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Items: 47


The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin.

Chagneau CV, Garcie C, Bossuet-Greif N, Tronnet S, Brachmann AO, Piel J, Nougayrède JP, Martin P, Oswald E.

mSphere. 2019 Oct 2;4(5). pii: e00414-19. doi: 10.1128/mSphere.00414-19.


Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917.

Massip C, Branchu P, Bossuet-Greif N, Chagneau CV, Gaillard D, Martin P, Boury M, Sécher T, Dubois D, Nougayrède JP, Oswald E.

PLoS Pathog. 2019 Sep 23;15(9):e1008029. doi: 10.1371/journal.ppat.1008029. eCollection 2019 Sep.


The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.

Bossuet-Greif N, Vignard J, Taieb F, Mirey G, Dubois D, Petit C, Oswald E, Nougayrède JP.

MBio. 2018 Mar 20;9(2). pii: e02393-17. doi: 10.1128/mBio.02393-17.


The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin.

Taieb F, Petit C, Nougayrède JP, Oswald E.

EcoSal Plus. 2016 Jul;7(1). doi: 10.1128/ecosalplus.ESP-0008-2016. Review.


The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli.

Garcie C, Tronnet S, Garénaux A, McCarthy AJ, Brachmann AO, Pénary M, Houle S, Nougayrède JP, Piel J, Taylor PW, Dozois CM, Genevaux P, Oswald E, Martin P.

J Infect Dis. 2016 Sep 15;214(6):916-24. doi: 10.1093/infdis/jiw294. Epub 2016 Jul 13.


Escherichia coli ClbS is a colibactin resistance protein.

Bossuet-Greif N, Dubois D, Petit C, Tronnet S, Martin P, Bonnet R, Oswald E, Nougayrède JP.

Mol Microbiol. 2016 Mar;99(5):897-908. doi: 10.1111/mmi.13272. Epub 2015 Dec 1.


HlyF Produced by Extraintestinal Pathogenic Escherichia coli Is a Virulence Factor That Regulates Outer Membrane Vesicle Biogenesis.

Murase K, Martin P, Porcheron G, Houle S, Helloin E, Pénary M, Nougayrède JP, Dozois CM, Hayashi T, Oswald E.

J Infect Dis. 2016 Mar 1;213(5):856-65. doi: 10.1093/infdis/jiv506. Epub 2015 Oct 22.


Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis.

Payros D, Secher T, Boury M, Brehin C, Ménard S, Salvador-Cartier C, Cuevas-Ramos G, Watrin C, Marcq I, Nougayrède JP, Dubois D, Bedu A, Garnier F, Clermont O, Denamur E, Plaisancié P, Theodorou V, Fioramonti J, Olier M, Oswald E.

Gut Microbes. 2014 May-Jun;5(3):313-25. doi: 10.4161/gmic.28932. Epub 2014 Jun 27.


The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli.

Marcq I, Martin P, Payros D, Cuevas-Ramos G, Boury M, Watrin C, Nougayrède JP, Olier M, Oswald E.

J Infect Dis. 2014 Jul 15;210(2):285-94. doi: 10.1093/infdis/jiu071. Epub 2014 Jan 31.


Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells.

Secher T, Samba-Louaka A, Oswald E, Nougayrède JP.

PLoS One. 2013 Oct 8;8(10):e77157. doi: 10.1371/journal.pone.0077157. eCollection 2013.


In vitro evolution of an archetypal enteropathogenic Escherichia coli strain.

Nisa S, Hazen TH, Assatourian L, Nougayrède JP, Rasko DA, Donnenberg MS.

J Bacteriol. 2013 Oct;195(19):4476-83. doi: 10.1128/JB.00704-13. Epub 2013 Aug 2.


Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli.

Martin P, Marcq I, Magistro G, Penary M, Garcie C, Payros D, Boury M, Olier M, Nougayrède JP, Audebert M, Chalut C, Schubert S, Oswald E.

PLoS Pathog. 2013;9(7):e1003437. doi: 10.1371/journal.ppat.1003437. Epub 2013 Jul 11.


The carbon storage regulator (Csr) system exerts a nutrient-specific control over central metabolism in Escherichia coli strain Nissle 1917.

Revelles O, Millard P, Nougayrède JP, Dobrindt U, Oswald E, Létisse F, Portais JC.

PLoS One. 2013 Jun 20;8(6):e66386. doi: 10.1371/journal.pone.0066386. Print 2013.


Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity.

Olier M, Marcq I, Salvador-Cartier C, Secher T, Dobrindt U, Boury M, Bacquié V, Pénary M, Gaultier E, Nougayrède JP, Fioramonti J, Oswald E.

Gut Microbes. 2012 Nov-Dec;3(6):501-9. doi: 10.4161/gmic.21737. Epub 2012 Aug 16.


[Microbiota and colorectal cancer: genotoxic bacteria in the intestinal tract].

Nougayrède JP, Oswald E.

Bull Acad Natl Med. 2011 Jun;195(6):1295-304; discussion 1304-5. French.


Cycle inhibiting factors (cifs): cyclomodulins that usurp the ubiquitin-dependent degradation pathway of host cells.

Taieb F, Nougayrède JP, Oswald E.

Toxins (Basel). 2011 Apr;3(4):356-68. doi: 10.3390/toxins3040356. Epub 2011 Mar 29. Review.


ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides.

Dubois D, Baron O, Cougnoux A, Delmas J, Pradel N, Boury M, Bouchon B, Bringer MA, Nougayrède JP, Oswald E, Bonnet R.

J Biol Chem. 2011 Oct 14;286(41):35562-70. doi: 10.1074/jbc.M111.221960. Epub 2011 Jul 27.


Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways.

Jubelin G, Taieb F, Duda DM, Hsu Y, Samba-Louaka A, Nobe R, Penary M, Watrin C, Nougayrède JP, Schulman BA, Stebbins CE, Oswald E.

PLoS Pathog. 2010 Sep 30;6(9):e1001128. doi: 10.1371/journal.ppat.1001128.


Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism.

Pinton P, Braicu C, Nougayrede JP, Laffitte J, Taranu I, Oswald IP.

J Nutr. 2010 Nov;140(11):1956-62. doi: 10.3945/jn.110.123919. Epub 2010 Sep 22.


Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells.

Cuevas-Ramos G, Petit CR, Marcq I, Boury M, Oswald E, Nougayrède JP.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11537-42. doi: 10.1073/pnas.1001261107. Epub 2010 Jun 7.


The enteropathogenic Escherichia coli effector Cif induces delayed apoptosis in epithelial cells.

Samba-Louaka A, Nougayrède JP, Watrin C, Oswald E, Taieb F.

Infect Immun. 2009 Dec;77(12):5471-7. doi: 10.1128/IAI.00860-09. Epub 2009 Sep 28.


Cif type III effector protein: a smart hijacker of the host cell cycle.

Samba-Louaka A, Taieb F, Nougayrède JP, Oswald E.

Future Microbiol. 2009 Sep;4(7):867-77. doi: 10.2217/fmb.09.60. Review.


Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.

Putze J, Hennequin C, Nougayrède JP, Zhang W, Homburg S, Karch H, Bringer MA, Fayolle C, Carniel E, Rabsch W, Oelschlaeger TA, Oswald E, Forestier C, Hacker J, Dobrindt U.

Infect Immun. 2009 Nov;77(11):4696-703. doi: 10.1128/IAI.00522-09. Epub 2009 Aug 31.


Enterohaemorrhagic Escherichia coli serogroup O111 inhibits NF-(kappa)B-dependent innate responses in a manner independent of a type III secreted OspG orthologue.

Nobe R, Nougayrède JP, Taieb F, Bardiau M, Cassart D, Navarro-Garcia F, Mainil J, Hayashi T, Oswald E.

Microbiology. 2009 Oct;155(Pt 10):3214-25. doi: 10.1099/mic.0.030759-0. Epub 2009 Jul 23.


Cycle inhibiting factors (CIFs) are a growing family of functional cyclomodulins present in invertebrate and mammal bacterial pathogens.

Jubelin G, Chavez CV, Taieb F, Banfield MJ, Samba-Louaka A, Nobe R, Nougayrède JP, Zumbihl R, Givaudan A, Escoubas JM, Oswald E.

PLoS One. 2009;4(3):e4855. doi: 10.1371/journal.pone.0004855. Epub 2009 Mar 24.


The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression.

Pinton P, Nougayrède JP, Del Rio JC, Moreno C, Marin DE, Ferrier L, Bracarense AP, Kolf-Clauw M, Oswald IP.

Toxicol Appl Pharmacol. 2009 May 15;237(1):41-8. doi: 10.1016/j.taap.2009.03.003. Epub 2009 Mar 14.


Cytolethal distending toxin type I and type IV genes are framed with lambdoid prophage genes in extraintestinal pathogenic Escherichia coli.

Tóth I, Nougayrède JP, Dobrindt U, Ledger TN, Boury M, Morabito S, Fujiwara T, Sugai M, Hacker J, Oswald E.

Infect Immun. 2009 Jan;77(1):492-500. doi: 10.1128/IAI.00962-08. Epub 2008 Nov 3.


Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island.

Johnson JR, Johnston B, Kuskowski MA, Nougayrede JP, Oswald E.

J Clin Microbiol. 2008 Dec;46(12):3906-11. doi: 10.1128/JCM.00949-08. Epub 2008 Oct 22.


Structure of the cyclomodulin Cif from pathogenic Escherichia coli.

Hsu Y, Jubelin G, Taieb F, Nougayrède JP, Oswald E, Stebbins CE.

J Mol Biol. 2008 Dec 12;384(2):465-77. doi: 10.1016/j.jmb.2008.09.051. Epub 2008 Sep 27.


Bacterial cyclomodulin Cif blocks the host cell cycle by stabilizing the cyclin-dependent kinase inhibitors p21 and p27.

Samba-Louaka A, Nougayrède JP, Watrin C, Jubelin G, Oswald E, Taieb F.

Cell Microbiol. 2008 Dec;10(12):2496-508. doi: 10.1111/j.1462-5822.2008.01224.x. Epub 2008 Aug 13.


EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability.

Peralta-Ramírez J, Hernandez JM, Manning-Cela R, Luna-Muñoz J, Garcia-Tovar C, Nougayréde JP, Oswald E, Navarro-Garcia F.

Infect Immun. 2008 Sep;76(9):3854-68. doi: 10.1128/IAI.00072-08. Epub 2008 Jun 16.


Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes.

Ogura Y, Ooka T, Asadulghani, Terajima J, Nougayrède JP, Kurokawa K, Tashiro K, Tobe T, Nakayama K, Kuhara S, Oswald E, Watanabe H, Hayashi T.

Genome Biol. 2007;8(7):R138.


Enteropathogenic Escherichia coli effector EspF interacts with host protein Abcf2.

Nougayrède JP, Foster GH, Donnenberg MS.

Cell Microbiol. 2007 Mar;9(3):680-93. Epub 2006 Oct 25.


Escherichia coli induces DNA double-strand breaks in eukaryotic cells.

Nougayrède JP, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E.

Science. 2006 Aug 11;313(5788):848-51.


Escherichia coli cyclomodulin Cif induces G2 arrest of the host cell cycle without activation of the DNA-damage checkpoint-signalling pathway.

Taieb F, Nougayrède JP, Watrin C, Samba-Louaka A, Oswald E.

Cell Microbiol. 2006 Dec;8(12):1910-21. Epub 2006 Jul 11.


Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle.

Nougayrède JP, Taieb F, De Rycke J, Oswald E.

Trends Microbiol. 2005 Mar;13(3):103-10. Review.


Bacterial toxins that modulate host cell-cycle progression.

Oswald E, Nougayrède JP, Taieb F, Sugai M.

Curr Opin Microbiol. 2005 Feb;8(1):83-91. Review.


Genetically engineered enteropathogenic Escherichia coli strain elicits a specific immune response and protects against a virulent challenge.

Boullier S, Nougayrède JP, Marchès O, Tasca C, Boury M, Oswald E, De Rycke J, Milon A.

Microbes Infect. 2003 Aug;5(10):857-67.


Adhesion of enteropathogenic Escherichia coli to host cells.

Nougayrède JP, Fernandes PJ, Donnenberg MS.

Cell Microbiol. 2003 Jun;5(6):359-72. Review.


Type III secretion-dependent cell cycle block caused in HeLa cells by enteropathogenic Escherichia coli O103.

Nougayrède JP, Boury M, Tasca C, Marchès O, Milon A, Oswald E, De Rycke J.

Infect Immun. 2001 Nov;69(11):6785-95.


Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function.

McNamara BP, Koutsouris A, O'Connell CB, Nougayréde JP, Donnenberg MS, Hecht G.

J Clin Invest. 2001 Mar;107(5):621-9.


Role of tir and intimin in the virulence of rabbit enteropathogenic Escherichia coli serotype O103:H2.

Marchès O, Nougayrède JP, Boullier S, Mainil J, Charlier G, Raymond I, Pohl P, Boury M, De Rycke J, Milon A, Oswald E.

Infect Immun. 2000 Apr;68(4):2171-82.


The long-term cytoskeletal rearrangement induced by rabbit enteropathogenic Escherichia coli is Esp dependent but intimin independent.

Nougayrède JP, Marchès O, Boury M, Mainil J, Charlier G, Pohl P, De Rycke J, Milon A, Oswald E.

Mol Microbiol. 1999 Jan;31(1):19-30.


A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase.

Pérès SY, Marchès O, Daigle F, Nougayrède JP, Herault F, Tasca C, De Rycke J, Oswald E.

Mol Microbiol. 1997 Jun;24(5):1095-107.


Interaction of Escherichia coli producing cytotoxic necrotizing factor with HeLa epithelial cells.

De Rycke J, Nougayrede JP, Oswald E, Mazars P.

Adv Exp Med Biol. 1997;412:363-6.


Mitotic block and delayed lethality in HeLa epithelial cells exposed to Escherichia coli BM2-1 producing cytotoxic necrotizing factor type 1.

De Rycke J, Mazars P, Nougayrede JP, Tasca C, Boury M, Herault F, Valette A, Oswald E.

Infect Immun. 1996 May;64(5):1694-705.

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