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Items: 29


Pluripotent Stem Cell-Derived Pancreatic Progenitors and β-Like Cells for Type 1 Diabetes Treatment.

Sambathkumar R, Migliorini A, Nostro MC.

Physiology (Bethesda). 2018 Nov 1;33(6):394-402. doi: 10.1152/physiol.00026.2018. Review.


The LIM homeodomain protein ISL1 mediates the function of TCF7L2 in pancreatic beta cells.

Shao W, Szeto V, Song Z, Tian L, Feng ZP, Nostro MC, Jin T.

J Mol Endocrinol. 2018 Jul;61(1):1-12. doi: 10.1530/JME-17-0181. Epub 2018 Apr 20.


Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017.

Ciccocioppo R, Dos Santos CC, Baumgart DC, Cangemi GC, Cardinale V, Ciacci C, De Coppi P, Haldar D, Klersy C, Nostro MC, Ott M, Piemonti L, Tomei AA, Uygun B, Vetrano S, Orlando G.

Cytotherapy. 2018 Mar;20(3):461-476. doi: 10.1016/j.jcyt.2017.12.004. Epub 2018 Feb 15.


Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.

Cogger KF, Sinha A, Sarangi F, McGaugh EC, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke JL, Screaton RA, Grompe M, Streeter PR, Powers AC, Brissova M, Kislinger T, Nostro MC.

Nat Commun. 2017 Aug 24;8(1):331. doi: 10.1038/s41467-017-00561-0.


Cell Therapy for Type 1 Diabetes: Current and Future Strategies.

Aghazadeh Y, Nostro MC.

Curr Diab Rep. 2017 Jun;17(6):37. doi: 10.1007/s11892-017-0863-6. Review.


Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors.

McGaugh EC, Nostro MC.

J Vis Exp. 2017 Mar 7;(121). doi: 10.3791/55265.


Generation of polyhormonal and multipotent pancreatic progenitor lineages from human pluripotent stem cells.

Korytnikov R, Nostro MC.

Methods. 2016 May 15;101:56-64. doi: 10.1016/j.ymeth.2015.10.017. Epub 2015 Oct 27.


Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.

Nostro MC, Sarangi F, Yang C, Holland A, Elefanty AG, Stanley EG, Greiner DL, Keller G.

Stem Cell Reports. 2015 Apr 14;4(4):591-604. doi: 10.1016/j.stemcr.2015.02.017. Epub 2015 Apr 2.


The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis.

Shao W, Xiong X, Ip W, Xu F, Song Z, Zeng K, Hernandez M, Liang T, Weng J, Gaisano H, Nostro MC, Jin T.

Mol Metab. 2015 Feb 4;4(4):344-52. doi: 10.1016/j.molmet.2015.01.008. eCollection 2015 Apr.


Recent advances in cell replacement therapies for the treatment of type 1 diabetes.

Cogger K, Nostro MC.

Endocrinology. 2015 Jan;156(1):8-15. doi: 10.1210/en.2014-1691. Review.


Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.

Fuerer C, Nostro MC, Constam DB.

J Biol Chem. 2014 Jun 20;289(25):17854-71. doi: 10.1074/jbc.M114.550301. Epub 2014 May 5.


Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.

Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8. doi: 10.1073/pnas.1303386110. Epub 2013 Aug 14.


Pancreatic differentiation.

Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2012 Jun 10.


Monolayer endoderm differentiation from human ESCs.

Cheng X, Ying L, Lu L, Galvão AM, Mills JA, Lin HC, Kotton DN, Shen SS, Nostro MC, Choi JK, Weiss MJ, French DL, Gadue P.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2012 Jun 10.


Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine.

Nostro MC, Keller G.

Semin Cell Dev Biol. 2012 Aug;23(6):701-10. doi: 10.1016/j.semcdb.2012.06.010. Epub 2012 Jun 26. Review.


Self-renewing endodermal progenitor lines generated from human pluripotent stem cells.

Cheng X, Ying L, Lu L, Galvão AM, Mills JA, Lin HC, Kotton DN, Shen SS, Nostro MC, Choi JK, Weiss MJ, French DL, Gadue P.

Cell Stem Cell. 2012 Apr 6;10(4):371-84. doi: 10.1016/j.stem.2012.02.024.


Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics.

Ungrin MD, Clarke G, Yin T, Niebrugge S, Nostro MC, Sarangi F, Wood G, Keller G, Zandstra PW.

Biotechnol Bioeng. 2012 Apr;109(4):853-66. doi: 10.1002/bit.24375. Epub 2011 Dec 2.


INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells.

Micallef SJ, Li X, Schiesser JV, Hirst CE, Yu QC, Lim SM, Nostro MC, Elliott DA, Sarangi F, Harrison LC, Keller G, Elefanty AG, Stanley EG.

Diabetologia. 2012 Mar;55(3):694-706. doi: 10.1007/s00125-011-2379-y. Epub 2011 Nov 26.


The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells.

Basford CL, Prentice KJ, Hardy AB, Sarangi F, Micallef SJ, Li X, Guo Q, Elefanty AG, Stanley EG, Keller G, Allister EM, Nostro MC, Wheeler MB.

Diabetologia. 2012 Feb;55(2):358-71. doi: 10.1007/s00125-011-2335-x. Epub 2011 Nov 11.


Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells.

Green MD, Chen A, Nostro MC, d'Souza SL, Schaniel C, Lemischka IR, Gouon-Evans V, Keller G, Snoeck HW.

Nat Biotechnol. 2011 Mar;29(3):267-72. doi: 10.1038/nbt.1788. Epub 2011 Feb 27.


Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.

Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G.

Development. 2011 Mar;138(5):861-71. doi: 10.1242/dev.055236. Epub 2011 Jan 26. Erratum in: Development. 2011 Mar;138(5).doi: 10.1242/dev.065904. Development. 2011 Apr;138(7):1445.


A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.

Cairney CJ, Sanguinetti G, Ranghini E, Chantry AD, Nostro MC, Bhattacharyya A, Svendsen CN, Keith WN, Bellantuono I.

Biochim Biophys Acta. 2009 Apr;1792(4):353-63. doi: 10.1016/j.bbadis.2009.01.015. Epub 2009 Feb 6.


Directed differentiation of pluripotent stem cells: from developmental biology to therapeutic applications.

Irion S, Nostro MC, Kattman SJ, Keller GM.

Cold Spring Harb Symp Quant Biol. 2008;73:101-10. doi: 10.1101/sqb.2008.73.065. Epub 2009 Mar 27. Review.


Notch induces cell cycle arrest and apoptosis in human erythroleukaemic TF-1 cells.

Chadwick N, Fennessy C, Nostro MC, Baron M, Brady G, Buckle AM.

Blood Cells Mol Dis. 2008 Nov-Dec;41(3):270-7. doi: 10.1016/j.bcmd.2008.06.003. Epub 2008 Aug 8.


Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.

Nostro MC, Cheng X, Keller GM, Gadue P.

Cell Stem Cell. 2008 Jan 10;2(1):60-71. doi: 10.1016/j.stem.2007.10.011.


Notch signaling induces apoptosis in primary human CD34+ hematopoietic progenitor cells.

Chadwick N, Nostro MC, Baron M, Mottram R, Brady G, Buckle AM.

Stem Cells. 2007 Jan;25(1):203-10. Epub 2006 Sep 14.


Germ layer induction from embryonic stem cells.

Gadue P, Huber TL, Nostro MC, Kattman S, Keller GM.

Exp Hematol. 2005 Sep;33(9):955-64. Review.


'Neurographic' palmaris brevis sign in type II degrees ulnar neuropathy at wrist.

Morini A, Della Sala WS, Bianchini G, Cannova R, Nostro MC, Orrico D.

Clin Neurophysiol. 2005 Jan;116(1):43-8.


Bcl-w expression in colorectal adenocarcinoma.

Wilson JW, Nostro MC, Balzi M, Faraoni P, Cianchi F, Becciolini A, Potten CS.

Br J Cancer. 2000 Jan;82(1):178-85.

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