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Items: 8

1.

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.

Tice CM, Noto PB, Fan KY, Zhao W, Lotesta SD, Dong C, Marcus AP, Zheng YJ, Chen G, Wu Z, Van Orden R, Zhou J, Bukhtiyarov Y, Zhao Y, Lipinski K, Howard L, Guo J, Kandpal G, Meng S, Hardy A, Krosky P, Gregg RE, Leftheris K, McKeever BM, Singh SB, Lala D, McGeehan GM, Zhuang L, Claremon DA.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5044-5050. doi: 10.1016/j.bmcl.2016.08.089. Epub 2016 Aug 29.

PMID:
27599745
2.

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.

Zheng Y, Zhuang L, Fan KY, Tice CM, Zhao W, Dong C, Lotesta SD, Leftheris K, Lindblom PR, Liu Z, Shimada J, Noto PB, Meng S, Hardy A, Howard L, Krosky P, Guo J, Lipinski K, Kandpal G, Bukhtiyarov Y, Zhao Y, Lala D, Van Orden R, Zhou J, Chen G, Wu Z, McKeever BM, McGeehan GM, Gregg RE, Claremon DA, Singh SB.

J Med Chem. 2016 Apr 14;59(7):3264-71. doi: 10.1021/acs.jmedchem.5b02029. Epub 2016 Mar 29.

PMID:
26990539
3.

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.

Lotesta SD, Marcus AP, Zheng Y, Leftheris K, Noto PB, Meng S, Kandpal G, Chen G, Zhou J, McKeever B, Bukhtiyarov Y, Zhao Y, Lala DS, Singh SB, McGeehan GM.

Bioorg Med Chem. 2016 Mar 15;24(6):1384-91. doi: 10.1016/j.bmc.2016.02.014. Epub 2016 Feb 9.

PMID:
26897089
4.

The medicinal chemistry of liver X receptor (LXR) modulators.

Tice CM, Noto PB, Fan KY, Zhuang L, Lala DS, Singh SB.

J Med Chem. 2014 Sep 11;57(17):7182-205. doi: 10.1021/jm500442z. Epub 2014 May 28.

PMID:
24832115
5.

Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.

Noto PB, Bukhtiyarov Y, Shi M, McKeever BM, McGeehan GM, Lala DS.

Mol Pharmacol. 2012 Oct;82(4):719-27. Epub 2012 Jul 18.

PMID:
22810003
6.

Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo.

Noto PB, Abbadessa G, Cassone M, Mateo GD, Agelan A, Wade JD, Szabo D, Kocsis B, Nagy K, Rozgonyi F, Otvos L Jr.

Protein Sci. 2008 Jul;17(7):1249-55. doi: 10.1110/ps.034330.108. Epub 2008 Apr 15.

7.

Epigenetic modulation of estrogen receptor-alpha by pRb family proteins: a novel mechanism in breast cancer.

Macaluso M, Montanari M, Noto PB, Gregorio V, Bronner C, Giordano A.

Cancer Res. 2007 Aug 15;67(16):7731-7.

8.

Nuclear and cytoplasmic interaction of pRb2/p130 and ER-beta in MCF-7 breast cancer cells.

Macaluso M, Montanari M, Noto PB, Gregorio V, Surmacz E, Giordano A.

Ann Oncol. 2006 Jun;17 Suppl 7:vii27-9.

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