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Bayesian analysis of isothermal titration calorimetry for binding thermodynamics.

Nguyen TH, Rustenburg AS, Krimmer SG, Zhang H, Clark JD, Novick PA, Branson K, Pande VS, Chodera JD, Minh DDL.

PLoS One. 2018 Sep 13;13(9):e0203224. doi: 10.1371/journal.pone.0203224. eCollection 2018.


ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network.

Chen S, Cui Y, Parashar S, Novick PJ, Ferro-Novick S.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6237-E6244. doi: 10.1073/pnas.1805032115. Epub 2018 Jun 18.


Two subunits of the exocyst, Sec3p and Exo70p, can function exclusively on the plasma membrane.

Liu D, Li X, Shen D, Novick P.

Mol Biol Cell. 2018 Mar 15;29(6):736-750. doi: 10.1091/mbc.E17-08-0518. Epub 2018 Jan 17.


Rewiring a Rab regulatory network reveals a possible inhibitory role for the vesicle tether, Uso1.

Yuan H, Davis S, Ferro-Novick S, Novick P.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8637-E8645. doi: 10.1073/pnas.1708394114. Epub 2017 Sep 25.


Regulation of membrane traffic by Rab GEF and GAP cascades.

Novick P.

Small GTPases. 2016 Oct;7(4):252-256. Epub 2016 Jul 18. Review.


The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p.

Stalder D, Novick PJ.

Mol Biol Cell. 2016 Feb 15;27(4):686-701. doi: 10.1091/mbc.E15-09-0651. Epub 2015 Dec 23.


Evolutionary dynamics of rhomboid proteases in Streptomycetes.

Novick PA, Carmona NM, Trujillo M.

BMC Res Notes. 2015 Jun 9;8:234. doi: 10.1186/s13104-015-1205-x.


Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum.

Casey AK, Chen S, Novick P, Ferro-Novick S, Wente SR.

Mol Biol Cell. 2015 Aug 1;26(15):2833-44. doi: 10.1091/mbc.E15-01-0053. Epub 2015 Jun 3.


Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum.

Chen S, Desai T, McNew JA, Gerard P, Novick PJ, Ferro-Novick S.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):418-23. doi: 10.1073/pnas.1423026112. Epub 2014 Dec 29.


The Rab GTPase YPT-1 associates with Golgi cisternae and Spitzenkörper microvesicles in Neurospora crassa.

Sánchez-León E, Bowman B, Seidel C, Fischer R, Novick P, Riquelme M.

Mol Microbiol. 2015 Feb;95(3):472-90. doi: 10.1111/mmi.12878. Epub 2014 Dec 22.


Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p.

Liu D, Novick P.

J Cell Biol. 2014 Oct 13;207(1):59-72. doi: 10.1083/jcb.201404122.


Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays.

Sadaghiani AM, Lee SM, Odegaard JI, Leveson-Gower DB, McPherson OM, Novick P, Kim MR, Koehler AN, Negrin R, Dolmetsch RE, Park CY.

Chem Biol. 2014 Oct 23;21(10):1278-1292. doi: 10.1016/j.chembiol.2014.08.016. Epub 2014 Oct 9.


Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature.

Ling Y, Hayano S, Novick P.

Mol Biol Cell. 2014 Nov 1;25(21):3389-400. doi: 10.1091/mbc.E14-06-1087. Epub 2014 Aug 27.


A pathway of a hundred genes starts with a single mutant: isolation of sec1-1.

Novick PJ.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9019-20. doi: 10.1073/pnas.1404892111. Epub 2014 Jun 23. No abstract available.


The Neurospora crassa exocyst complex tethers Spitzenkörper vesicles to the apical plasma membrane during polarized growth.

Riquelme M, Bredeweg EL, Callejas-Negrete O, Roberson RW, Ludwig S, Beltrán-Aguilar A, Seiler S, Novick P, Freitag M.

Mol Biol Cell. 2014 Apr;25(8):1312-26. doi: 10.1091/mbc.E13-06-0299. Epub 2014 Feb 12.


Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners.

Stalder D, Mizuno-Yamasaki E, Ghassemian M, Novick PJ.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):19995-20002. doi: 10.1073/pnas.1320029110. Epub 2013 Nov 18.


SWEETLEAD: an in silico database of approved drugs, regulated chemicals, and herbal isolates for computer-aided drug discovery.

Novick PA, Ortiz OF, Poelman J, Abdulhay AY, Pande VS.

PLoS One. 2013 Nov 1;8(11):e79568. doi: 10.1371/journal.pone.0079568. eCollection 2013.


Transposable element evolution in Heliconius suggests genome diversity within Lepidoptera.

Lavoie CA, Platt RN 2nd, Novick PA, Counterman BA, Ray DA.

Mob DNA. 2013 Oct 2;4(1):21. doi: 10.1186/1759-8753-4-21.


Different polarisome components play distinct roles in Slt2p-regulated cortical ER inheritance in Saccharomyces cerevisiae.

Li X, Ferro-Novick S, Novick P.

Mol Biol Cell. 2013 Oct;24(19):3145-54. doi: 10.1091/mbc.E13-05-0268. Epub 2013 Aug 7.


The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p.

Shen D, Yuan H, Hutagalung A, Verma A, Kümmel D, Wu X, Reinisch K, McNew JA, Novick P.

J Cell Biol. 2013 Aug 5;202(3):509-26. doi: 10.1083/jcb.201211148. Epub 2013 Jul 29.


ER structure and function.

Chen S, Novick P, Ferro-Novick S.

Curr Opin Cell Biol. 2013 Aug;25(4):428-33. doi: 10.1016/ Epub 2013 Mar 13. Review.


Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected].

Walker JR, Novick PA, Parsons WH, McGregor M, Zablocki J, Pande VS, Du Bois J.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18102-7. doi: 10.1073/pnas.1206952109. Epub 2012 Oct 17. Erratum in: Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21551.


ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p.

Chen S, Novick P, Ferro-Novick S.

Nat Cell Biol. 2012 Jun 24;14(7):707-16. doi: 10.1038/ncb2523.


GTPase networks in membrane traffic.

Mizuno-Yamasaki E, Rivera-Molina F, Novick P.

Annu Rev Biochem. 2012;81:637-59. doi: 10.1146/annurev-biochem-052810-093700. Epub 2012 Mar 29. Review.


Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.

Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC.

Nature. 2012 Mar 25;484(7395):529-33. doi: 10.1038/nature10975.


Design of β-amyloid aggregation inhibitors from a predicted structural motif.

Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS.

J Med Chem. 2012 Apr 12;55(7):3002-10. doi: 10.1021/jm201332p. Epub 2012 Mar 15.


The genome of the green anole lizard and a comparative analysis with birds and mammals.

Alföldi J, Di Palma F, Grabherr M, Williams C, Kong L, Mauceli E, Russell P, Lowe CB, Glor RE, Jaffe JD, Ray DA, Boissinot S, Shedlock AM, Botka C, Castoe TA, Colbourne JK, Fujita MK, Moreno RG, ten Hallers BF, Haussler D, Heger A, Heiman D, Janes DE, Johnson J, de Jong PJ, Koriabine MY, Lara M, Novick PA, Organ CL, Peach SE, Poe S, Pollock DD, de Queiroz K, Sanger T, Searle S, Smith JD, Smith Z, Swofford R, Turner-Maier J, Wade J, Young S, Zadissa A, Edwards SV, Glenn TC, Schneider CJ, Losos JB, Lander ES, Breen M, Ponting CP, Lindblad-Toh K.

Nature. 2011 Aug 31;477(7366):587-91. doi: 10.1038/nature10390.


Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution.

Rajadas J, Liu CW, Novick P, Kelley NW, Inayathullah M, Lemieux MC, Pande VS.

PLoS One. 2011;6(7):e21776. doi: 10.1371/journal.pone.0021776. Epub 2011 Jul 22.


Role of Rab GTPases in membrane traffic and cell physiology.

Hutagalung AH, Novick PJ.

Physiol Rev. 2011 Jan;91(1):119-49. doi: 10.1152/physrev.00059.2009. Review.


The evolution and diversity of DNA transposons in the genome of the Lizard Anolis carolinensis.

Novick PA, Smith JD, Floumanhaft M, Ray DA, Boissinot S.

Genome Biol Evol. 2011;3:1-14. doi: 10.1093/gbe/evq080. Epub 2010 Dec 2.


Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes.

Vasan N, Hutagalung A, Novick P, Reinisch KM.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14176-81. doi: 10.1073/pnas.1009419107. Epub 2010 Jul 26.


Membrane traffic.

Pfeffer SR, Novick PJ.

Curr Opin Cell Biol. 2010 Aug;22(4):419-21. doi: 10.1016/ Epub 2010 Jun 19. No abstract available.


Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p.

Mizuno-Yamasaki E, Medkova M, Coleman J, Novick P.

Dev Cell. 2010 May 18;18(5):828-40. doi: 10.1016/j.devcel.2010.03.016.


Activation of the mitogen-activated protein kinase, Slt2p, at bud tips blocks a late stage of endoplasmic reticulum inheritance in Saccharomyces cerevisiae.

Li X, Du Y, Siegel S, Ferro-Novick S, Novick P.

Mol Biol Cell. 2010 May 15;21(10):1772-82. doi: 10.1091/mbc.E09-06-0532. Epub 2010 Mar 31.


Establishing a role for the GTPase Ypt1p at the late Golgi.

Sclafani A, Chen S, Rivera-Molina F, Reinisch K, Novick P, Ferro-Novick S.

Traffic. 2010 Apr;11(4):520-32. doi: 10.1111/j.1600-0854.2010.01031.x. Epub 2010 Jan 6.


Independent and parallel lateral transfer of DNA transposons in tetrapod genomes.

Novick P, Smith J, Ray D, Boissinot S.

Gene. 2010 Jan 1;449(1-2):85-94. doi: 10.1016/j.gene.2009.08.017. Epub 2009 Sep 10.


A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway.

Rivera-Molina FE, Novick PJ.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14408-13. doi: 10.1073/pnas.0906536106. Epub 2009 Aug 4.


Analysis of SEC9 suppression reveals a relationship of SNARE function to cell physiology.

Williams DC, Novick PJ.

PLoS One. 2009;4(5):e5449. doi: 10.1371/journal.pone.0005449. Epub 2009 May 6.


The evolutionary dynamics of autonomous non-LTR retrotransposons in the lizard Anolis carolinensis shows more similarity to fish than mammals.

Novick PA, Basta H, Floumanhaft M, McClure MA, Boissinot S.

Mol Biol Evol. 2009 Aug;26(8):1811-22. doi: 10.1093/molbev/msp090. Epub 2009 May 6.


An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components.

Hutagalung AH, Coleman J, Pypaert M, Novick PJ.

Mol Biol Cell. 2009 Jan;20(1):153-63. doi: 10.1091/mbc.E08-02-0157. Epub 2008 Oct 22.


Identification and verification of Sro7p as an effector of the Sec4p Rab GTPase.

Grosshans BL, Novick P.

Methods Enzymol. 2008;438:95-108. doi: 10.1016/S0076-6879(07)38007-5.


Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body.

Chang W, Zaarour RF, Reck-Peterson S, Rinn J, Singer RH, Snyder M, Novick P, Mooseker MS.

RNA. 2008 Mar;14(3):491-502. doi: 10.1261/rna.665008. Epub 2008 Jan 24.


Preoperative external beam radiotherapy and reduced dose brachytherapy for carcinoma of the cervix: survival and pathological response.

Jacinto AA, Castilho MS, Novaes PE, Novick PR, Viani GA, Salvajoli JV, Ferrigno R, Pellizzon AC, Lima SS, Maia MA, Fogaroli RC.

Radiat Oncol. 2007 Feb 22;2:9.


A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p.

Dong G, Medkova M, Novick P, Reinisch KM.

Mol Cell. 2007 Feb 9;25(3):455-62.


Interactions between Rabs, tethers, SNAREs and their regulators in exocytosis.

Novick P, Medkova M, Dong G, Hutagalung A, Reinisch K, Grosshans B.

Biochem Soc Trans. 2006 Nov;34(Pt 5):683-6.


Ptc1p regulates cortical ER inheritance via Slt2p.

Du Y, Walker L, Novick P, Ferro-Novick S.

EMBO J. 2006 Oct 4;25(19):4413-22. Epub 2006 Sep 14.


Rabs and their effectors: achieving specificity in membrane traffic.

Grosshans BL, Ortiz D, Novick P.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11821-7. Epub 2006 Aug 1. Review.


The exocyst defrocked, a framework of rods revealed.

Munson M, Novick P.

Nat Struct Mol Biol. 2006 Jul;13(7):577-81. Review.


Rtn1p is involved in structuring the cortical endoplasmic reticulum.

De Craene JO, Coleman J, Estrada de Martin P, Pypaert M, Anderson S, Yates JR 3rd, Ferro-Novick S, Novick P.

Mol Biol Cell. 2006 Jul;17(7):3009-20. Epub 2006 Apr 19.

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