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Items: 1 to 50 of 75

1.

Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases.

Ross MH, Esser AK, Fox GC, Schmieder AH, Yang X, Hu G, Pan D, Su X, Xu Y, Novack DV, Walsh T, Colditz GA, Lukaszewicz GH, Cordell E, Novack J, Fitzpatrick JAJ, Waning DL, Mohammad KS, Guise TA, Lanza GM, Weilbaecher KN.

Cancer Res. 2017 Nov 15;77(22):6299-6312. doi: 10.1158/0008-5472.CAN-17-1225. Epub 2017 Aug 30.

2.

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation.

Alippe Y, Wang C, Ricci B, Xiao J, Qu C, Zou W, Novack DV, Abu-Amer Y, Civitelli R, Mbalaviele G.

Sci Rep. 2017 Jul 26;7(1):6630. doi: 10.1038/s41598-017-07014-0.

3.

Inflammatory osteolysis: a conspiracy against bone.

Mbalaviele G, Novack DV, Schett G, Teitelbaum SL.

J Clin Invest. 2017 Jun 1;127(6):2030-2039. doi: 10.1172/JCI93356. Epub 2017 Jun 1. Review.

4.

Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy.

Wong TTW, Zhang R, Hai P, Zhang C, Pleitez MA, Aft RL, Novack DV, Wang LV.

Sci Adv. 2017 May 17;3(5):e1602168. doi: 10.1126/sciadv.1602168. eCollection 2017 May.

5.

Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.

Briseño CG, Gargaro M, Durai V, Davidson JT, Theisen DJ, Anderson DA 3rd, Novack DV, Murphy TL, Murphy KM.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3957-3962. doi: 10.1073/pnas.1619863114. Epub 2017 Mar 27.

6.

Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis.

Sandal I, Karydis A, Luo J, Prislovsky A, Whittington KB, Rosloniec EF, Dong C, Novack DV, Mydel P, Zheng SG, Radic MZ, Brand DD.

Arthritis Res Ther. 2016 Oct 26;18(1):249.

7.

Editorial: Inflammatory Osteoclasts: A Different Breed of Bone Eaters?

Novack DV.

Arthritis Rheumatol. 2016 Dec;68(12):2834-2836. doi: 10.1002/art.39835. No abstract available.

8.

Pulsed low-dose RANKL as a potential therapeutic for postmenopausal osteoporosis.

Cline-Smith A, Gibbs J, Shashkova E, Buchwald ZS, Novack DV, Aurora R.

JCI Insight. 2016 Aug 18;1(13). pii: e88839.

9.

Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner.

Tucci JR, Whitford GM, McAlister WH, Novack DV, Mumm S, Keaveny TM, Whyte MP.

J Bone Miner Res. 2017 Jan;32(1):188-195. doi: 10.1002/jbmr.2923. Epub 2016 Oct 14.

10.

Novel ERα positive breast cancer model with estrogen independent growth in the bone microenvironment.

Capietto AH, Chan SR, Ricci B, Allen JA, Su X, Novack DV, Schreiber RD, Faccio R.

Oncotarget. 2016 Aug 2;7(31):49751-49764. doi: 10.18632/oncotarget.10443.

11.

Osteoclasts-Key Players in Skeletal Health and Disease.

Novack DV, Mbalaviele G.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0011-2015. Review.

12.

Antagonizing Integrin β3 Increases Immunosuppression in Cancer.

Su X, Esser AK, Amend SR, Xiang J, Xu Y, Ross MH, Fox GC, Kobayashi T, Steri V, Roomp K, Fontana F, Hurchla MA, Knolhoff BL, Meyer MA, Morgan EA, Tomasson JC, Novack JS, Zou W, Faccio R, Novack DV, Robinson SD, Teitelbaum SL, DeNardo DG, Schneider JG, Weilbaecher KN.

Cancer Res. 2016 Jun 15;76(12):3484-95. doi: 10.1158/0008-5472.CAN-15-2663. Epub 2016 May 23.

13.

Idiopathic Acquired Osteosclerosis in a Middle-Aged Woman With Systemic Lupus Erythematosus.

Guañabens N, Mumm S, Gifre L, Ruiz-Gaspà S, Demertzis JL, Stolina M, Novack DV, Whyte MP.

J Bone Miner Res. 2016 Sep;31(9):1774-82. doi: 10.1002/jbmr.2842. Epub 2016 May 9.

14.

Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9.

Phatarakijnirund V, Mumm S, McAlister WH, Novack DV, Wenkert D, Clements KL, Whyte MP.

Bone. 2016 Mar;84:289-298. doi: 10.1016/j.bone.2015.11.022. Epub 2015 Dec 31.

15.

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.

Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA.

Cell Rep. 2016 Jan 5;14(1):82-92. doi: 10.1016/j.celrep.2015.12.016. Epub 2015 Dec 24.

16.

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

Decker CE, Yang Z, Rimer R, Park-Min KH, Macaubas C, Mellins ED, Novack DV, Faccio R.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15654-9. doi: 10.1073/pnas.1511285112. Epub 2015 Dec 7.

17.

NLRP12 provides a critical checkpoint for osteoclast differentiation.

Krauss JL, Zeng R, Hickman-Brecks CL, Wilson JE, Ting JP, Novack DV.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10455-60. doi: 10.1073/pnas.1500196112. Epub 2015 Aug 3.

18.

Reply: Response to: Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis Might Be Secondary to Systemic Mastocytosis.

Whyte MP, Madson KL, McAlister WH, Mumm S, Novack DV, Blair JC, Shaw NJ.

J Bone Miner Res. 2015 Aug;30(8):1537. doi: 10.1002/jbmr.2561. Epub 2015 Jun 10. No abstract available.

19.

Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65).

Frederiksen AL, Larsen MJ, Brusgaard K, Novack DV, Knudsen PJ, Schrøder HD, Qiu W, Eckhardt C, McAlister WH, Kassem M, Mumm S, Frost M, Whyte MP.

J Bone Miner Res. 2016 Jan;31(1):163-72. doi: 10.1002/jbmr.2590. Epub 2015 Aug 6.

20.

Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms.

Zeng R, Faccio R, Novack DV.

J Bone Miner Res. 2015 Dec;30(12):2287-99. doi: 10.1002/jbmr.2584. Epub 2015 Aug 6.

21.

Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts.

Zamani A, Decker C, Cremasco V, Hughes L, Novack DV, Faccio R.

J Bone Miner Res. 2015 Oct;30(10):1852-63. doi: 10.1002/jbmr.2533. Epub 2015 Aug 26.

22.

Inhibition of CaMKK2 reverses age-associated decline in bone mass.

Pritchard ZJ, Cary RL, Yang C, Novack DV, Voor MJ, Sankar U.

Bone. 2015 Jun;75:120-7. doi: 10.1016/j.bone.2015.01.021. Epub 2015 Feb 25.

23.

A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells.

Buchwald ZS, Yang C, Nellore S, Shashkova EV, Davis JL, Cline A, Ko J, Novack DV, DiPaolo R, Aurora R.

J Bone Miner Res. 2015 Aug;30(8):1508-22. doi: 10.1002/jbmr.2472. Epub 2015 May 21.

24.

Response to: A rapid skeletal turnover in radiographic mimic of osteopetrosis might be secondary to systemic mastocytosis.

Whyte MP, Madson KL, McAlister WH, Mumm S, Novack DV, Blair JC, Shaw NJ.

J Bone Miner Res. 2015 May;30(5):946. doi: 10.1002/jbmr.2455. No abstract available. Erratum in: J Bone Miner Res. 2015 Aug;30(8):1537.

25.

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G.

FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804. Epub 2014 Dec 4.

26.

Immunohistochemistry of skeletal tissues.

Idleburg C, DeLassus EN, Novack DV.

Methods Mol Biol. 2015;1226:87-95. doi: 10.1007/978-1-4939-1619-1_8.

PMID:
25331045
27.

Juvenile Paget's disease with heterozygous duplication within TNFRSF11A encoding RANK.

Whyte MP, Tau C, McAlister WH, Zhang X, Novack DV, Preliasco V, Santini-Araujo E, Mumm S.

Bone. 2014 Nov;68:153-61. doi: 10.1016/j.bone.2014.07.019. Epub 2014 Jul 23.

28.

NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.

Noort AR, van Zoest KP, Weijers EM, Koolwijk P, Maracle CX, Novack DV, Siemerink MJ, Schlingemann RO, Tak PP, Tas SW.

J Pathol. 2014 Nov;234(3):375-85. doi: 10.1002/path.4403. Epub 2014 Aug 28.

29.

Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts.

Amend SR, Uluckan O, Hurchla M, Leib D, Novack DV, Silva M, Frazier W, Weilbaecher KN.

J Bone Miner Res. 2015 Jan;30(1):106-15. doi: 10.1002/jbmr.2308.

30.

Rapid skeletal turnover in a radiographic mimic of osteopetrosis.

Whyte MP, Madson KL, Mumm S, McAlister WH, Novack DV, Blair JC, Helliwell TR, Stolina M, Abernethy LJ, Shaw NJ.

J Bone Miner Res. 2014 Dec;29(12):2601-9. doi: 10.1002/jbmr.2289.

31.

p38MAPK plays a crucial role in stromal-mediated tumorigenesis.

Alspach E, Flanagan KC, Luo X, Ruhland MK, Huang H, Pazolli E, Donlin MJ, Marsh T, Piwnica-Worms D, Monahan J, Novack DV, McAllister SS, Stewart SA.

Cancer Discov. 2014 Jun;4(6):716-29. doi: 10.1158/2159-8290.CD-13-0743. Epub 2014 Mar 26.

32.

Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer.

Capietto AH, Kim S, Sanford DE, Linehan DC, Hikida M, Kumosaki T, Novack DV, Faccio R.

J Exp Med. 2013 Oct 21;210(11):2257-71. doi: 10.1084/jem.20130281. Epub 2013 Oct 14.

33.

Acute severe hypercalcemia after traumatic fractures and immobilization in hypophosphatasia complicated by chronic renal failure.

Whyte MP, Leelawattana R, Reinus WR, Yang C, Mumm S, Novack DV.

J Clin Endocrinol Metab. 2013 Dec;98(12):4606-12. doi: 10.1210/jc.2013-1811. Epub 2013 Sep 24.

34.

Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice.

Buchwald ZS, Kiesel JR, Yang C, DiPaolo R, Novack DV, Aurora R.

Bone. 2013 Sep;56(1):163-73. doi: 10.1016/j.bone.2013.05.024. Epub 2013 Jun 10.

35.

Anti-cancer IAP antagonists promote bone metastasis: a cautionary tale.

Yang C, Novack DV.

J Bone Miner Metab. 2013 Sep;31(5):496-506. doi: 10.1007/s00774-013-0479-0. Epub 2013 Jun 6. Review.

36.

Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.

Cary RL, Waddell S, Racioppi L, Long F, Novack DV, Voor MJ, Sankar U.

J Bone Miner Res. 2013 Jul;28(7):1599-610. doi: 10.1002/jbmr.1890.

37.

Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.

Yang C, Davis JL, Zeng R, Vora P, Su X, Collins LI, Vangveravong S, Mach RH, Piwnica-Worms D, Weilbaecher KN, Faccio R, Novack DV.

Cancer Discov. 2013 Feb;3(2):212-23. doi: 10.1158/2159-8290.CD-12-0271. Epub 2012 Dec 26.

38.

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.

Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN.

J Clin Invest. 2012 Oct;122(10):3579-92. doi: 10.1172/JCI38576. Epub 2012 Sep 17.

39.

Creation and preliminary characterization of a leptin knockout rat.

Vaira S, Yang C, McCoy A, Keys K, Xue S, Weinstein EJ, Novack DV, Cui X.

Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.

40.

Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.

Cremasco V, Decker CE, Stumpo D, Blackshear PJ, Nakayama KI, Nakayama K, Lupu TS, Graham DB, Novack DV, Faccio R.

J Bone Miner Res. 2012 Dec;27(12):2452-63. doi: 10.1002/jbmr.1701.

41.

A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy.

Flentie K, Kocher B, Gammon ST, Novack DV, McKinney JS, Piwnica-Worms D.

Cancer Discov. 2012 Jul;2(7):624-37. doi: 10.1158/2159-8290.CD-11-0201. Epub 2012 May 3.

42.

Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.

Bonar SL, Brydges SD, Mueller JL, McGeough MD, Pena C, Chen D, Grimston SK, Hickman-Brecks CL, Ravindran S, McAlinden A, Novack DV, Kastner DL, Civitelli R, Hoffman HM, Mbalaviele G.

PLoS One. 2012;7(4):e35979. doi: 10.1371/journal.pone.0035979. Epub 2012 Apr 27.

43.

Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis.

Mavers M, Cuda CM, Misharin AV, Gierut AK, Agrawal H, Weber E, Novack DV, Haines GK 3rd, Balomenos D, Perlman H.

Arthritis Rheum. 2012 Jan;64(1):141-52. doi: 10.1002/art.33311.

44.

CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.

Zhang K, Kim S, Cremasco V, Hirbe AC, Collins L, Piwnica-Worms D, Novack DV, Weilbaecher K, Faccio R.

Cancer Res. 2011 Jul 15;71(14):4799-808. doi: 10.1158/0008-5472.CAN-10-3922. Epub 2011 May 20. Erratum in: Cancer Res. 2012 Jan 15;72(2):568.

45.
46.

Unique personalities within the NF-κB family: distinct functions for p65 and RelB in the osteoclast.

Novack DV.

Adv Exp Med Biol. 2011;691:163-7. doi: 10.1007/978-1-4419-6612-4_17. No abstract available.

PMID:
21153320
47.

NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.

Yang C, McCoy K, Davis JL, Schmidt-Supprian M, Sasaki Y, Faccio R, Novack DV.

PLoS One. 2010 Nov 8;5(11):e15383. doi: 10.1371/journal.pone.0015383.

48.

Role of NF-κB in the skeleton.

Novack DV.

Cell Res. 2011 Jan;21(1):169-82. doi: 10.1038/cr.2010.159. Epub 2010 Nov 16. Review.

49.

Dysosteosclerosis presents as an "osteoclast-poor" form of osteopetrosis: comprehensive investigation of a 3-year-old girl and literature review.

Whyte MP, Wenkert D, McAlister WH, Novack DV, Nenninger AR, Zhang X, Huskey M, Mumm S.

J Bone Miner Res. 2010 Nov;25(11):2527-39. doi: 10.1002/jbmr.131. Review.

50.

The FOX(O1) blasts off.

Novack DV.

Cell Metab. 2010 Mar 3;11(3):175-6. doi: 10.1016/j.cmet.2010.02.009.

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