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Efficacy of topical tenofovir against transmission of a tenofovir-resistant SHIV in macaques.

Dobard CW, Sharma S, Cong ME, West R, Makarova N, Holder A, Pau CP, Hanson DL, Novembre FJ, Garcia-Lerma JG, Heneine W.

Retrovirology. 2015 Aug 8;12:69. doi: 10.1186/s12977-015-0195-z.


Longitudinal cerebral metabolic changes in pig-tailed macaques infected with the neurovirulent virus SIVsmmFGb.

Li CX, Zhang X, Komery A, Li Y, Mao H, Herndon JG, Novembre FJ.

J Neurovirol. 2014 Dec;20(6):612-9. doi: 10.1007/s13365-014-0286-y. Epub 2014 Nov 7.


A longitudinal magnetization transfer imaging evaluation of brain injury in a macaque model of neuroAIDS.

Li CX, Herndon JG, Novembre FJ, Zhang X.

AIDS Res Hum Retroviruses. 2015 Mar;31(3):335-41. doi: 10.1089/aid.2014.0166. Epub 2014 Nov 6.


Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose.

Sholukh AM, Byrareddy SN, Shanmuganathan V, Hemashettar G, Lakhashe SK, Rasmussen RA, Watkins JD, Vyas HK, Thorat S, Brandstoetter T, Mukhtar MM, Yoon JK, Novembre FJ, Villinger F, Landucci G, Forthal DN, Ratcliffe S, Tuero I, Robert-Guroff M, Polonis VR, Bilska M, Montefiori DC, Johnson WE, Ertl HC, Ruprecht RM.

Retrovirology. 2014 Jan 20;11:8. doi: 10.1186/1742-4690-11-8.


Live attenuated Rev-independent Nef¯SIV enhances acquisition of heterologous SIVsmE660 in acutely vaccinated rhesus macaques.

Byrareddy SN, Ayash-Rashkovsky M, Kramer VG, Lee SJ, Correll M, Novembre FJ, Villinger F, Johnson WE, von Gegerfelt A, Felber BK, Ruprecht RM.

PLoS One. 2013 Sep 30;8(9):e75556. doi: 10.1371/journal.pone.0075556. eCollection 2013.


Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue.

Dobard C, Sharma S, Martin A, Pau CP, Holder A, Kuklenyik Z, Lipscomb J, Hanson DL, Smith J, Novembre FJ, García-Lerma JG, Heneine W.

J Virol. 2012 Jan;86(2):718-25. doi: 10.1128/JVI.05842-11. Epub 2011 Nov 9.


Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection.

Lakhashe SK, Wang W, Siddappa NB, Hemashettar G, Polacino P, Hu SL, Villinger F, Else JG, Novembre FJ, Yoon JK, Lee SJ, Montefiori DC, Ruprecht RM, Rasmussen RA.

PLoS One. 2011;6(7):e22010. doi: 10.1371/journal.pone.0022010. Epub 2011 Jul 20.


Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.

Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM.

Vaccine. 2011 Aug 5;29(34):5611-22. doi: 10.1016/j.vaccine.2011.06.017. Epub 2011 Jul 14.


Longitudinal diffusion tensor imaging and perfusion MRI investigation in a macaque model of neuro-AIDS: a preliminary study.

Li C, Zhang X, Komery A, Li Y, Novembre FJ, Herndon JG.

Neuroimage. 2011 Sep 1;58(1):286-92. doi: 10.1016/j.neuroimage.2011.05.068. Epub 2011 Jun 1.


An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.

Watkins JD, Siddappa NB, Lakhashe SK, Humbert M, Sholukh A, Hemashettar G, Wong YL, Yoon JK, Wang W, Novembre FJ, Villinger F, Ibegbu C, Patel K, Corti D, Agatic G, Vanzetta F, Bianchi S, Heeney JL, Sallusto F, Lanzavecchia A, Ruprecht RM.

PLoS One. 2011 Mar 31;6(3):e18207. doi: 10.1371/journal.pone.0018207.


Editorial neuroAIDS review.

Shapshak P, Kangueane P, Fujimura RK, Commins D, Chiappelli F, Singer E, Levine AJ, Minagar A, Novembre FJ, Somboonwit C, Nath A, Sinnott JT.

AIDS. 2011 Jan 14;25(2):123-41. doi: 10.1097/QAD.0b013e328340fd42. Review. No abstract available.


A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly.

Sciaranghella G, Lakhashe SK, Ayash-Rashkovsky M, Mirshahidi S, Siddappa NB, Novembre FJ, Velu V, Amara RR, Zhou C, Li S, Li Z, Frankel FR, Ruprecht RM.

Vaccine. 2011 Jan 10;29(3):476-86. doi: 10.1016/j.vaccine.2010.10.072. Epub 2010 Nov 9.


Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis.

Siddappa NB, Hemashettar G, Wong YL, Lakhashe S, Rasmussen RA, Watkins JD, Novembre FJ, Villinger F, Else JG, Montefiori DC, Ruprecht RM.

J Med Primatol. 2011 Apr;40(2):120-8. doi: 10.1111/j.1600-0684.2010.00454.x. Epub 2010 Nov 2.


R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.

Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM.

PLoS One. 2010 Jul 21;5(7):e11689. doi: 10.1371/journal.pone.0011689.


AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.

García A, Siddappa NB, Li Q, Haase AT, Paul K, Stroud F, Zhang X, Fountain JA, Villinger F, Novembre FJ, Else JG, Evan Secor W, Ruprecht RM.

J Med Primatol. 2010 Oct;39(5):356-60. doi: 10.1111/j.1600-0684.2010.00416.x.


Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes.

Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM.

J Infect Dis. 2010 Apr 15;201(8):1155-63. doi: 10.1086/651274.


Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine.

Parikh UM, Dobard C, Sharma S, Cong ME, Jia H, Martin A, Pau CP, Hanson DL, Guenthner P, Smith J, Kersh E, Garcia-Lerma JG, Novembre FJ, Otten R, Folks T, Heneine W.

J Virol. 2009 Oct;83(20):10358-65. doi: 10.1128/JVI.01073-09. Epub 2009 Aug 5.


Reduced genetic diversity in lymphoid and central nervous system tissues and selection-induced tissue-specific compartmentalization of neuropathogenic SIVsmmFGb during acute infection.

Reeve AB, Patel K, Pearce NC, Augustus KV, Domingues HG, O'Neil SP, Novembre FJ.

AIDS Res Hum Retroviruses. 2009 Jun;25(6):583-601. doi: 10.1089/aid.2008.0240.


Probable deceleration of progression of Simian AIDS affected by opiate dependency: studies with a rhesus macaque/SIVsmm9 model.

Donahoe RM, O'neil SP, Marsteller FA, Novembre FJ, Anderson DC, Lankford-Turner P, McClure HH.

J Acquir Immune Defic Syndr. 2009 Mar 1;50(3):241-9. doi: 10.1097/QAI.0b013e3181967354.


Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infection.

Siddappa NB, Song R, Kramer VG, Chenine AL, Velu V, Ong H, Rasmussen RA, Grisson RD, Wood C, Zhang H, Kankasa C, Amara RR, Else JG, Novembre FJ, Montefiori DC, Ruprecht RM.

J Virol. 2009 Feb;83(3):1422-32. doi: 10.1128/JVI.02066-08. Epub 2008 Nov 19. Erratum in: J Virol. 2009 Aug;83(16):8297.


SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys.

Humbert M, Rasmussen RA, Song R, Ong H, Sharma P, Chenine AL, Kramer VG, Siddappa NB, Xu W, Else JG, Novembre FJ, Strobert E, O'Neil SP, Ruprecht RM.

Retrovirology. 2008 Oct 17;5:94. doi: 10.1186/1742-4690-5-94.


Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates.

Juompan LY, Hutchinson K, Montefiori DC, Nidtha S, Villinger F, Novembre FJ.

AIDS Res Hum Retroviruses. 2008 Apr;24(4):573-86. doi: 10.1089/aid.2007.0182.


Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses.

Münch J, Rajan D, Schindler M, Specht A, Rücker E, Novembre FJ, Nerrienet E, Müller-Trutwin MC, Peeters M, Hahn BH, Kirchhoff F.

J Virol. 2007 Dec;81(24):13852-64. Epub 2007 Oct 10.


Efficacy of a multigenic protein vaccine containing multimeric HIV gp160 against heterologous SHIV clade C challenges.

Rasmussen RA, Ong H, Song R, Chenine AL, Ayash-Rashkovsky M, Hu SL, Polacino P, Else JG, Novembre FJ, Ruprecht RM; Clade C Program Project.

AIDS. 2007 Sep 12;21(14):1841-8.


Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.

Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F.

Cell. 2006 Jun 16;125(6):1055-67.


A combination DNA and attenuated simian immunodeficiency virus vaccine strategy provides enhanced protection from simian/human immunodeficiency virus-induced disease.

Amara RR, Patel K, Niedziela G, Nigam P, Sharma S, Staprans SI, Montefiori DC, Chenareddi L, Herndon JG, Robinson HL, McClure HM, Novembre FJ.

J Virol. 2005 Dec;79(24):15356-67.


Active simian immunodeficiency virus (strain smmPGm) infection in macaque central nervous system correlates with neurologic disease.

Smith MS, Niu Y, Buch S, Li Z, Adany I, Pinson DM, Potula R, Novembre FJ, Narayan O.

J Acquir Immune Defic Syndr. 2005 Apr 15;38(5):518-30.


Correlation of acute humoral response with brain virus burden and survival time in pig-tailed macaques infected with the neurovirulent simian immunodeficiency virus SIVsmmFGb.

O'Neil SP, Suwyn C, Anderson DC, Niedziela G, Bradley J, Novembre FJ, Herndon JG, McClure HM.

Am J Pathol. 2004 Apr;164(4):1157-72.


Rapid CD4(+) T-cell loss induced by human immunodeficiency virus type 1(NC) in uninfected and previously infected chimpanzees.

Novembre FJ, de Rosayro J, Nidtha S, O'Neil SP, Gibson TR, Evans-Strickfaden T, Hart CE, McClure HM.

J Virol. 2001 Feb;75(3):1533-9. Erratum in: J Virol 2001 Jun;75(11):5441.


Progressive infection in a subset of HIV-1-positive chimpanzees.

O'Neil SP, Novembre FJ, Hill AB, Suwyn C, Hart CE, Evans-Strickfaden T, Anderson DC, deRosayro J, Herndon JG, Saucier M, McClure HM.

J Infect Dis. 2000 Oct;182(4):1051-62. Epub 2000 Sep 8.


In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS.

Villinger F, Bucur S, Chikkala NF, Brar SS, Bostik P, Mayne AE, Adams J, Lee ME, Novembre FJ, Gately MK, Ansari AA, Hillyer CD.

AIDS Res Hum Retroviruses. 2000 May 20;16(8):751-63.


Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj.

Hodge S, de Rosayro J, Glenn A, Ojukwu IC, Dewhurst S, McClure HM, Bischofberger N, Anderson DC, Klumpp SA, Novembre FJ.

J Virol. 1999 Oct;73(10):8630-9.


Pathogenesis of simian immunodeficiency virus infection.

Whetter LE, Ojukwu IC, Novembre FJ, Dewhurst S.

J Gen Virol. 1999 Jul;80 ( Pt 7):1557-68. Review. No abstract available.


Species-specific changes in the CCR5 gene from African and Asian nonhuman primates.

Saksena NK, Wang B, Novembre FJ, Bolton W, Smit TK, Lal RB.

AIDS Res Hum Retroviruses. 1999 Mar 20;15(5):479-83. No abstract available.


Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14.

Hodge S, Novembre FJ, Whetter L, Gelbard HA, Dewhurst S.

Virology. 1998 Dec 20;252(2):354-63.


Isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey.

Novembre FJ, De Rosayro J, O'Neil SP, Anderson DC, Klumpp SA, McClure HM.

J Virol. 1998 Nov;72(11):8841-51.


Costimulatory pathways in lymphocyte proliferation induced by the simian immunodeficiency virus SIVsmmPBj14.

Whetter L, Novembre FJ, Saucier M, Gummuluru S, Dewhurst S.

J Virol. 1998 Jul;72(7):6155-8.


The tyrosine-17 residue of Nef in SIVsmmPBj14 is required for acute pathogenesis and contributes to replication in macrophages.

Saucier M, Hodge S, Dewhurst S, Gibson T, Gibson JP, McClure HM, Novembre FJ.

Virology. 1998 May 10;244(2):261-72.


Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1.

Novembre FJ, Saucier M, Anderson DC, Klumpp SA, O'Neil SP, Brown CR 2nd, Hart CE, Guenthner PC, Swenson RB, McClure HM.

J Virol. 1997 May;71(5):4086-91.


Immune and hematopoietic parameters in HIV-1-infected chimpanzees during clinical progression toward AIDS.

Villinger F, Brar SS, Brice GT, Chikkala NF, Novembre FJ, Mayne AE, Bucur S, Hillyer CD, Ansari AA.

J Med Primatol. 1997 Feb-Apr;26(1-2):11-8.


Characterization of a novel baboon virus closely resembling human T-cell leukemia virus.

Vincent MJ, Novembre FJ, Yamshchikov VF, McClure HM, Compans RW.

Virology. 1996 Dec 1;226(1):57-65.


Deletion of the nef gene abrogates the ability of SIV smmPBj to induce acutely lethal disease in pigtail macaques.

Novembre FJ, Lewis MG, Saucier MM, Yalley-Ogunro J, Brennan T, McKinnon K, Bellah S, McClure HM.

AIDS Res Hum Retroviruses. 1996 May 20;12(8):727-36.


Simian immunodeficiency virus variants: threat of new lentiviruses.

McClure HM, Novembre FJ.

Am J Med Sci. 1996 Jan;311(1):30-3. Review.


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