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Items: 1 to 50 of 844

1.

The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner.

Srikantan S, Deng Y, Cheng ZM, Luo A, Qin Y, Gao Q, Sande-Docor GM, Tao S, Zhang X, Harper N, Shannon CE, Fourcaudot M, Li Z, Kasinath BS, Harrison S, Ahuja S, Reddick RL, Dong LQ, Abdul-Ghani M, Norton L, Aguiar RCT, Dahia PLM.

Nat Commun. 2019 Oct 17;10(1):4720. doi: 10.1038/s41467-019-12661-0.

PMID:
31624249
2.

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.

Wojnarowicz PM, Lima E Silva R, Ohnaka M, Lee SB, Chin Y, Kulukian A, Chang SH, Desai B, Garcia Escolano M, Shah R, Garcia-Cao M, Xu S, Kadam R, Goldgur Y, Miller MA, Ouerfelli O, Yang G, Arakawa T, Albanese SK, Garland WA, Stoller G, Chaudhary J, Norton L, Soni RK, Philip J, Hendrickson RC, Iavarone A, Dannenberg AJ, Chodera JD, Pavletich N, Lasorella A, Campochiaro PA, Benezra R.

Cell Rep. 2019 Oct 1;29(1):62-75.e7. doi: 10.1016/j.celrep.2019.08.073.

3.

Reducing Streptococcal Testing in Patients <3 Years Old in an Emergency Department.

Ahluwalia T, Jain S, Norton L, Meade J, Etherton-Still J, Myers A.

Pediatrics. 2019 Oct;144(4). pii: e20190174. doi: 10.1542/peds.2019-0174. Epub 2019 Sep 11.

PMID:
31511313
4.

Evaluating clonal hematopoiesis in tumor infiltrating leukocytes in breast cancer and secondary hematologic malignancies.

Comen EA, Bowman RL, Selenica P, Kleppe M, Farnoud NR, Pareja F, Weigelt B, Hill CE, Alon A, Geyer FC, Akturk G, Reis-Filho JS, Norton L, Levine RL.

J Natl Cancer Inst. 2019 Aug 27. pii: djz157. doi: 10.1093/jnci/djz157. [Epub ahead of print]

PMID:
31504684
5.

Homologous recombination DNA repair defects in PALB2-associated breast cancers.

Li A, Geyer FC, Blecua P, Lee JY, Selenica P, Brown DN, Pareja F, Lee SSK, Kumar R, Rivera B, Bi R, Piscuoglio S, Wen HY, Lozada JR, Gularte-Mérida R, Cavallone L; kConFab Investigators, Rezoug Z, Nguyen-Dumont T, Peterlongo P, Tondini C, Terkelsen T, Rønlund K, Boonen SE, Mannerma A, Winqvist R, Janatova M, Rajadurai P, Xia B, Norton L, Robson ME, Ng PS, Looi LM, Southey MC, Weigelt B, Soo-Hwang T, Tischkowitz M, Foulkes WD, Reis-Filho JS.

NPJ Breast Cancer. 2019 Aug 8;5:23. doi: 10.1038/s41523-019-0115-9. eCollection 2019.

6.

A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites.

McCormick B, Craig HE, Chu JY, Carlin LM, Canel M, Wollweber F, Toivakka M, Michael M, Astier AL, Norton L, Lilja J, Felton JM, Sasaki T, Ivaska J, Hers I, Dransfield I, Rossi AG, Vermeren S.

J Immunol. 2019 Sep 15;203(6):1579-1588. doi: 10.4049/jimmunol.1900443. Epub 2019 Aug 19.

7.

Electronic Pill Bottles or Bidirectional Text Messaging to Improve Hypertension Medication Adherence (Way 2 Text): a Randomized Clinical Trial.

Mehta SJ, Volpp KG, Troxel AB, Day SC, Lim R, Marcus N, Norton L, Anderson S, Asch DA.

J Gen Intern Med. 2019 Aug 8. doi: 10.1007/s11606-019-05241-x. [Epub ahead of print]

PMID:
31396815
8.

The Landscape of Somatic Genetic Alterations in Breast Cancers from CHEK2 Germline Mutation Carriers.

Mandelker D, Kumar R, Pei X, Selenica P, Setton J, Arunachalam S, Ceyhan-Birsoy O, Brown DN, Norton L, Robson ME, Wen HY, Powell S, Riaz N, Weigelt B, Reis-Filho JS.

JNCI Cancer Spectr. 2019 Apr 27;3(2):pkz027. doi: 10.1093/jncics/pkz027. eCollection 2019 Jun.

9.

Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial.

Muss HB, Polley MC, Berry DA, Liu H, Cirrincione CT, Theodoulou M, Mauer AM, Kornblith AB, Partridge AH, Dressler LG, Cohen HJ, Kartcheske PA, Perez EA, Wolff AC, Gralow JR, Burstein HJ, Mahmood AA, Sutton LM, Magrinat G, Parker BA, Hart RD, Grenier D, Hurria A, Jatoi A, Norton L, Hudis CA, Winer EP, Carey L.

J Clin Oncol. 2019 Sep 10;37(26):2338-2348. doi: 10.1200/JCO.19.00647. Epub 2019 Jul 24.

PMID:
31339827
10.

A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy.

Kumar R, de Vijver MV, Tortora G, Ciardiello F, Goldkorn T, Miller WH Jr, Norton L.

Cancer Res. 2019 Sep 1;79(17):4315-4323. doi: 10.1158/0008-5472.CAN-19-0989. Epub 2019 Jun 18. Review.

PMID:
31213466
11.

Pathologic complete response rate according to HER2 detection methods in HER2-positive breast cancer treated with neoadjuvant systemic therapy.

Krystel-Whittemore M, Xu J, Brogi E, Ventura K, Patil S, Ross DS, Dang C, Robson M, Norton L, Morrow M, Wen HY.

Breast Cancer Res Treat. 2019 Aug;177(1):61-66. doi: 10.1007/s10549-019-05295-9. Epub 2019 May 29.

PMID:
31144151
12.

Phase I Study of Intermittent High-Dose Lapatinib Alternating with Capecitabine for HER2-Positive Breast Cancer Patients with Central Nervous System Metastases.

Morikawa A, de Stanchina E, Pentsova E, Kemeny MM, Li BT, Tang K, Patil S, Fleisher M, Van Poznak C, Norton L, Seidman AD.

Clin Cancer Res. 2019 Jul 1;25(13):3784-3792. doi: 10.1158/1078-0432.CCR-18-3502. Epub 2019 Apr 15.

PMID:
30988080
13.

p21CIP1 Promotes Mammary Cancer-Initiating Cells via Activation of Wnt/TCF1/CyclinD1 Signaling.

Benard O, Qian X, Liang H, Ren Z, Suyama K, Norton L, Hazan RB.

Mol Cancer Res. 2019 Jul;17(7):1571-1581. doi: 10.1158/1541-7786.MCR-18-1044. Epub 2019 Apr 9.

PMID:
30967481
14.

Rationale and Design of EMPOWER, a Pragmatic Randomized Trial of Automated Hovering in Patients With Congestive Heart Failure.

Mehta SJ, Volpp KG, Asch DA, Goldberg LR, Russell LB, Norton LA, Iannotte LG, Troxel AB.

Circ Cardiovasc Qual Outcomes. 2019 Apr;12(4):e005126. doi: 10.1161/CIRCOUTCOMES.118.005126.

PMID:
30939922
15.

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation.

Tomar D, Jaña F, Dong Z, Quinn WJ 3rd, Jadiya P, Breves SL, Daw CC, Srikantan S, Shanmughapriya S, Nemani N, Carvalho E, Tripathi A, Worth AM, Zhang X, Razmpour R, Seelam A, Rhode S, Mehta AV, Murray M, Slade D, Ramirez SH, Mishra P, Gerhard GS, Caplan J, Norton L, Sharma K, Rajan S, Balciunas D, Wijesinghe DS, Ahima RS, Baur JA, Madesh M.

Cell Rep. 2019 Mar 26;26(13):3709-3725.e7. doi: 10.1016/j.celrep.2019.02.107.

16.

Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia.

Freites-Martinez A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME.

JAMA Dermatol. 2019 Jun 1;155(6):724-728. doi: 10.1001/jamadermatol.2018.5071. Erratum in: JAMA Dermatol. 2019 Apr 10;:.

PMID:
30840033
17.

Informed consent for functional MRI research on comatose patients following severe brain injury: balancing the social benefits of research against patient autonomy.

Bruni T, Graham M, Norton L, Gofton T, Owen AM, Weijer C.

J Med Ethics. 2019 May;45(5):299-303. doi: 10.1136/medethics-2018-104867. Epub 2019 Feb 25.

18.

Supporting data sharing.

Kirk R, Norton L.

NPJ Breast Cancer. 2019 Feb 13;5:8. doi: 10.1038/s41523-019-0103-0. eCollection 2019. No abstract available.

19.

Feasibility of population screening tests to establish a healthy ageing trajectory.

Gordon SJ, Grimmer KA, Baker N, Bell E, Coveney J, Jordaan JH, Lind C, Marin T, Murray J, Norton LH, Perimal-Lewis L, Sparrow K, Steffens MA, Thomas J, Kidd M.

SAGE Open Med. 2019 Jan 11;7:2050312118822440. doi: 10.1177/2050312118822440. eCollection 2019.

20.

Intermittent Dieting: Theoretical Considerations for the Athlete.

Peos JJ, Norton LE, Helms ER, Galpin AJ, Fournier P.

Sports (Basel). 2019 Jan 16;7(1). pii: E22. doi: 10.3390/sports7010022. Review.

21.

The Genomic Landscape of Mucinous Breast Cancer.

Pareja F, Lee JY, Brown DN, Piscuoglio S, Gularte-Mérida R, Selenica P, Da Cruz Paula A, Arunachalam S, Kumar R, Geyer FC, Silveira C, da Silva EM, Li A, Marchiò C, Ng CKY, Mariani O, Fuhrmann L, Wen HY, Norton L, Vincent-Salomon A, Brogi E, Reis-Filho JS, Weigelt B.

J Natl Cancer Inst. 2019 Jan 11. doi: 10.1093/jnci/djy216. [Epub ahead of print]

PMID:
30649385
22.

Phase II Study of Weekly Paclitaxel with Trastuzumab and Pertuzumab in Patients with Human Epidermal Growth Receptor 2 Overexpressing Metastatic Breast Cancer: 5-Year Follow-up.

Wang R, Smyth LM, Iyengar N, Chandarlapaty S, Modi S, Jochelson M, Patil S, Norton L, Hudis CA, Dang CT.

Oncologist. 2019 Aug;24(8):e646-e652. doi: 10.1634/theoncologist.2018-0512. Epub 2019 Jan 2.

PMID:
30602614
23.

Reply to "Multicentric Ipsilateral Invasive Breast Carcinomas Might Have Higher 21-Gene Recurrence Score Compared with Multifocal Ipsilateral Invasive Breast Carcinomas".

Grabenstetter A, Brogi E, Chou J, Morrow M, Dickler M, Norton L, Wen H.

Ann Surg Oncol. 2019 Jan;26(1):310-311. doi: 10.1245/s10434-018-7078-1. Epub 2018 Nov 19. No abstract available.

PMID:
30456683
24.

Effect of Community Health Worker Support on Clinical Outcomes of Low-Income Patients Across Primary Care Facilities: A Randomized Clinical Trial.

Kangovi S, Mitra N, Norton L, Harte R, Zhao X, Carter T, Grande D, Long JA.

JAMA Intern Med. 2018 Dec 1;178(12):1635-1643. doi: 10.1001/jamainternmed.2018.4630.

PMID:
30422224
25.

Practice Standards for the Emergency Nurse Practitioner Specialty.

Campo TM, Comer A, Dowling Evans D, Kincaid K, Norton L, Ramirez EG, Roberts E, Smith A, Stackhouse K, Wilbeck J.

Adv Emerg Nurs J. 2018 Oct/Dec;40(4):240-245. doi: 10.1097/TME.0000000000000209. No abstract available.

PMID:
30365437
26.

Research challenges for cultural ecosystem services and public health in (peri-)urban environments.

Chen X, de Vries S, Assmuth T, Dick J, Hermans T, Hertel O, Jensen A, Jones L, Kabisch S, Lanki T, Lehmann I, Maskell L, Norton L, Reis S.

Sci Total Environ. 2019 Feb 15;651(Pt 2):2118-2129. doi: 10.1016/j.scitotenv.2018.09.030. Epub 2018 Sep 5. Review.

27.

Multifocal/Multicentric Ipsilateral Invasive Breast Carcinomas with Similar Histology: Is Multigene Testing of All Individual Foci Necessary?

Grabenstetter A, Brogi E, Chou JF, Morrow M, Dickler M, Norton L, Wen HY.

Ann Surg Oncol. 2019 Feb;26(2):329-335. doi: 10.1245/s10434-018-6866-y. Epub 2018 Oct 8.

PMID:
30298311
28.

Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer.

Chen F, Ma K, Madajewski B, Zhuang L, Zhang L, Rickert K, Marelli M, Yoo B, Turker MZ, Overholtzer M, Quinn TP, Gonen M, Zanzonico P, Tuesca A, Bowen MA, Norton L, Subramony JA, Wiesner U, Bradbury MS.

Nat Commun. 2018 Oct 8;9(1):4141. doi: 10.1038/s41467-018-06271-5.

29.

Meta-Analysis of Gypsum Effects on Crop Yields and Chemistry of Soils, Plant Tissues, and Vadose Water at Various Research Sites in the USA.

Kost D, Ladwig KJ, Chen L, DeSutter TM, Espinoza L, Norton LD, Smeal D, Torbert HA, Watts DB, Wolkowski RP, Dick WA.

J Environ Qual. 2018 Sep;47(5):1284-1292. doi: 10.2134/jeq2018.04.0163.

PMID:
30272800
30.

Effect of Chronic Hyperglycemia on Glucose Metabolism in Subjects With Normal Glucose Tolerance.

Shannon C, Merovci A, Xiong J, Tripathy D, Lorenzo F, McClain D, Abdul-Ghani M, Norton L, DeFronzo RA.

Diabetes. 2018 Dec;67(12):2507-2517. doi: 10.2337/db18-0439. Epub 2018 Sep 13.

31.

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.

Razavi P, Chang MT, Xu G, Bandlamudi C, Ross DS, Vasan N, Cai Y, Bielski CM, Donoghue MTA, Jonsson P, Penson A, Shen R, Pareja F, Kundra R, Middha S, Cheng ML, Zehir A, Kandoth C, Patel R, Huberman K, Smyth LM, Jhaveri K, Modi S, Traina TA, Dang C, Zhang W, Weigelt B, Li BT, Ladanyi M, Hyman DM, Schultz N, Robson ME, Hudis C, Brogi E, Viale A, Norton L, Dickler MN, Berger MF, Iacobuzio-Donahue CA, Chandarlapaty S, Scaltriti M, Reis-Filho JS, Solit DB, Taylor BS, Baselga J.

Cancer Cell. 2018 Sep 10;34(3):427-438.e6. doi: 10.1016/j.ccell.2018.08.008.

32.

Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors.

Pareja F, Brandes AH, Basili T, Selenica P, Geyer FC, Fan D, Da Cruz Paula A, Kumar R, Brown DN, Gularte-Mérida R, Alemar B, Bi R, Lim RS, de Bruijn I, Fujisawa S, Gardner R, Feng E, Li A, da Silva EM, Lozada JR, Blecua P, Cohen-Gould L, Jungbluth AA, Rakha EA, Ellis IO, Edelweiss MIA, Palazzo J, Norton L, Hollmann T, Edelweiss M, Rubin BP, Weigelt B, Reis-Filho JS.

Nat Commun. 2018 Aug 30;9(1):3533. doi: 10.1038/s41467-018-05886-y.

33.

Comparison of Reduced-Volume High-Intensity Interval Training and High-Volume Training on Endurance Performance in Triathletes.

Mallol M, Bentley DJ, Norton L, Norton K, Mejuto G, Yanci J.

Int J Sports Physiol Perform. 2019 Feb 1;14(2):239-245. doi: 10.1123/ijspp.2018-0359. Epub 2019 Jan 2.

PMID:
30080432
34.

Comparison of Pharmacy Claims and Electronic Pill Bottles for Measurement of Medication Adherence Among Myocardial Infarction Patients.

Mehta SJ, Asch DA, Troxel AB, Lim R, Lewey J, Wang W, Zhu J, Norton L, Marcus N, Volpp KG.

Med Care. 2019 Feb;57(2):e9-e14. doi: 10.1097/MLR.0000000000000950.

PMID:
30045159
35.

4th ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)†.

Cardoso F, Senkus E, Costa A, Papadopoulos E, Aapro M, André F, Harbeck N, Aguilar Lopez B, Barrios CH, Bergh J, Biganzoli L, Boers-Doets CB, Cardoso MJ, Carey LA, Cortés J, Curigliano G, Diéras V, El Saghir NS, Eniu A, Fallowfield L, Francis PA, Gelmon K, Johnston SRD, Kaufman B, Koppikar S, Krop IE, Mayer M, Nakigudde G, Offersen BV, Ohno S, Pagani O, Paluch-Shimon S, Penault-Llorca F, Prat A, Rugo HS, Sledge GW, Spence D, Thomssen C, Vorobiof DA, Xu B, Norton L, Winer EP.

Ann Oncol. 2018 Aug 1;29(8):1634-1657. doi: 10.1093/annonc/mdy192. No abstract available.

36.

Agreement between pre-exercise screening questionnaires completed online versus face-to-face.

Norton L, Thomas J, Bevan N, Norton K.

PLoS One. 2018 Jun 26;13(6):e0199836. doi: 10.1371/journal.pone.0199836. eCollection 2018.

37.

Improving Guideline-Based Streptococcal Pharyngitis Testing: A Quality Improvement Initiative.

Norton LE, Lee BR, Harte L, Mann K, Newland JG, Grimes RA, Myers AL.

Pediatrics. 2018 Jul;142(1). pii: e20172033. doi: 10.1542/peds.2017-2033. Epub 2018 Jun 20.

38.

Geomorphology-based unit hydrograph models for flood risk management: case study in Brazilian watersheds with contrasting physiographic characteristics.

Beskow S, Nunes GS, Mello CR, Caldeira TL, Norton LD, Steinmetz AA, Vargas MM, Ávila LF.

An Acad Bras Cienc. 2018 Apr-Jun;90(2):1873-1890. doi: 10.1590/0001-3765201820170430. Epub 2018 May 21.

39.

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas.

Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, Edelweiss M, Wen HC, Piscuoglio S, Schultheis AM, Martelotto LG, Pareja F, Kumar R, Brandes A, Fan D, Basili T, Da Cruz Paula A, Lozada JR, Blecua P, Muenst S, Jungbluth AA, Foschini MP, Wen HY, Brogi E, Palazzo J, Rubin BP, Ng CKY, Norton L, Varga Z, Ellis IO, Rakha EA, Chandarlapaty S, Weigelt B, Reis-Filho JS.

Nat Commun. 2018 May 8;9(1):1816. doi: 10.1038/s41467-018-04128-5.

40.

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.

Mattos-Arruda L, Weigelt B, Cortes J, Won HH, Ng CKY, Nuciforo P, Bidard FC, Aura C, Saura C, Peg V, Piscuoglio S, Oliveira M, Smolders Y, Patel P, Norton L, Tabernero J, Berger MF, Seoane J, Reis-Filho JS.

Ann Oncol. 2018 Nov 1;29(11):2268. doi: 10.1093/annonc/mdx804. No abstract available.

PMID:
29718117
41.

Phase II Study of Paclitaxel and Dasatinib in Metastatic Breast Cancer.

Morris PG, Rota S, Cadoo K, Zamora S, Patil S, D'Andrea G, Gilewski T, Bromberg J, Dang C, Dickler M, Modi S, Seidman AD, Sklarin N, Norton L, Hudis CA, Fornier MN.

Clin Breast Cancer. 2018 Oct;18(5):387-394. doi: 10.1016/j.clbc.2018.03.010. Epub 2018 Mar 15.

42.

Long-term tracking of biodiversity is more important than ever.

Norton L.

Nature. 2018 Apr;556(7701):309. doi: 10.1038/d41586-018-04626-y. No abstract available.

PMID:
29670270
43.

Gender equality in academic science.

Norton L.

FEBS Lett. 2018 May;592(9):1461-1463. doi: 10.1002/1873-3468.13056. Epub 2018 Apr 27. No abstract available.

44.

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding.

Martyn GE, Wienert B, Yang L, Shah M, Norton LJ, Burdach J, Kurita R, Nakamura Y, Pearson RCM, Funnell APW, Quinlan KGR, Crossley M.

Nat Genet. 2018 Apr;50(4):498-503. doi: 10.1038/s41588-018-0085-0. Epub 2018 Apr 2.

PMID:
29610478
45.

Relationships between older adults' use of time and cardio-respiratory fitness, obesity and cardio-metabolic risk: A compositional isotemporal substitution analysis.

Dumuid D, Lewis LK, Olds TS, Maher C, Bondarenko C, Norton L.

Maturitas. 2018 Apr;110:104-110. doi: 10.1016/j.maturitas.2018.02.003. Epub 2018 Feb 7.

PMID:
29563028
46.

Changes in Physical Activity Behaviour and Health Risk Factors Following a Randomised Controlled Pilot Workplace Exercise Intervention.

Burn N, Norton LH, Drummond C, Ian Norton K.

AIMS Public Health. 2017 May 10;4(2):189-201. doi: 10.3934/publichealth.2017.2.189. eCollection 2017.

47.

The 21-Gene Recurrence Score in Male Breast Cancer.

Turashvili G, Gonzalez-Loperena M, Brogi E, Dickler M, Norton L, Morrow M, Wen HY.

Ann Surg Oncol. 2018 Jun;25(6):1530-1535. doi: 10.1245/s10434-018-6411-z. Epub 2018 Mar 8.

48.

The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.

Weigelt B, Bi R, Kumar R, Blecua P, Mandelker DL, Geyer FC, Pareja F, James PA; kConFab Investigators, Couch FJ, Eccles DM, Blows F, Pharoah P, Li A, Selenica P, Lim RS, Jayakumaran G, Waddell N, Shen R, Norton L, Wen HY, Powell SN, Riaz N, Robson ME, Reis-Filho JS, Chenevix-Trench G.

J Natl Cancer Inst. 2018 Sep 1;110(9):1030-1034. doi: 10.1093/jnci/djy028.

49.

The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.

Chen X, Ayala I, Shannon C, Fourcaudot M, Acharya NK, Jenkinson CP, Heikkinen S, Norton L.

Diabetes. 2018 Apr;67(4):554-568. doi: 10.2337/db17-0318. Epub 2018 Jan 9.

50.

Breast carcinoma with 21-gene recurrence score lower than 18: rate of locoregional recurrence in a large series with clinical follow-up.

Turashvili G, Brogi E, Morrow M, Dickler M, Norton L, Hudis C, Wen HY.

BMC Cancer. 2018 Jan 6;18(1):42. doi: 10.1186/s12885-017-3985-y.

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