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Items: 43


Acute kidney injury in paediatric patients with sickle cell disease is associated with increased morbidity and resource utilization.

McCormick M, Richardson T, Warady BA, Novelli EM, Kalpatthi R.

Br J Haematol. 2020 Feb 6. doi: 10.1111/bjh.16384. [Epub ahead of print]


Targeting P-Selectin Adhesion Molecule in Molecular Imaging: P-Selectin Expression as a Valuable Imaging Biomarker of Inflammation in Cardiovascular Disease.

Perkins LA, Anderson CJ, Novelli EM.

J Nucl Med. 2019 Dec;60(12):1691-1697. doi: 10.2967/jnumed.118.225169. Epub 2019 Oct 10.


Decoding the role of SOD2 in sickle cell disease.

Dosunmu-Ogunbi AM, Wood KC, Novelli EM, Straub AC.

Blood Adv. 2019 Sep 10;3(17):2679-2687. doi: 10.1182/bloodadvances.2019000527. Review.


Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice.

Novelli EM, Little-Ihrig L, Knupp HE, Rogers NM, Yao M, Baust JJ, Meijles D, St Croix CM, Ross MA, Pagano PJ, DeVallance ER, Miles G, Potoka KP, Isenberg JS, Gladwin MT.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1150-L1164. doi: 10.1152/ajplung.00302.2018. Epub 2019 Mar 20.


Measuring success: utility of biomarkers in sickle cell disease clinical trials and care.

Kalpatthi R, Novelli EM.

Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):482-492. doi: 10.1182/asheducation-2018.1.482. Review.


Pathophysiology of Sickle Cell Disease.

Sundd P, Gladwin MT, Novelli EM.

Annu Rev Pathol. 2019 Jan 24;14:263-292. doi: 10.1146/annurev-pathmechdis-012418-012838. Epub 2018 Oct 17.


Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.

Bilan VP, Schneider F, Novelli EM, Kelley EE, Shiva S, Gladwin MT, Jackson EK, Tofovic SP.

Pulm Circ. 2018 Jul-Sep;8(3):2045894018791557. doi: 10.1177/2045894018791557. Epub 2018 Jul 13.


Disease severity and slower psychomotor speed in adults with sickle cell disease.

Jorgensen DR, Metti A, Butters MA, Mettenburg JM, Rosano C, Novelli EM.

Blood Adv. 2017 Sep 14;1(21):1790-1795. doi: 10.1182/bloodadvances.2017008219. eCollection 2017 Sep 26.


The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.

Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ.

Sci Signal. 2017 Oct 17;10(501). pii: eaaj1784. doi: 10.1126/scisignal.aaj1784.


The association of smartphone-based activity space measures with cognitive functioning and pain sickle cell disease.

Jonassaint CR, Birenboim A, Jorgensen DR, Novelli EM, Rosso AL.

Br J Haematol. 2018 May;181(3):395-397. doi: 10.1111/bjh.14598. Epub 2017 Jul 17. No abstract available.


Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.

Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, Zhang Y, Kato GJ.

Am J Hematol. 2017 Mar;92(3):E31-E34. doi: 10.1002/ajh.24635. Epub 2017 Feb 3. No abstract available.


TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.

Rogers NM, Sharifi-Sanjani M, Yao M, Ghimire K, Bienes-Martinez R, Mutchler SM, Knupp HE, Baust J, Novelli EM, Ross M, St Croix C, Kutten JC, Czajka CA, Sembrat JC, Rojas M, Labrousse-Arias D, Bachman TN, Vanderpool RR, Zuckerbraun BS, Champion HC, Mora AL, Straub AC, Bilonick RA, Calzada MJ, Isenberg JS.

Cardiovasc Res. 2017 Jan;113(1):15-29. doi: 10.1093/cvr/cvw218. Epub 2016 Oct 13.


Can Neuroimaging Markers of Vascular Pathology Explain Cognitive Performance in Adults With Sickle Cell Anemia? A review of the Literature.

Jorgensen DR, Rosano C, Novelli EM.

Hemoglobin. 2016 Nov;40(6):381-387. doi: 10.1080/03630269.2016.1242493. Review.


Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years' experience.

Makubi A, Mmbando BP, Novelli EM, Lwakatare J, Soka D, Marik H, Tibarazwa K, Ngaeje M, Newton CR, Gladwin MT, Makani J.

Br J Haematol. 2017 Jun;177(6):930-937. doi: 10.1111/bjh.14330. Epub 2016 Sep 21.


Cognitive functioning in children from Nigeria with sickle cell anemia.

Oluwole OB, Noll RB, Winger DG, Akinyanju O, Novelli EM.

Pediatr Blood Cancer. 2016 Nov;63(11):1990-7. doi: 10.1002/pbc.26126. Epub 2016 Jul 9.


Crises in Sickle Cell Disease.

Novelli EM, Gladwin MT.

Chest. 2016 Apr;149(4):1082-93. doi: 10.1016/j.chest.2015.12.016. Epub 2015 Dec 28. Review.


Brain venular pattern by 7T MRI correlates with memory and haemoglobin in sickle cell anaemia.

Novelli EM, Elizabeth Sarles C, Jay Aizenstein H, Ibrahim TS, Butters MA, Connelly Ritter A, Erickson KI, Rosano C.

Psychiatry Res. 2015 Jul 30;233(1):18-22. doi: 10.1016/j.pscychresns.2015.04.005. Epub 2015 Apr 25.


Quantitative microfluidic fluorescence microscopy to study vaso-occlusion in sickle cell disease.

Jimenez MA, Tutuncuoglu E, Barge S, Novelli EM, Sundd P.

Haematologica. 2015 Oct;100(10):e390-3. doi: 10.3324/haematol.2015.126631. Epub 2015 May 14. No abstract available.


Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease.

Novelli EM, Hildesheim M, Rosano C, Vanderpool R, Simon M, Kato GJ, Gladwin MT.

PLoS One. 2014 Dec 5;9(12):e114309. doi: 10.1371/journal.pone.0114309. eCollection 2014.


First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease.

George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Yousem SA, Toyoda Y, Champion HC, Pilewski JM, Gladwin MT.

Pulm Circ. 2013 Dec;3(4):952-8. doi: 10.1086/674749.


Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension.

Rogers NM, Yao M, Sembrat J, George MP, Knupp H, Ross M, Sharifi-Sanjani M, Milosevic J, St Croix C, Rajkumar R, Frid MG, Hunter KS, Mazzaro L, Novelli EM, Stenmark KR, Gladwin MT, Ahmad F, Champion HC, Isenberg JS.

Pulm Circ. 2013 Dec;3(4):936-51. doi: 10.1086/674754.


Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation.

Cardenes N, Corey C, Geary L, Jain S, Zharikov S, Barge S, Novelli EM, Shiva S.

Blood. 2014 May 1;123(18):2864-72. doi: 10.1182/blood-2013-09-529420. Epub 2014 Mar 27.


Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury.

Yao M, Rogers NM, Csányi G, Rodriguez AI, Ross MA, St Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ, Isenberg JS.

J Am Soc Nephrol. 2014 Jun;25(6):1171-86. doi: 10.1681/ASN.2013040433. Epub 2014 Feb 7. Erratum in: J Am Soc Nephrol. 2014 Aug;25(8):1884.


Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease.

Novelli EM, Kato GJ, Hildesheim ME, Barge S, Meyer MP, Lozier J, Hassett AC, Ragni MV, Isenberg JS, Gladwin MT.

Haematologica. 2013 Nov;98(11):e132-4. doi: 10.3324/haematol.2013.092635. No abstract available.


Vasculopathy, inflammation, and blood flow in leg ulcers of patients with sickle cell anemia.

Minniti CP, Delaney KM, Gorbach AM, Xu D, Lee CC, Malik N, Koroulakis A, Antalek M, Maivelett J, Peters-Lawrence M, Novelli EM, Lanzkron SM, Axelrod KC, Kato GJ.

Am J Hematol. 2014 Jan;89(1):1-6. doi: 10.1002/ajh.23571. Epub 2013 Sep 19.


Unraveling restrictive chronic lung disease in sickle cell disease.

Jain S, Gladwin MT, Novelli EM.

Int J Tuberc Lung Dis. 2013 Sep;17(9):1123-4. doi: 10.5588/ijtld.13.0509. No abstract available.


A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease.

Wun T, Soulieres D, Frelinger AL, Krishnamurti L, Novelli EM, Kutlar A, Ataga KI, Knupp CL, McMahon LE, Strouse JJ, Zhou C, Heath LE, Nwachuku CE, Jakubowski JA, Riesmeyer JS, Winters KJ.

J Hematol Oncol. 2013 Feb 17;6:17. doi: 10.1186/1756-8722-6-17.


Phase II prospective open-label trial of recombinant interleukin-11 in desmopressin-unresponsive von Willebrand disease and mild or moderate haemophilia A.

Ragni MV, Novelli EM, Murshed A, Merricks EP, Kloos MT, Nichols TC.

Thromb Haemost. 2013 Feb;109(2):248-54. doi: 10.1160/TH12-06-0447. Epub 2012 Dec 13.


Venous thromboembolism in cirrhosis.

Yang ZJ, Costa KA, Novelli EM, Smith RE.

Clin Appl Thromb Hemost. 2014 Mar;20(2):169-78. doi: 10.1177/1076029612461846. Epub 2012 Oct 17. Review.


Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management.

Rogers NM, Yao M, Novelli EM, Thomson AW, Roberts DD, Isenberg JS.

Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1117-25. doi: 10.1152/ajprenal.00359.2012. Epub 2012 Aug 8. Review.


Chest pain, dyspnea, petechiae, and melena in a 58-year-old woman - what is it?

Mehta RS, Ragni MV, Novelli EM.

Platelets. 2013;24(5):415-8. doi: 10.3109/09537104.2012.699642. Epub 2012 Jun 27. No abstract available.


Pulmonary embolism in sickle cell disease: a case-control study.

Novelli EM, Huynh C, Gladwin MT, Moore CG, Ragni MV.

J Thromb Haemost. 2012 May;10(5):760-6. doi: 10.1111/j.1538-7836.2012.04697.x.


Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates.

Novelli EM, Kato GJ, Ragni MV, Zhang Y, Hildesheim ME, Nouraie M, Barge S, Meyer MP, Hassett AC, Gordeuk VR, Gladwin MT, Isenberg JS.

Am J Hematol. 2012 Mar;87(3):326-30. doi: 10.1002/ajh.22274. Epub 2012 Feb 8.


Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom.

Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Taylor JG 6th, Hannoush H, Goldsmith JC, Gladwin MT, Gordeuk VR; Walk-PHASST Investigators.

Circulation. 2011 Sep 27;124(13):1452-60. doi: 10.1161/CIRCULATIONAHA.111.032920. Epub 2011 Sep 6.


Knee pain: ACL, MCL, or CML?

Novelli EM, Redner RL.

Blood. 2010 Jul 1;115(26):5287. No abstract available.


Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.

Novelli EM, Hittner JB, Davenport GC, Ouma C, Were T, Obaro S, Kaplan S, Ong'echa JM, Perkins DJ.

Br J Haematol. 2010 Jun;149(5):711-21. doi: 10.1111/j.1365-2141.2010.08147.x. Epub 2010 Apr 16.


Genetics of bleeding disorders in women.

Novelli EM, Ragni MV.

Semin Thromb Hemost. 2008 Sep;34(6):509-19. doi: 10.1055/s-0028-1103362. Epub 2008 Nov 28. Review.


Retrovirus-mediated gene transfer to human hematopoietic stem cells.

Swaney WP, Novelli EM, Bahnson AB, Barranger JA.

Methods Mol Med. 2002;69:187-202. No abstract available.


Human hematopoietic stem/progenitor cells generate CD5+ B lymphoid cells in NOD/SCID mice.

Novelli EM, Ramírez M, Leung W, Civin CI.

Stem Cells. 1999;17(5):242-52.


Biology of CD34+CD38- cells in lymphohematopoiesis.

Novelli EM, Ramirez M, Civin CI.

Leuk Lymphoma. 1998 Oct;31(3-4):285-93. Review.


In vivo engraftment potential of clinical hematopoietic grafts.

Leung W, Ramírez M, Novelli EM, Civin CI.

J Investig Med. 1998 Aug;46(6):303-11.


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