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Items: 44

1.

Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease.

Karachi C, Grabli D, Bernard FA, Tandé D, Wattiez N, Belaid H, Bardinet E, Prigent A, Nothacker HP, Hunot S, Hartmann A, Lehéricy S, Hirsch EC, François C.

J Clin Invest. 2010 Aug;120(8):2745-54. doi: 10.1172/JCI42642. Epub 2010 Jul 12.

2.

Pharmacological characterization of a selective agonist for bombesin receptor subtype-3.

Zhang L, Nothacker HP, Wang Z, Bohn LM, Civelli O.

Biochem Biophys Res Commun. 2009 Sep 18;387(2):283-8. doi: 10.1016/j.bbrc.2009.07.006. Epub 2009 Jul 4.

3.

Fusion of diphtheria toxin and urotensin II produces a neurotoxin selective for cholinergic neurons in the rat mesopontine tegmentum.

Clark SD, Alderson HL, Winn P, Latimer MP, Nothacker HP, Civelli O.

J Neurochem. 2007 Jul;102(1):112-20. Epub 2007 Apr 10.

4.

A Drosophila adenosine receptor activates cAMP and calcium signaling.

Dolezelova E, Nothacker HP, Civelli O, Bryant PJ, Zurovec M.

Insect Biochem Mol Biol. 2007 Apr;37(4):318-29. Epub 2007 Jan 5.

PMID:
17368195
5.

Differential expression of the thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat pituitary.

Nagasaki H, Wang Z, Jackson VR, Lin S, Nothacker HP, Civelli O.

J Mol Endocrinol. 2006 Aug;37(1):39-50.

PMID:
16901922
6.

A study of the rat neuropeptide B/neuropeptide W system using in situ techniques.

Jackson VR, Lin SH, Wang Z, Nothacker HP, Civelli O.

J Comp Neurol. 2006 Jul 20;497(3):367-83.

PMID:
16736466
7.

GPR39 receptor expression in the mouse brain.

Jackson VR, Nothacker HP, Civelli O.

Neuroreport. 2006 May 29;17(8):813-6.

PMID:
16708020
8.

Salusin beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1.

Wang Z, Takahashi T, Saito Y, Nagasaki H, Ly NK, Nothacker HP, Reinscheid RK, Yang J, Chang JK, Shichiri M, Civelli O.

Eur J Pharmacol. 2006 Jun 13;539(3):145-50. Epub 2006 Apr 5.

PMID:
16697365
9.

Orphan GPCRs and their ligands.

Civelli O, Saito Y, Wang Z, Nothacker HP, Reinscheid RK.

Pharmacol Ther. 2006 Jun;110(3):525-32. Epub 2005 Nov 9. Review.

PMID:
16289308
10.

From heart to mind. The urotensin II system and its evolving neurophysiological role.

Nothacker HP, Clark S.

FEBS J. 2005 Nov;272(22):5694-702. Review.

11.

Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells.

Arai AC, Xia YF, Suzuki E, Kessler M, Civelli O, Nothacker HP.

J Neurophysiol. 2005 Nov;94(5):3648-52.

12.

Urotensin II acts as a modulator of mesopontine cholinergic neurons.

Clark SD, Nothacker HP, Blaha CD, Tyler CJ, Duangdao DM, Grupke SL, Helton DR, Leonard CS, Civelli O.

Brain Res. 2005 Oct 19;1059(2):139-48. Epub 2005 Sep 23.

PMID:
16183039
13.

Proadrenomedullin N-terminal peptide and cortistatin activation of MrgX2 receptor is based on a common structural motif.

Nothacker HP, Wang Z, Zeng H, Mahata SK, O'Connor DT, Civelli O.

Eur J Pharmacol. 2005 Sep 5;519(1-2):191-3.

PMID:
16111673
14.

Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons.

Huitron-Resendiz S, Kristensen MP, Sánchez-Alavez M, Clark SD, Grupke SL, Tyler C, Suzuki C, Nothacker HP, Civelli O, Criado JR, Henriksen SJ, Leonard CS, de Lecea L.

J Neurosci. 2005 Jun 8;25(23):5465-74.

15.

The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat.

Clark SD, Nothacker HP, Wang Z, Saito Y, Leslie FM, Civelli O.

Brain Res. 2001 Dec 27;923(1-2):120-7.

PMID:
11743979
17.

Functional genomics and the discovery of new drug targets.

Civelli O, Nothacker HP.

Diabetes Technol Ther. 1999 Spring;1(1):71-6. Review.

PMID:
11475307
18.

Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors.

Civelli O, Nothacker HP, Saito Y, Wang Z, Lin SH, Reinscheid RK.

Trends Neurosci. 2001 Apr;24(4):230-7. Review.

PMID:
11250008
19.

Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist.

Nothacker HP, Wang Z, Zhu Y, Reinscheid RK, Lin SH, Civelli O.

Mol Pharmacol. 2000 Dec;58(6):1601-8.

PMID:
11093801
20.

Human urotensin II mediates vasoconstriction via an increase in inositol phosphates.

Saetrum Opgaard O, Nothacker H, Ehlert FJ, Krause DN.

Eur J Pharmacol. 2000 Oct 13;406(2):265-71.

PMID:
11020490
21.
22.

Melanin-concentrating hormone receptor: an orphan receptor fits the key.

Saito Y, Nothacker HP, Civelli O.

Trends Endocrinol Metab. 2000 Oct;11(8):299-303. Review.

PMID:
10996523
23.

Orphan receptors, novel neuropeptides and reverse pharmaceutical research.

Civelli O, Reinscheid RK, Nothacker HP.

Brain Res. 1999 Nov 27;848(1-2):63-5. Review.

PMID:
10612697
24.

Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction.

Nothacker HP, Wang Z, McNeill AM, Saito Y, Merten S, O'Dowd B, Duckles SP, Civelli O.

Nat Cell Biol. 1999 Oct;1(6):383-5. No abstract available.

PMID:
10559967
25.

Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice.

Köster A, Montkowski A, Schulz S, Stübe EM, Knaudt K, Jenck F, Moreau JL, Nothacker HP, Civelli O, Reinscheid RK.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10444-9.

26.

Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding.

Neal CR Jr, Mansour A, Reinscheid R, Nothacker HP, Civelli O, Akil H, Watson SJ Jr.

J Comp Neurol. 1999 Oct 4;412(4):563-605.

27.

Orphan receptors and the concept of reverse physiology: discovery of the novel neuropeptide orphanin FQ/nociceptin.

Reinscheid RK, Nothacker HP, Civelli O.

Results Probl Cell Differ. 1999;26:193-214.

PMID:
10453465
28.

Molecular characterization of the melanin-concentrating-hormone receptor.

Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, Civelli O.

Nature. 1999 Jul 15;400(6741):265-9.

PMID:
10421368
29.

Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat.

Neal CR Jr, Mansour A, Reinscheid R, Nothacker HP, Civelli O, Watson SJ Jr.

J Comp Neurol. 1999 Apr 19;406(4):503-47.

30.

Reverse physiology: discovery of the novel neuropeptide, orphanin FQ/nociceptin.

Civelli O, Nothacker HP, Reinscheid R.

Crit Rev Neurobiol. 1998;12(3):163-76. Review.

PMID:
9847053
31.

Three different prohormones yield a variety of Hydra-RFamide (Arg-Phe-NH2) neuropeptides in Hydra magnipapillata.

Darmer D, Hauser F, Nothacker HP, Bosch TC, Williamson M, Grimmelikhuijzen CJ.

Biochem J. 1998 Jun 1;332 ( Pt 2):403-12.

32.

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress.

Jenck F, Moreau JL, Martin JR, Kilpatrick GJ, Reinscheid RK, Monsma FJ Jr, Nothacker HP, Civelli O.

Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14854-8.

34.

Orphan receptors and their natural ligands.

Civelli O, Nothacker HP, Bourson A, Ardati A, Monsma F, Reinscheid R.

J Recept Signal Transduct Res. 1997 Jan-May;17(1-3):545-50. Review. No abstract available.

PMID:
9029514
35.

Primary structure and tissue distribution of the orphanin FQ precursor.

Nothacker HP, Reinscheid RK, Mansour A, Henningsen RA, Ardati A, Monsma FJ Jr, Watson SJ, Civelli O.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8677-82.

36.

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ Jr, Civelli O.

Science. 1995 Nov 3;270(5237):792-4.

PMID:
7481766
37.

Molecular cloning of a novel, putative G protein-coupled receptor from sea anemones structurally related to members of the FSH, TSH, LH/CG receptor family from mammals.

Nothacker HP, Grimmelikhuijzen CJ.

Biochem Biophys Res Commun. 1994 Apr 15;200(1):668. No abstract available.

PMID:
8166744
39.

The expansion behaviour of sea anemones may be coordinated by two inhibitory neuropeptides, Antho-KAamide and Antho-RIamide.

McFarlane ID, Hudman D, Nothacker HP, Grimmelikhuijzen CJ.

Proc Biol Sci. 1993 Aug 23;253(1337):183-8.

PMID:
8397415
40.

The peptidergic nervous system of coelenterates.

Grimmelikhuijzen CJ, Darmer D, Schmutzler C, Carstensen K, Moosler A, Nothacker HP, Reinscheid RK, Vollert H, Rinehart KL, McFarlane ID.

Prog Brain Res. 1992;92:137-48. Review. No abstract available.

PMID:
1363845
41.
42.

Isolation of L-3-phenyllactyl-Phe-Lys-Ala-NH2 (Antho-KAamide), a novel neuropeptide from sea anemones.

Nothacker HP, Rinehart KL, Grimmelikhuijzen CJ.

Biochem Biophys Res Commun. 1991 Sep 30;179(3):1205-11.

PMID:
1681803
43.

Isolation of L-3-phenyllactyl-Leu-Arg-Asn-NH2 (Antho-RNamide), a sea anemone neuropeptide containing an unusual amino-terminal blocking group.

Grimmelikhuijzen CJ, Rinehart KL, Jacob E, Graff D, Reinscheid RK, Nothacker HP, Staley AL.

Proc Natl Acad Sci U S A. 1990 Jul;87(14):5410-4.

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