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Items: 1 to 50 of 87

1.

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.

Joshi K, Robert de Massy M, Ismail M, Reading JL, Uddin I, Woolston A, Hatipoglu E, Oakes T, Rosenthal R, Peacock T, Ronel T, Noursadeghi M, Turati V, Furness AJS, Georgiou A, Wong YNS, Ben Aissa A, Werner Sunderland M, Jamal-Hanjani M, Veeriah S, Birkbak NJ, Wilson GA, Hiley CT, Ghorani E, Guerra-Assunção JA, Herrero J, Enver T, Hadrup SR, Hackshaw A, Peggs KS, McGranahan N, Swanton C; TRACERx Consortium, Quezada SA, Chain B.

Nat Med. 2019 Oct 4. doi: 10.1038/s41591-019-0592-2. [Epub ahead of print]

PMID:
31591606
2.

Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae.

Periselneris J, Ercoli G, Pollard T, Chimalapati S, Camberlein E, Szylar G, Hyams C, Tomlinson G, Petersen FC, Floto RA, Noursadeghi M, Brown JS.

MBio. 2019 Sep 24;10(5). pii: e02144-19. doi: 10.1128/mBio.02144-19.

3.

Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface.

Weight CM, Venturini C, Pojar S, Jochems SP, Reiné J, Nikolaou E, Solórzano C, Noursadeghi M, Brown JS, Ferreira DM, Heyderman RS.

Nat Commun. 2019 Jul 16;10(1):3060. doi: 10.1038/s41467-019-11005-2.

4.

Blood transcriptomic stratification of short-term risk in contacts of tuberculosis.

Roe J, Venturini C, Gupta RK, Gurry C, Chain BM, Sun Y, Southern J, Jackson C, Lipman MC, Miller RF, Martineau AR, Abubakar I, Noursadeghi M.

Clin Infect Dis. 2019 Mar 28. pii: ciz252. doi: 10.1093/cid/ciz252. [Epub ahead of print]

PMID:
30919880
5.

Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Dheda K, Lenders L, Srivastava S, Magombedze G, Wainwright H, Raj P, Bush SJ, Pollara G, Steyn R, Davids M, Pooran A, Pennel T, Linegar A, McNerney R, Moodley L, Pasipanodya JG, Turner CT, Noursadeghi M, Warren RM, Wakeland E, Gumbo T.

Am J Respir Crit Care Med. 2019 Aug 1;200(3):370-380. doi: 10.1164/rccm.201807-1361OC.

6.

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Petrillo C, Thorne LG, Unali G, Schiroli G, Giordano AMS, Piras F, Cuccovillo I, Petit SJ, Ahsan F, Noursadeghi M, Clare S, Genovese P, Gentner B, Naldini L, Towers GJ, Kajaste-Rudnitski A.

Cell Stem Cell. 2018 Dec 6;23(6):820-832.e9. doi: 10.1016/j.stem.2018.10.008. Epub 2018 Nov 8.

7.

Cohort study protocol: Bioresource in Adult Infectious Diseases (BioAID).

Shallcross LJ, Mentzer A, Rahman S, Cooke GS, Sriskandan S, Noursadeghi M.

Wellcome Open Res. 2018 Aug 8;3:97. doi: 10.12688/wellcomeopenres.14690.1. eCollection 2018.

8.

Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis.

Lachmandas E, Rios-Miguel AB, Koeken VACM, van der Pasch E, Kumar V, Matzaraki V, Li Y, Oosting M, Joosten LAB, Notebaart RA, Noursadeghi M, Netea MG, van Crevel R, Pollara G.

J Infect Dis. 2018 Jun 5;218(1):165-170. doi: 10.1093/infdis/jiy173.

9.

HIV gp120 in the Lungs of Antiretroviral Therapy-treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci.

Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M, Dockrell DH.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1604-1615. doi: 10.1164/rccm.201708-1755OC.

10.

A pilot study to understand feasibility and acceptability of stool and cord blood sample collection for a large-scale longitudinal birth cohort.

Bailey SR, Townsend CL, Dent H, Mallet C, Tsaliki E, Riley EM, Noursadeghi M, Lawley TD, Rodger AJ, Brocklehurst P, Field N.

BMC Pregnancy Childbirth. 2017 Dec 28;17(1):439. doi: 10.1186/s12884-017-1627-7.

11.

18F-Fluorodeoxyglucose positron emission tomography-computed tomography imaging in HIV-infected patients with lymphadenopathy, with or without fever and/or splenomegaly.

Jain L, Mackenzie S, Bomanji JB, Shortman R, Noursadeghi M, Edwards SG, Miller RF.

Int J STD AIDS. 2018 Jun;29(7):691-694. doi: 10.1177/0956462417745960. Epub 2017 Dec 4.

PMID:
29198183
12.

Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation.

Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE, Turner CT, Larbi A, Birault V, Noursadeghi M, Mabbott NA, Rustin MHA, Krueger JG, Akbar AN.

J Allergy Clin Immunol. 2018 Sep;142(3):844-856. doi: 10.1016/j.jaci.2017.10.032. Epub 2017 Nov 17.

13.

Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection.

Bell LCK, Noursadeghi M.

Nat Rev Microbiol. 2018 Feb;16(2):80-90. doi: 10.1038/nrmicro.2017.128. Epub 2017 Nov 7. Review.

PMID:
29109555
14.

Quantitative Characterization of the T Cell Receptor Repertoire of Naïve and Memory Subsets Using an Integrated Experimental and Computational Pipeline Which Is Robust, Economical, and Versatile.

Oakes T, Heather JM, Best K, Byng-Maddick R, Husovsky C, Ismail M, Joshi K, Maxwell G, Noursadeghi M, Riddell N, Ruehl T, Turner CT, Uddin I, Chain B.

Front Immunol. 2017 Oct 12;8:1267. doi: 10.3389/fimmu.2017.01267. eCollection 2017.

15.

Mismatch between suspected pyelonephritis and microbiological diagnosis: a cohort study from a UK teaching hospital.

Shallcross L, Gaskell K, Fox-Lewis A, Bergstrom M, Noursadeghi M.

J Hosp Infect. 2018 Feb;98(2):219-222. doi: 10.1016/j.jhin.2017.09.029. Epub 2017 Oct 4.

16.

Tumor Necrosis Factor (TNF) Bioactivity at the Site of an Acute Cell-Mediated Immune Response Is Preserved in Rheumatoid Arthritis Patients Responding to Anti-TNF Therapy.

Byng-Maddick R, Turner CT, Pollara G, Ellis M, Guppy NJ, Bell LCK, Ehrenstein MR, Noursadeghi M.

Front Immunol. 2017 Aug 4;8:932. doi: 10.3389/fimmu.2017.00932. eCollection 2017.

17.

A Four-Biomarker Blood Signature Discriminates Systemic Inflammation Due to Viral Infection Versus Other Etiologies.

Sampson DL, Fox BA, Yager TD, Bhide S, Cermelli S, McHugh LC, Seldon TA, Brandon RA, Sullivan E, Zimmerman JJ, Noursadeghi M, Brandon RB.

Sci Rep. 2017 Jun 6;7(1):2914. doi: 10.1038/s41598-017-02325-8.

18.

A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.

Mlcochova P, Sutherland KA, Watters SA, Bertoli C, de Bruin RA, Rehwinkel J, Neil SJ, Lenzi GM, Kim B, Khwaja A, Gage MC, Georgiou C, Chittka A, Yona S, Noursadeghi M, Towers GJ, Gupta RK.

EMBO J. 2017 Mar 1;36(5):604-616. doi: 10.15252/embj.201696025. Epub 2017 Jan 25.

19.

Validation of Immune Cell Modules in Multicellular Transcriptomic Data.

Pollara G, Murray MJ, Heather JM, Byng-Maddick R, Guppy N, Ellis M, Turner CT, Chain BM, Noursadeghi M.

PLoS One. 2017 Jan 3;12(1):e0169271. doi: 10.1371/journal.pone.0169271. eCollection 2017.

20.

Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis.

Roe JK, Thomas N, Gil E, Best K, Tsaliki E, Morris-Jones S, Stafford S, Simpson N, Witt KD, Chain B, Miller RF, Martineau A, Noursadeghi M.

JCI Insight. 2016 Oct 6;1(16):e87238. doi: 10.1172/jci.insight.87238.

21.

Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL.

JCI Insight. 2016 Sep 22;1(15):e88843. doi: 10.1172/jci.insight.88843.

22.

Cell-type-specific modulation of innate immune signalling by vitamin D in human mononuclear phagocytes.

Kundu R, Theodoraki A, Haas CT, Zhang Y, Chain B, Kriston-Vizi J, Noursadeghi M, Khoo B.

Immunology. 2017 Jan;150(1):55-63. doi: 10.1111/imm.12669. Epub 2016 Oct 3.

23.

Diagnostic 'omics' for active tuberculosis.

Haas CT, Roe JK, Pollara G, Mehta M, Noursadeghi M.

BMC Med. 2016 Mar 23;14:37. doi: 10.1186/s12916-016-0583-9. Review.

24.

In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis.

Bell LC, Pollara G, Pascoe M, Tomlinson GS, Lehloenya RJ, Roe J, Meldau R, Miller RF, Ramsay A, Chain BM, Dheda K, Noursadeghi M.

PLoS Pathog. 2016 Mar 17;12(3):e1005469. doi: 10.1371/journal.ppat.1005469. eCollection 2016 Mar.

25.

Does tuberculosis threaten our ageing populations?

Byng-Maddick R, Noursadeghi M.

BMC Infect Dis. 2016 Mar 11;16:119. doi: 10.1186/s12879-016-1451-0. Review.

26.

Dynamic Perturbations of the T-Cell Receptor Repertoire in Chronic HIV Infection and following Antiretroviral Therapy.

Heather JM, Best K, Oakes T, Gray ER, Roe JK, Thomas N, Friedman N, Noursadeghi M, Chain B.

Front Immunol. 2016 Jan 11;6:644. doi: 10.3389/fimmu.2015.00644. eCollection 2015.

27.

Are the public getting the message about antimicrobial resistance?

Shallcross LJ, Berin M, Roe J, Noursadeghi M.

Arch Public Health. 2015 Nov 12;73:55. doi: 10.1186/s13690-015-0108-6. eCollection 2015.

28.

Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea.

Lapp T, Zaher SS, Haas CT, Becker DL, Thrasivoulou C, Chain BM, Larkin DF, Noursadeghi M.

Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7250-9. doi: 10.1167/iovs.15-16941.

PMID:
26544793
29.

Transcriptional Profiling of Endobronchial Ultrasound-Guided Lymph Node Samples Aids Diagnosis of Mediastinal Lymphadenopathy.

Tomlinson GS, Thomas N, Chain BM, Best K, Simpson N, Hardavella G, Brown J, Bhowmik A, Navani N, Janes SM, Miller RF, Noursadeghi M.

Chest. 2016 Feb;149(2):535-544. doi: 10.1378/chest.15-0647. Epub 2016 Jan 12.

30.

Towards host-directed therapies for tuberculosis.

Zumla A, Maeurer M; Host-Directed Therapies Network, Chakaya J, Hoelscher M, Ntoumi F, Rustomjee R, Vilaplana C, Yeboah-Manu D, Rasolof V, Munderi P, Singh N, Aklillu E, Padayatchi N, Macete E, Kapata N, Mulenga M, Kibiki G, Mfinanga S, Nyirenda T, Maboko L, Garcia-Basteiro A, Rakotosamimanana N, Bates M, Mwaba P, Reither K, Gagneux S, Edwards S, Mfinanga E, Abdulla S, Cardona PJ, Russell JB, Gant V, Noursadeghi M, Elkington P, Bonnet M, Menendez C, Dieye TN, Diarra B, Maiga A, Aseffa A, Parida S, Wejse C, Petersen E, Kaleebu P, Oliver M, Craig G, Corrah T, Tientcheu L, Antonio M, Rao M, McHugh TD, Sheikh A, Ippolito G, Ramjee G, Kaufmann SH, Churchyard G, Steyn A, Grobusch M, Sanne I, Martinson N, Madansein R, Wilkinson RJ, Mayosi B, Schito M, Wallis RS.

Nat Rev Drug Discov. 2015 Aug;14(8):511-2. doi: 10.1038/nrd4696. Epub 2015 Jul 17.

PMID:
26184493
31.

A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody.

Chain B, Arnold J, Akthar S, Brandt M, Davis D, Noursadeghi M, Lapp T, Ji C, Sankuratri S, Zhang Y, Govada L, Saridakis E, Chayen N.

PLoS One. 2015 Jun 1;10(6):e0128381. doi: 10.1371/journal.pone.0128381. eCollection 2015.

32.

elCID: An electronic Clinical Infection Database to support integrated clinical services and research in infectious diseases.

Marks M, Pollara G, Miller D, Bhatt S, Reynolds C, Gant V, Noursadeghi M.

J Infect. 2015 Sep;71(3):402-405. doi: 10.1016/j.jinf.2015.04.007. Epub 2015 Apr 17. No abstract available.

33.

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis.

Jarvis JN, Meintjes G, Bicanic T, Buffa V, Hogan L, Mo S, Tomlinson G, Kropf P, Noursadeghi M, Harrison TS.

PLoS Pathog. 2015 Apr 8;11(4):e1004754. doi: 10.1371/journal.ppat.1004754. eCollection 2015 Apr.

34.

Paradoxical reactions and immune reconstitution inflammatory syndrome in tuberculosis.

Bell LC, Breen R, Miller RF, Noursadeghi M, Lipman M.

Int J Infect Dis. 2015 Mar;32:39-45. doi: 10.1016/j.ijid.2014.12.030. Review.

35.

Importance of bacterial replication and alveolar macrophage-independent clearance mechanisms during early lung infection with Streptococcus pneumoniae.

Camberlein E, Cohen JM, José R, Hyams CJ, Callard R, Chimalapati S, Yuste J, Edwards LA, Marshall H, van Rooijen N, Noursadeghi M, Brown JS.

Infect Immun. 2015 Mar;83(3):1181-9. doi: 10.1128/IAI.02788-14. Epub 2015 Jan 12.

36.

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.

Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J.

Nat Commun. 2014 Oct 20;5:5236. doi: 10.1038/ncomms6236.

PMID:
25327457
37.

TLR-mediated inflammatory responses to Streptococcus pneumoniae are highly dependent on surface expression of bacterial lipoproteins.

Tomlinson G, Chimalapati S, Pollard T, Lapp T, Cohen J, Camberlein E, Stafford S, Periselneris J, Aldridge C, Vollmer W, Picard C, Casanova JL, Noursadeghi M, Brown J.

J Immunol. 2014 Oct 1;193(7):3736-45. doi: 10.4049/jimmunol.1401413. Epub 2014 Aug 29.

38.

Interactions between HIV-1 and the cell-autonomous innate immune system.

Towers GJ, Noursadeghi M.

Cell Host Microbe. 2014 Jul 9;16(1):10-8. doi: 10.1016/j.chom.2014.06.009. Review.

39.

Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.

Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK.

Retrovirology. 2014 Mar 21;11:25. doi: 10.1186/1742-4690-11-25.

40.

Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells.

Kundu R, Chain BM, Coussens AK, Khoo B, Noursadeghi M.

Eur J Immunol. 2014 Jun;44(6):1781-90. doi: 10.1002/eji.201344157. Epub 2014 Apr 10.

41.

The immune system as a biomonitor: explorations in innate and adaptive immunity.

Thomas N, Heather J, Pollara G, Simpson N, Matjeka T, Shawe-Taylor J, Noursadeghi M, Chain B.

Interface Focus. 2013 Apr 6;3(2):20120099. doi: 10.1098/rsfs.2012.0099.

42.

HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin-10.

Tomlinson GS, Bell LC, Walker NF, Tsang J, Brown JS, Breen R, Lipman M, Katz DR, Miller RF, Chain BM, Elkington PT, Noursadeghi M.

J Infect Dis. 2014 Apr 1;209(7):1055-65. doi: 10.1093/infdis/jit621. Epub 2013 Nov 21.

43.

HIV-1 evades innate immune recognition through specific cofactor recruitment.

Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ.

Nature. 2013 Nov 21;503(7476):402-405. doi: 10.1038/nature12769. Epub 2013 Nov 6.

44.

The clinical and ecological impact of childhood pneumococcal vaccination.

Gil E, Noursadeghi M, Brown JS.

Br J Hosp Med (Lond). 2013 Apr;74(4):212-6. Review. No abstract available.

PMID:
23571392
45.

Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b.

Hyams C, Trzcinski K, Camberlein E, Weinberger DM, Chimalapati S, Noursadeghi M, Lipsitch M, Brown JS.

Infect Immun. 2013 Jan;81(1):354-63. doi: 10.1128/IAI.00862-12. Epub 2012 Nov 12.

46.

Needles and the damage done: reasons for admission and financial costs associated with injecting drug use in a Central London Teaching Hospital.

Marks M, Pollock E, Armstrong M, Morris-Jones S, Kidd M, Gothard P, Noursadeghi M, Doherty JF.

J Infect. 2013 Jan;66(1):95-102. doi: 10.1016/j.jinf.2012.10.004. Epub 2012 Oct 12.

PMID:
23068454
47.

An unusual cause of fever in an HIV-positive patient.

Sayer RA, Whitehorn J, Cartledge JD, Shipley M, Noursadeghi M.

Int J STD AIDS. 2012 Jun;23(6):453-4. doi: 10.1258/ijsa.2009.009375.

PMID:
22807546
48.

Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation.

Tomlinson GS, Booth H, Petit SJ, Potton E, Towers GJ, Miller RF, Chain BM, Noursadeghi M.

PLoS One. 2012;7(6):e40348. doi: 10.1371/journal.pone.0040348. Epub 2012 Jun 29.

49.

Innate immune interferon responses to human immunodeficiency virus-1 infection.

Hughes R, Towers G, Noursadeghi M.

Rev Med Virol. 2012 Jul;22(4):257-66. doi: 10.1002/rmv.1708. Epub 2012 Feb 22. Review.

PMID:
22359246
50.

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.

Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, KewalRamani VN, Noursadeghi M, Jenner RG, James LC, Bushman FD, Towers GJ.

PLoS Pathog. 2011 Dec;7(12):e1002439. doi: 10.1371/journal.ppat.1002439. Epub 2011 Dec 8.

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