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Items: 1 to 50 of 113

1.

Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis.

Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M, Zhang L, Ye S, Nourshargh S, Xiao Q.

J Am Heart Assoc. 2018 Feb 8;7(4). pii: e008187. doi: 10.1161/JAHA.117.008187.

2.

Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.

Schulz-Fincke AC, Tikhomirov AS, Braune A, Girbl T, Gilberg E, Bajorath J, Blaut M, Nourshargh S, Gütschow M.

Biochemistry. 2018 Feb 6;57(5):742-752. doi: 10.1021/acs.biochem.7b00906. Epub 2018 Jan 16.

PMID:
29286643
3.

Human CD8+ EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK.

Callender LA, Carroll EC, Beal RWJ, Chambers ES, Nourshargh S, Akbar AN, Henson SM.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12675. Epub 2017 Oct 12.

4.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.

PMID:
29023707
5.

Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S, Pennington DJ, Barnes MR, Brohi K.

PLoS Med. 2017 Jul 17;14(7):e1002352. doi: 10.1371/journal.pmed.1002352. eCollection 2017 Jul.

6.

Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation.

Gittens BR, Bodkin JV, Nourshargh S, Perretti M, Cooper D.

J Immunol. 2017 Jun 1;198(11):4458-4469. doi: 10.4049/jimmunol.1600709. Epub 2017 Apr 24.

7.

Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation.

Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S, Voisin MB.

Sci Rep. 2017 Mar 13;7:44189. doi: 10.1038/srep44189.

8.

Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments.

Barzilai S, Yadav SK, Morrell S, Roncato F, Klein E, Stoler-Barak L, Golani O, Feigelson SW, Zemel A, Nourshargh S, Alon R.

Cell Rep. 2017 Jan 17;18(3):685-699. doi: 10.1016/j.celrep.2016.12.076.

9.

Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle.

Herrera C, Voisin MB, Escalante T, Rucavado A, Nourshargh S, Gutiérrez JM.

PLoS One. 2016 Dec 16;11(12):e0168643. doi: 10.1371/journal.pone.0168643. eCollection 2016.

10.

Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment.

Ma B, Whiteford JR, Nourshargh S, Woodfin A.

J Pathol. 2016 Nov;240(3):291-303. doi: 10.1002/path.4776.

11.

Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation.

Reglero-Real N, Colom B, Bodkin JV, Nourshargh S.

Arterioscler Thromb Vasc Biol. 2016 Oct;36(10):2048-2057. doi: 10.1161/ATVBAHA.116.307610. Epub 2016 Aug 11. Review.

12.

Reverse Migration of Neutrophils: Where, When, How, and Why?

Nourshargh S, Renshaw SA, Imhof BA.

Trends Immunol. 2016 May;37(5):273-286. doi: 10.1016/j.it.2016.03.006. Epub 2016 Apr 4. Review.

PMID:
27055913
13.

ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia.

Woodfin A, Beyrau M, Voisin MB, Ma B, Whiteford JR, Hordijk PL, Hogg N, Nourshargh S.

Blood. 2016 Feb 18;127(7):898-907. doi: 10.1182/blood-2015-08-664995. Epub 2015 Dec 8.

14.

Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states.

Madalli S, Beyrau M, Whiteford J, Duchene J, Singh Nandhra I, Patel NS, Motwani MP, Gilroy DW, Thiemermann C, Nourshargh S, Scotland RS.

Biol Sex Differ. 2015 Nov 26;6:27. doi: 10.1186/s13293-015-0047-5. eCollection 2015.

15.

Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction.

Armstrong PC, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD.

Blood. 2015 Sep 3;126(10):e11-8. doi: 10.1182/blood-2015-01-621656. Epub 2015 Jul 27.

16.

A Targeting Microbubble for Ultrasound Molecular Imaging.

Yeh JS, Sennoga CA, McConnell E, Eckersley R, Tang MX, Nourshargh S, Seddon JM, Haskard DO, Nihoyannopoulos P.

PLoS One. 2015 Jul 10;10(7):e0129681. doi: 10.1371/journal.pone.0129681. eCollection 2015.

17.

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo.

Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K, Imhof BA, Nourshargh S.

Immunity. 2015 Jun 16;42(6):1075-86. doi: 10.1016/j.immuni.2015.05.010. Epub 2015 Jun 2.

18.

Quantitative ultrasound molecular imaging.

Yeh JS, Sennoga CA, McConnell E, Eckersley R, Tang MX, Nourshargh S, Seddon JM, Haskard DO, Nihoyannopoulos P.

Ultrasound Med Biol. 2015 Sep;41(9):2478-96. doi: 10.1016/j.ultrasmedbio.2015.04.011. Epub 2015 Jun 1.

PMID:
26044707
19.

Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage.

Herrera C, Escalante T, Voisin MB, Rucavado A, Morazán D, Macêdo JK, Calvete JJ, Sanz L, Nourshargh S, Gutiérrez JM, Fox JW.

PLoS Negl Trop Dis. 2015 Apr 24;9(4):e0003731. doi: 10.1371/journal.pntd.0003731. eCollection 2015 Apr.

20.

Leukocyte migration into inflamed tissues.

Nourshargh S, Alon R.

Immunity. 2014 Nov 20;41(5):694-707. doi: 10.1016/j.immuni.2014.10.008. Epub 2014 Nov 20. Review.

21.

Shed syndecan-2 inhibits angiogenesis.

De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S, Whiteford JR.

J Cell Sci. 2014 Nov 1;127(Pt 21):4788-99. doi: 10.1242/jcs.153015.

22.

Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.

Finsterbusch M, Voisin MB, Beyrau M, Williams TJ, Nourshargh S.

J Exp Med. 2014 Jun 30;211(7):1307-14. doi: 10.1084/jem.20132413. Epub 2014 Jun 9.

23.

ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.

Halai K, Whiteford J, Ma B, Nourshargh S, Woodfin A.

J Cell Sci. 2014 Feb 1;127(Pt 3):620-9. doi: 10.1242/jcs.137463. Epub 2013 Dec 6.

24.

Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.

Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T, Imhof BA, Balkwill FR, Nourshargh S.

FASEB J. 2013 Oct;27(10):4244-53. doi: 10.1096/fj.13-230441. Epub 2013 Jul 3.

25.

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.

Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M.

Blood. 2013 Jul 25;122(4):608-17. doi: 10.1182/blood-2013-04-496661. Epub 2013 Jun 3.

26.

Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.

Alazawi W, Heath H, Waters JA, Woodfin A, O'Brien AJ, Scarzello AJ, Ma B, Lopez-Otalora Y, Jacobs M, Petts G, Goldin RD, Nourshargh S, Gamero AM, Foster GR.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8656-61. doi: 10.1073/pnas.1221652110. Epub 2013 May 7.

27.

Neutrophil transmigration: emergence of an adhesive cascade within venular walls.

Voisin MB, Nourshargh S.

J Innate Immun. 2013;5(4):336-47. doi: 10.1159/000346659. Epub 2013 Mar 2. Review.

28.

L2. Neutrophil transmigration in vivo: mechanisms, dynamics and contribution to dissemination of systemic inflammation.

Nourshargh S.

Presse Med. 2013 Apr;42(4 Pt 2):498-9. doi: 10.1016/j.lpm.2013.01.004. Epub 2013 Feb 23. Review. No abstract available.

PMID:
23462339
29.

Learning in motion: pericytes instruct migrating innate leukocytes.

Alon R, Nourshargh S.

Nat Immunol. 2013 Jan;14(1):14-5. doi: 10.1038/ni.2489. No abstract available.

PMID:
23238752
30.

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.

Beyrau M, Bodkin JV, Nourshargh S.

Open Biol. 2012 Nov;2(11):120134. doi: 10.1098/rsob.120134. Review.

31.

CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.

Ma L, Cheung KC, Kishore M, Nourshargh S, Mauro C, Marelli-Berg FM.

J Immunol. 2012 Oct 15;189(8):4104-11. doi: 10.4049/jimmunol.1201739. Epub 2012 Sep 10.

32.

The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.

Avari P, Huang W, Averill S, Colom B, Imhof BA, Nourshargh S, Priestley JV.

Brain Behav. 2012 Jul;2(4):402-14. doi: 10.1002/brb3.63.

33.

Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31.

Kishore M, Ma L, Cornish G, Nourshargh S, Marelli-Berg FM.

PLoS One. 2012;7(6):e39433. doi: 10.1371/journal.pone.0039433. Epub 2012 Jun 19.

34.

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.

Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S.

J Exp Med. 2012 Jun 4;209(6):1219-34. doi: 10.1084/jem.20111622. Epub 2012 May 21.

35.

The peritoneal tumour microenvironment of high-grade serous ovarian cancer.

Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FN, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S, Balkwill FR.

J Pathol. 2012 Jun;227(2):136-45. doi: 10.1002/path.4002. Epub 2012 Apr 18.

36.

Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.

Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD, Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML, Nourshargh S.

FASEB J. 2012 Mar;26(3):1064-76. doi: 10.1096/fj.11-196220. Epub 2011 Nov 16.

37.

Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148.

Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR.

Mol Biol Cell. 2011 Oct;22(19):3609-24. doi: 10.1091/mbc.E11-02-0099. Epub 2011 Aug 3.

38.

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.

Woodfin A, Voisin MB, Beyrau M, Colom B, Caille D, Diapouli FM, Nash GB, Chavakis T, Albelda SM, Rainger GE, Meda P, Imhof BA, Nourshargh S.

Nat Immunol. 2011 Jun 26;12(8):761-9. doi: 10.1038/ni.2062.

39.

CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism.

Veninga H, de Groot DM, McCloskey N, Owens BM, Dessing MC, Verbeek JS, Nourshargh S, van Eenennaam H, Boots AM, Hamann J.

J Leukoc Biol. 2011 Mar;89(3):413-21. doi: 10.1189/jlb.0510280. Epub 2010 Dec 17.

PMID:
21169517
40.

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.

Ma L, Mauro C, Cornish GH, Chai JG, Coe D, Fu H, Patton D, Okkenhaug K, Franzoso G, Dyson J, Nourshargh S, Marelli-Berg FM.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19461-6. doi: 10.1073/pnas.1011748107. Epub 2010 Oct 26.

41.

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.

Nourshargh S, Hordijk PL, Sixt M.

Nat Rev Mol Cell Biol. 2010 May;11(5):366-78. doi: 10.1038/nrm2889. Review.

PMID:
20414258
42.

The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature.

Leoni G, Voisin MB, Carlson K, Getting S, Nourshargh S, Perretti M.

Br J Pharmacol. 2010 May;160(1):171-80. doi: 10.1111/j.1476-5381.2010.00688.x. Epub 2010 Mar 19.

43.

Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.

Voisin MB, Pröbstl D, Nourshargh S.

Am J Pathol. 2010 Jan;176(1):482-95. doi: 10.2353/ajpath.2010.090510. Epub 2009 Dec 11.

44.

Recent developments and complexities in neutrophil transmigration.

Woodfin A, Voisin MB, Nourshargh S.

Curr Opin Hematol. 2010 Jan;17(1):9-17. doi: 10.1097/MOH.0b013e3283333930. Review.

45.

Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.

Scheiermann C, Colom B, Meda P, Patel NS, Voisin MB, Marrelli A, Woodfin A, Pitzalis C, Thiemermann C, Aurrand-Lions M, Imhof BA, Nourshargh S.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1509-15. doi: 10.1161/ATVBAHA.109.187559. Epub 2009 Jul 2.

46.

Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo.

Voisin MB, Woodfin A, Nourshargh S.

Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1193-9. doi: 10.1161/ATVBAHA.109.187450. Epub 2009 Jun 4.

47.

Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.

Little MA, Smyth L, Salama AD, Mukherjee S, Smith J, Haskard D, Nourshargh S, Cook HT, Pusey CD.

Am J Pathol. 2009 Apr;174(4):1212-20. doi: 10.2353/ajpath.2009.080458. Epub 2009 Mar 5.

48.

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.

Woodfin A, Voisin MB, Imhof BA, Dejana E, Engelhardt B, Nourshargh S.

Blood. 2009 Jun 11;113(24):6246-57. doi: 10.1182/blood-2008-11-188375. Epub 2009 Feb 10.

49.

Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves.

Scheiermann C, Meda P, Aurrand-Lions M, Madani R, Yiangou Y, Coffey P, Salt TE, Ducrest-Gay D, Caille D, Howell O, Reynolds R, Lobrinus A, Adams RH, Yu AS, Anand P, Imhof BA, Nourshargh S.

Science. 2007 Nov 30;318(5855):1472-5.

50.

PECAM-1: a multi-functional molecule in inflammation and vascular biology.

Woodfin A, Voisin MB, Nourshargh S.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2514-23. Epub 2007 Sep 13. Review.

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