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Items: 22

1.

LTA1 and dmLT enterotoxin-based proteins activate antigen-presenting cells independent of PKA and despite distinct cell entry mechanisms.

Valli E, Baudier RL, Harriett AJ, Norton EB.

PLoS One. 2020 Jan 13;15(1):e0227047. doi: 10.1371/journal.pone.0227047. eCollection 2020.

2.

Human Cytomegalovirus Alters Host Cell Mitochondrial Function during Acute Infection.

Combs JA, Norton EB, Saifudeen ZR, Bentrup KHZ, Katakam PV, Morris CA, Myers L, Kaur A, Sullivan DE, Zwezdaryk KJ.

J Virol. 2020 Jan 6;94(2). pii: e01183-19. doi: 10.1128/JVI.01183-19. Print 2020 Jan 6.

PMID:
31694945
3.

LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice.

Valli E, Harriett AJ, Nowakowska MK, Baudier RL, Provosty WB, McSween Z, Lawson LB, Nakanishi Y, Norton EB.

Sci Rep. 2019 Oct 22;9(1):15128. doi: 10.1038/s41598-019-51356-w.

4.

Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli.

Maciel M Jr, Bauer D, Baudier RL, Bitoun J, Clements JD, Poole ST, Smith MA, Kaminski RW, Savarino SJ, Norton EB.

Infect Immun. 2019 Oct 18;87(11). pii: e00460-19. doi: 10.1128/IAI.00460-19. Print 2019 Nov.

PMID:
31427449
5.

Altered responses to pneumococcal vaccination in an elderly diabetic Japanese vaccine trial: The risk of concurrent vaccination strategies.

Norton EB.

J Diabetes Complications. 2019 Mar;33(3):189-190. doi: 10.1016/j.jdiacomp.2018.12.007. Epub 2018 Dec 21. No abstract available.

PMID:
30651178
6.

The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT.

Clements JD, Norton EB.

mSphere. 2018 Jul 25;3(4). pii: e00215-18. doi: 10.1128/mSphere.00215-18. Review.

7.

Evaluating the A-Subunit of the Heat-Labile Toxin (LT) As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC).

Norton EB, Branco LM, Clements JD.

PLoS One. 2015 Aug 25;10(8):e0136302. doi: 10.1371/journal.pone.0136302. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138938.

8.

The novel adjuvant dmLT promotes dose sparing, mucosal immunity and longevity of antibody responses to the inactivated polio vaccine in a murine model.

Norton EB, Bauer DL, Weldon WC, Oberste MS, Lawson LB, Clements JD.

Vaccine. 2015 Apr 15;33(16):1909-15. doi: 10.1016/j.vaccine.2015.02.069. Epub 2015 Mar 9.

9.

Serum and mucosal antibody responses to inactivated polio vaccine after sublingual immunization using a thermoresponsive gel delivery system.

White JA, Blum JS, Hosken NA, Marshak JO, Duncan L, Zhu C, Norton EB, Clements JD, Koelle DM, Chen D, Weldon WC, Oberste MS, Lal M.

Hum Vaccin Immunother. 2014;10(12):3611-21. doi: 10.4161/hv.32253.

10.

Simultaneous exposure to Escherichia coli heat-labile and heat-stable enterotoxins increases fluid secretion and alters cyclic nucleotide and cytokine production by intestinal epithelial cells.

Read LT, Hahn RW, Thompson CC, Bauer DL, Norton EB, Clements JD.

Infect Immun. 2014 Dec;82(12):5308-16. doi: 10.1128/IAI.02496-14. Epub 2014 Oct 6.

11.

Mesenchymal stem cells as a novel vaccine platform.

Tomchuck SL, Norton EB, Garry RF, Bunnell BA, Morris CA, Freytag LC, Clements JD.

Front Cell Infect Microbiol. 2012 Nov 16;2:140. doi: 10.3389/fcimb.2012.00140. eCollection 2012.

12.

The A subunit of Escherichia coli heat-labile enterotoxin functions as a mucosal adjuvant and promotes IgG2a, IgA, and Th17 responses to vaccine antigens.

Norton EB, Lawson LB, Mahdi Z, Freytag LC, Clements JD.

Infect Immun. 2012 Jul;80(7):2426-35. doi: 10.1128/IAI.00181-12. Epub 2012 Apr 23.

13.

Impact of primary influenza infection on the immune response to secondary bacterial infection in aged mice.

Cross RW, Betancourt AM, Schur MJ, Norton EB, Roy D, Hartley T, Voss TG.

Influenza Other Respir Viruses. 2011 May;5(Suppl 1):198-201.

14.

Defending the mucosa: adjuvant and carrier formulations for mucosal immunity.

Lawson LB, Norton EB, Clements JD.

Curr Opin Immunol. 2011 Jun;23(3):414-20. doi: 10.1016/j.coi.2011.03.009. Epub 2011 Apr 19. Review.

PMID:
21511452
15.

Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.

Norton EB, Lawson LB, Freytag LC, Clements JD.

Clin Vaccine Immunol. 2011 Apr;18(4):546-51. doi: 10.1128/CVI.00538-10. Epub 2011 Feb 2.

16.

Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model.

Norton EB, Clements JD, Voss TG, Cárdenas-Freytag L.

J Virol. 2010 Mar;84(6):2983-95. doi: 10.1128/JVI.01805-09. Epub 2010 Jan 6.

17.

Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.

Yamashita A, Norton EB, Kaplan JA, Niu C, Loganzo F, Hernandez R, Beyer CF, Annable T, Musto S, Discafani C, Zask A, Ayral-Kaloustian S.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5317-22.

PMID:
15454219
18.

Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV.

Bloom JD, Dushin RG, Curran KJ, Donahue F, Norton EB, Terefenko E, Jones TR, Ross AA, Feld B, Lang SA, DiGrandi MJ.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3401-6.

PMID:
15177441
19.

Clinical predictors of bloodstream infections and mortality in hospitalized Malawian children.

Norton EB, Archibald LK, Nwanyanwu OC, Kazembe PN, Dobbie H, Reller LB, Jarvis WR, Jason J.

Pediatr Infect Dis J. 2004 Feb;23(2):145-51; discussion 151-5.

PMID:
14872181
20.

Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV.

Bloom JD, DiGrandi MJ, Dushin RG, Curran KJ, Ross AA, Norton EB, Terefenko E, Jones TR, Feld B, Lang SA.

Bioorg Med Chem Lett. 2003 Sep 1;13(17):2929-32.

PMID:
14611860
21.

Use of bis-(chiral alpha-methylbenzyl)glycine esters for synthesis of enantiopure beta-hydroxyamino esters.

Yamashita A, Norton EB, Williamson RT, Ho DM, Sinishtaj S, Mansour TS.

Org Lett. 2003 Sep 4;5(18):3305-8.

PMID:
12943413
22.

5-Aminolaevulinic acid dehydratase: metals, mutants and mechanism.

Shoolingin-Jordan PM, Spencer P, Sarwar M, Erskine PE, Cheung KM, Cooper JB, Norton EB.

Biochem Soc Trans. 2002 Aug;30(4):584-90. Review.

PMID:
12196142

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