


Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence.

Wang B, Zhao A, Xie Q, Olinares PD, Chait BT, Novick RP, Muir TW.

Cell Chem Biol. 2017 Jan 19;24(1):76-86. doi: 10.1016/j.chembiol.2016.12.008. Epub 2017 Jan 5.


Phage-inducible islands in the Gram-positive cocci.

Martínez-Rubio R, Quiles-Puchalt N, Martí M, Humphrey S, Ram G, Smyth D, Chen J, Novick RP, Penadés JR.

ISME J. 2017 Apr;11(4):1029-1042. doi: 10.1038/ismej.2016.163. Epub 2016 Dec 13.


The Floating (Pathogenicity) Island: A Genomic Dessert.

Novick RP, Ram G.

Trends Genet. 2016 Feb;32(2):114-126. doi: 10.1016/j.tig.2015.11.005. Epub 2015 Dec 29. Review.


Virus Satellites Drive Viral Evolution and Ecology.

Frígols B, Quiles-Puchalt N, Mir-Sanchis I, Donderis J, Elena SF, Buckling A, Novick RP, Marina A, Penadés JR.

PLoS Genet. 2015 Oct 23;11(10):e1005609. doi: 10.1371/journal.pgen.1005609. eCollection 2015 Oct.


An insight into staphylococcal pathogenicity island-mediated interference with phage late gene transcription.

Ram G, Chen J, Ross HF, Novick RP.

Bacteriophage. 2015 Jun 11;5(2):e1028608. eCollection 2015 Apr-Jun.


Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence.

Wang B, Zhao A, Novick RP, Muir TW.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10679-84. doi: 10.1073/pnas.1506030112. Epub 2015 Aug 10.


Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus.

Johnson JG, Wang B, Debelouchina GT, Novick RP, Muir TW.

Chembiochem. 2015 May 4;16(7):1093-100. doi: 10.1002/cbic.201500006. Epub 2015 Mar 20.


An rpsL-based allelic exchange vector for Staphylococcus aureus.

Chen J, Ram G, Yoong P, Penadés JR, Shopsin B, Novick RP.

Plasmid. 2015 May;79:8-14. doi: 10.1016/j.plasmid.2015.02.002. Epub 2015 Feb 7.


Bacteriophage-mediated spread of bacterial virulence genes.

Penadés JR, Chen J, Quiles-Puchalt N, Carpena N, Novick RP.

Curr Opin Microbiol. 2015 Feb;23:171-8. doi: 10.1016/j.mib.2014.11.019. Epub 2014 Dec 19. Review.


Pathogenicity island-directed transfer of unlinked chromosomal virulence genes.

Chen J, Ram G, Penadés JR, Brown S, Novick RP.

Mol Cell. 2015 Jan 8;57(1):138-49. doi: 10.1016/j.molcel.2014.11.011. Epub 2014 Dec 11.


Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages.

Chen J, Carpena N, Quiles-Puchalt N, Ram G, Novick RP, Penadés JR.

ISME J. 2015 May;9(5):1260-3. doi: 10.1038/ismej.2014.187. Epub 2014 Oct 14.


Precisely modulated pathogenicity island interference with late phage gene transcription.

Ram G, Chen J, Ross HF, Novick RP.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14536-41. doi: 10.1073/pnas.1406749111. Epub 2014 Sep 22.


Single-copy vectors for integration at the SaPI1 attachment site for Staphylococcus aureus.

Chen J, Yoong P, Ram G, Torres VJ, Novick RP.

Plasmid. 2014 Nov;76:1-7. doi: 10.1016/j.plasmid.2014.08.001. Epub 2014 Sep 2.


Staphylococcal pathogenicity island DNA packaging system involving cos-site packaging and phage-encoded HNH endonucleases.

Quiles-Puchalt N, Carpena N, Alonso JC, Novick RP, Marina A, Penadés JR.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6016-21. doi: 10.1073/pnas.1320538111. Epub 2014 Apr 7.


Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions.

Wang B, Zhao A, Novick RP, Muir TW.

Mol Cell. 2014 Mar 20;53(6):929-40. doi: 10.1016/j.molcel.2014.02.029.


Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils.

Nielsen A, Månsson M, Bojer MS, Gram L, Larsen TO, Novick RP, Frees D, Frøkiær H, Ingmer H.

PLoS One. 2014 Jan 8;9(1):e84992. doi: 10.1371/journal.pone.0084992. eCollection 2014.


A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria.

Quiles-Puchalt N, Tormo-Más MÁ, Campoy S, Toledo-Arana A, Monedero V, Lasa I, Novick RP, Christie GE, Penadés JR.

Nucleic Acids Res. 2013 Aug;41(15):7260-75. doi: 10.1093/nar/gkt508. Epub 2013 Jun 14.


Intravital two-photon microscopy of host-pathogen interactions in a mouse model of Staphylococcus aureus skin abscess formation.

Liese J, Rooijakkers SH, van Strijp JA, Novick RP, Dustin ML.

Cell Microbiol. 2013 Jun;15(6):891-909. doi: 10.1111/cmi.12085. Epub 2012 Dec 24.


Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism.

Ram G, Chen J, Kumar K, Ross HF, Ubeda C, Damle PK, Lane KD, Penadés JR, Christie GE, Novick RP.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16300-5. doi: 10.1073/pnas.1204615109. Epub 2012 Sep 18.


Nasal carriage as a source of agr-defective Staphylococcus aureus bacteremia.

Smyth DS, Kafer JM, Wasserman GA, Velickovic L, Mathema B, Holzman RS, Knipe TA, Becker K, von Eiff C, Peters G, Chen L, Kreiswirth BN, Novick RP, Shopsin B.

J Infect Dis. 2012 Oct;206(8):1168-77. Epub 2012 Aug 2.


Control of Staphylococcus aureus pathogenicity island excision.

Mir-Sanchis I, Martínez-Rubio R, Martí M, Chen J, Lasa Í, Novick RP, Tormo-Más MÁ, Penadés JR.

Mol Microbiol. 2012 Sep;85(5):833-45. doi: 10.1111/j.1365-2958.2012.08145.x. Epub 2012 Jul 11.


The roles of SaPI1 proteins gp7 (CpmA) and gp6 (CpmB) in capsid size determination and helper phage interference.

Damle PK, Wall EA, Spilman MS, Dearborn AD, Ram G, Novick RP, Dokland T, Christie GE.

Virology. 2012 Oct 25;432(2):277-82. doi: 10.1016/j.virol.2012.05.026. Epub 2012 Jun 17.


Allele-dependent differences in quorum-sensing dynamics result in variant expression of virulence genes in Staphylococcus aureus.

Geisinger E, Chen J, Novick RP.

J Bacteriol. 2012 Jun;194(11):2854-64. doi: 10.1128/JB.06685-11. Epub 2012 Mar 30.


Structure-function analysis of the SaPIbov1 replication origin in Staphylococcus aureus.

Ubeda C, Tormo-Más MÁ, Penadés JR, Novick RP.

Plasmid. 2012 Mar;67(2):183-90. doi: 10.1016/j.plasmid.2012.01.006. Epub 2012 Jan 20.


Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo.

Alonzo F 3rd, Benson MA, Chen J, Novick RP, Shopsin B, Torres VJ.

Mol Microbiol. 2012 Jan;83(2):423-35. doi: 10.1111/j.1365-2958.2011.07942.x. Epub 2011 Dec 20.


Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner.

Benson MA, Lilo S, Wasserman GA, Thoendel M, Smith A, Horswill AR, Fraser J, Novick RP, Shopsin B, Torres VJ.

Mol Microbiol. 2011 Aug;81(3):659-75. doi: 10.1111/j.1365-2958.2011.07720.x. Epub 2011 Jun 16.


RinA controls phage-mediated packaging and transfer of virulence genes in Gram-positive bacteria.

Ferrer MD, Quiles-Puchalt N, Harwich MD, Tormo-Más MÁ, Campoy S, Barbé J, Lasa I, Novick RP, Christie GE, Penadés JR.

Nucleic Acids Res. 2011 Aug;39(14):5866-78. doi: 10.1093/nar/gkr158. Epub 2011 Mar 30.


Mutations in agr do not persist in natural populations of methicillin-resistant Staphylococcus aureus.

Shopsin B, Eaton C, Wasserman GA, Mathema B, Adhikari RP, Agolory S, Altman DR, Holzman RS, Kreiswirth BN, Novick RP.

J Infect Dis. 2010 Nov 15;202(10):1593-9. doi: 10.1086/656915. Epub 2010 Oct 13.


The complete genomes of Staphylococcus aureus bacteriophages 80 and 80α--implications for the specificity of SaPI mobilization.

Christie GE, Matthews AM, King DG, Lane KD, Olivarez NP, Tallent SM, Gill SR, Novick RP.

Virology. 2010 Nov 25;407(2):381-90. doi: 10.1016/j.virol.2010.08.036. Epub 2010 Sep 25.


Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein.

Viana D, Blanco J, Tormo-Más MA, Selva L, Guinane CM, Baselga R, Corpa J, Lasa I, Novick RP, Fitzgerald JR, Penadés JR.

Mol Microbiol. 2010 Sep;77(6):1583-94.


The phage-related chromosomal islands of Gram-positive bacteria.

Novick RP, Christie GE, Penadés JR.

Nat Rev Microbiol. 2010 Aug;8(8):541-51. doi: 10.1038/nrmicro2393. Review.


Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands.

Tormo-Más MA, Mir I, Shrestha A, Tallent SM, Campoy S, Lasa I, Barbé J, Novick RP, Christie GE, Penadés JR.

Nature. 2010 Jun 10;465(7299):779-82. doi: 10.1038/nature09065. Epub 2010 May 16.


Climate change and the integrity of science.

Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman PJ, Blackburn E, Blamont JE, Botchan MR, Boyer JS, Boyle EA, Branton D, Briggs SP, Briggs WR, Brill WJ, Britten RJ, Broecker WS, Brown JH, Brown PO, Brunger AT, Cairns J Jr, Canfield DE, Carpenter SR, Carrington JC, Cashmore AR, Castilla JC, Cazenave A, Chapin FS 3rd, Ciechanover AJ, Clapham DE, Clark WC, Clayton RN, Coe MD, Conwell EM, Cowling EB, Cowling RM, Cox CS, Croteau RB, Crothers DM, Crutzen PJ, Daily GC, Dalrymple GB, Dangl JL, Darst SA, Davies DR, Davis MB, De Camilli PV, Dean C, DeFries RS, Deisenhofer J, Delmer DP, DeLong EF, DeRosier DJ, Diener TO, Dirzo R, Dixon JE, Donoghue MJ, Doolittle RF, Dunne T, Ehrlich PR, Eisenstadt SN, Eisner T, Emanuel KA, Englander SW, Ernst WG, Falkowski PG, Feher G, Ferejohn JA, Fersht A, Fischer EH, Fischer R, Flannery KV, Frank J, Frey PA, Fridovich I, Frieden C, Futuyma DJ, Gardner WR, Garrett CJ, Gilbert W, Goldberg RB, Goodenough WH, Goodman CS, Goodman M, Greengard P, Hake S, Hammel G, Hanson S, Harrison SC, Hart SR, Hartl DL, Haselkorn R, Hawkes K, Hayes JM, Hille B, Hökfelt T, House JS, Hout M, Hunten DM, Izquierdo IA, Jagendorf AT, Janzen DH, Jeanloz R, Jencks CS, Jury WA, Kaback HR, Kailath T, Kay P, Kay SA, Kennedy D, Kerr A, Kessler RC, Khush GS, Kieffer SW, Kirch PV, Kirk K, Kivelson MG, Klinman JP, Klug A, Knopoff L, Kornberg H, Kutzbach JE, Lagarias JC, Lambeck K, Landy A, Langmuir CH, Larkins BA, Le Pichon XT, Lenski RE, Leopold EB, Levin SA, Levitt M, Likens GE, Lippincott-Schwartz J, Lorand L, Lovejoy CO, Lynch M, Mabogunje AL, Malone TF, Manabe S, Marcus J, Massey DS, McWilliams JC, Medina E, Melosh HJ, Meltzer DJ, Michener CD, Miles EL, Mooney HA, Moore PB, Morel FM, Mosley-Thompson ES, Moss B, Munk WH, Myers N, Nair GB, Nathans J, Nester EW, Nicoll RA, Novick RP, O'Connell JF, Olsen PE, Opdyke ND, Oster GF, Ostrom E, Pace NR, Paine RT, Palmiter RD, Pedlosky J, Petsko GA, Pettengill GH, Philander SG, Piperno DR, Pollard TD, Price PB Jr, Reichard PA, Reskin BF, Ricklefs RE, Rivest RL, Roberts JD, Romney AK, Rossmann MG, Russell DW, Rutter WJ, Sabloff JA, Sagdeev RZ, Sahlins MD, Salmond A, Sanes JR, Schekman R, Schellnhuber J, Schindler DW, Schmitt J, Schneider SH, Schramm VL, Sederoff RR, Shatz CJ, Sherman F, Sidman RL, Sieh K, Simons EL, Singer BH, Singer MF, Skyrms B, Sleep NH, Smith BD, Snyder SH, Sokal RR, Spencer CS, Steitz TA, Strier KB, Südhof TC, Taylor SS, Terborgh J, Thomas DH, Thompson LG, Tjian RT, Turner MG, Uyeda S, Valentine JW, Valentine JS, Van Etten JL, van Holde KE, Vaughan M, Verba S, von Hippel PH, Wake DB, Walker A, Walker JE, Watson EB, Watson PJ, Weigel D, Wessler SR, West-Eberhard MJ, White TD, Wilson WJ, Wolfenden RV, Wood JA, Woodwell GM, Wright HE Jr, Wu C, Wunsch C, Zoback ML.

Science. 2010 May 7;328(5979):689-90. doi: 10.1126/science.328.5979.689. No abstract available. Erratum in: Science. 2010 May 14;328(5980):826.


Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC.

George Cisar EA, Geisinger E, Muir TW, Novick RP.

Mol Microbiol. 2009 Oct;74(1):44-57. doi: 10.1111/j.1365-2958.2009.06849.x. Epub 2009 Aug 24.


Specificity of staphylococcal phage and SaPI DNA packaging as revealed by integrase and terminase mutations.

Ubeda C, Olivarez NP, Barry P, Wang H, Kong X, Matthews A, Tallent SM, Christie GE, Novick RP.

Mol Microbiol. 2009 Apr;72(1):98-108.


agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides.

Geisinger E, Muir TW, Novick RP.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1216-21. doi: 10.1073/pnas.0807760106. Epub 2009 Jan 15.


Killing niche competitors by remote-control bacteriophage induction.

Selva L, Viana D, Regev-Yochay G, Trzcinski K, Corpa JM, Lasa I, Novick RP, Penadés JR.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1234-8. doi: 10.1073/pnas.0809600106. Epub 2009 Jan 13.


Phage-mediated intergeneric transfer of toxin genes.

Chen J, Novick RP.

Science. 2009 Jan 2;323(5910):139-41. doi: 10.1126/science.1164783.


Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains.

Shopsin B, Drlica-Wagner A, Mathema B, Adhikari RP, Kreiswirth BN, Novick RP.

J Infect Dis. 2008 Oct 15;198(8):1171-4. doi: 10.1086/592051.


Quorum sensing in staphylococci.

Novick RP, Geisinger E.

Annu Rev Genet. 2008;42:541-64. doi: 10.1146/annurev.genet.42.110807.091640. Review.


agr function in clinical Staphylococcus aureus isolates.

Traber KE, Lee E, Benson S, Corrigan R, Cantera M, Shopsin B, Novick RP.

Microbiology. 2008 Aug;154(Pt 8):2265-74. doi: 10.1099/mic.0.2007/011874-0.


Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis.

George EA, Novick RP, Muir TW.

J Am Chem Soc. 2008 Apr 9;130(14):4914-24. doi: 10.1021/ja711126e. Epub 2008 Mar 12.


Regulatory organization of the staphylococcal sae locus.

Adhikari RP, Novick RP.

Microbiology. 2008 Mar;154(Pt 3):949-59. doi: 10.1099/mic.0.2007/012245-0.


Medicine. Combating impervious bugs.

Novick RP.

Science. 2008 Feb 15;319(5865):910-1. doi: 10.1126/science.1154769. No abstract available.


Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins.

Tormo MA, Ferrer MD, Maiques E, Ubeda C, Selva L, Lasa I, Calvete JJ, Novick RP, Penadés JR.

J Bacteriol. 2008 Apr;190(7):2434-40. doi: 10.1128/JB.01349-07. Epub 2008 Jan 25.


Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor.

Geisinger E, George EA, Chen J, Muir TW, Novick RP.

J Biol Chem. 2008 Apr 4;283(14):8930-8. doi: 10.1074/jbc.M710227200. Epub 2008 Jan 25. Erratum in: J Biol Chem. 2012 May 25;287(22):18588. Chen, John [added].

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