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Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment.

Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE.

Sci Transl Med. 2019 Feb 20;11(480). pii: eaau0683. doi: 10.1126/scitranslmed.aau0683.


TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine.

Pascual-Reguant A, Bayat Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE, Esplugues E.

Mucosal Immunol. 2017 Nov;10(6):1431-1442. doi: 10.1038/mi.2017.5. Epub 2017 Feb 15.


Dysregulation of proinflammatory versus anti-inflammatory human TH17 cell functionalities in the autoinflammatory Schnitzler syndrome.

Noster R, de Koning HD, Maier E, Prelog M, Lainka E, Zielinski CE.

J Allergy Clin Immunol. 2016 Oct;138(4):1161-1169.e6. doi: 10.1016/j.jaci.2015.12.1338. Epub 2016 Mar 31.


IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.

Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE.

Sci Transl Med. 2014 Jun 18;6(241):241ra80. doi: 10.1126/scitranslmed.3008706.

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