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Luciferase-Based Detection of Antibodies for the Diagnosis of HPV-Associated Head and Neck Squamous Cell Carcinoma.

Burbelo PD, Chaturvedi A, Notkins AL, Gunti S.

Diagnostics (Basel). 2019 Aug 6;9(3). pii: E89. doi: 10.3390/diagnostics9030089.


Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer Therapeutics.

Chen C, Notkins AL, Lan MS.

Mol Cancer Res. 2019 Aug;17(8):1597-1604. doi: 10.1158/1541-7786.MCR-19-0286. Epub 2019 May 21. Review.


Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance.

Wang L, Sun ZS, Xiang B, Wei CJ, Wang Y, Sun K, Chen G, Lan MS, Carmona GN, Notkins AL, Cai T.

J Transl Med. 2018 Oct 25;16(1):297. doi: 10.1186/s12967-018-1665-6.


Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

Khandelwal S, Ravi J, Rauova L, Johnson A, Lee GM, Gilner JB, Gunti S, Notkins AL, Kuchibhatla M, Frank M, Poncz M, Cines DB, Arepally GM.

Blood. 2018 Dec 6;132(23):2431-2440. doi: 10.1182/blood-2018-03-834598. Epub 2018 Oct 11.


Decrease in the ratio of polyreactive IgG titers with IgG concentration is associated with long-term complications of primary Sjögren's syndrome.

Argyropoulou OD, Gunti S, Kapsogeorgou EK, Notkins AL, Tzioufas AG.

Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):239-240. Epub 2018 Aug 14. No abstract available.


Polyreactive antibodies in CLL correlate with the level of immunoglobulins not the number of B lymphocytes.

Gunti S, Herman SEM, Gottumukkala RVSRK, Xiong Y, Sun C, Carmona GN, Wiestner A, Notkins AL.

Leuk Lymphoma. 2019 Jan;60(1):242-245. doi: 10.1080/10428194.2018.1464159. Epub 2018 May 9. No abstract available.


Ultrarapid Measurement of Diagnostic Antibodies by Magnetic Capture of Immune Complexes.

Burbelo PD, Gunti S, Keller JM, Morse CG, Deeks SG, Lionakis MS, Kapoor A, Li Q, Cohen JI, Notkins AL, Alevizos I.

Sci Rep. 2017 Jun 19;7(1):3818. doi: 10.1038/s41598-017-03786-7.


Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2.

Xu H, Cai T, Carmona GN, Abuhatzira L, Notkins AL.

J Transl Med. 2016 Sep 26;14(1):278.


Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation.

Gunti S, Messer RJ, Xu C, Yan M, Coleman WG Jr, Peterson KE, Hasenkrug KJ, Notkins AL.

Sci Rep. 2015 Oct 14;5:15066. doi: 10.1038/srep15066.


Polyreactive antibodies in the circulation of patients with systemic lupus erythematosus.

Gunti S, Kampylafka EI, Tzioufas AG, Notkins AL.

Lupus. 2015 Dec;24(14):1567-9. doi: 10.1177/0961203315603144. Epub 2015 Sep 18. No abstract available.


Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib.

Sun C, Tian X, Lee YS, Gunti S, Lipsky A, Herman SE, Salem D, Stetler-Stevenson M, Yuan C, Kardava L, Moir S, Maric I, Valdez J, Soto S, Marti GE, Farooqui MZ, Notkins AL, Wiestner A, Aue G.

Blood. 2015 Nov 5;126(19):2213-9. doi: 10.1182/blood-2015-04-639203. Epub 2015 Sep 3. Erratum in: Blood. 2016 Aug 18;128(7):1020.


Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2β, and GAD65.

Abuhatzira L, Xu H, Tahhan G, Boulougoura A, Schäffer AA, Notkins AL.

FASEB J. 2015 Oct;29(10):4374-83. doi: 10.1096/fj.15-273649. Epub 2015 Jul 6.


The Ia-2β intronic miRNA, miR-153, is a negative regulator of insulin and dopamine secretion through its effect on the Cacna1c gene in mice.

Xu H, Abuhatzira L, Carmona GN, Vadrevu S, Satin LS, Notkins AL.

Diabetologia. 2015 Oct;58(10):2298-306. doi: 10.1007/s00125-015-3683-8. Epub 2015 Jul 4.


Combining quantitative 2D and 3D image analysis in the serial block face SEM: application to secretory organelles of pancreatic islet cells.

Shomorony A, Pfeifer CR, Aronova MA, Zhang G, Cai T, Xu H, Notkins AL, Leapman RD.

J Microsc. 2015 Aug;259(2):155-164. doi: 10.1111/jmi.12276. Epub 2015 Jul 2.


Polyreactive Antibodies: Function and Quantification.

Gunti S, Notkins AL.

J Infect Dis. 2015 Jul 15;212 Suppl 1:S42-6. doi: 10.1093/infdis/jiu512. Review.


Pathophysiologic changes in IA-2/IA-2β null mice are secondary to alterations in the secretion of hormones and neurotransmitters.

Cai T, Notkins AL.

Acta Diabetol. 2016 Feb;53(1):7-12. doi: 10.1007/s00592-015-0750-z. Epub 2015 Apr 11.


Impact of natural IgM concentration on gene therapy with adenovirus type 5 vectors.

Qiu Q, Xu Z, Tian J, Moitra R, Gunti S, Notkins AL, Byrnes AP.

J Virol. 2015 Mar;89(6):3412-6. doi: 10.1128/JVI.03217-14. Epub 2014 Dec 31.


The minimal promoter region of the dense-core vesicle protein IA-2: transcriptional regulation by CREB.

Cai T, Hirai H, Xu H, Notkins AL.

Acta Diabetol. 2015 Jun;52(3):573-80. doi: 10.1007/s00592-014-0689-5. Epub 2014 Dec 21.


Quantitative analysis of mouse pancreatic islet architecture by serial block-face SEM.

Pfeifer CR, Shomorony A, Aronova MA, Zhang G, Cai T, Xu H, Notkins AL, Leapman RD.

J Struct Biol. 2015 Jan;189(1):44-52. doi: 10.1016/j.jsb.2014.10.013. Epub 2014 Nov 8.


Luciferase immunoprecipitation systems for measuring antibodies in autoimmune and infectious diseases.

Burbelo PD, Lebovitz EE, Notkins AL.

Transl Res. 2015 Feb;165(2):325-35. doi: 10.1016/j.trsl.2014.08.006. Epub 2014 Sep 1. Review.


The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning.

Carmona GN, Nishimura T, Schindler CW, Panlilio LV, Notkins AL.

Neuroscience. 2014 Jun 6;269:35-42. doi: 10.1016/j.neuroscience.2014.03.023. Epub 2014 Mar 21.


Polyreactive antibodies plus complement enhance the phagocytosis of cells made apoptotic by UV-light or HIV.

Zhou ZH, Wild T, Xiong Y, Sylvers P, Zhang Y, Zhang L, Wahl L, Wahl SM, Kozlowski S, Notkins AL.

Sci Rep. 2013;3:2271. doi: 10.1038/srep02271.


Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain.

Mandemakers W, Abuhatzira L, Xu H, Caromile LA, Hébert SS, Snellinx A, Morais VA, Matta S, Cai T, Notkins AL, De Strooper B.

Diabetologia. 2013 Jul;56(7):1547-56. doi: 10.1007/s00125-013-2901-5. Epub 2013 Apr 18.


Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β.

Punia S, Rumery KK, Yu EA, Lambert CM, Notkins AL, Weaver DR.

Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E762-76. doi: 10.1152/ajpendo.00513.2011. Epub 2012 Jul 11.


Pictorial demonstration of the simultaneous binding of multiple unrelated antigens to individual polyreactive antibody-producing B cells.

Xiong Y, Zhou ZH, Notkins AL.

Scand J Immunol. 2012 Sep;76(3):342-3. doi: 10.1111/j.1365-3083.2012.02746.x. No abstract available.


Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cells.

Harashima S, Horiuchi T, Wang Y, Notkins AL, Seino Y, Inagaki N.

J Diabetes Investig. 2012 Feb 20;3(1):52-61. doi: 10.1111/j.2040-1124.2011.00138.x.


Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles.

Cai T, Hirai H, Zhang G, Zhang M, Takahashi N, Kasai H, Satin LS, Leapman RD, Notkins AL.

Diabetologia. 2011 Sep;54(9):2347-57. doi: 10.1007/s00125-011-2221-6. Epub 2011 Jul 6.


Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1.

Cai T, Chen X, Wang R, Xu H, You Y, Zhang T, Lan MS, Notkins AL.

Endocrinology. 2011 May;152(5):1961-9. doi: 10.1210/en.2010-1065. Epub 2011 Feb 22.


Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2beta.

Burbelo PD, Hirai H, Issa AT, Kingman A, Lernmark A, Ivarsson SA, Notkins AL, Iadarola MJ.

Diabetes Care. 2010 Apr;33(4):754-6. doi: 10.2337/dc09-1938. Epub 2010 Jan 19.


IA-2 modulates dopamine secretion in PC12 cells.

Nishimura T, Harashima S, Yafang H, Notkins AL.

Mol Cell Endocrinol. 2010 Feb 5;315(1-2):81-6. doi: 10.1016/j.mce.2009.09.023. Epub 2009 Sep 30.


Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.

Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL.

FASEB J. 2009 Sep;23(9):3226-32. doi: 10.1096/fj.09-132019. Epub 2009 May 11.


Comment on: Torii et al. (2009) Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes 58:682-692.

Hu Y, Nishimura T, Zhang A, Notkins AL.

Diabetes. 2009 May;58(5):e8. doi: 10.2337/db09-0168. No abstract available.


Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.

Nishimura T, Kubosaki A, Ito Y, Notkins AL.

Neuroscience. 2009 Mar 17;159(2):427-37. doi: 10.1016/j.neuroscience.2009.01.022.


Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.

Cai T, Hirai H, Fukushige T, Yu P, Zhang G, Notkins AL, Krause M.

PLoS Genet. 2009 Apr;5(4):e1000447. doi: 10.1371/journal.pgen.1000447. Epub 2009 Apr 3.


Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.

Kim SM, Theilig F, Qin Y, Cai T, Mizel D, Faulhaber-Walter R, Hirai H, Bachmann S, Briggs JP, Notkins AL, Schnermann J.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F382-9. doi: 10.1152/ajprenal.90543.2008. Epub 2008 Nov 19.


Neutralizing the impact factor culture.

Notkins AL.

Science. 2008 Oct 10;322(5899):191. doi: 10.1126/science.322.5899.191a. No abstract available.


A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2.

Burbelo PD, Hirai H, Leahy H, Lernmark A, Ivarsson SA, Iadarola MJ, Notkins AL.

Diabetes Care. 2008 Sep;31(9):1824-6. doi: 10.2337/dc08-0286. Epub 2008 Jun 5.


Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens.

Hirai H, Miura J, Hu Y, Larsson H, Larsson K, Lernmark A, Ivarsson SA, Wu T, Kingman A, Tzioufas AG, Notkins AL.

Clin Immunol. 2008 Jun;127(3):366-74. doi: 10.1016/j.clim.2008.01.018. Epub 2008 Mar 24.


Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.

Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL.

J Endocrinol. 2008 Mar;196(3):573-81. doi: 10.1677/JOE-07-0496.


The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies.

Zhou ZH, Zhang Y, Hu YF, Wahl LM, Cisar JO, Notkins AL.

Cell Host Microbe. 2007 Mar 15;1(1):51-61.


RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.

Zhang G, Hirai H, Cai T, Miura J, Yu P, Huang H, Schiller MR, Swaim WD, Leapman RD, Notkins AL.

J Endocrinol. 2007 Nov;195(2):313-21.


Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells.

Zhou ZH, Tzioufas AG, Notkins AL.

J Autoimmun. 2007 Dec;29(4):219-28. Epub 2007 Sep 20. Review.


Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction.

Harashima SI, Harashima C, Nishimura T, Hu Y, Notkins AL.

Clin Exp Immunol. 2007 Oct;150(1):49-60. Epub 2007 Aug 28.


Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice.

Khil LY, Jun HS, Kwon H, Yoo JK, Kim S, Notkins AL, Yoon JW.

Diabetologia. 2007 Oct;50(10):2147-55. Epub 2007 Aug 4.


Human chorionic gonadotropin prevents Sjögren's syndrome-like exocrinopathy in mice.

Li N, Shigihara T, Tzioufas AG, Notkins AL, Yoon JW, Jun HS.

Arthritis Rheum. 2007 Jul;56(7):2211-5.


Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.

Kubosaki A, Nakamura S, Notkins AL.

Diabetes. 2005 Dec;54 Suppl 2:S46-51.


The IA-2 interactome.

Hu YF, Zhang HL, Cai T, Harashima S, Notkins AL.

Diabetologia. 2005 Dec;48(12):2576-81. Epub 2005 Nov 5.


Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.

Kubosaki A, Nakamura S, Clark A, Morris JF, Notkins AL.

Endocrinology. 2006 Feb;147(2):811-5. Epub 2005 Nov 3.


The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.

Harashima S, Clark A, Christie MR, Notkins AL.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9. Epub 2005 Jun 6.

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