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Items: 1 to 50 of 317

1.

Editorial: Special issue of Biophysical Reviews dedicated to the joint 10th Asian Biophysics Association Symposium and 42nd Australian Society for Biophysics Meeting, Melbourne, Australia, December 2-6, 2018.

Battle AR, Norton RS, Böcking T, Noji H, Kim KK, Nagayama K.

Biophys Rev. 2019 Jun;11(3):245-247. doi: 10.1007/s12551-019-00553-y. Epub 2019 May 21. No abstract available.

2.

Mapping the chemical and sequence space of the ShKT superfamily.

Shafee T, Mitchell ML, Norton RS.

Toxicon. 2019 Jul;165:95-102. doi: 10.1016/j.toxicon.2019.04.008. Epub 2019 May 4.

PMID:
31063742
3.

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework.

Nielsen LD, Foged MM, Albert A, Bertelsen AB, Søltoft CL, Robinson SD, Petersen SV, Purcell AW, Olivera BM, Norton RS, Vasskog T, Safavi-Hemami H, Teilum K, Ellgaard L.

J Biol Chem. 2019 May 31;294(22):8745-8759. doi: 10.1074/jbc.RA119.007491. Epub 2019 Apr 11.

PMID:
30975904
4.

Evolution of cnidarian trans-defensins: Sequence, structure and exploration of chemical space.

Mitchell ML, Shafee T, Papenfuss AT, Norton RS.

Proteins. 2019 Jul;87(7):551-560. doi: 10.1002/prot.25679. Epub 2019 Mar 18.

PMID:
30811678
5.

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe.

Akter M, Drinkwater N, Devine SM, Drew SC, Krishnarjuna B, Debono CO, Wang G, Scanlon MJ, Scammells PJ, McGowan S, MacRaild CA, Norton RS.

ChemMedChem. 2019 Mar 5;14(5):603-612. doi: 10.1002/cmdc.201800802. Epub 2019 Feb 13.

PMID:
30653832
6.

Interaction of merozoite surface protein 2 with lipid membranes.

Lu C, Zheng X, Zhang W, Zhao H, MacRaild CA, Norton RS, Zhuang Y, Wang J, Zhang X.

FEBS Lett. 2019 Feb;593(3):288-295. doi: 10.1002/1873-3468.13320. Epub 2019 Jan 10.

PMID:
30588612
7.

Modulation of the aggregation of an amyloidogenic sequence by flanking-disordered region in the intrinsically disordered antigen merozoite surface protein 2.

Zhang W, Zhang J, MacRaild CA, Norton RS, Anders RF, Zhang X.

Eur Biophys J. 2019 Jan;48(1):99-110. doi: 10.1007/s00249-018-1337-8. Epub 2018 Nov 15.

PMID:
30443712
8.

Anti-Infective Peptides to Enhance the Host Innate Response: Design, Development and Delivery.

Norton RS.

Protein Pept Lett. 2018;25(12):1101-1107. doi: 10.2174/0929866525666181101104945. Review.

PMID:
30381058
9.

Transient antibody-antigen interactions mediate the strain-specific recognition of a conserved malaria epitope.

Krishnarjuna B, Sugiki T, Morales RAV, Seow J, Fujiwara T, Wilde KL, Norton RS, MacRaild CA.

Commun Biol. 2018 May 31;1:58. doi: 10.1038/s42003-018-0063-1. eCollection 2018.

10.

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.

Sadek MM, Barlow N, Leung EWW, Williams-Noonan BJ, Yap BK, Shariff FM, Caradoc-Davies TT, Nicholson SE, Chalmers DK, Thompson PE, Law RHP, Norton RS.

ACS Chem Biol. 2018 Oct 19;13(10):2930-2938. doi: 10.1021/acschembio.8b00561. Epub 2018 Sep 18.

PMID:
30226743
11.

Venoms to the rescue.

Holford M, Daly M, King GF, Norton RS.

Science. 2018 Aug 31;361(6405):842-844. doi: 10.1126/science.aau7761. No abstract available.

PMID:
30166472
12.

Probing the correlation between insulin activity and structural stability through introduction of the rigid A6-A11 bond.

Ong SC, Belgi A, van Lierop B, Delaine C, Andrikopoulos S, MacRaild CA, Norton RS, Haworth NL, Robinson AJ, Forbes BE.

J Biol Chem. 2018 Jul 27;293(30):11928-11943. doi: 10.1074/jbc.RA118.002486. Epub 2018 Jun 13.

PMID:
29899115
13.

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold.

Krishnarjuna B, Villegas-Moreno J, Mitchell ML, Csoti A, Peigneur S, Amero C, Pennington MW, Tytgat J, Panyi G, Norton RS.

Toxicon. 2018 Aug;150:50-59. doi: 10.1016/j.toxicon.2018.05.006. Epub 2018 May 19.

PMID:
29772211
14.

Corrigendum to "Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK" [Peptides 99 (2018) 169-178].

Krishnarjuna B, MacRaild CA, Sunanda P, Morales RAV, Peigneur S, Macrander J, Yu HH, Daly M, Raghothama S, Dhawan V, Chauhan S, Tytgat J, Pennington MW, Norton RS.

Peptides. 2018 Mar;101:234. doi: 10.1016/j.peptides.2018.01.008. Epub 2018 Feb 1. No abstract available.

PMID:
29361315
15.

Sea Anemones: Quiet Achievers in the Field of Peptide Toxins.

Prentis PJ, Pavasovic A, Norton RS.

Toxins (Basel). 2018 Jan 8;10(1). pii: E36. doi: 10.3390/toxins10010036. Review.

16.

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.

Law RHP, Wu G, Leung EWW, Hidaka K, Quek AJ, Caradoc-Davies TT, Jeevarajah D, Conroy PJ, Kirby NM, Norton RS, Tsuda Y, Whisstock JC.

Blood Adv. 2017 May 9;1(12):766-771. doi: 10.1182/bloodadvances.2016004150. eCollection 2017 May 9.

17.

Characterisation of peptide interactions that regulate PKCε activation.

Chandrashekaran IR, Norton RS, Schmitz-Peiffer C.

FEBS Lett. 2018 Jan;592(2):179-189. doi: 10.1002/1873-3468.12953. Epub 2018 Jan 10.

18.

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK.

Krishnarjuna B, MacRaild CA, Sunanda P, Morales RAV, Peigneur S, Macrander J, Yu HH, Daly M, Raghothama S, Dhawan V, Chauhan S, Tytgat J, Pennington MW, Norton RS.

Peptides. 2018 Jan;99:169-178. doi: 10.1016/j.peptides.2017.10.001. Epub 2017 Oct 6. Erratum in: Peptides. 2018 Jan 17;:.

PMID:
28993277
19.

Peptide therapeutics from venom: Current status and potential.

Pennington MW, Czerwinski A, Norton RS.

Bioorg Med Chem. 2018 Jun 1;26(10):2738-2758. doi: 10.1016/j.bmc.2017.09.029. Epub 2017 Sep 23. Review.

20.

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages.

Sadek MM, Barzegar Amiri Olia M, Nowell CJ, Barlow Ν, Schiesser CH, Nicholson SE, Norton RS.

Bioorg Med Chem. 2017 Oct 15;25(20):5743-5748. doi: 10.1016/j.bmc.2017.08.054. Epub 2017 Sep 5.

PMID:
28927902
21.

Venom-derived peptide inhibitors of voltage-gated potassium channels.

Norton RS, Chandy KG.

Neuropharmacology. 2017 Dec;127:124-138. doi: 10.1016/j.neuropharm.2017.07.002. Epub 2017 Jul 5. Review.

PMID:
28689025
22.

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats.

Bergmann R, Kubeil M, Zarschler K, Chhabra S, Tajhya RB, Beeton C, Pennington MW, Bachmann M, Norton RS, Stephan H.

Sci Rep. 2017 Jun 16;7(1):3756. doi: 10.1038/s41598-017-03998-x.

23.

Lipid interactions modulate the structural and antigenic properties of the C-terminal domain of the malaria antigen merozoite surface protein 2.

Das SC, Morales RAV, Seow J, Krishnarjuna B, Dissanayake R, Anders RF, MacRaild CA, Norton RS.

FEBS J. 2017 Aug;284(16):2649-2662. doi: 10.1111/febs.14135. Epub 2017 Jul 5.

24.

Reinvestigation of the biological activity of d-allo-ShK protein.

Dang B, Chhabra S, Pennington MW, Norton RS, Kent SBH.

J Biol Chem. 2017 Jul 28;292(30):12599-12605. doi: 10.1074/jbc.M117.793943. Epub 2017 Jun 8.

25.

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering.

Chittoor B, Krishnarjuna B, Morales RAV, MacRaild CA, Sadek M, Leung EWW, Robinson SD, Pennington MW, Norton RS.

Biochemistry. 2017 May 16;56(19):2455-2466. doi: 10.1021/acs.biochem.7b00120. Epub 2017 May 2.

PMID:
28437072
26.

Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease.

Chandy KG, Norton RS.

Curr Opin Chem Biol. 2017 Jun;38:97-107. doi: 10.1016/j.cbpa.2017.02.015. Epub 2017 Apr 14. Review.

PMID:
28412597
27.

Enhancing the therapeutic potential of peptide toxins.

Norton RS.

Expert Opin Drug Discov. 2017 Jun;12(6):611-623. doi: 10.1080/17460441.2017.1317243. Epub 2017 Apr 20. Review.

PMID:
28398099
28.

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.

Tanner MR, Tajhya RB, Huq R, Gehrmann EJ, Rodarte KE, Atik MA, Norton RS, Pennington MW, Beeton C.

Clin Immunol. 2017 Jul;180:45-57. doi: 10.1016/j.clim.2017.03.014. Epub 2017 Apr 4.

29.

Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue.

Drane SB, Robinson SD, MacRaild CA, Chhabra S, Chittoor B, Morales RA, Leung EW, Belgi A, Espino SS, Olivera BM, Robinson AJ, Chalmers DK, Norton RS.

Toxicon. 2017 Apr;129:113-122. doi: 10.1016/j.toxicon.2017.02.012. Epub 2017 Feb 17.

PMID:
28216409
30.

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2.

Seow J, Morales RA, MacRaild CA, Krishnarjuna B, McGowan S, Dingjan T, Jaipuria G, Rouet R, Wilde KL, Atreya HS, Richards JS, Anders RF, Christ D, Drinkwater N, Norton RS.

J Mol Biol. 2017 Mar 24;429(6):836-846. doi: 10.1016/j.jmb.2017.02.003. Epub 2017 Feb 8.

PMID:
28189425
31.

Antimalarial drug discovery targeting apical membrane antigen 1.

Devine SM, MacRaild CA, Norton RS, Scammells PJ.

Medchemcomm. 2016 Nov 4;8(1):13-20. doi: 10.1039/c6md00495d. eCollection 2017 Jan 1. Review.

32.

Immunology: Channelling potassium to fight cancer.

Chandy KG, Norton RS.

Nature. 2016 Sep 22;537(7621):497-499. doi: 10.1038/nature19467. Epub 2016 Sep 14. No abstract available.

PMID:
27626384
33.

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.

Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC.

Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12.

PMID:
27617429
34.

The ways and means of fragment-based drug design.

Doak BC, Norton RS, Scanlon MJ.

Pharmacol Ther. 2016 Nov;167:28-37. doi: 10.1016/j.pharmthera.2016.07.003. Epub 2016 Jul 22. Review.

PMID:
27452339
35.

Applications of (19)F-NMR in Fragment-Based Drug Discovery.

Norton RS, Leung EW, Chandrashekaran IR, MacRaild CA.

Molecules. 2016 Jul 16;21(7). pii: E860. doi: 10.3390/molecules21070860. Review.

36.

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.

Wang G, Drinkwater N, Drew DR, MacRaild CA, Chalmers DK, Mohanty B, Lim SS, Anders RF, Beeson JG, Thompson PE, McGowan S, Simpson JS, Norton RS, Scanlon MJ.

J Mol Biol. 2016 Oct 9;428(20):3986-3998. doi: 10.1016/j.jmb.2016.07.001. Epub 2016 Jul 14.

PMID:
27422009
37.

Enabling Noninvasive Systemic Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] via the Buccal Mucosa.

Jin L, Boyd BJ, Larson IC, Pennington MW, Norton RS, Nicolazzo JA.

J Pharm Sci. 2016 Jul;105(7):2173-9. doi: 10.1016/j.xphs.2016.05.008. Epub 2016 Jun 13.

PMID:
27312508
38.

Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase.

Harjani JR, Yap BK, Leung EW, Lucke A, Nicholson SE, Scanlon MJ, Chalmers DK, Thompson PE, Norton RS, Baell JB.

J Med Chem. 2016 Jun 23;59(12):5799-809. doi: 10.1021/acs.jmedchem.6b00386. Epub 2016 Jun 8.

PMID:
27214043
39.

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction.

Yap BK, Harjani JR, Leung EW, Nicholson SE, Scanlon MJ, Chalmers DK, Thompson PE, Baell JB, Norton RS.

FEBS Lett. 2016 Mar;590(6):696-704. doi: 10.1002/1873-3468.12115. Epub 2016 Mar 6.

40.

Stereoselective synthesis and structural elucidation of dicarba peptides.

Gleeson EC, Wang ZJ, Robinson SD, Chhabra S, MacRaild CA, Jackson WR, Norton RS, Robinson AJ.

Chem Commun (Camb). 2016 Mar 25;52(24):4446-9. doi: 10.1039/c5cc10540d.

PMID:
26892179
41.

Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases.

Jin L, Zhou QT, Chan HK, Larson IC, Pennington MW, Morales RAV, Boyd BJ, Norton RS, Nicolazzo JA.

J Pharm Sci. 2016 Feb;105(2):650-656. doi: 10.1016/j.xphs.2015.10.025. Epub 2016 Jan 12.

PMID:
26869426
42.

Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2.

Krishnarjuna B, Andrew D, MacRaild CA, Morales RA, Beeson JG, Anders RF, Richards JS, Norton RS.

Sci Rep. 2016 Feb 11;6:20613. doi: 10.1038/srep20613.

43.

Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.

Green BR, Gajewiak J, Chhabra S, Skalicky JJ, Zhang MM, Rivier JE, Bulaj G, Olivera BM, Yoshikami D, Norton RS.

J Biol Chem. 2016 Mar 25;291(13):7205-20. doi: 10.1074/jbc.M115.697672. Epub 2016 Jan 27.

44.

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials.

Krishnarjuna B, Lim SS, Devine SM, Debono CO, Lam R, Chandrashekaran IR, Jaipuria G, Yagi H, Atreya HS, Scanlon MJ, MacRaild CA, Scammells PJ, Norton RS.

J Mol Recognit. 2016 Jun;29(6):281-91. doi: 10.1002/jmr.2529. Epub 2016 Jan 24.

PMID:
26804042
45.

A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold.

Robinson SD, Chhabra S, Belgi A, Chittoor B, Safavi-Hemami H, Robinson AJ, Papenfuss AT, Purcell AW, Norton RS.

Structure. 2016 Feb 2;24(2):293-9. doi: 10.1016/j.str.2015.11.015. Epub 2016 Jan 7.

46.

Antibody Recognition of Disordered Antigens.

MacRaild CA, Richards JS, Anders RF, Norton RS.

Structure. 2016 Jan 5;24(1):148-157. doi: 10.1016/j.str.2015.10.028. Epub 2015 Dec 17.

47.

Neutron reflection study of the interaction of the eukaryotic pore-forming actinoporin equinatoxin II with lipid membranes reveals intermediate states in pore formation.

Wacklin HP, Bremec BB, Moulin M, Rojko N, Haertlein M, Forsyth T, Anderluh G, Norton RS.

Biochim Biophys Acta. 2016 Apr;1858(4):640-52. doi: 10.1016/j.bbamem.2015.12.019. Epub 2015 Dec 17.

48.

Structural Dynamics of the Potassium Channel Blocker ShK: SRLS Analysis of (15)N Relaxation.

Meirovitch E, Tchaicheeyan O, Sher I, Norton RS, Chill JH.

J Phys Chem B. 2015 Dec 10;119(49):15130-7. doi: 10.1021/acs.jpcb.5b07875. Epub 2015 Nov 25.

PMID:
26551165
49.

Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions.

Guy AJ, Irani V, MacRaild CA, Anders RF, Norton RS, Beeson JG, Richards JS, Ramsland PA.

PLoS One. 2015 Oct 29;10(10):e0141729. doi: 10.1371/journal.pone.0141729. eCollection 2015.

50.

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.

Yagi H, Conroy PJ, Leung EW, Law RH, Trapani JA, Voskoboinik I, Whisstock JC, Norton RS.

J Biol Chem. 2015 Oct 16;290(42):25213-26. doi: 10.1074/jbc.M115.668384. Epub 2015 Aug 25.

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